Best TWAS P=9.49e-12 · Best GWAS P=2.41e-11 conditioned to 0.00134
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | FAM86B1 | 0.02 | 0.02 | lasso | 3 | 0.01 | 1.3e-02 | 5.3 | 5.1 | 2.6e-07 | 0.52 | 0.02 | 0.93 | FALSE |
2 | GTEx | Adipose Subcutaneous | ERI1 | 0.05 | 0.00 | enet | 10 | 0.00 | 5.5e-01 | 4.5 | -5.8 | 6.6e-09 | -0.59 | 0.11 | 0.67 | FALSE |
3 | GTEx | Adipose Subcutaneous | AF131215.2 | 0.24 | 0.15 | lasso | 7 | 0.14 | 3.5e-11 | -5.0 | 5.2 | 2.1e-07 | 0.49 | 0.76 | 0.24 | FALSE |
4 | GTEx | Adipose Subcutaneous | FAM85A | 0.06 | 0.06 | enet | 10 | 0.07 | 3.3e-06 | -4.7 | 5.5 | 4.6e-08 | 0.39 | 0.13 | 0.82 | FALSE |
5 | GTEx | Adrenal Gland | FAM86B3P | 0.16 | 0.00 | enet | 18 | 0.03 | 2.2e-02 | 4.4 | -5.3 | 1.3e-07 | -0.31 | 0.06 | 0.17 | FALSE |
6 | GTEx | Adrenal Gland | AF131215.2 | 0.20 | 0.16 | enet | 12 | 0.13 | 2.2e-05 | 4.8 | 5.2 | 1.5e-07 | 0.49 | 0.74 | 0.25 | FALSE |
7 | GTEx | Adrenal Gland | AF131215.9 | 0.18 | 0.16 | lasso | 10 | 0.18 | 3.5e-07 | 4.8 | 5.3 | 1.2e-07 | 0.50 | 0.74 | 0.24 | FALSE |
8 | GTEx | Artery Aorta | ERI1 | 0.11 | 0.08 | lasso | 5 | 0.10 | 5.1e-06 | 5.5 | -5.1 | 2.9e-07 | -0.49 | 0.21 | 0.78 | FALSE |
9 | GTEx | Artery Aorta | AF131215.2 | 0.09 | 0.09 | lasso | 7 | 0.08 | 2.0e-05 | -5.0 | 5.3 | 9.8e-08 | 0.51 | 0.57 | 0.39 | FALSE |
10 | GTEx | Artery Aorta | AF131215.9 | 0.13 | 0.05 | lasso | 6 | 0.07 | 1.3e-04 | 5.2 | 5.2 | 1.7e-07 | 0.50 | 0.68 | 0.28 | FALSE |
11 | GTEx | Artery Coronary | AF131215.2 | 0.11 | 0.02 | enet | 27 | 0.05 | 6.5e-03 | -4.3 | 5.6 | 1.7e-08 | 0.43 | 0.08 | 0.65 | FALSE |
12 | GTEx | Artery Tibial | ERI1 | 0.05 | 0.02 | lasso | 7 | 0.01 | 3.2e-02 | 4.9 | -5.2 | 2.0e-07 | -0.46 | 0.36 | 0.32 | FALSE |
13 | GTEx | Artery Tibial | AF131215.2 | 0.07 | 0.03 | enet | 24 | 0.05 | 1.8e-04 | -3.7 | 5.2 | 2.5e-07 | 0.42 | 0.08 | 0.91 | FALSE |
14 | GTEx | Artery Tibial | FAM85A | 0.09 | 0.06 | enet | 18 | 0.08 | 1.5e-06 | -4.7 | 5.2 | 1.8e-07 | 0.41 | 0.11 | 0.85 | FALSE |
15 | GTEx | Brain Cortex | FAM86B3P | 0.14 | 0.05 | enet | 9 | 0.07 | 5.1e-03 | 4.4 | -5.2 | 2.0e-07 | -0.51 | 0.10 | 0.51 | FALSE |
16 | GTEx | Brain Frontal Cortex BA9 | FAM86B3P | 0.16 | 0.13 | enet | 27 | 0.10 | 1.1e-03 | 4.7 | -5.3 | 1.1e-07 | -0.47 | 0.04 | 0.87 | FALSE |
17 | GTEx | Breast Mammary Tissue | AF131215.2 | 0.16 | 0.15 | lasso | 6 | 0.12 | 1.1e-06 | -5.0 | 5.2 | 2.3e-07 | 0.53 | 0.71 | 0.24 | FALSE |
18 | GTEx | Cells Transformed fibroblasts | ERI1 | 0.34 | 0.35 | lasso | 7 | 0.35 | 1.9e-27 | 5.5 | -5.8 | 6.3e-09 | -0.45 | 0.11 | 0.89 | FALSE |
