Best TWAS P=1.06e-18 · Best GWAS P=4.6e-20 conditioned to 0.0196
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Esophagus Muscularis | GRB14 | 0.14 | 0.09 | lasso | 7 | 0.06 | 0.00016 | 8.6 | -8.8 | 1.1e-18 | -0.47 | 0.17 | 0.65 | TRUE |
| 2 | GTEx | Thyroid | COBLL1 | 0.07 | 0.05 | lasso | 3 | 0.05 | 0.00015 | -5.8 | 6.0 | 1.5e-09 | 0.57 | 0.57 | 0.24 | TRUE |
| 3 | METSIM | Adipose | GRB14 | 0.04 | 0.00 | bslmm | 376 | 0.01 | 0.01630 | -3.4 | -5.4 | 5.6e-08 | -0.26 | 0.12 | 0.15 | FALSE |
| 4 | The Cancer Genome Atlas | Colon Adenocarcinoma | GRB14 | 0.09 | 0.01 | blup | 82 | 0.03 | 0.00464 | 7.6 | -6.5 | 6.2e-11 | -0.55 | 0.02 | 0.64 | FALSE |