TWAS hub - CPSF4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.064	0.022	9.6e-08	0.060	0.07	0.053	0.069	0.065	8.8e-08	6.6e-09	4.9e-07	7.7e-09	2.1e-08
2	GTEx	Cells Transformed fibroblasts	0.082	0.039	3.9e-03	0.033	NA	0.031	NA	0.032	1.6e-03	NA	2.2e-03	NA	1.8e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Ever smoked	16.2	28.4	35.9	-6.0	-4.6
Smoking Status	12.4	29.7	36.2	-6.0	-4.8
Past tobacco smoking	11.9	21.8	28.5	5.3	3.9
BMI	10.9	63.0	65.9	-8.1	-7.8
Seen a psychiatrist for nerves, anxiety, tension or depression	10.3	13.4	17.9	-3.0	-4.2
Birth weight of first child	10.1	18.3	31.0	2.4	5.6
Maternal smoking around birth	10.0	14.4	21.3	-2.8	-4.6
Body mass index (BMI)	9.6	40.9	43.3	-6.6	-6.2
Waist circumference	8.9	32.4	35.6	-6.0	-5.4
Leg fat percentage (left)	8.9	32.1	33.0	-5.6	-5.7
Pack years of smoking	8.8	12.9	13.5	-3.5	-3.7
Supplements: Calcium	8.7	9.6	11.1	3.3	2.8
Alcohol intake versus 10 years previously	8.3	12.5	14.8	-3.2	-3.9
Leg fat mass (left)	8.2	32.1	32.9	-5.7	-5.6
Leg fat percentage (right)	8.0	28.9	29.3	-5.3	-5.4
Diabetes (self-reported)	7.9	12.2	12.9	-3.4	-3.6
Arm fat percentage (left)	7.9	31.4	32.0	-5.5	-5.7
Arm fat percentage (right)	7.8	30.9	31.2	-5.5	-5.6
Leg fat mass (right)	7.8	30.4	31.4	-5.6	-5.4
Type 2 Diabetes (T2D) (2018)	7.6	14.2	14.2	-3.8	-3.8
Pack years adult smoking proportion	7.5	11.5	12.2	-3.3	-3.5
Arm fat mass (right)	7.5	30.8	33.2	-5.8	-5.3
Father’s age at death	7.4	9.9	10.9	3.0	3.3
Arm fat mass (left)	7.2	29.7	32.0	-5.7	-5.2
Age at first live birth	6.9	12.3	15.4	3.0	3.9
Smoking status: Previous	6.7	10.0	12.6	-3.5	-2.7
Whole body fat mass	6.6	27.7	27.8	-5.3	-5.2
Blood White Count	6.5	48.0	60.8	-5.9	-7.8
Body fat percentage	6.4	25.4	27.5	-4.8	-5.2
Supplements: Fish oil (including cod liver oil)	6.4	8.3	13.9	3.7	1.7
Mother’s age at death	6.3	7.9	8.9	2.6	3.0
Average weekly beer plus cider intake	6.0	8.6	9.3	-2.8	-3.1
Bipolar Disorder (2018)	5.9	9.3	9.5	-3.1	-3.0
Supplements: Glucosamine	5.9	7.8	10.3	3.2	2.3
Wheeze or whistling in the chest in last year	5.8	10.3	13.3	-2.7	-3.7
Handedness (chirality/laterality): Left-handed	5.8	7.0	11.0	-3.3	-1.7
Chronic bronchitis/emphysema (mother)	5.7	6.7	9.8	-1.9	-3.1
Pulse rate, automated reading	5.6	18.2	25.5	-5.0	-3.3
Average weekly spirits intake	5.5	6.9	7.2	-2.7	-2.6
Chronotype (morning person)	5.4	12.4	14.1	3.8	3.3
Hand grip strength (left)	5.3	14.1	17.5	3.3	4.2
Age at First Birth	5.1	7.5	9.9	3.1	2.2
Medication for cholesterol, blood pressure or diabetes	5.1	8.5	11.2	2.4	3.3
Mineral and other dietary supplements	5.0	6.7	11.6	-3.4	-1.3