19 | GTEx | Cells Transformed fibroblasts | FAM86B3P | 0.23 | 0.33 | lasso | 11 | 0.38 | 8.4e-30 | 4.7 | 5.1 | 2.8e-07 | 0.52 | 0.09 | 0.90 | FALSE |
20 | GTEx | Esophagus Gastroesophageal Junction | MSRA | 0.11 | -0.01 | enet | 30 | -0.01 | 8.0e-01 | 6.0 | -5.7 | 1.2e-08 | -0.49 | 0.15 | 0.21 | FALSE |
21 | GTEx | Esophagus Muscularis | ERI1 | 0.12 | 0.09 | enet | 13 | 0.08 | 7.7e-06 | 4.3 | -5.3 | 1.2e-07 | -0.47 | 0.68 | 0.31 | FALSE |
22 | GTEx | Heart Atrial Appendage | MFHAS1 | 0.34 | 0.23 | enet | 56 | 0.19 | 5.7e-09 | -4.7 | 5.4 | 6.9e-08 | 0.32 | 0.29 | 0.70 | FALSE |
23 | GTEx | Heart Left Ventricle | AF131215.2 | 0.05 | 0.01 | enet | 11 | 0.01 | 1.5e-01 | 4.8 | 5.1 | 2.8e-07 | 0.49 | 0.34 | 0.28 | FALSE |
24 | GTEx | Nerve Tibial | ERI1 | 0.07 | 0.01 | enet | 16 | 0.01 | 4.2e-02 | -3.8 | -5.7 | 1.6e-08 | -0.52 | 0.22 | 0.40 | FALSE |
25 | GTEx | Prostate | AF131215.2 | 0.18 | 0.02 | lasso | 6 | 0.02 | 9.6e-02 | 3.0 | 5.2 | 2.0e-07 | 0.43 | 0.08 | 0.50 | FALSE |
26 | GTEx | Skin Sun Exposed Lower leg | FAM85A | 0.09 | 0.04 | enet | 28 | 0.04 | 1.4e-04 | -4.7 | 5.9 | 2.9e-09 | 0.36 | 0.10 | 0.80 | FALSE |
27 | GTEx | Testis | FAM86B3P | 0.15 | 0.14 | lasso | 7 | 0.13 | 2.2e-06 | 4.4 | -5.1 | 2.6e-07 | -0.51 | 0.03 | 0.97 | FALSE |
28 | GTEx | Thyroid | SGK223 | 0.19 | 0.35 | enet | 16 | 0.36 | 1.1e-28 | 4.8 | -5.3 | 1.2e-07 | -0.51 | 0.08 | 0.91 | FALSE |
29 | NTR | Blood | MSRA | 0.02 | 0.01 | blup | 833 | 0.01 | 2.3e-05 | 3.9 | -6.8 | 9.5e-12 | -0.61 | 0.54 | 0.45 | TRUE |
30 | ROSMAP | Brain Pre-frontal Cortex | XKR6 | 0.11 | 0.10 | enet | 23 | 0.13 | 1.2e-16 | -3.7 | 5.5 | 4.5e-08 | 0.52 | 0.88 | 0.11 | FALSE |
31 | ROSMAP | Brain Pre-frontal Cortex | SGK223 | 0.07 | 0.02 | blup | 427 | 0.05 | 4.3e-07 | 3.1 | 5.2 | 1.7e-07 | 0.42 | 0.28 | 0.69 | FALSE |
32 | ROSMAP | Brain Pre-frontal Cortex | RP11-481A20.11 | 0.06 | 0.04 | blup | 286 | 0.04 | 2.2e-06 | 4.1 | 5.6 | 2.5e-08 | 0.49 | 0.46 | 0.52 | FALSE |
33 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | ERI1 | 0.05 | 0.01 | blup | 72 | 0.01 | 5.0e-02 | 5.5 | -5.2 | 1.5e-07 | -0.33 | 0.01 | 0.83 | FALSE |
34 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RP1L1 | 0.02 | 0.01 | lasso | 2 | 0.01 | 4.1e-03 | 4.5 | 5.2 | 2.3e-07 | 0.38 | 0.01 | 0.54 | FALSE |
35 | The Cancer Genome Atlas | Lung Adenocarcinoma | ERI1 | 0.06 | 0.04 | blup | 72 | 0.04 | 1.5e-05 | 5.3 | -5.4 | 8.1e-08 | -0.40 | 0.01 | 0.99 | FALSE |