Hub : Genes

ZFAS1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.064	0.032	6.1e-03	0.051	NA	0.030	NA	0.026	1.1e-04	NA	2.6e-03	NA	4.7e-03
2	GTEx	Esophagus Mucosa	0.154	0.048	1.1e-04	0.005	NA	0.008	NA	0.006	1.3e-01	NA	8.9e-02	NA	1.2e-01
3	GTEx	Skin Not Sun Exposed Suprapubic	0.163	0.053	8.8e-05	0.038	NA	0.071	NA	0.018	3.5e-03	NA	1.0e-04	NA	3.3e-02
4	GTEx	Skin Sun Exposed Lower leg	0.073	0.031	2.5e-03	0.031	NA	0.050	NA	0.048	1.3e-03	NA	5.8e-05	NA	7.6e-05
5	GTEx	Whole Blood	0.072	0.025	4.7e-05	0.059	NA	0.048	NA	0.053	3.6e-06	NA	3.0e-05	NA	1.2e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	1.4	2.2	4.7	1.4	-1.1	-1.1	-2.2	-1.4
Bipolar Disorder or Schizophrenia	0.2	0.4	1.8	-0.1	-0.0	1.3	-0.1	-0.5
Depressed Affect (Nagel 2018)	1.0	2.1	4.7	-1.2	0.6	2.0	2.2	0.3
Depression (Nagel 2018)	5.3	7.9	17.4	-0.6	2.4	4.2	3.9	0.8
Intelligence (Savage-Jansen 2018)	3.6	11.0	23.1	-1.8	2.4	4.8	4.7	-0.9
Neuroticism (Nagel 2018)	0.5	1.3	2.9	-1.2	-0.9	1.7	1.0	0.1
Schizophrenia (2018)	1.2	2.4	6.8	-1.3	0.8	2.6	1.7	0.5
Schizophrenia vs Biploar Disorder	4.0	5.3	6.6	-2.4	2.0	2.6	2.5	1.9
Worry (Nagel 2018)	0.7	1.5	4.5	-0.9	-0.9	2.1	1.0	0.6
Alzheimer’s Disease (in mother)	0.2	0.2	0.5	-0.4	0.6	0.1	0.2	0.7
Alzheimer’s Disease (in father)	2.6	2.8	9.3	0.3	1.1	3.0	1.5	-1.1
Alzheimer’s Disease (including proxy)	1.1	1.5	5.4	0.1	1.2	2.3	0.8	0.4
Crohns Disease (2017)	0.3	0.6	1.8	-0.7	-0.2	0.4	-0.8	1.3
Irritable Bowel Disease (IBD)	0.2	0.6	2.1	0.1	0.6	1.4	-0.0	0.7
Ulcerative Colitis (UC)	0.8	1.6	4.3	0.9	1.4	2.1	0.9	-0.2
Major Depression (MDD)	1.3	1.6	4.0	0.8	0.6	2.0	1.3	-1.2
Reaction Time	2.7	5.1	12.8	-0.6	1.5	3.6	3.2	0.0
Verbal and Numeric Reasoning (VNR)	4.0	9.6	20.4	-2.5	1.5	4.5	4.4	-0.0
Breast Cancer	0.1	0.3	1.1	-0.6	-1.0	-0.3	-0.1	-0.4
Ovarian Cancer	1.5	1.9	4.7	0.1	1.0	1.4	2.2	-1.5
Prostate Cancer	0.4	0.6	1.5	0.8	-0.3	-0.4	-0.8	-1.2
Age at First Birth	0.8	1.1	1.9	-0.0	1.4	1.0	1.1	1.2
Bipolar Disorder (2011)	0.6	0.6	1.8	0.1	-0.4	0.2	-1.3	0.9
Body Mass Index (BMI) (2010)	4.1	5.6	11.8	-2.3	-2.2	-3.4	-1.7	1.8
Coronary Artery Disease (CAD)	1.1	1.3	2.1	-0.2	-1.4	-1.5	-1.5	-0.2
Crohns Disease (2012)	0.7	1.1	3.3	-1.0	-1.8	-0.6	-0.5	0.7
Mean Putamen Volume	1.4	1.6	5.3	-1.2	-2.3	-1.2	-0.2	0.1
Fasting Glucose	1.9	2.3	4.1	-1.1	-1.7	-2.0	-1.7	0.8
HbA1C	0.6	0.6	1.3	1.1	-0.1	-1.1	-0.1	-0.7
HDL Cholesterol	0.7	1.2	2.4	1.0	-0.2	-1.4	-1.5	-1.0
LDL Cholesterol	0.9	1.4	3.6	-1.6	-1.9	0.4	0.6	0.1
Lupus	0.2	0.4	1.5	0.4	1.2	-0.2	0.3	0.2
Neuroticism (2016)	0.5	0.7	1.5	-0.7	0.8	0.8	1.2	-0.3
Primary Biliary Cirrhosis	0.2	0.3	0.7	-0.3	-0.8	-0.8	-0.6	-0.1
Rheumatoid Arthritis	1.4	1.9	5.1	0.3	-2.3	-0.6	-2.0	-0.1
Schizophrenia (2014)	1.4	3.0	7.5	-1.5	1.1	2.7	1.9	0.9
Triglycerides	1.1	1.8	5.1	-2.3	-1.5	-0.5	-0.2	1.1
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.4	0.6	-0.0	0.4	-0.6	-0.4
