Hub : Genes

ZKSCAN5

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Lung 0.0865 0.0359 0.00110 0.048 NA 0.018 NA 0.029 0.00015 NA 0.01500 NA 0.00270
2 GTEx Nerve Tibial 0.1220 0.0508 0.00460 0.042 NA 0.016 NA 0.020 0.00055 NA 0.02400 NA 0.01400
3 METSIM Adipose 0.0473 0.0195 0.00013 0.005 0.021 0.016 0.019 0.012 0.05700 0.00032 0.00160 0.00067 0.00540
4 TCGA Brain Lower Grade Glioma 0.0336 0.0199 0.00015 0.037 0.028 0.033 NA 0.033 0.00004 0.00030 0.00011 NA 0.00010
5 TCGA Prostate Adenocarcinoma 0.0284 0.0208 0.00310 0.027 0.026 0.028 NA 0.027 0.00067 0.00082 0.00054 NA 0.00068

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 3.0 4.8 8.4 2.9 1.4 -0.8 -2.9 -2.2
Bipolar Disorder or Schizophrenia 1.0 2.4 5.6 2.4 0.5 -0.6 -1.8 -1.5
Depressed Affect (Nagel 2018) 0.5 1.0 1.6 1.3 -1.1 0.1 -1.0 -1.1
Depression (Nagel 2018) 2.6 3.9 6.1 1.6 -2.1 -1.2 -2.3 -2.5
Intelligence (Savage-Jansen 2018) 0.8 2.4 6.6 -1.3 -1.6 -2.6 -0.9 -0.2
Neuroticism (Nagel 2018) 0.3 0.8 2.7 -0.5 -1.6 -0.4 0.9 -0.1
Schizophrenia (2018) 0.1 0.2 0.5 0.7 -0.5 -0.2 -0.1 0.3
Schizophrenia vs Biploar Disorder 3.4 4.4 7.7 -1.9 -1.4 1.3 2.8 2.6
Worry (Nagel 2018) 2.8 5.9 11.5 -2.9 -2.0 -0.2 3.4 2.3
Alzheimer’s Disease (in mother) 0.3 0.4 0.8 0.1 -0.9 0.5 -0.7 0.6
Alzheimer’s Disease (in father) 1.1 1.2 2.7 -1.4 -0.1 -1.1 0.6 1.6
Alzheimer’s Disease (including proxy) 1.5 2.1 5.9 -1.5 -1.4 0.2 0.8 2.4
Crohns Disease (2017) 1.8 3.9 9.6 -2.5 -3.1 -1.5 0.3 1.1
Irritable Bowel Disease (IBD) 2.6 6.1 11.7 -3.3 -3.4 -1.9 0.9 2.0
Ulcerative Colitis (UC) 2.1 3.9 7.7 -2.8 -2.4 -1.0 1.1 2.0
Major Depression (MDD) 1.0 1.2 3.3 0.4 0.4 -1.2 -1.8 -0.8
Reaction Time 2.0 3.8 7.1 1.8 -0.0 -1.4 -2.5 -2.7
Verbal and Numeric Reasoning (VNR) 0.4 0.9 2.2 -1.1 -0.0 -1.5 -0.9 -0.1
Breast Cancer 1.1 2.5 4.5 -2.0 2.1 -1.8 0.8 0.2
Ovarian Cancer 0.7 0.9 2.3 1.0 0.3 -0.5 -1.5 -0.9
Prostate Cancer 0.1 0.1 0.4 -0.2 0.1 0.2 -0.5 -0.6
Age at First Birth 3.9 5.7 10.6 -2.4 -0.2 1.3 3.2 3.3
Bipolar Disorder (2011) 1.4 1.3 3.5 1.2 -0.6 -1.1 -1.9 0.0
Body Mass Index (BMI) (2010) 0.8 1.1 2.0 0.9 0.5 -0.8 -1.4 -1.3
Coronary Artery Disease (CAD) 0.1 0.1 0.4 0.7 -0.1 -0.1 0.0 0.0
Crohns Disease (2012) 1.6 2.5 6.2 -2.1 -2.5 -0.6 0.5 1.2
Mean Putamen Volume 1.1 1.3 5.9 0.1 2.4 -0.4 -0.7 -0.1
Fasting Glucose 0.5 0.5 1.7 1.3 0.1 0.7 0.3 0.6
HbA1C 5.0 5.6 17.4 -0.1 -2.2 4.2 1.7 1.7
HDL Cholesterol 1.2 2.1 3.3 -1.6 -0.3 1.3 1.8 1.6
LDL Cholesterol 0.2 0.4 0.8 0.8 -0.6 0.9 0.2 -0.1
Lupus 0.1 0.2 0.5 -0.2 0.5 -0.7 0.0 0.1
Neuroticism (2016) 0.7 1.1 3.4 0.9 -0.4 0.3 -0.9 -1.9
Primary Biliary Cirrhosis 1.0 1.5 5.8 1.0 0.1 2.4 0.2 0.8
Rheumatoid Arthritis 4.7 6.5 16.8 -1.8 -0.3 1.5 3.2 4.1
Schizophrenia (2014) 0.1 0.3 0.7 0.8 -0.3 -0.5 -0.6 -0.4
Triglycerides 0.8 1.3 3.0 0.2 -0.0 -1.7 -1.3 -1.2
Type 2 Diabetes (T2D) (2012) 2.6 3.0 8.4 0.6 -2.9 2.5 0.5 0.0