Relative age voice broke	4.9	7.5	7.7	2.7	2.8
Medication: Simvastatin	4.9	7.2	7.9	-2.8	-2.6
Medication: Amlodipine	4.9	6.9	8.0	-2.8	-2.4
Medication: Aspirin	4.9	6.4	9.3	-3.0	-1.9
Medication: Blood pressure	4.8	8.5	9.1	-2.8	-3.0
Schizophrenia vs Biploar Disorder	4.7	6.1	7.9	2.8	2.1
Current tobacco smoking	4.7	7.7	8.4	-2.9	-2.6
Alcohol drinker status: Never	4.7	5.6	8.2	2.9	1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	4.6	6.1	7.1	-2.7	-2.3
Trunk fat percentage	4.4	17.7	19.1	-4.0	-4.4
Diabetes diagnosed by doctor	4.4	7.2	7.3	-2.7	-2.7
Vascular/heart problems diagnosed by doctor	4.4	11.9	12.5	3.4	3.5
Pulse rate	4.3	7.2	8.2	-2.9	-2.5
Number of full sisters	4.3	5.3	5.9	-2.2	-2.4
Overall health rating	4.3	9.3	9.7	-3.1	-3.0
Trunk fat mass	4.2	18.1	18.1	-4.3	-4.2
Nervous feelings	4.2	7.8	8.2	2.7	2.9
Townsend deprivation index at recruitment	4.1	5.7	5.8	-2.4	-2.4
Worry (Nagel 2018)	4.0	8.4	10.3	2.6	3.2
Medication: Metformin	4.0	5.6	5.9	-2.4	-2.3
Medication: Cholesterol lowering	4.0	6.3	9.3	-1.8	-3.1
Shortness of breath walking on level ground	3.9	4.6	6.4	-1.7	-2.5
Sitting height	3.8	26.8	33.2	4.5	5.8
Medication for pain relief, constipation, heartburn	3.8	6.5	7.4	2.7	2.4
Ever had prostate specific antigen (PSA) test	3.8	4.4	6.1	2.5	1.6
Rheumatoid Arthritis	3.7	5.0	6.8	2.6	1.8
Suffer from ‘nerves’	3.7	5.8	7.6	2.0	2.8
Medication: Aspirin	3.7	4.8	7.1	-2.7	-1.6
Smoking status: Current	3.6	5.7	6.3	-2.5	-2.2
Diabetes (mother)	3.5	4.4	6.6	-1.5	-2.6
Hand grip strength (right)	3.5	9.5	10.7	2.9	3.3
Stomach or abdominal pain in last month	3.5	4.4	6.5	-1.5	-2.5
Financial difficulties in last 2 years	3.5	4.7	5.1	-2.1	-2.3
Hayfever/allergic rhinitis (self-reported)	3.5	4.7	9.2	3.0	-0.3
Hypertension (Self-reported)	3.5	9.7	10.5	-3.0	-3.2
Fractured/broken bones in last 5 years	3.5	4.5	5.1	2.2	2.0
High blood pressure	3.4	9.5	10.2	-3.0	-3.2
Hip circumference	3.4	14.6	16.3	-4.0	-3.6
Medication: Lisinopril	3.3	4.3	5.5	-1.8	-2.3
Impedance of whole body	3.3	16.7	21.9	4.7	3.4
Ulcerative Colitis	3.2	4.7	4.7	2.1	2.2
Mean time to correctly identify matches	3.2	6.2	8.4	-2.9	-2.0
Had other major operations	3.1	3.8	5.4	-2.3	-1.5
Medication: Ibuprofen (e.g. Nurofen)	3.1	3.9	4.8	-2.2	-1.7
Impedance of arm (left)	3.1	14.6	18.7	4.3	3.2
Leg pain on walking	3.0	3.8	4.4	-2.1	-1.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.0	3.5	4.4	1.6	2.1
Depression (Nagel 2018)	2.9	4.4	6.0	-2.5	-1.7
Irritable Bowel Disease (IBD)	2.9	7.0	9.2	2.2	3.0
Impedance of leg (right)	2.9	13.9	17.6	4.2	3.2