Ulcerative Colitis	1.0	1.5	3.3	1.8	0.5	1.3	0.2	-1.5
Blood Eosinophil Count	0.3	2.6	4.5	1.2	1.4	2.1	1.7	-1.4
Blood Platelet Count	0.6	6.5	11.4	1.4	-2.2	-2.0	-3.2	-3.4
Blood Red Count	0.6	6.0	17.6	1.1	2.4	4.2	2.0	-1.3
Blood White Count	0.3	2.1	5.5	-2.4	-0.1	-0.8	-0.8	1.9
Heel T-Score	0.6	4.4	10.7	-1.0	-3.3	-1.7	-2.6	-0.7
BMI	3.9	22.5	46.5	-3.9	-4.4	-5.3	-6.8	2.0
Height	6.9	133.3	193.2	10.1	12.6	10.7	13.9	-9.9
Waist Hip Ratio (WHR)	0.4	1.8	5.7	-0.2	1.2	1.3	2.4	0.3
Systolic Blood Pressure	2.3	11.3	30.3	-2.4	-2.1	-5.5	-2.7	2.9
Smoking Status	1.5	3.6	10.4	-1.1	1.4	0.9	3.2	1.9
Allergy or Eczema	0.6	1.7	4.5	-1.7	0.1	2.1	0.9	0.6
Cardiovascular Disease	1.0	3.4	7.6	-2.5	-0.7	-1.6	-0.6	2.8
Hypothyroidism (self reported)	0.6	1.4	3.2	0.4	1.4	0.7	1.8	-1.0
Respiratory disease	1.5	3.4	8.8	1.1	2.3	3.0	1.3	0.3
Type 2 Diabetes (T2D) (2018)	0.7	1.3	2.1	-1.5	-1.0	-1.3	-0.3	1.3
Lung FEV1/FVC ratio	1.6	8.0	19.9	-1.2	-3.6	-4.5	-2.4	0.2
Lung FVC	3.7	19.1	32.7	2.9	5.7	4.7	5.5	-1.4
Neuroticism	0.8	2.0	4.5	-1.1	-0.8	2.1	1.9	-0.1
Chronotype (morning person)	0.5	1.2	1.8	1.3	0.9	1.2	1.0	-0.8
Hair Pigment	0.3	9.3	18.8	1.7	2.9	3.9	4.3	-1.2
Tanning	0.2	2.7	5.1	1.1	1.6	2.2	1.8	-1.1
Hand grip strength (left)	2.1	5.6	7.9	1.8	2.8	2.5	2.7	-1.8
Number of treatments/medications taken	1.3	2.3	5.4	-2.1	-0.6	-1.0	-0.5	2.3
Average weekly spirits intake	0.3	0.4	0.7	-0.5	-0.9	0.5	0.7	-0.5
Sensitivity / hurt feelings	0.4	0.7	1.9	-0.8	-1.4	0.2	-0.8	0.0
Frequency of depressed mood in last 2 weeks	7.0	9.8	25.9	-1.2	2.2	5.1	4.0	0.9
Hearing difficulty/problems: Yes	1.0	1.5	3.5	-0.3	0.7	1.7	1.9	0.5
Relative age of first facial hair	0.4	0.8	2.1	1.1	0.4	-0.4	-1.4	-0.6
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.4	-1.2	-0.7	-1.2	1.0	0.5
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.1	0.6	0.6	-1.0	-0.8	0.1
Ever had hysterectomy (womb removed)	0.1	0.1	0.2	0.0	0.5	0.1	0.3	-0.1
Systolic blood pressure, automated reading	1.4	4.1	12.2	-1.2	-1.3	-3.5	-1.8	1.3
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	0.2	-0.0	0.2	0.2	-0.4
Angina	0.5	0.6	1.5	-1.2	-0.6	-0.8	-0.6	0.2
Medication for hormone replacement therapy	1.2	1.4	2.5	-1.6	-0.2	-1.2	-1.3	1.1
Vitamin and mineral supplements	1.0	1.3	2.9	-0.4	-1.2	-1.7	-1.4	0.2
Supplements: Zinc	1.3	1.4	2.1	-1.5	-0.8	1.4	1.1	1.0
Medication: Co-codamol	0.4	0.4	1.1	0.4	0.6	0.6	1.0	0.1
Medication: Metformin	1.2	1.7	2.7	-1.6	-1.3	-1.4	-0.2	1.4
Diabetes (father)	0.9	1.1	2.8	-0.5	-1.0	-1.7	-1.1	0.5
Diabetes (mother)	0.9	1.1	2.4	0.2	-1.2	-0.2	-1.6	-1.2
Severe depression (siblings)	0.6	0.7	1.9	-0.5	-0.5	-0.1	-1.4	-1.0
Pack years adult smoking proportion	0.1	0.1	0.4	-0.1	-0.3	0.1	-0.6	-0.3
Impedance of leg (right)	0.1	0.6	3.0	0.1	-1.7	0.1	0.0	-0.2
Leg fat-free mass (left)	1.0	5.2	8.9	1.9	3.0	1.7	1.7	-2.8
Trunk fat percentage	3.2	12.9	20.8	-3.2	-3.5	-4.1	-4.6	2.2
