Best TWAS P=1.62e-10 · Best GWAS P=1.84e-11 conditioned to 6.95e-06
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ARFGEF2 | 0.09 | 0.05 | lasso | 8 | 0.10 | 9.2e-13 | -6.3 | 6.4 | 1.6e-10 | -0.41 | 0.04 | 0.96 | TRUE |
| 2 | GTEx | Colon Sigmoid | CSE1L | 0.18 | 0.12 | lasso | 11 | 0.09 | 4.4e-04 | -5.1 | 5.1 | 2.7e-07 | -0.48 | 0.48 | 0.30 | FALSE |
| 3 | GTEx | Skin Not Sun Exposed Suprapubic | ZFAS1 | 0.16 | 0.04 | enet | 19 | 0.07 | 1.0e-04 | -2.7 | -5.4 | 5.1e-08 | 0.48 | 0.07 | 0.84 | FALSE |
| 4 | GTEx | Skin Sun Exposed Lower leg | CSE1L | 0.08 | 0.03 | lasso | 2 | 0.03 | 9.5e-04 | -5.5 | 5.1 | 2.9e-07 | -0.45 | 0.49 | 0.12 | FALSE |
| 5 | GTEx | Skin Sun Exposed Lower leg | ZFAS1 | 0.07 | 0.03 | enet | 14 | 0.05 | 5.8e-05 | -5.8 | -6.0 | 1.8e-09 | 0.55 | 0.37 | 0.51 | FALSE |
| 6 | GTEx | Testis | ARFGEF2 | 0.20 | 0.20 | lasso | 7 | 0.24 | 5.4e-11 | -4.1 | 5.4 | 5.0e-08 | -0.51 | 0.20 | 0.80 | FALSE |
| 7 | METSIM | Adipose | ARFGEF2 | 0.04 | 0.03 | lasso | 12 | 0.02 | 9.8e-05 | -6.2 | 5.6 | 1.7e-08 | -0.50 | 0.18 | 0.80 | FALSE |
| 8 | NTR | Blood | SNORD12B | 0.03 | 0.05 | lasso | 8 | 0.05 | 1.9e-14 | -5.8 | 5.9 | 3.8e-09 | -0.51 | 0.42 | 0.58 | FALSE |
| 9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ARFGEF2 | 0.05 | 0.04 | lasso | 5 | 0.05 | 3.2e-06 | -6.3 | 6.3 | 2.6e-10 | -0.58 | 0.04 | 0.96 | FALSE |
| 10 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | C20orf199 | 0.05 | 0.06 | lasso | 4 | 0.06 | 1.0e-04 | -5.8 | -5.8 | 8.2e-09 | 0.51 | 0.00 | 0.96 | FALSE |