Ulcerative Colitis 1.6 2.4 4.6 -2.1 -1.4 -0.9 1.3 1.6
Blood Eosinophil Count 0.4 2.9 11.5 1.7 0.0 3.4 -0.3 0.3
Blood Platelet Count 1.6 18.5 45.2 1.8 0.7 -6.7 -6.3 -2.1
Blood Red Count 1.6 15.6 22.1 2.5 -4.1 4.2 -4.0 -4.7
Blood White Count 3.8 27.9 62.3 7.9 2.9 2.3 -6.5 -4.7
Heel T-Score 1.0 8.1 14.8 3.9 -0.3 2.3 -3.6 -2.7
BMI 6.4 37.2 74.6 7.5 3.0 -0.8 -8.6 -6.8
Height 2.3 44.0 71.9 -7.0 -5.9 -3.9 8.5 7.0
Waist Hip Ratio (WHR) 1.6 7.2 11.2 2.4 2.7 -1.7 -3.4 -3.0
Systolic Blood Pressure 0.1 0.7 2.6 0.6 -0.3 -0.8 -1.6 -0.2
Smoking Status 8.5 20.3 33.8 4.7 4.1 -1.9 -5.8 -5.0
Allergy or Eczema 3.6 9.5 28.7 0.4 -1.8 5.4 2.8 2.7
Cardiovascular Disease 2.1 7.0 13.6 2.8 0.5 -2.3 -3.7 -2.9
Hypothyroidism (self reported) 1.6 3.6 6.6 -2.2 -1.0 0.7 2.3 2.6
Respiratory disease 1.2 2.7 11.0 1.5 -0.4 3.3 0.2 -0.6
Type 2 Diabetes (T2D) (2018) 3.3 6.1 14.0 3.7 -1.0 -0.1 -3.7 -1.3
Lung FEV1/FVC ratio 0.9 4.8 9.4 -1.9 -2.8 -3.1 -0.9 1.6
Lung FVC 0.5 2.7 4.5 -1.9 -0.8 -1.3 2.1 1.8
Neuroticism 0.3 0.7 2.5 -1.0 -0.1 0.1 1.6 0.5
Chronotype (morning person) 3.6 8.4 17.9 -3.2 -0.2 1.3 4.2 3.5
Hair Pigment 0.1 2.2 6.8 1.7 -2.6 0.2 -1.1 0.2
Tanning 0.1 0.7 2.1 -0.8 1.5 -0.5 0.5 0.4
Hand grip strength (left) 4.0 10.6 16.3 -4.0 -1.0 -2.1 4.0 3.9
Number of treatments/medications taken 1.2 2.2 4.4 2.1 -0.4 1.5 -1.6 -1.2
Average weekly spirits intake 2.1 2.6 6.0 2.5 0.3 0.1 -2.4 -1.0
Sensitivity / hurt feelings 0.2 0.4 1.2 -0.7 -0.1 0.2 1.1 0.1
Frequency of depressed mood in last 2 weeks 1.3 1.8 3.6 1.5 -1.9 -0.4 -1.1 -1.3
Hearing difficulty/problems: Yes 0.5 0.7 1.5 1.0 0.3 0.5 -1.2 -0.9
Relative age of first facial hair 0.8 1.7 3.2 -0.2 1.8 -0.7 1.7 1.3
Other serious medical condition/disability diagnosed by doctor 1.0 1.3 5.3 0.9 0.7 2.3 0.2 0.3
Ever used hormone-replacement therapy (HRT) 0.7 0.8 2.4 -0.8 -0.8 -1.6 -0.2 -0.7
Ever had hysterectomy (womb removed) 0.2 0.2 0.8 -0.1 -0.5 0.9 0.2 -0.3
Systolic blood pressure, automated reading 0.7 2.0 5.4 1.7 -0.6 -0.3 -2.3 -1.0
Eye problems/disorders: Diabetes related eye disease 1.0 1.1 3.0 1.7 0.5 1.2 -0.8 0.1
Angina 1.7 2.3 3.3 1.8 1.4 0.4 -1.7 -1.8
Medication for hormone replacement therapy 0.2 0.2 0.5 0.4 -0.2 -0.5 -0.2 -0.7
Vitamin and mineral supplements 2.1 2.9 7.2 -0.2 -1.2 -2.7 -1.7 -1.7
Supplements: Zinc 0.1 0.1 0.2 -0.1 0.4 -0.4 -0.2 0.3
Medication: Co-codamol 0.2 0.3 0.9 1.0 -0.3 0.2 -0.6 -0.2
Medication: Metformin 1.8 2.5 6.1 2.3 -0.6 -0.4 -2.5 -0.9
Diabetes (father) 0.3 0.4 0.7 -0.7 0.2 0.7 0.8 0.1
Diabetes (mother) 3.7 4.7 6.1 2.5 2.3 0.8 -2.4 -2.3
Severe depression (siblings) 1.2 1.4 2.1 1.4 1.2 0.6 -1.4 -1.0
Pack years adult smoking proportion 5.1 7.8 13.4 3.4 0.2 -0.8 -3.7 -3.6
Impedance of leg (right) 0.8 4.0 9.6 -3.0 0.1 -0.0 3.1 1.0
Leg fat-free mass (left) 0.4 2.0 3.4 1.8 -0.4 -1.8 -1.9 -0.5
Trunk fat percentage 3.0 11.9 22.7 4.3 1.6 -0.7 -4.8 -3.9