Hand grip strength (right)	2.8	7.7	12.8	1.6	3.0	2.9	3.6	-2.4
Townsend deprivation index at recruitment	0.4	0.5	1.0	-1.0	1.0	-0.5	-0.0	0.7
Current tobacco smoking	0.2	0.3	0.6	0.4	0.8	-0.6	0.7	-0.0
Average weekly fortified wine intake	0.7	0.8	1.5	0.7	0.6	0.7	1.2	-1.1
Maternal smoking around birth	0.5	0.7	1.3	0.0	1.0	1.1	1.0	-0.6
Fed-up feelings	0.6	1.1	2.0	-0.7	0.3	1.4	1.4	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	3.2	4.3	8.1	-1.0	2.1	2.8	2.7	0.7
Relative age voice broke	0.4	0.6	2.2	-0.3	-0.6	-0.4	-1.5	0.6
Taking other prescription medications	0.5	0.8	3.6	-0.7	0.1	-0.1	-0.1	1.9
Age when periods started (menarche)	0.4	0.9	2.4	-0.6	-1.6	-0.6	-0.9	0.5
Bilateral oophorectomy (both ovaries removed)	1.6	1.8	3.2	-0.9	1.7	0.1	1.4	1.8
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	3.4	-0.2	-1.7	-0.8	-1.8	-0.5
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	3.5	1.9	-0.3	-0.0	-0.5	-1.4
Qualifications: CSEs or equivalent	0.3	0.4	0.7	0.6	-0.6	0.0	-0.8	-0.8
Serious illness, injury or assault to yourself	0.4	0.5	1.6	-0.7	0.4	-0.0	1.3	-0.3
High blood pressure	1.7	4.7	11.9	-2.1	-0.7	-2.3	-1.1	3.4
Hayfever, allergic rhinitis or eczema	0.5	1.1	3.6	-1.9	-0.9	0.5	-0.7	0.6
Multivitamins +/- minerals	0.4	0.5	1.4	-1.2	-0.1	0.7	0.5	0.7
Stomach or abdominal pain in last month	0.2	0.3	1.3	-0.2	0.1	-1.1	-0.1	0.0
Supplements: Glucosamine	0.4	0.5	1.3	-1.1	-0.5	-0.3	0.5	0.7
Diverticular disease/diverticulitis (self-reported)	1.5	1.7	3.5	-0.6	-1.8	-1.9	-0.8	0.9
Medication: Atenolol	1.1	1.4	3.3	0.1	-0.9	-1.8	-1.7	-0.0
Medication: Levothyroxine sodium	1.8	3.0	6.2	1.3	1.8	1.5	2.5	-1.2
Sitting height	5.1	36.4	65.4	3.4	7.0	6.8	8.1	-3.2
Chronic bronchitis/emphysema (father)	1.1	1.3	1.8	1.3	-0.7	-1.4	-1.4	-0.7
High blood pressure (mother)	3.4	4.8	6.2	-2.5	-1.9	-2.4	-2.1	1.9
Body mass index (BMI)	3.7	15.6	26.2	-3.6	-3.5	-4.6	-5.1	2.3
Impedance of leg (left)	0.1	0.5	2.2	-0.0	-1.5	0.0	0.2	0.3
Leg predicted mass (left)	1.0	5.3	9.1	1.9	3.0	1.6	1.8	-2.8
Trunk fat mass	1.2	4.9	8.6	-2.0	-1.7	-2.9	-2.9	1.0
Waist circumference	1.0	3.5	5.5	-2.2	-1.4	-2.3	-2.1	0.9
Number of incorrect matches in round	0.5	0.9	2.4	-0.7	0.2	-0.8	-0.9	1.5
Past tobacco smoking	3.4	6.2	12.4	2.9	0.1	-0.7	-3.1	-3.5
Alcohol usually taken with meals	0.4	0.7	2.9	-0.7	-0.1	0.3	0.4	1.7
Nervous feelings	0.7	1.4	4.6	1.1	-0.2	2.1	0.6	-0.8
Frequency of tenseness / restlessness in last 2 weeks	2.0	3.1	12.7	0.1	1.0	3.6	1.2	-0.5
Hearing difficulty/problems with background noise	3.4	5.4	14.3	0.4	1.9	3.8	3.0	0.1
Hair/balding pattern: Pattern 2	0.4	0.6	1.4	-0.8	-0.7	0.3	0.3	1.2
Had menopause	1.1	1.3	3.0	1.6	1.7	0.4	1.1	0.0
Had other major operations	1.8	2.2	3.9	-2.0	-1.7	-1.0	-1.5	0.9
Forced vital capacity (FVC)	11.4	43.7	64.3	5.5	8.0	7.3	7.4	-4.0
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	4.5	-0.1	-1.6	-1.5	-2.1	-0.8
