Best TWAS P=5.87e-10 · Best GWAS P=3.36e-10 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CPSF4 | 0.06 | 0.06 | blup | 313 | 0.07 | 6.6e-09 | -6.3 | -5.5 | 3.0e-08 | 0.90 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | GS1-259H13.2 | 0.23 | 0.12 | lasso | 1 | 0.09 | 1.8e-05 | -5.4 | 5.4 | 5.8e-08 | -0.75 | 0.45 | 0.50 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | CPSF4 | 0.08 | 0.03 | lasso | 4 | 0.03 | 1.8e-03 | -5.6 | -5.7 | 1.5e-08 | 0.77 | 0.16 | 0.61 | FALSE |
| 4 | GTEx | Esophagus Mucosa | GS1-259H13.2 | 0.07 | 0.07 | lasso | 3 | 0.05 | 1.7e-04 | -5.5 | 5.6 | 1.8e-08 | -0.78 | 0.21 | 0.70 | FALSE |
| 5 | GTEx | Lung | ZKSCAN5 | 0.09 | 0.05 | lasso | 2 | 0.03 | 2.7e-03 | -5.6 | 5.5 | 3.4e-08 | -0.75 | 0.24 | 0.46 | FALSE |
| 6 | GTEx | Lung | GS1-259H13.2 | 0.09 | 0.07 | lasso | 4 | 0.05 | 8.4e-05 | -5.5 | 5.5 | 3.6e-08 | -0.74 | 0.38 | 0.54 | FALSE |
| 7 | GTEx | Nerve Tibial | GS1-259H13.2 | 0.15 | 0.10 | lasso | 4 | 0.09 | 3.4e-07 | -5.5 | 5.4 | 5.4e-08 | -0.73 | 0.47 | 0.52 | FALSE |
| 8 | GTEx | Thyroid | GS1-259H13.2 | 0.26 | 0.05 | enet | 30 | 0.08 | 7.6e-07 | -5.6 | 5.4 | 6.1e-08 | -0.59 | 0.40 | 0.57 | FALSE |
| 9 | METSIM | Adipose | GS1-259H13.2 | 0.04 | 0.03 | lasso | 3 | 0.02 | 1.4e-03 | -5.6 | 5.6 | 2.1e-08 | -0.74 | 0.16 | 0.81 | FALSE |
| 10 | ROSMAP | Brain Pre-frontal Cortex | GS1-259H13.2 | 0.07 | 0.05 | bslmm | 305 | 0.06 | 6.9e-08 | -5.7 | 5.5 | 4.4e-08 | -0.81 | 0.19 | 0.81 | FALSE |
| 11 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ZKSCAN5 | 0.03 | 0.04 | lasso | 2 | 0.03 | 1.0e-04 | -6.2 | -6.2 | 5.9e-10 | 0.98 | 0.01 | 0.99 | TRUE |