Weight	2.9	14.2	16.8	-4.1	-3.4
Hypothyroidism/myxoedema (self-reported)	2.9	5.7	7.1	2.7	2.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.9	6.2	10.6	1.3	3.3
Ulcerative Colitis (UC)	2.8	5.3	7.0	1.9	2.6
Impedance of leg (left)	2.8	13.4	17.0	4.1	3.1
Emphysema/chronic bronchitis	2.8	3.2	4.2	-2.0	-1.5
Age at last live birth	2.8	4.1	5.4	1.7	2.3
Illness, injury, bereavement, stress in last 2 years	2.8	3.4	4.4	1.6	2.1
Commuting to job workplace: Public transport	2.8	3.4	4.0	-1.7	-2.0
Reaction Time	2.7	5.1	6.7	-2.6	-1.9
Allergy or Eczema	2.7	7.1	14.0	3.7	-0.3
Medication: Paracetamol	2.7	4.1	4.6	-1.9	-2.1
Heart disease (siblings)	2.7	3.4	5.2	-2.3	-1.2
Cardiovascular Disease	2.6	8.5	8.6	-2.9	-2.9
Hayfever, allergic rhinitis or eczema	2.6	5.7	11.3	3.4	-0.4
Chest pain or discomfort	2.6	3.8	3.8	-2.0	-1.9
Family relationship satisfaction	2.6	3.1	4.1	-2.0	-1.5
Myopia	2.6	3.7	5.5	2.3	1.4
Hypothyroidism (self reported)	2.5	5.6	6.5	2.5	2.2
Medication: Levothyroxine sodium	2.5	4.2	5.2	2.3	1.8
Impedance of arm (right)	2.5	11.8	14.8	3.9	2.9
Happiness	2.5	3.0	3.8	-1.9	-1.5
Standing height	2.5	24.3	28.9	4.4	5.4
Mouth/teeth dental problems: Loose teeth	2.5	3.0	3.8	-1.9	-1.5
Medication: Ibuprofen	2.5	3.0	3.1	-1.7	-1.8
Height	2.4	46.1	57.9	5.8	7.6
Loud music exposure frequency	2.4	2.6	2.9	-1.7	-1.5
Exposure to tobacco smoke outside home	2.4	3.1	4.8	-2.2	-1.2
Crohns Disease (2012)	2.3	3.7	4.1	1.8	2.0
Bilateral oophorectomy (both ovaries removed)	2.3	2.7	4.3	-1.0	-2.1
Pulse wave peak to peak time	2.3	2.7	2.7	1.6	1.6
Commuting to job workplace: Walk	2.3	2.5	2.7	1.5	1.6
Bipolar Disorder (2011)	2.2	2.1	2.3	-1.5	-1.4
Forced expiratory volume in 1-second (FEV1), Best measure	2.2	6.9	10.9	1.7	3.3
Medication: Paracetamol	2.2	3.6	4.2	-1.8	-2.0
Gout (self-reported)	2.2	3.1	3.3	-1.8	-1.7
Ever had bowel cancer screening	2.2	2.5	2.6	1.6	1.6
Medication: Blood pressure	2.2	4.2	5.0	-2.2	-1.9
Fed-up feelings	2.1	3.9	4.2	-1.9	-2.0
Heel bone mineral density (BMD) T-score, automated (right)	2.1	4.9	5.6	-2.4	-2.0
Loneliness, isolation	2.1	2.9	3.1	-1.6	-1.7
Financial situation satisfaction	2.1	2.6	2.9	-1.6	-1.7
Bipolar Disorder or Schizophrenia	2.0	5.0	6.1	-2.0	-2.5
Angina	2.0	2.7	3.3	-1.4	-1.8
Age started oral contraceptive pill	2.0	2.5	2.6	1.6	1.6
Waist Hip Ratio (WHR)	1.9	8.6	10.9	-3.3	-2.5
Forced vital capacity (FVC), Best measure	1.9	7.1	10.4	2.0	3.2
Forced expiratory volume in 1-second (FEV1)	1.8	6.1	10.8	1.2	3.3
Peak expiratory flow (PEF)	1.8	4.2	4.2	2.0	2.1
Medication: Allopurinol	1.8	2.4	2.7	-1.5	-1.6
Crohns Disease (2017)	1.7	3.8	5.0	1.6	2.2