Ever unenthusiastic/disinterested for a whole week	3.3	4.0	8.3	0.9	1.8	2.4	2.9	-1.5
Qualifications: None of the above	1.9	4.0	10.3	-1.2	-1.9	-3.2	-1.4	1.6
Financial difficulties in last 2 years	1.9	2.6	6.6	-2.6	-0.1	1.3	1.3	1.7
Mouth/teeth dental problems	0.6	1.0	2.4	0.9	0.9	0.8	1.5	-0.6
Heart attack	2.0	2.6	8.7	-1.4	-0.7	-2.9	-0.6	1.2
Allergy	0.4	0.9	2.4	0.9	-0.6	-1.6	0.4	-0.8
Pain all over the body in last month	1.1	1.1	3.0	-1.5	-1.7	-0.4	-0.4	0.3
Diabetes (self-reported)	0.8	1.2	3.2	-1.8	-0.3	-0.5	0.7	1.3
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	2.1	-0.8	-0.7	-1.5	-1.1	-0.1
Medication: Ramipril	1.8	2.4	3.2	-1.3	-1.8	-1.8	-1.5	1.2
Medication: Simvastatin	0.9	1.3	3.1	-1.0	-0.7	-1.3	-1.8	0.1
Fluid intelligence score	1.3	2.6	6.1	-1.7	0.5	2.5	1.8	0.7
Illnesses of siblings	0.4	0.6	1.4	0.4	-1.2	0.0	-0.3	-1.2
Neuroticism score	0.6	1.2	4.0	-0.4	-0.6	2.0	1.2	-0.3
Weight	0.1	0.4	1.2	-0.0	0.8	-0.4	-0.2	-1.1
Impedance of arm (right)	0.0	0.2	0.5	0.2	-0.7	0.4	-0.5	-0.0
Arm fat percentage (right)	5.5	21.5	35.9	-3.9	-4.3	-5.5	-6.0	2.9
Trunk fat-free mass	3.6	20.9	28.6	4.1	5.3	3.7	4.8	-4.8
Hip circumference	0.4	1.7	3.7	-1.3	-0.6	-1.7	-1.9	-0.2
Time employed in main current job	0.6	0.7	1.6	0.5	-0.8	-1.1	-1.3	-0.1
Alcohol intake versus 10 years previously	0.6	1.0	2.0	-1.4	0.0	-1.1	-0.2	1.2
Father’s age at death	1.0	1.3	3.1	-0.0	-0.8	-1.6	-1.8	-0.5
Worrier / anxious feelings	1.1	2.2	4.1	-1.7	-0.6	2.0	1.7	0.8
Frequency of tiredness / lethargy in last 2 weeks	5.3	8.7	18.9	-0.2	2.5	4.3	4.3	-0.2
Falls in the last year	2.6	3.6	6.1	-1.4	0.7	2.1	2.5	2.3
Hair/balding pattern: Pattern 3	1.1	1.6	2.9	0.7	1.2	1.7	1.2	-1.2
Number of live births	0.2	0.3	0.6	0.4	0.5	-0.8	0.4	0.5
Forced expiratory volume in 1-second (FEV1)	6.6	22.3	30.8	4.3	5.6	4.8	5.2	-3.4
Pulse rate	0.1	0.3	0.7	-0.8	-0.1	0.5	0.3	0.5
Happiness	8.6	10.5	25.8	1.3	3.5	5.1	3.5	-0.1
Noisy workplace	0.4	0.5	1.3	-0.6	-0.7	1.1	0.3	0.3
Qualifications: A levels/AS levels or equivalent	2.4	5.3	11.2	0.5	2.6	3.3	2.5	-1.4
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	0.9	-0.9	0.1	0.5	0.3	0.9
Mouth/teeth dental problems: Dentures	0.8	1.4	3.7	-1.8	0.2	-0.4	-0.3	1.9
Asthma	1.5	3.0	7.9	0.3	2.1	2.8	1.1	1.1
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	2.2	-1.3	-1.5	-0.2	-1.3	1.1
Medication: Cholesterol lowering	2.8	4.4	11.4	-3.4	-2.0	-1.2	-0.5	2.2
Depression (self-reported)	0.4	0.5	1.0	0.5	1.0	0.6	-0.2	-0.8
Medication: Lansoprazole	0.4	0.4	1.6	-0.5	0.2	0.4	0.2	1.3
Prospective memory result	0.7	0.8	4.2	-0.2	-0.1	-2.0	0.2	0.0
Lung cancer (father)	4.0	4.6	10.0	-2.5	1.5	1.3	1.6	3.2
Illnesses of mother	0.1	0.2	0.4	0.5	0.0	-0.5	0.1	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	6.3	20.1	25.2	4.3	5.0	4.8	4.7	-3.4
Pulse wave Arterial Stiffness index	0.9	1.1	3.3	1.1	0.8	-0.5	0.2	-1.8
Impedance of arm (left)	0.1	0.4	0.9	-0.5	-1.0	0.5	-0.3	0.5