Hand grip strength (right) 2.5 6.9 12.9 -3.1 -0.5 -1.7 3.6 3.0
Townsend deprivation index at recruitment 3.7 5.2 10.4 2.4 2.1 -0.6 -2.3 -3.2
Current tobacco smoking 3.7 6.0 10.2 2.5 2.5 0.4 -3.2 -2.6
Average weekly fortified wine intake 0.3 0.3 1.1 -0.0 0.1 0.7 0.3 1.0
Maternal smoking around birth 5.5 8.0 20.6 4.5 0.2 0.8 -3.0 -3.1
Fed-up feelings 1.0 1.9 4.3 2.1 -0.3 0.4 -1.7 -1.4
Frequency of unenthusiasm / disinterest in last 2 weeks 3.1 4.1 7.7 2.2 0.5 -0.5 -2.8 -2.7
Relative age voice broke 2.4 3.7 7.6 -2.8 -0.2 -1.6 2.1 1.9
Taking other prescription medications 1.4 2.2 10.1 0.6 -0.5 3.2 0.5 0.5
Age when periods started (menarche) 0.8 1.8 6.6 -1.4 -0.4 -2.6 0.4 0.3
Bilateral oophorectomy (both ovaries removed) 2.0 2.3 4.0 2.0 0.2 1.9 -1.3 -1.5
Heel bone mineral density (BMD) T-score, automated (left) 1.1 2.5 5.0 1.4 0.7 -1.5 -2.2 -1.7
Tinnitus: Yes, but not now, but have in the past 0.5 0.5 1.2 0.6 0.9 1.1 -0.4 0.2
Qualifications: CSEs or equivalent 0.8 1.0 1.9 1.2 0.2 0.4 -1.1 -1.4
Serious illness, injury or assault to yourself 0.8 1.0 2.8 0.6 1.7 0.9 0.3 0.8
High blood pressure 2.7 7.5 13.7 3.2 0.7 -1.5 -3.7 -3.3
Hayfever, allergic rhinitis or eczema 2.7 5.8 20.6 0.4 0.0 4.5 2.1 2.0
Multivitamins +/- minerals 2.2 2.8 6.7 0.0 1.5 2.6 1.3 1.8
Stomach or abdominal pain in last month 2.5 3.1 6.8 2.6 1.0 2.6 -1.0 -0.5
Supplements: Glucosamine 4.3 5.6 12.1 -2.1 -0.3 1.2 3.5 3.1
Diverticular disease/diverticulitis (self-reported) 0.8 1.0 2.5 -0.4 0.6 1.0 1.6 1.0
Medication: Atenolol 1.5 1.9 5.5 0.1 0.2 -2.4 -1.6 -1.1
Medication: Levothyroxine sodium 1.3 2.2 4.1 -1.9 -0.7 0.6 1.6 2.0
Sitting height 3.6 25.6 39.3 -5.4 -4.3 -1.4 6.2 6.3
Chronic bronchitis/emphysema (father) 1.2 1.4 3.8 1.5 0.7 1.9 -0.7 -0.0
High blood pressure (mother) 0.4 0.6 1.1 -0.3 -1.0 0.6 1.0 0.6
Body mass index (BMI) 5.7 24.1 50.0 6.0 2.1 -1.0 -7.1 -5.4
Impedance of leg (left) 0.8 4.0 9.5 -3.0 -0.3 -0.3 3.1 1.1
Leg predicted mass (left) 0.4 2.1 3.5 1.8 -0.4 -1.8 -1.9 -0.5
Trunk fat mass 2.5 10.7 21.3 4.2 1.1 -1.2 -4.6 -3.5
Waist circumference 5.2 19.1 40.1 5.2 2.2 -1.4 -6.3 -4.6
Number of incorrect matches in round 0.2 0.4 1.1 -1.1 0.0 -0.8 0.2 0.4
Past tobacco smoking 7.3 13.5 25.1 -3.8 -2.5 2.0 5.0 4.2
Alcohol usually taken with meals 0.1 0.1 0.3 -0.3 -0.5 0.2 0.3 -0.4
Nervous feelings 2.7 5.1 11.7 -2.5 -1.2 -0.2 3.4 2.4
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 1.1 0.0 -1.1 -0.3 0.3 -0.1
Hearing difficulty/problems with background noise 1.1 1.7 3.7 0.9 0.9 -0.9 -1.6 -1.9
Hair/balding pattern: Pattern 2 0.5 0.6 1.0 0.4 -0.6 1.0 0.9 1.0
Had menopause 0.8 1.1 2.6 -1.1 -0.2 0.1 1.6 1.2
Had other major operations 1.4 1.8 4.3 1.4 0.8 -0.3 -2.1 -1.4
Forced vital capacity (FVC) 1.5 5.7 8.0 -2.8 -1.8 -2.8 2.2 2.1
Heel bone mineral density (BMD) T-score, automated (right) 1.3 3.1 6.7 2.0 0.9 -0.9 -2.6 -1.8
