Best TWAS P=7.25e-15 · Best GWAS P=3.17e-14 conditioned to 0.0878
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | DPY19L3 | 0.07 | 0.05 | lasso | 2 | 0.06 | 8.7e-08 | -5.4 | -5.4 | 6.2e-08 | -0.01 | 0.01 | 0.99 | TRUE |
2 | GTEx | Adipose Subcutaneous | PEPD | 0.30 | 0.25 | lasso | 6 | 0.26 | 2.5e-21 | 5.7 | 5.2 | 2.3e-07 | 0.73 | 1.00 | 0.00 | FALSE |
3 | GTEx | Breast Mammary Tissue | PEPD | 0.16 | 0.06 | lasso | 4 | 0.04 | 3.5e-03 | 5.7 | 6.0 | 1.9e-09 | 0.78 | 0.43 | 0.52 | FALSE |
4 | GTEx | Colon Transverse | PEPD | 0.14 | 0.16 | lasso | 2 | 0.13 | 1.2e-06 | 5.7 | 5.6 | 2.4e-08 | 0.71 | 0.64 | 0.22 | FALSE |
5 | GTEx | Esophagus Mucosa | PEPD | 0.37 | 0.32 | enet | 20 | 0.39 | 9.5e-28 | 5.7 | 7.0 | 2.7e-12 | 0.87 | 0.03 | 0.97 | FALSE |
6 | METSIM | Adipose | CHST8 | 0.22 | 0.17 | lasso | 4 | 0.17 | 3.7e-25 | 5.7 | 5.9 | 2.9e-09 | 0.73 | 1.00 | 0.00 | FALSE |
7 | METSIM | Adipose | PEPD | 0.19 | 0.18 | lasso | 5 | 0.17 | 2.3e-24 | 5.7 | 5.7 | 1.0e-08 | 0.73 | 1.00 | 0.00 | FALSE |
8 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | PEPD | 0.06 | 0.01 | blup | 114 | 0.04 | 2.6e-04 | 7.5 | 6.9 | 6.2e-12 | 0.84 | 0.01 | 0.96 | FALSE |
9 | The Cancer Genome Atlas | Colon Adenocarcinoma | PEPD | 0.13 | 0.06 | blup | 113 | 0.10 | 1.2e-06 | 5.0 | 7.8 | 7.3e-15 | 0.86 | 0.01 | 0.99 | TRUE |
10 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PEPD | 0.04 | 0.05 | blup | 113 | 0.03 | 1.9e-04 | -4.9 | 5.3 | 1.1e-07 | 0.53 | 0.51 | 0.24 | FALSE |
11 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ZNF507 | 0.05 | 0.03 | blup | 39 | 0.05 | 1.3e-06 | -5.0 | -5.3 | 1.1e-07 | -0.04 | 0.01 | 0.99 | FALSE |
12 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | PEPD | 0.16 | 0.07 | lasso | 3 | 0.05 | 3.1e-03 | 7.4 | 7.3 | 2.6e-13 | 0.95 | 0.01 | 0.96 | FALSE |
13 | The Cancer Genome Atlas | Thyroid Carcinoma | DPY19L3 | 0.05 | 0.04 | enet | 9 | 0.05 | 2.1e-05 | -5.0 | -5.3 | 8.6e-08 | -0.02 | 0.02 | 0.97 | FALSE |
14 | The Cancer Genome Atlas | Thyroid Carcinoma | ZNF507 | 0.14 | 0.14 | lasso | 5 | 0.18 | 2.4e-17 | -4.9 | -5.2 | 1.8e-07 | -0.04 | 0.01 | 0.99 | FALSE |