Arm fat mass (right)	1.9	7.9	15.3	-2.3	-2.3	-3.4	-3.9	1.2
Trunk predicted mass	3.6	20.5	28.7	4.0	5.4	3.6	4.7	-4.8
Standing height	7.2	71.7	101.7	7.2	8.9	8.5	10.1	-7.3
Length of working week for main job	1.8	1.9	3.3	-1.1	-1.7	-1.2	-1.8	0.9
Exposure to tobacco smoke at home	1.2	1.3	3.3	-0.9	-1.8	-1.1	-0.8	0.8
Breastfed as a baby	0.2	0.3	0.6	-0.4	0.5	-0.3	0.8	0.5
Tense / ‘highly strung’	2.0	3.3	11.0	0.6	0.8	3.3	2.1	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.4	0.2	0.1	1.2	0.2	-0.7
Hair/balding pattern: Pattern 4	0.3	0.8	2.8	1.7	0.7	-0.7	-0.1	-0.2
Birth weight of first child	3.4	6.1	17.1	2.1	1.7	4.1	1.7	-1.8
Peak expiratory flow (PEF)	1.9	4.4	7.2	2.7	2.2	1.5	1.6	-2.2
Pulse wave reflection index	0.4	0.5	1.7	-0.2	-0.2	-1.3	0.2	-0.7
Ever highly irritable/argumentative for 2 days	3.1	3.7	10.1	-0.4	1.6	2.4	3.2	0.3
Loud music exposure frequency	0.3	0.4	1.0	0.3	-0.6	-0.6	-0.3	-1.0
Qualifications: O levels/GCSEs or equivalent	3.9	6.2	14.1	-0.4	3.1	3.8	2.4	0.9
Mouth/teeth dental problems: Bleeding gums	2.8	3.7	6.4	-1.6	-2.5	-1.9	-2.4	0.3
Blood clot in the leg (DVT)	1.0	1.3	4.3	1.2	0.2	0.7	0.4	-2.1
Medication: Paracetamol	1.1	1.8	3.8	-0.8	-1.9	-1.5	-1.0	1.2
Headache pain in last month	0.4	0.7	1.9	0.1	0.5	1.0	1.4	-0.6
Medication for cholesterol, blood pressure or diabetes	3.0	4.9	8.7	2.9	1.9	1.9	1.1	-2.7
Glaucoma (self-reported)	1.1	1.3	4.0	0.7	-0.6	-2.0	-1.2	-0.6
Gout (self-reported)	0.8	1.1	4.1	0.5	2.0	0.8	0.8	0.2
Hypothyroidism/myxoedema (self-reported)	1.2	2.3	3.1	1.6	1.7	0.0	1.7	-1.8
Medication: Amlodipine	0.7	1.0	2.0	0.2	1.4	0.1	1.0	1.4
Medication: Ventolin 100micrograms inhaler	0.6	0.8	2.2	1.0	0.8	1.5	0.2	-0.1
Birth weight	1.0	2.1	5.3	0.6	1.5	2.3	1.6	-0.5
Chronic bronchitis/emphysema (mother)	0.5	0.6	0.9	-0.9	-1.0	0.9	-0.4	0.5
High blood pressure (siblings)	0.6	0.9	2.8	-0.4	1.0	0.3	-0.5	1.7
Forced vital capacity (FVC), Best measure	10.8	39.6	55.7	5.2	7.5	7.2	6.8	-4.0
Body fat percentage	4.7	18.4	28.9	-3.7	-4.2	-5.0	-5.4	2.6
Leg fat percentage (right)	5.6	20.5	30.4	-3.5	-4.8	-5.5	-5.5	2.5
Arm fat-free mass (right)	1.9	9.8	14.6	2.6	3.8	2.5	3.2	-3.3
Exposure to tobacco smoke outside home	1.7	2.3	6.3	0.4	-1.4	-0.1	-2.5	-1.8
Comparative body size at age 10	0.2	0.6	1.8	0.5	0.4	0.7	-1.3	0.3
Number of full brothers	1.7	2.2	5.6	-2.0	0.8	0.7	0.5	2.4
Worry too long after embarrassment	0.5	0.9	1.5	1.0	-1.2	0.6	-0.4	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	3.8	-0.3	0.1	1.9	0.4	0.5
Wheeze or whistling in the chest in last year	0.5	0.9	1.6	-1.0	-0.8	-0.6	-1.0	1.3
Number of children fathered	6.2	7.0	14.2	-2.1	-2.7	-3.8	-2.5	1.7
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.1	2.9	-1.7	-0.8	-1.0	-0.5	1.0
Age at first live birth	0.3	0.5	1.1	-0.4	-1.1	-0.5	-0.9	-0.1
Pulse wave peak to peak time	0.5	0.6	1.9	-0.6	-0.2	0.9	0.2	1.4