Ever unenthusiastic/disinterested for a whole week 0.7 0.8 1.3 1.2 -0.8 -0.1 -1.1 -1.0
Qualifications: None of the above 0.7 1.4 2.1 1.0 1.2 -0.7 -1.4 -1.4
Financial difficulties in last 2 years 1.9 2.6 5.0 2.2 1.5 0.4 -1.7 -1.7
Mouth/teeth dental problems 0.3 0.4 1.0 -1.0 -0.5 -0.9 0.2 0.2
Heart attack 0.3 0.4 1.4 -0.1 0.4 -0.6 -0.2 -1.2
Allergy 2.4 5.5 22.2 -0.9 0.3 -4.7 -1.6 -1.5
Pain all over the body in last month 0.7 0.8 1.6 1.3 1.1 -0.5 -0.7 -0.7
Diabetes (self-reported) 3.4 5.3 12.3 3.5 -1.1 0.4 -3.4 -1.1
Hayfever/allergic rhinitis (self-reported) 7.2 9.5 26.0 0.4 -0.1 5.1 2.8 3.7
Medication: Ramipril 0.3 0.4 1.6 -0.5 0.5 0.0 0.1 1.2
Medication: Simvastatin 2.4 3.6 8.5 2.5 0.4 -1.1 -2.9 -1.3
Fluid intelligence score 1.1 2.3 5.9 -2.4 -0.5 -2.2 -0.2 0.7
Illnesses of siblings 2.2 3.1 8.8 -0.1 1.2 3.0 1.5 1.7
Neuroticism score 0.1 0.1 0.2 0.3 -0.4 0.2 0.5 -0.3
Weight 1.5 7.6 15.4 3.4 0.4 -1.9 -3.9 -2.6
Impedance of arm (right) 0.9 4.3 10.5 -2.7 0.1 0.8 3.2 1.6
Arm fat percentage (right) 5.0 19.5 38.2 5.5 2.5 -0.3 -6.2 -4.8
Trunk fat-free mass 0.2 1.3 3.8 -0.1 -1.2 -1.9 0.0 1.1
Hip circumference 1.8 7.7 16.5 3.6 0.8 -1.0 -4.1 -2.8
Time employed in main current job 0.4 0.4 1.6 -0.2 -1.3 -0.1 0.0 -0.7
Alcohol intake versus 10 years previously 4.9 7.3 14.4 3.8 1.0 0.7 -3.5 -2.8
Father’s age at death 3.9 5.3 10.9 -3.3 -0.1 0.4 2.9 2.6
Worrier / anxious feelings 0.9 1.7 3.8 -1.9 -0.6 -1.7 1.1 0.3
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.7 2.1 1.5 0.2 0.6 -0.7 -0.4
Falls in the last year 0.4 0.6 0.9 -0.8 1.0 0.5 0.9 0.6
Hair/balding pattern: Pattern 3 1.1 1.6 3.2 -1.8 -0.9 0.4 1.4 1.4
Number of live births 1.3 1.8 4.8 1.1 -0.9 -0.0 -1.5 -2.2
Forced expiratory volume in 1-second (FEV1) 2.4 8.0 11.8 -3.2 -2.9 -3.4 1.9 2.4
Pulse rate 4.6 7.7 9.7 2.6 2.5 -2.5 -3.1 -3.1
Happiness 1.4 1.7 2.5 1.6 1.0 1.5 -1.1 -1.3
Noisy workplace 1.0 1.2 4.1 -0.1 0.6 -2.0 -1.0 -0.7
Qualifications: A levels/AS levels or equivalent 0.1 0.3 0.7 -0.4 0.4 -0.3 0.6 0.9
Serious illness, injury or assault of a close relative in last 2 years 1.1 1.3 5.3 -0.1 0.2 2.3 0.9 0.6
Mouth/teeth dental problems: Dentures 0.5 0.9 3.5 1.9 0.1 0.9 -0.2 -0.1
Asthma 0.4 0.8 2.3 0.9 -0.9 1.5 -0.2 -0.4
Medication: Ibuprofen (e.g. Nurofen) 1.2 1.5 4.0 1.6 0.5 0.1 -2.0 -1.0
Medication: Cholesterol lowering 2.6 4.0 8.4 2.9 0.2 -0.7 -2.7 -1.9
Depression (self-reported) 1.4 1.6 5.3 1.3 -0.7 2.3 0.6 0.6
Medication: Lansoprazole 0.8 0.9 1.6 -0.6 -0.8 1.2 0.6 1.3
Prospective memory result 2.3 2.8 4.4 2.0 2.0 2.1 -0.6 -1.2
Lung cancer (father) 0.1 0.1 0.3 0.2 0.2 0.5 0.5 0.3
Illnesses of mother 0.6 0.7 1.0 -1.0 0.5 1.0 0.8 0.8
Forced expiratory volume in 1-second (FEV1), Best measure 2.8 8.9 10.5 -3.2 -3.1 -3.0 2.6 2.9
Pulse wave Arterial Stiffness index 3.0 3.5 6.5 1.6 2.2 -1.0 -1.7 -2.5
Impedance of arm (left) 1.3 5.9 15.5 -3.0 -0.1 0.9 3.9 2.1
