Best TWAS P=2.11e-10 · Best GWAS P=5.46e-12 conditioned to 0.00334
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Hypothalamus | AC004453.8 | 0.54 | 0.13 | lasso | 7 | 0.16 | 1.8e-04 | -2.3 | -5.2 | 2.2e-07 | 0.55 | 0.05 | 0.27 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | ZMIZ2 | 0.12 | 0.09 | lasso | 4 | 0.06 | 2.3e-05 | -5.5 | -5.7 | 9.5e-09 | 0.68 | 0.03 | 0.97 | FALSE |
| 3 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PPIA | 0.05 | 0.02 | enet | 5 | 0.03 | 7.7e-05 | -6.9 | -6.3 | 2.1e-10 | 0.82 | 0.00 | 0.95 | TRUE |