Health satisfaction	0.6	0.8	2.3	-1.0	-0.1	0.6	0.4	1.5
Shortness of breath walking on level ground	0.7	0.8	2.0	0.8	0.2	-1.1	-1.4	-0.2
Qualifications: College or University degree	1.6	4.9	12.6	1.0	1.3	3.5	1.8	-2.4
Eye problems/disorders: None of the above	0.8	1.0	2.7	-1.7	-0.2	0.5	0.5	1.3
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.9	-0.9	0.3	-0.4	0.3	0.9
Emphysema/chronic bronchitis	0.4	0.5	1.3	0.2	0.9	-0.4	-0.0	1.1
Medication for pain relief, constipation, heartburn	1.7	2.9	5.6	1.9	1.6	1.4	0.9	-2.4
Neck or shoulder pain in last month	0.7	1.0	2.1	-0.4	0.6	1.5	1.2	1.0
Medication: Blood pressure	2.5	4.4	5.8	-2.0	-1.6	-2.3	-2.1	2.4
Angina (self-reported)	0.5	0.7	1.5	-1.2	-0.7	-1.0	-0.6	0.0
Migraine (self-reported)	0.3	0.4	1.1	-0.8	-1.0	-0.3	0.1	0.3
Medication: Ibuprofen	0.9	1.1	2.1	-0.8	-1.5	0.0	-1.3	1.1
Medication: Allopurinol	0.3	0.4	1.4	0.2	1.2	0.7	-0.2	-0.4
Medication: Omeprazole	0.3	0.4	1.0	1.0	0.8	-0.4	0.2	-0.3
Medication: Seretide 50 evohaler	1.5	1.7	3.6	1.9	1.5	1.4	-0.6	-0.4
Mean time to correctly identify matches	3.6	6.9	14.3	0.4	2.4	3.7	3.8	-0.7
Heart disease (mother)	2.2	2.6	4.3	-0.5	2.0	2.1	2.1	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.0	-0.7	0.6	0.3	0.7	1.0
Whole body fat mass	1.6	6.6	11.9	-2.2	-2.1	-3.2	-3.5	1.1
Leg fat mass (right)	2.2	8.4	14.0	-2.4	-2.7	-3.7	-3.6	1.3
Arm predicted mass (right)	1.8	9.4	15.1	2.4	3.9	2.4	3.3	-3.1
Pulse rate, automated reading	0.0	0.1	0.3	-0.3	0.5	-0.3	0.3	0.4
Alcohol intake frequency.	0.1	0.3	0.6	0.6	-0.1	0.4	-0.5	-0.8
Comparative height size at age 10	12.0	66.0	88.2	7.2	8.8	8.1	9.4	-6.8
Number of full sisters	1.1	1.4	4.1	-1.5	0.4	-0.2	-0.5	2.0
Suffer from ‘nerves’	0.5	0.7	3.2	0.3	-0.4	1.8	0.2	-0.3
Overall health rating	0.2	0.4	1.5	-1.2	-0.1	0.2	0.2	0.8
Chest pain or discomfort	0.2	0.2	0.9	-0.4	0.1	0.9	0.2	0.0
Had major operations	0.5	0.6	2.0	-0.7	0.7	0.4	0.1	1.4
Age at last live birth	0.1	0.2	0.5	-0.0	-0.2	0.7	0.3	0.6
Family relationship satisfaction	7.1	8.7	24.0	1.6	2.9	4.9	2.9	-0.6
Leg pain on walking	0.7	0.9	2.7	-0.2	1.1	0.6	1.6	0.3
Qualifications: NVQ or HND or HNC or equivalent	2.2	2.6	5.1	-1.8	-1.9	-0.9	-2.3	0.6
Commuting to job workplace: Car/motor vehicle	1.0	1.2	3.3	0.2	-0.8	-1.8	-1.3	-0.4
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	3.3	1.8	0.5	-0.1	-0.7	-1.3
Medication: Aspirin	0.3	0.4	1.2	-0.6	-0.2	-1.1	-0.1	0.6
Supplements: Vitamin C	2.0	2.4	5.6	0.6	1.2	2.4	2.2	0.0
Knee pain experienced in last month	0.3	0.5	1.7	-0.4	-0.1	-1.3	-0.3	0.7
Hypertension (Self-reported)	1.7	4.7	13.0	-2.4	-0.8	-1.9	-0.7	3.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.2	0.5	0.4	-0.2	-0.3	0.4
Illnesses of father: Heart disease	0.2	0.3	0.7	0.2	-0.4	-0.9	-0.0	-0.8
Illnesses of siblings: Diabetes	0.2	0.2	0.5	-0.1	-0.3	-0.4	0.7	-0.5
Smoking status: Previous	3.9	5.8	10.5	-2.3	0.4	1.8	3.2	3.2