Arm fat mass (right) 4.2 17.4 36.2 5.2 1.6 -1.1 -6.0 -4.4
Trunk predicted mass 0.2 1.3 3.5 -0.1 -1.3 -1.9 0.0 1.1
Standing height 2.1 21.0 34.7 -5.0 -3.5 -2.3 5.9 5.3
Length of working week for main job 0.2 0.2 0.4 -0.5 -0.5 -0.6 0.0 0.6
Exposure to tobacco smoke at home 0.6 0.7 1.8 0.9 -0.5 1.3 0.1 0.8
Breastfed as a baby 0.4 0.5 2.3 0.2 -0.3 -0.2 -1.5 -0.2
Tense / ‘highly strung’ 0.3 0.4 0.9 -0.3 -1.0 -0.8 0.6 0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.5 4.2 1.5 -0.0 -0.2 -0.9 -2.1
Hair/balding pattern: Pattern 4 1.1 2.7 6.4 -2.5 -1.8 -1.9 0.2 -0.1
Birth weight of first child 8.2 14.9 27.7 -5.3 -2.2 -5.2 2.8 2.7
Peak expiratory flow (PEF) 1.8 4.1 7.9 -2.0 -2.3 -0.2 1.9 2.8
Pulse wave reflection index 0.9 1.1 2.5 -1.0 1.6 -1.3 0.1 -0.6
Ever highly irritable/argumentative for 2 days 0.5 0.6 0.9 0.3 1.0 -0.7 -0.9 -0.6
Loud music exposure frequency 2.0 2.1 4.5 1.6 0.9 -0.7 -1.6 -2.1
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 0.7 0.9 0.7 -0.1 -0.7 -0.8
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 1.3 -1.1 0.4 -0.5 0.6 0.5
Blood clot in the leg (DVT) 0.6 0.8 1.7 0.6 1.3 1.0 -0.5 0.7
Medication: Paracetamol 1.9 3.1 5.4 2.0 1.6 -0.0 -1.8 -2.3
Headache pain in last month 0.7 1.1 1.9 1.4 0.9 1.4 -0.6 -0.7
Medication for cholesterol, blood pressure or diabetes 3.7 6.1 10.2 -3.2 0.2 0.9 3.2 3.0
Glaucoma (self-reported) 1.2 1.4 3.4 -1.4 -1.1 -1.9 0.2 -0.4
Gout (self-reported) 1.6 2.2 3.9 1.5 -0.7 -1.1 -2.0 -1.8
Hypothyroidism/myxoedema (self-reported) 1.9 3.6 6.4 -2.1 -1.1 1.1 2.2 2.5
Medication: Amlodipine 4.0 5.5 10.8 2.3 1.6 0.0 -3.3 -3.0
Medication: Ventolin 100micrograms inhaler 0.4 0.5 1.3 1.2 0.4 0.4 -0.7 -0.7
Birth weight 0.8 1.8 3.3 -1.5 -0.6 -1.8 1.3 1.1
Chronic bronchitis/emphysema (mother) 4.1 4.8 9.6 3.1 1.1 1.7 -1.8 -2.7
High blood pressure (siblings) 1.1 1.6 5.0 -0.4 -1.5 -2.2 -0.0 -0.6
Forced vital capacity (FVC), Best measure 2.2 8.1 10.1 -3.2 -2.2 -2.5 3.2 3.0
Body fat percentage 4.3 16.8 31.9 5.2 1.9 -0.5 -5.6 -4.7
Leg fat percentage (right) 5.9 21.4 41.8 5.3 1.8 -0.9 -6.5 -5.8
Arm fat-free mass (right) 0.3 1.8 4.2 1.2 -1.1 -2.0 -1.4 -0.1
Exposure to tobacco smoke outside home 1.4 1.8 4.6 1.1 -0.3 -1.1 -1.5 -2.1
Comparative body size at age 10 0.4 1.2 3.4 -0.7 1.8 0.4 0.7 1.2
Number of full brothers 1.4 1.7 4.0 1.5 -0.5 -0.8 -1.2 -2.0
Worry too long after embarrassment 0.4 0.6 1.0 -0.9 -1.0 -1.0 0.7 0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 6.3 8.1 18.2 4.3 0.3 0.3 -2.7 -3.9
Wheeze or whistling in the chest in last year 3.7 6.6 13.1 3.6 -0.0 0.9 -3.1 -3.0
Number of children fathered 0.9 1.0 1.6 1.3 0.7 0.5 -1.2 -0.9
Reason for reducing amount of alcohol drunk: Health precaution 1.2 1.4 2.8 0.9 -0.1 -1.4 -1.2 -1.7
Age at first live birth 5.1 9.1 16.8 -4.0 -1.6 -0.8 3.1 4.1
Pulse wave peak to peak time 3.6 4.3 7.8 -1.8 -2.4 0.8 2.0 2.8
