Best TWAS P=1.03e-09 · Best GWAS P=2.64e-08 conditioned to 0.0016
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adrenal Gland | RABEP1 | 0.13 | 0.03 | lasso | 13 | 0.02 | 7.2e-02 | -4.3 | -5.3 | 1.1e-07 | -0.80 | 0.03 | 0.83 | FALSE |
2 | GTEx | Brain Putamen basal ganglia | AC012146.7 | 0.30 | 0.03 | enet | 23 | 0.03 | 7.6e-02 | 4.1 | -6.1 | 1.0e-09 | -0.45 | 0.08 | 0.25 | TRUE |
3 | GTEx | Esophagus Gastroesophageal Junction | DHX33 | 0.12 | 0.08 | lasso | 5 | 0.07 | 1.8e-03 | 5.5 | -5.4 | 7.5e-08 | -0.96 | 0.02 | 0.96 | FALSE |
4 | GTEx | Esophagus Gastroesophageal Junction | RABEP1 | 0.19 | -0.01 | lasso | 13 | 0.00 | 4.2e-01 | 4.5 | -5.2 | 1.7e-07 | -0.82 | 0.03 | 0.79 | FALSE |
5 | GTEx | Esophagus Gastroesophageal Junction | GP1BA | 0.35 | 0.16 | lasso | 11 | 0.18 | 5.9e-07 | 4.3 | 5.8 | 5.2e-09 | 0.56 | 0.18 | 0.71 | FALSE |
6 | GTEx | Esophagus Muscularis | RABEP1 | 0.13 | 0.09 | lasso | 10 | 0.10 | 2.1e-06 | 5.5 | -5.3 | 1.2e-07 | -0.94 | 0.02 | 0.98 | FALSE |
7 | GTEx | Skin Sun Exposed Lower leg | AC012146.7 | 0.21 | 0.07 | enet | 17 | 0.18 | 1.3e-14 | 2.6 | -5.1 | 2.9e-07 | -0.45 | 0.95 | 0.01 | FALSE |
8 | ROSMAP | Brain Pre-frontal Cortex | RABEP1 | 0.20 | 0.22 | bslmm | 546 | 0.20 | 7.4e-25 | 4.5 | -5.3 | 1.0e-07 | -0.75 | 0.44 | 0.54 | FALSE |
9 | ROSMAP | Brain Pre-frontal Cortex | RPAIN | 0.06 | 0.06 | lasso | 3 | 0.06 | 3.1e-08 | 5.5 | -5.8 | 5.4e-09 | -0.98 | 0.00 | 1.00 | FALSE |
10 | The Cancer Genome Atlas | Glioblastoma Multiforme | NUP88 | 0.12 | 0.07 | enet | 12 | 0.09 | 1.2e-03 | 4.5 | -5.1 | 2.8e-07 | -0.78 | 0.02 | 0.67 | FALSE |
11 | The Cancer Genome Atlas | Glioblastoma Multiforme | RABEP1 | 0.23 | 0.13 | blup | 79 | 0.15 | 3.4e-05 | 4.6 | -5.7 | 1.0e-08 | -0.77 | 0.06 | 0.84 | FALSE |
12 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GP1BA | 0.02 | 0.02 | blup | 49 | 0.02 | 9.3e-03 | 4.3 | 5.3 | 9.4e-08 | 0.33 | 0.01 | 0.61 | FALSE |
13 | The Cancer Genome Atlas | Soft Tissue Sarcoma | INCA1 | 0.06 | 0.00 | enet | 11 | 0.00 | 1.7e-01 | 4.3 | 5.2 | 1.8e-07 | 0.30 | 0.00 | 0.30 | FALSE |
14 | The Cancer Genome Atlas | Thyroid Carcinoma | RABEP1 | 0.04 | 0.03 | enet | 5 | 0.03 | 1.5e-03 | -4.4 | -5.6 | 2.3e-08 | -0.67 | 0.09 | 0.82 | FALSE |