Forced expiratory volume in 1-second (FEV1), predicted	2.4	5.0	8.5	1.4	2.8	2.2	2.9	-1.3
Whole body fat-free mass	2.4	13.8	21.4	3.2	4.6	2.9	3.6	-4.0
Leg fat-free mass (right)	1.2	6.5	12.2	1.9	3.5	2.1	2.2	-2.7
Arm fat percentage (left)	5.6	22.3	36.1	-4.1	-4.4	-5.4	-6.0	3.1
Average weekly red wine intake	0.3	0.4	1.5	-0.2	0.6	0.0	-0.1	1.2
Handedness (chirality/laterality): Left-handed	1.0	1.2	3.4	-0.3	-0.4	-1.9	-1.4	0.5
Mood swings	0.8	1.4	2.3	-0.3	-1.5	-1.5	-1.1	-1.0
Loneliness, isolation	6.5	8.9	18.5	-1.7	2.2	4.3	4.2	0.8
Long-standing illness, disability or infirmity	1.2	1.8	5.5	-2.4	-0.1	-0.2	1.4	1.3
Ever had bowel cancer screening	0.8	1.0	2.0	0.6	1.3	0.6	1.4	-0.6
Diabetes diagnosed by doctor	1.0	1.7	3.6	-1.9	-0.8	-1.4	0.2	1.4
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	3.0	-1.7	0.4	-0.1	0.2	1.7
Friendships satisfaction	4.9	6.1	10.6	1.7	2.9	3.2	3.0	-0.3
Qualifications: nursing, teaching	1.1	1.7	2.7	0.7	1.3	1.1	1.6	-1.5
Commuting to job workplace: Walk	1.1	1.2	2.5	-1.6	-0.9	1.3	0.7	0.6
Eye problems/disorders: Cataract	0.6	0.7	2.9	1.7	0.4	-0.3	-0.6	-0.4
Mouth/teeth dental problems: Mouth ulcers	2.4	3.9	7.5	2.7	1.9	2.1	1.4	-1.4
Medication for cholesterol	1.2	1.8	5.8	0.8	0.2	2.4	1.3	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.8	-0.1	0.4	0.2	0.8	0.9
Back pain experienced in last month	1.4	2.0	3.4	1.4	1.9	1.2	1.8	-0.3
Mineral and other dietary supplements	1.8	2.5	5.4	-0.3	-1.5	-2.2	-2.3	0.0
Breast cancer (self-reported)	0.3	0.4	0.9	-0.9	-1.0	-0.2	0.5	0.2
Asthma (self-reported)	1.2	2.3	6.5	0.1	1.8	2.5	0.9	1.0
Osteoporosis (self-reported)	2.2	2.7	5.7	-0.1	-1.9	-2.1	-2.4	0.2
Osteoarthritis (self-reported)	2.0	2.6	6.3	-2.5	-1.7	-1.1	-1.0	1.2
Medication: Aspirin	0.3	0.5	1.8	-0.1	-0.4	-1.3	-0.5	0.2
Medication: Gliclazide	0.4	0.4	1.1	1.0	0.6	-0.4	0.1	-0.8
Illnesses of father: None of the above (group 1)	1.2	1.5	3.5	0.3	1.3	1.9	1.3	0.7
Smoking status: Current	0.3	0.4	2.0	0.3	0.3	-1.4	0.2	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.6	5.7	1.9	1.6	0.5	0.8	-2.4
Whole body water mass	2.4	13.6	20.6	3.3	4.5	2.8	3.5	-4.0
Leg predicted mass (right)	1.3	6.9	12.7	2.0	3.6	2.1	2.3	-2.8
Arm fat mass (left)	2.0	8.4	14.8	-2.7	-2.3	-3.5	-3.9	1.6
Number of self-reported non-cancer illnesses	1.7	3.0	6.5	-2.4	-0.9	-1.2	-0.5	2.5
Average weekly champagne plus white wine intake	3.7	5.1	11.1	-0.2	-2.0	-3.2	-3.3	-0.1
Miserableness	1.5	2.7	5.7	-0.6	1.4	2.4	2.2	-0.6
Guilty feelings	0.4	0.6	1.1	0.4	-1.0	-0.8	-0.5	-1.0
Wears glasses or contact lenses	1.1	1.3	2.9	-0.1	-1.6	-1.7	-0.8	-0.3
Ever taken oral contraceptive pill	0.9	1.0	2.1	-0.3	1.1	1.1	1.5	0.3
Hearing aid user	1.3	1.4	3.8	-0.2	0.7	2.0	1.4	0.9
Mother’s age at death	2.0	2.5	6.5	-1.7	-0.9	-1.1	-1.0	2.6
Financial situation satisfaction	2.0	2.4	6.3	-1.2	1.1	1.0	2.5	1.4
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.6	-0.6	-0.8	-0.5	0.3	0.6