Health satisfaction 1.7 2.2 3.2 1.8 -1.1 1.4 -1.4 -1.6
Shortness of breath walking on level ground 2.2 2.6 6.7 2.6 -1.0 1.5 -1.3 -1.1
Qualifications: College or University degree 0.2 0.7 1.2 -0.6 -0.9 0.2 1.1 1.0
Eye problems/disorders: None of the above 0.2 0.2 0.9 0.3 1.0 -0.2 0.0 0.2
Mouth/teeth dental problems: Loose teeth 1.6 2.0 2.6 1.4 1.6 0.5 -1.6 -1.6
Emphysema/chronic bronchitis 1.7 1.9 2.4 1.5 1.4 -0.9 -1.5 -1.5
Medication for pain relief, constipation, heartburn 2.1 3.6 8.3 -2.2 -0.5 -0.4 2.9 2.1
Neck or shoulder pain in last month 1.4 2.0 6.0 1.0 1.7 2.5 0.2 0.6
Medication: Blood pressure 3.6 6.4 12.1 2.9 0.5 -0.8 -3.3 -3.5
Angina (self-reported) 1.6 2.0 2.9 1.6 1.4 0.5 -1.6 -1.7
Migraine (self-reported) 0.8 1.0 2.2 -1.2 -0.2 0.4 1.0 1.5
Medication: Ibuprofen 1.3 1.5 2.7 1.6 1.1 0.6 -1.6 -1.0
Medication: Allopurinol 0.9 1.1 2.3 1.5 0.3 -0.2 -1.5 -1.0
Medication: Omeprazole 0.6 0.7 1.5 0.8 0.8 0.7 -1.2 -0.6
Medication: Seretide 50 evohaler 1.8 2.0 6.4 1.4 2.5 1.2 0.1 -0.4
Mean time to correctly identify matches 2.3 4.4 7.6 1.9 -1.4 -1.2 -2.7 -2.8
Heart disease (mother) 2.1 2.5 3.9 1.4 1.1 -1.6 -1.7 -2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 2.6 -0.5 1.6 0.3 -0.3 -0.6
Whole body fat mass 3.9 16.5 32.1 5.2 1.6 -1.2 -5.7 -4.4
Leg fat mass (right) 4.9 19.0 37.3 5.3 1.6 -1.4 -6.1 -5.0
Arm predicted mass (right) 0.3 1.7 4.5 1.1 -1.0 -2.1 -1.4 -0.2
Pulse rate, automated reading 7.1 22.9 36.4 3.4 2.4 -6.0 -5.2 -5.8
Alcohol intake frequency. 1.1 2.6 7.8 -0.4 -1.9 2.8 0.8 1.0
Comparative height size at age 10 0.3 1.8 5.4 0.2 -1.6 0.2 0.9 2.3
Number of full sisters 3.7 4.5 10.1 2.3 -0.2 -0.5 -2.7 -3.2
Suffer from ‘nerves’ 3.0 4.7 7.2 -2.6 -2.7 -0.1 2.7 1.6
Overall health rating 2.2 4.8 9.2 3.0 0.2 0.3 -2.9 -2.4
Chest pain or discomfort 2.1 3.0 5.8 1.9 0.2 -0.7 -2.4 -2.2
Had major operations 1.5 1.8 4.0 -0.8 0.7 1.1 1.6 2.0
Age at last live birth 2.0 2.9 6.0 -2.4 -1.6 -0.3 1.4 1.9
Family relationship satisfaction 1.6 2.0 3.4 1.4 1.8 0.3 -1.6 -1.4
Leg pain on walking 1.7 2.1 3.4 1.9 -0.9 0.9 -1.6 -1.6
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.4 0.7 0.5 -0.9 0.7 -0.6 -0.5
Commuting to job workplace: Car/motor vehicle 0.3 0.3 0.7 0.4 0.3 0.7 -0.6 0.8
Illness, injury, bereavement, stress in last 2 years 2.1 2.6 4.9 -2.0 -2.2 -1.2 1.4 0.8
Medication: Aspirin 1.8 2.4 7.7 1.5 -0.3 -0.7 -2.8 -1.3
Supplements: Vitamin C 1.0 1.1 1.8 -1.2 -1.0 0.6 1.3 1.1
Knee pain experienced in last month 0.5 0.7 2.0 1.4 -0.5 0.9 -0.6 -0.0
Hypertension (Self-reported) 2.6 7.2 13.2 3.2 0.3 -1.4 -3.6 -3.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.0 1.2 4.1 -0.5 -0.4 2.0 0.1 1.1
Illnesses of father: Heart disease 0.4 0.6 2.8 0.5 0.1 0.0 -0.3 -1.7
Illnesses of siblings: Diabetes 0.5 0.6 2.3 -0.1 -0.3 1.5 0.6 0.7
Smoking status: Previous 3.6 5.4 10.1 2.7 1.2 -1.6 -3.2 -2.4