Ever unenthusiastic/disinterested for a whole week	1.7	2.1	2.9	-1.7	-1.2
Health satisfaction	1.7	2.2	3.2	-1.1	-1.8
Blood Platelet Count	1.6	18.6	32.7	-5.7	-2.1
Frequency of depressed mood in last 2 weeks	1.6	2.3	2.4	-1.6	-1.5
Number of children fathered	1.6	1.8	1.9	-1.3	-1.4
Angina (self-reported)	1.6	2.1	2.7	-1.3	-1.6
Heart disease (mother)	1.6	1.9	2.2	-1.5	-1.3
Number of self-reported non-cancer illnesses	1.6	2.8	5.2	-0.6	-2.3
Diastolic blood pressure, automated reading	1.6	4.9	5.5	-2.4	-2.1
HbA1C	1.5	1.7	3.3	1.8	-0.2
Eye problems/disorders: Diabetes related eye disease	1.5	1.6	3.2	0.0	-1.8
Severe depression (siblings)	1.5	1.7	2.2	-1.1	-1.5
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.4	4.6	-2.1	-1.5
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	3.4	1.8	0.4
Hearing difficulty/problems with background noise	1.5	2.5	4.2	-2.1	-0.8
Pain all over the body in last month	1.5	1.6	1.6	-1.2	-1.3
Worrier / anxious feelings	1.5	2.8	4.3	1.1	2.1
Pulse wave Arterial Stiffness index	1.5	1.8	1.8	-1.3	-1.4
Wears glasses or contact lenses	1.5	1.7	2.1	1.5	1.1
Had menopause	1.4	1.7	2.0	1.4	1.2
Allergy	1.4	3.2	5.5	-2.4	0.9
Hair/balding pattern: Pattern 3	1.4	2.1	3.0	1.1	1.7
Prospective memory result	1.4	1.7	2.9	-0.7	-1.7
Heel T-Score	1.3	10.3	16.2	-2.1	-4.0
Number of treatments/medications taken	1.3	2.4	4.5	-0.5	-2.1
Fluid intelligence score	1.3	2.8	5.2	0.6	2.3
Hair/balding pattern: Pattern 4	1.3	3.1	6.0	0.5	2.5
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	2.4	-1.6	-0.8
Average weekly red wine intake	1.3	1.9	2.3	-1.5	-1.2
Ovarian Cancer	1.2	1.6	2.1	-1.4	-1.0
Chronic bronchitis/emphysema (father)	1.2	1.4	2.7	-0.1	-1.6
Forced vital capacity (FVC)	1.2	4.7	8.1	1.2	2.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.9	2.1	-1.3	-1.5
Migraine (self-reported)	1.2	1.5	1.8	1.1	1.3
Medication: Seretide 50 evohaler	1.2	1.4	2.4	-0.6	-1.5
Supplements: Vitamin C	1.2	1.4	1.7	1.1	1.3
Irritability	1.2	2.0	2.5	-1.2	-1.6
Body Mass Index (BMI) (2010)	1.1	1.6	1.6	-1.2	-1.3
HDL Cholesterol	1.1	1.8	2.8	0.9	1.7
Type 2 Diabetes (T2D) (2012)	1.1	1.2	2.3	1.5	-0.4
Medication: Atenolol	1.1	1.4	2.7	-1.6	-0.2
Leg predicted mass (left)	1.1	5.6	8.0	-2.8	-1.8
Mouth/teeth dental problems: Dentures	1.1	1.8	2.9	-0.9	-1.7
Glaucoma (self-reported)	1.1	1.3	2.6	0.1	1.6
Number of full brothers	1.1	1.4	2.0	-0.9	-1.4
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.2	3.4	1.0	1.8
Leg fat-free mass (left)	1.0	5.5	8.0	-2.8	-1.8
Had major operations	1.0	1.2	1.7	1.3	0.9
Medication: Bendroflumethiazide	1.0	1.6	1.9	-1.4	-1.1
