Best TWAS P=4.04e-09 · Best GWAS P=2.34e-07 conditioned to 0.016
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | NOP14 | 0.12 | 0.06 | enet | 11 | 0.09 | 2.9e-07 | -3.7 | 5.6 | 2.6e-08 | 0.17 | 0.15 | 0.80 | TRUE |
| 2 | GTEx | Colon Transverse | GRK4 | 0.27 | 0.25 | enet | 18 | 0.25 | 2.4e-12 | -4.4 | 5.2 | 1.6e-07 | 0.15 | 0.06 | 0.93 | FALSE |
| 3 | GTEx | Whole Blood | HTT | 0.10 | 0.00 | enet | 15 | 0.03 | 1.4e-03 | 5.2 | 5.9 | 4.0e-09 | 0.60 | 0.03 | 0.81 | TRUE |
| 4 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | GRK4 | 0.09 | 0.18 | lasso | 5 | 0.20 | 1.5e-22 | -5.1 | 5.1 | 3.1e-07 | 0.16 | 0.02 | 0.98 | FALSE |
| 5 | The Cancer Genome Atlas | Lung Adenocarcinoma | C4orf44 | 0.03 | 0.04 | lasso | 4 | 0.05 | 2.9e-06 | -4.6 | 5.2 | 1.6e-07 | 0.48 | 0.04 | 0.92 | FALSE |
| 6 | The Cancer Genome Atlas | Soft Tissue Sarcoma | GRK4 | 0.08 | 0.07 | blup | 77 | 0.09 | 4.4e-06 | -4.3 | 5.1 | 2.9e-07 | 0.18 | 0.10 | 0.86 | FALSE |
| 7 | The Cancer Genome Atlas | Soft Tissue Sarcoma | SH3BP2 | 0.08 | 0.03 | blup | 53 | 0.02 | 2.8e-02 | 4.6 | 5.1 | 2.9e-07 | 0.29 | 0.00 | 0.23 | FALSE |