Forced expiratory volume in 1-second (FEV1), predicted 1.2 2.5 5.4 -1.8 -0.6 -2.3 1.1 1.5
Whole body fat-free mass 0.2 1.3 3.9 0.8 -1.0 -2.0 -0.9 0.3
Leg fat-free mass (right) 0.3 1.7 3.3 1.5 -0.8 -1.8 -1.5 -0.1
Arm fat percentage (left) 5.0 19.7 38.3 5.5 2.5 -0.3 -6.2 -4.9
Average weekly red wine intake 1.4 2.0 4.8 1.1 -0.6 -0.7 -2.2 -1.7
Handedness (chirality/laterality): Left-handed 4.1 4.9 7.2 1.8 1.2 -2.4 -2.7 -2.6
Mood swings 0.4 0.7 2.3 1.5 -0.3 0.1 -0.6 -0.8
Loneliness, isolation 1.2 1.7 3.3 1.8 1.0 0.6 -1.5 -1.4
Long-standing illness, disability or infirmity 1.4 2.2 7.3 0.4 -1.9 2.7 0.3 0.3
Ever had bowel cancer screening 1.3 1.5 2.7 -1.7 0.0 -0.6 1.4 1.5
Diabetes diagnosed by doctor 2.2 3.7 8.8 2.7 -1.5 -0.3 -3.0 -0.5
Ever had stillbirth, spontaneous miscarriage or termination 1.2 1.2 3.6 0.6 1.3 -0.4 -0.6 -1.9
Friendships satisfaction 0.3 0.4 1.5 -0.7 1.2 -0.1 -0.2 0.1
Qualifications: nursing, teaching 0.5 0.7 1.3 -0.4 -0.5 1.1 0.9 1.1
Commuting to job workplace: Walk 1.4 1.5 2.9 -1.7 1.0 -1.0 1.5 0.5
Eye problems/disorders: Cataract 1.0 1.1 3.1 -0.3 -1.8 -1.3 -0.2 -0.7
Mouth/teeth dental problems: Mouth ulcers 0.2 0.4 0.5 -0.7 -0.6 0.7 0.6 0.6
Medication for cholesterol 0.8 1.2 2.9 -0.7 0.5 1.4 1.7 0.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.8 2.1 5.0 -2.2 -0.7 0.1 1.6 1.6
Back pain experienced in last month 1.3 2.0 8.0 -0.9 -2.8 0.7 0.4 0.6
Mineral and other dietary supplements 5.4 7.3 13.3 1.4 0.6 -3.7 -3.3 -3.1
Breast cancer (self-reported) 0.3 0.3 0.8 0.4 -0.4 0.8 0.1 0.9
Asthma (self-reported) 0.5 1.0 3.1 0.9 -1.0 1.8 0.0 -0.2
Osteoporosis (self-reported) 0.3 0.4 1.1 -1.0 0.0 -0.1 0.8 0.2
Osteoarthritis (self-reported) 0.6 0.8 1.9 0.4 -1.4 1.3 -0.1 -0.4
Medication: Aspirin 2.3 3.0 8.6 1.8 0.3 -0.6 -2.9 -1.7
Medication: Gliclazide 0.3 0.3 1.0 0.2 -0.7 0.1 -0.4 1.0
Illnesses of father: None of the above (group 1) 0.1 0.2 0.3 0.6 0.5 0.5 -0.3 -0.1
Smoking status: Current 3.2 5.0 8.4 2.1 2.4 0.5 -2.9 -2.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 3.1 6.6 10.7 -3.3 -2.8 -3.1 1.7 1.3
Whole body water mass 0.3 1.5 4.3 0.8 -1.2 -2.1 -1.0 0.3
Leg predicted mass (right) 0.3 1.8 3.3 1.6 -0.8 -1.8 -1.6 -0.2
Arm fat mass (left) 4.2 17.2 35.9 5.1 1.7 -1.2 -6.0 -4.4
Number of self-reported non-cancer illnesses 1.6 2.8 7.4 2.3 -0.2 2.7 -1.0 -0.6
Average weekly champagne plus white wine intake 0.4 0.5 2.4 0.0 0.4 -1.5 -0.1 0.2
Miserableness 0.5 0.9 2.3 0.8 -0.5 -0.5 -0.9 -1.5
Guilty feelings 0.9 1.4 4.8 1.1 0.5 -0.3 -0.8 -2.2
Wears glasses or contact lenses 0.6 0.6 1.2 -1.1 0.5 0.7 0.7 0.9
Ever taken oral contraceptive pill 0.5 0.6 1.5 0.3 -1.1 1.2 -0.3 0.1
Hearing aid user 2.3 2.6 5.1 -0.3 -2.3 1.9 1.3 1.6
Mother’s age at death 5.1 6.3 11.7 -2.9 -0.7 0.7 3.4 3.3
Financial situation satisfaction 0.8 0.9 2.2 1.5 0.1 0.8 -1.3 -0.4
Tinnitus: Yes, now most or all of the time 0.2 0.2 0.9 -0.1 -0.9 -0.4 -0.1 -0.0