Risk taking	1.0	1.5	2.4	-1.5	-0.8
Breast Cancer	0.9	2.2	4.3	0.2	2.1
Medication: Co-codamol	0.9	1.1	1.4	-1.2	-0.9
Qualifications: CSEs or equivalent	0.9	1.2	1.7	-0.8	-1.3
High blood pressure (mother)	0.9	1.3	2.5	1.6	0.4
Hearing aid user	0.9	1.0	1.9	1.4	0.4
Basal metabolic rate	0.9	4.7	7.2	-2.7	-1.5
Arm predicted mass (left)	0.9	4.7	6.9	-2.6	-1.6
Alzheimer’s Disease (including proxy)	0.8	1.1	1.9	0.6	1.4
Relative age of first facial hair	0.8	1.7	3.2	1.8	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	1.8	-0.9	-1.4
Depression (self-reported)	0.8	1.0	1.6	0.6	-1.3
Medication: Lansoprazole	0.8	1.0	1.7	1.3	0.5
Birth weight	0.8	1.7	2.8	0.8	1.7
Leg fat-free mass (right)	0.8	4.3	6.4	-2.5	-1.5
Osteoporosis (self-reported)	0.8	1.0	1.2	0.9	1.1
Leg predicted mass (right)	0.8	4.5	6.7	-2.6	-1.5
Guilty feelings	0.8	1.2	1.5	-1.2	-1.0
Arm fat-free mass (left)	0.8	4.0	6.2	-2.5	-1.4
Alzheimer’s Disease (in father)	0.7	0.8	1.6	-0.1	1.3
Diabetes (father)	0.7	0.9	1.4	1.2	0.6
Knee pain experienced in last month	0.7	1.1	2.1	-0.1	-1.5
Mood swings	0.7	1.4	1.9	-0.9	-1.4
Depressed Affect (Nagel 2018)	0.6	1.2	1.3	-1.0	-1.1
Primary Biliary Cirrhosis	0.6	0.8	0.8	0.9	-0.9
Respiratory disease	0.6	1.3	2.3	0.5	-1.5
Systolic blood pressure, automated reading	0.6	1.7	2.8	-0.8	-1.7
Mouth/teeth dental problems	0.6	0.9	1.0	0.8	1.0
Number of live births	0.6	0.8	1.1	-0.7	-1.0
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	1.2	0.5	1.1
Medication: Ventolin 100micrograms inhaler	0.6	0.8	1.3	-0.6	-1.2
Arm fat-free mass (right)	0.6	3.2	5.1	-2.3	-1.2
Worry too long after embarrassment	0.6	1.1	1.2	1.1	0.9
Arm predicted mass (right)	0.6	3.3	5.4	-2.3	-1.1
Eye problems/disorders: Glaucoma	0.6	0.7	1.2	-0.4	1.1
Fasting Glucose	0.5	0.6	1.1	-0.4	-1.1
Neuroticism	0.5	1.1	1.4	0.9	1.2
Taking other prescription medications	0.5	0.8	1.2	1.1	-0.6
Qualifications: None of the above	0.5	1.1	1.2	-1.0	-1.1
Illnesses of siblings	0.5	0.7	1.4	1.2	-0.0
Falls in the last year	0.5	0.6	0.8	0.9	0.7
Exposure to tobacco smoke at home	0.5	0.6	1.2	-0.1	-1.1
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	1.0	-1.0	-0.8
Headache pain in last month	0.5	0.9	1.8	-0.2	-1.3
Neck or shoulder pain in last month	0.5	0.7	1.1	0.6	-1.0
Alcohol intake frequency.	0.5	1.1	2.1	1.5	0.2
Medication for cholesterol	0.5	0.7	0.8	0.9	0.8
Pain type(s) experienced in last month: Hip pain	0.5	0.6	0.8	-0.9	-0.7
Medication: Atorvastatin	0.5	0.6	0.9	0.5	-0.9
Ever depressed for a whole week	0.5	0.6	1.0	-1.0	-0.4
Coronary Artery Disease (CAD)	0.4	0.4	0.7	0.8	-0.4
