Best TWAS P=3.12e-11 · Best GWAS P=1.48e-10 conditioned to 0.000604
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | DHX36 | 0.05 | 0.06 | blup | 357 | 0.05 | 1.3e-06 | -5.1 | -5.7 | 1.1e-08 | 0.58 | 0.90 | 0.10 | FALSE |
2 | GTEx | Adipose Subcutaneous | ARHGEF26 | 0.10 | 0.06 | enet | 8 | 0.07 | 2.2e-06 | -5.1 | 5.3 | 9.4e-08 | -0.56 | 0.83 | 0.16 | FALSE |
3 | GTEx | Ovary | ARHGEF26 | 0.14 | 0.03 | enet | 15 | 0.06 | 1.4e-02 | 5.6 | 6.6 | 3.1e-11 | -0.53 | 0.08 | 0.43 | TRUE |
4 | GTEx | Pancreas | ARHGEF26 | 0.26 | 0.26 | lasso | 5 | 0.28 | 3.2e-12 | -4.6 | 5.7 | 1.4e-08 | -0.62 | 0.93 | 0.07 | FALSE |
5 | GTEx | Skin Not Sun Exposed Suprapubic | ARHGEF26 | 0.13 | 0.11 | lasso | 4 | 0.07 | 6.8e-05 | -4.6 | 5.5 | 2.9e-08 | -0.60 | 0.59 | 0.38 | FALSE |
6 | GTEx | Spleen | DHX36 | 0.39 | 0.09 | enet | 21 | 0.34 | 2.1e-09 | -3.0 | -5.6 | 1.9e-08 | 0.58 | 0.58 | 0.35 | FALSE |
7 | GTEx | Thyroid | ARHGEF26 | 0.09 | 0.07 | enet | 17 | 0.08 | 1.9e-06 | -4.8 | 5.6 | 1.7e-08 | -0.62 | 0.28 | 0.70 | FALSE |
8 | METSIM | Adipose | ARHGEF26 | 0.07 | 0.08 | lasso | 6 | 0.07 | 3.5e-11 | -5.1 | 5.2 | 1.9e-07 | -0.46 | 0.92 | 0.08 | FALSE |
9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SGEF | 0.04 | 0.04 | enet | 12 | 0.04 | 1.1e-05 | -5.0 | 5.9 | 2.8e-09 | -0.63 | 0.17 | 0.77 | FALSE |