Commuting to job workplace: Public transport 2.2 2.7 4.4 2.1 2.1 1.4 -0.8 -1.4
Eye problems/disorders: Glaucoma 0.9 1.1 3.2 -1.0 -0.8 -1.8 -0.4 -0.6
Medication: Blood pressure 1.7 3.2 7.7 1.9 1.3 -0.8 -2.8 -1.6
Pain type(s) experienced in last month: Hip pain 1.1 1.4 3.2 0.6 -0.6 0.2 -1.8 -1.7
Supplements: Fish oil (including cod liver oil) 5.9 7.7 12.7 -1.7 -1.0 3.3 3.6 3.3
High cholesterol (Self-reported) 0.1 0.2 0.5 0.7 -0.3 0.5 -0.3 0.2
Medication: Bendroflumethiazide 1.5 2.3 3.9 1.1 -1.6 -1.2 -2.0 -1.6
Medication: Paracetamol 2.1 3.2 6.0 2.1 1.2 -0.4 -2.0 -2.5
Medication: Lisinopril 2.4 3.2 5.1 2.3 0.7 -1.1 -2.2 -2.0
Medication: Atorvastatin 1.4 1.7 6.0 1.0 1.0 2.4 0.4 -0.6
Illnesses of father: High blood pressure 0.3 0.3 0.7 -0.4 0.4 -0.8 0.7 0.6
Alcohol drinker status: Never 3.6 4.3 7.8 -1.7 -0.6 2.8 2.6 1.9
Ever smoked 9.4 16.5 29.8 4.5 2.9 -1.6 -5.5 -4.6
Basal metabolic rate 0.4 2.1 4.5 1.6 -0.6 -2.1 -1.8 -0.4
Leg fat percentage (left) 6.2 22.4 44.1 5.6 1.5 -0.8 -6.6 -5.8
Arm fat-free mass (left) 0.4 2.0 4.0 1.4 -1.0 -2.0 -1.8 -0.3
Number of operations (self-reported) 0.3 0.4 1.1 0.1 0.8 1.1 0.0 -0.5
Average weekly beer plus cider intake 4.7 6.8 12.8 3.0 0.9 -0.1 -3.6 -3.4
Irritability 0.6 1.1 2.7 1.6 0.8 0.8 -0.9 -0.8
Risk taking 0.5 0.7 1.3 0.7 1.1 -0.3 -0.7 -1.0
Ever had prostate specific antigen (PSA) test 2.3 2.6 4.8 -1.7 -0.2 2.0 2.2 1.2
Fractured/broken bones in last 5 years 2.3 3.0 7.0 -2.0 -0.6 1.1 2.6 1.6
Age started oral contraceptive pill 1.6 2.0 3.7 -1.4 -1.9 0.3 1.8 0.9
Diastolic blood pressure, automated reading 2.3 7.1 11.5 2.1 0.9 -2.8 -3.3 -3.4
Ever depressed for a whole week 0.2 0.2 0.4 0.6 -0.4 0.2 -0.0 -0.6
Unable to work because of sickness or disability 0.3 0.3 0.9 0.7 0.0 0.4 -0.3 -0.9
Commuting to job workplace: Cycle 0.9 1.1 3.9 -0.6 -0.3 -2.0 -0.1 -1.2
Myopia 1.3 1.9 5.8 -1.3 0.2 0.2 2.4 1.3
Vascular/heart problems diagnosed by doctor 3.3 9.1 16.3 -3.5 -0.7 1.4 4.0 3.8
Cholesterol lowering medication 0.1 0.2 0.6 0.3 -0.8 -0.2 -0.5 -0.0
Medication: Omeprazole (e.g. Zanprol) 0.2 0.3 0.9 0.2 -0.2 1.0 -0.6 -0.0
Pain experienced in last month 0.3 0.6 2.1 -0.6 -0.5 -1.5 0.2 0.3
Supplements: Calcium 4.8 5.3 11.9 -2.8 0.4 0.8 3.5 2.4
Basal cell carcinoma (self-reported) 0.1 0.2 0.3 -0.4 -0.6 -0.1 0.3 0.4
Heart attack/myocardial infarction (self-reported) 0.2 0.3 0.9 -0.4 0.1 -0.7 0.1 -1.0
Deep venous thrombosis (DVT) (self-reported) 0.8 1.1 2.3 0.4 1.5 1.4 -0.2 0.9
Heart disease (siblings) 5.1 6.2 12.8 1.4 1.2 -3.6 -2.2 -3.2
Alcohol drinker status: Previous 1.0 1.1 3.1 0.6 -1.7 -0.3 -1.0 -1.0
Pack years of smoking 5.5 8.1 13.4 3.6 -0.1 -0.9 -3.7 -3.6
Impedance of whole body 1.1 5.8 14.8 -3.2 -0.3 0.6 3.8 1.9
Leg fat mass (left) 4.9 19.3 38.5 5.5 1.4 -1.4 -6.2 -4.9
Arm predicted mass (left) 0.4 2.2 3.8 1.6 -0.9 -1.9 -2.0 -0.5