Blood Red Count	0.4	3.4	4.4	-1.6	-2.1
Lung FEV1/FVC ratio	0.4	1.9	3.8	0.2	1.9
Lung FVC	0.4	1.9	3.3	0.6	1.8
Sensitivity / hurt feelings	0.4	0.7	0.7	0.8	0.9
Hearing difficulty/problems: Yes	0.4	0.6	1.0	-0.5	-1.0
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	0.9	0.2	-0.9
Vitamin and mineral supplements	0.4	0.5	1.1	-1.0	0.2
Age when periods started (menarche)	0.4	1.1	1.9	0.5	1.4
Hair/balding pattern: Pattern 2	0.4	0.5	0.9	1.0	-0.3
Noisy workplace	0.4	0.5	0.9	-1.0	0.0
Pulse wave reflection index	0.4	0.5	1.0	0.1	1.0
Blood clot in the leg (DVT)	0.4	0.5	0.7	-0.6	-0.8
Medication: Omeprazole	0.4	0.5	0.9	-0.4	-1.0
Whole body fat-free mass	0.4	2.3	4.0	-2.0	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	1.1	1.0	0.6
Back pain experienced in last month	0.4	0.6	0.7	0.7	0.9
Whole body water mass	0.4	2.5	4.3	-2.1	-0.8
Miserableness	0.4	0.7	0.9	-0.9	-0.7
Illnesses of father: High blood pressure	0.4	0.5	0.7	0.8	0.5
Intelligence (Savage-Jansen 2018)	0.3	1.0	1.6	-0.7	1.3
Neuroticism (2016)	0.3	0.5	1.0	-0.2	-1.0
Triglycerides	0.3	0.5	0.8	-0.9	-0.5
Blood Eosinophil Count	0.3	2.4	3.6	1.1	-1.9
Multivitamins +/- minerals	0.3	0.4	0.9	0.9	-0.0
Number of incorrect matches in round	0.3	0.4	0.8	0.2	0.9
Illnesses of mother	0.3	0.4	0.8	0.1	0.9
Breastfed as a baby	0.3	0.4	0.8	-0.9	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.5	0.7	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	0.4	-0.6	-0.5
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.3	-0.5	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.5	0.7	0.3
Illnesses of siblings: Diabetes	0.3	0.3	0.6	0.8	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.5	-0.4	-0.7
Friendships satisfaction	0.3	0.4	0.6	-0.4	0.8
Commuting to job workplace: Cycle	0.3	0.4	0.5	-0.6	0.7
Pain experienced in last month	0.3	0.5	0.6	-0.6	0.8
Basal cell carcinoma (self-reported)	0.3	0.4	0.6	0.8	0.4
Alcohol drinker status: Previous	0.3	0.3	0.4	-0.5	-0.6
Neuroticism (Nagel 2018)	0.2	0.4	0.6	0.5	0.7
Alzheimer’s Disease (in mother)	0.2	0.2	0.5	-0.7	-0.1
Major Depression (MDD)	0.2	0.2	0.3	-0.5	-0.4
Verbal and Numeric Reasoning (VNR)	0.2	0.6	1.0	-0.4	1.0
LDL Cholesterol	0.2	0.2	0.5	0.0	-0.7
Schizophrenia (2014)	0.2	0.4	0.6	-0.5	-0.8
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.6	-0.2	0.7
Ever had hysterectomy (womb removed)	0.2	0.2	0.4	0.6	0.1
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.4	-0.2	-0.6
Serious illness, injury or assault to yourself	0.2	0.2	0.4	-0.0	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.4	0.6	0.0
