TWAS
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Models
Genes
Traits
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Traits
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Arm fat mass (left)
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chr2:99,468,341-101,731,705
Best TWAS P=5.91e-13 · Best GWAS P=1.88e-12 conditioned to 0.067
99.5M
100M
100.5M
101M
101.5M
0
2
4
6
8
10
12
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Artery Aorta
AFF3
0.14
0.06
lasso
5
0.07
1.2e-04
-7.0
-7.2
5.9e-13
0.84
0.01
0.99
TRUE
4
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
LONRF2
0.06
0.04
blup
69
0.04
3.4e-05
4.7
-6.1
1.1e-09
0.68
0.55
0.43
FALSE
3
GTEx
Thyroid
CHST10
0.05
0.05
lasso
5
0.03
2.6e-03
-4.8
-5.9
2.9e-09
0.60
0.38
0.42
FALSE
2
GTEx
Skin Sun Exposed Lower leg
LONRF2
0.05
0.03
lasso
2
0.02
9.3e-03
4.9
-5.7
1.1e-08
0.56
0.19
0.48
FALSE