Commuting to job workplace: Public transport	0.7	0.8	1.4	-0.9	0.4	1.2	1.1	0.7
Eye problems/disorders: Glaucoma	1.9	2.2	3.8	1.5	-0.9	-1.9	-1.6	-1.3
Medication: Blood pressure	0.5	0.9	3.3	0.3	0.7	-1.8	-0.2	0.7
Pain type(s) experienced in last month: Hip pain	1.0	1.2	1.8	0.2	-1.3	-1.2	-1.1	-1.3
Supplements: Fish oil (including cod liver oil)	1.0	1.3	2.4	-0.4	1.0	1.4	1.6	1.0
High cholesterol (Self-reported)	0.3	0.5	1.9	-1.4	-0.5	0.0	0.0	0.3
Medication: Bendroflumethiazide	0.3	0.5	1.6	-0.8	0.2	-0.2	-0.3	1.2
Medication: Paracetamol	1.5	2.4	4.1	-1.3	-2.0	-1.4	-1.2	1.6
Medication: Lisinopril	0.1	0.2	0.7	0.0	0.1	-0.8	-0.4	0.1
Medication: Atorvastatin	0.5	0.6	1.4	-0.3	-0.0	0.6	1.0	1.2
Illnesses of father: High blood pressure	0.3	0.3	1.0	-0.5	0.5	-1.0	-0.1	0.3
Alcohol drinker status: Never	0.3	0.4	1.0	-0.3	0.7	-0.6	0.2	1.0
Ever smoked	2.2	3.9	7.9	-2.1	0.2	0.7	2.6	2.8
Basal metabolic rate	1.5	8.6	13.5	2.5	3.7	2.2	2.6	-3.4
Leg fat percentage (left)	5.6	20.3	31.3	-3.6	-4.4	-5.6	-5.4	2.9
Arm fat-free mass (left)	1.8	9.2	15.4	2.6	3.9	2.2	3.0	-3.1
Number of operations (self-reported)	0.3	0.4	0.8	-0.2	-0.5	-0.9	-0.6	0.6
Average weekly beer plus cider intake	2.1	3.0	7.0	-0.9	-1.6	-2.1	-2.7	-0.2
Irritability	2.1	3.5	8.5	1.0	1.2	2.9	2.3	-1.1
Risk taking	0.4	0.6	1.4	-0.5	-1.1	-1.2	-0.5	0.1
Ever had prostate specific antigen (PSA) test	0.7	0.8	2.0	0.7	1.4	0.0	0.9	-0.8
Fractured/broken bones in last 5 years	1.1	1.4	2.3	-1.5	-1.4	-1.3	-0.1	1.0
Age started oral contraceptive pill	0.6	0.7	2.0	1.4	0.7	0.5	0.1	-0.9
Diastolic blood pressure, automated reading	1.1	3.5	10.3	-0.3	-1.6	-3.2	-2.1	0.1
Ever depressed for a whole week	2.6	3.2	7.3	-0.7	0.1	2.7	2.5	-1.4
Unable to work because of sickness or disability	0.5	0.6	1.2	-0.0	0.7	1.0	1.1	-0.8
Commuting to job workplace: Cycle	0.7	0.9	1.7	-0.9	0.5	1.3	1.2	0.5
Myopia	2.4	3.5	6.9	-1.7	-0.9	-2.3	-1.1	2.6
Vascular/heart problems diagnosed by doctor	1.4	3.9	7.0	1.8	0.9	2.5	1.5	-2.6
Cholesterol lowering medication	0.4	0.6	0.8	0.8	0.6	-0.7	-0.9	-0.7
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.5	-0.1	0.6	0.3	0.4	0.7
Pain experienced in last month	0.1	0.1	0.2	-0.2	0.0	0.4	0.0	0.5
Supplements: Calcium	0.4	0.5	1.2	-0.6	-0.0	1.1	0.9	0.4
Basal cell carcinoma (self-reported)	0.4	0.4	1.0	0.8	0.5	0.5	-0.1	-1.0
Heart attack/myocardial infarction (self-reported)	1.6	2.1	6.6	-1.4	-0.6	-2.6	-0.4	1.1
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	3.8	1.2	0.4	0.9	0.6	-2.0
Heart disease (siblings)	0.6	0.8	1.2	-0.6	1.1	0.7	0.9	1.0
Alcohol drinker status: Previous	0.1	0.1	0.5	0.1	0.1	0.7	-0.1	0.1
Pack years of smoking	0.0	0.1	0.1	-0.3	-0.3	-0.0	-0.3	-0.1
Impedance of whole body	0.1	0.7	2.4	-0.6	-1.6	0.3	-0.2	0.8
Leg fat mass (left)	2.1	8.4	14.8	-2.3	-2.5	-3.9	-3.7	1.4
Arm predicted mass (left)	1.7	8.6	14.7	2.4	3.8	2.2	2.9	-3.0