Asthma	0.2	0.4	0.9	0.2	-0.9
Lung cancer (father)	0.2	0.3	0.4	0.7	-0.3
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.2	-0.5	-0.4
High blood pressure (siblings)	0.2	0.2	0.4	-0.2	0.6
Long-standing illness, disability or infirmity	0.2	0.3	0.5	0.7	-0.5
Asthma (self-reported)	0.2	0.5	0.8	0.4	-0.9
Illnesses of father: None of the above (group 1)	0.2	0.2	0.3	-0.3	-0.6
Average weekly champagne plus white wine intake	0.2	0.3	0.6	-0.8	0.1
Ever taken oral contraceptive pill	0.2	0.2	0.2	-0.4	-0.4
High cholesterol (Self-reported)	0.2	0.3	0.4	0.5	-0.6
Unable to work because of sickness or disability	0.2	0.3	0.5	-0.2	-0.7
Cholesterol lowering medication	0.2	0.3	0.4	-0.7	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.4	-0.4	-0.6
Schizophrenia (2018)	0.1	0.3	0.5	-0.0	-0.7
Lupus	0.1	0.2	0.3	0.5	0.3
Hair Pigment	0.1	2.9	3.3	-1.8	-1.6
Medication for hormone replacement therapy	0.1	0.1	0.1	0.1	-0.3
Average weekly fortified wine intake	0.1	0.1	0.2	0.4	-0.0
Alcohol usually taken with meals	0.1	0.1	0.1	0.2	0.3
Heart attack	0.1	0.1	0.2	-0.4	0.2
Medication: Ramipril	0.1	0.1	0.1	-0.1	0.4
Trunk fat-free mass	0.1	0.6	1.2	-1.1	0.2
Time employed in main current job	0.1	0.1	0.1	0.3	0.2
Qualifications: A levels/AS levels or equivalent	0.1	0.1	0.2	-0.2	0.5
Trunk predicted mass	0.1	0.6	1.1	-1.1	0.2
Length of working week for main job	0.1	0.1	0.2	-0.4	0.4
Tense / ‘highly strung’	0.1	0.1	0.2	0.1	0.4
Comparative body size at age 10	0.1	0.2	0.3	-0.0	0.6
Qualifications: College or University degree	0.1	0.3	0.4	0.4	0.6
Eye problems/disorders: None of the above	0.1	0.1	0.3	0.5	-0.2
Illnesses of father: Heart disease	0.1	0.1	0.2	-0.2	-0.4
Qualifications: nursing, teaching	0.1	0.2	0.2	0.5	0.3
Eye problems/disorders: Cataract	0.1	0.1	0.1	-0.2	0.3
Breast cancer (self-reported)	0.1	0.1	0.1	-0.3	-0.2
Osteoarthritis (self-reported)	0.1	0.2	0.2	0.4	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.1	0.1	-0.4
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.2	-0.1	0.5
Prostate Cancer	0.0	0.0	0.0	0.1	0.1
Mean Putamen Volume	0.0	0.0	0.0	0.2	-0.1
Systolic Blood Pressure	0.0	0.2	0.4	0.1	-0.6
Tanning	0.0	0.3	0.5	-0.1	0.7
Supplements: Zinc	0.0	0.0	0.0	-0.0	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.0	0.0	-0.0	0.1
Neuroticism score	0.0	0.0	0.0	-0.2	-0.1
Comparative height size at age 10	0.0	0.2	0.3	0.5	-0.1
Medication: Gliclazide	0.0	0.0	0.1	-0.1	-0.2
Tinnitus: Yes, now most or all of the time	0.0	0.0	0.0	0.0	0.1
Number of operations (self-reported)	0.0	0.0	0.0	-0.1	-0.2

Hub : Genes

CPSF4

Models

Trait associations