Hub : Genes

SH3BP2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.1321	0.0464	4.0e-04	0.030	NA	0.053	NA	0.038	2.1e-03	NA	5.7e-05	NA	5.4e-04
2	GTEx	Cells Transformed fibroblasts	0.1460	0.0430	7.1e-06	0.120	NA	0.130	NA	0.126	2.8e-09	NA	6.2e-10	NA	1.2e-09
3	NTR	Blood	0.0352	0.0144	4.9e-03	0.008	0.008	0.005	0.009	0.008	7.3e-04	0.0011	7.0e-03	0.00064	1.3e-03
4	TCGA	Soft Tissue Sarcoma	0.0800	0.0390	6.4e-03	0.029	0.018	0.003	NA	0.011	7.7e-03	0.0280	2.0e-01	NA	6.7e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.2	0.3	0.6	0.2	-0.8	-0.6	-0.2
Bipolar Disorder or Schizophrenia	0.3	0.7	1.1	-1.0	-0.7	-1.1	0.4
Depressed Affect (Nagel 2018)	0.3	0.5	1.2	1.1	0.3	0.9	0.1
Depression (Nagel 2018)	1.3	1.9	4.0	-1.6	0.6	0.8	2.0
Intelligence (Savage-Jansen 2018)	2.8	8.5	13.3	3.5	-1.3	-2.5	-3.6
Neuroticism (Nagel 2018)	0.5	1.2	3.6	0.9	-0.5	0.5	-1.9
Schizophrenia (2018)	0.4	0.9	2.3	-1.5	-0.3	-0.9	0.6
Schizophrenia vs Biploar Disorder	0.8	1.1	1.7	-1.3	1.1	-0.3	1.1
Worry (Nagel 2018)	0.5	1.0	2.9	0.7	-0.6	-0.3	-1.7
Alzheimer’s Disease (in mother)	1.7	2.0	5.2	-0.0	-1.6	-0.5	-2.3
Alzheimer’s Disease (in father)	2.2	2.4	4.3	-1.4	-2.1	-0.5	-1.7
Alzheimer’s Disease (including proxy)	1.2	1.8	3.1	-1.3	-1.8	-0.3	-1.5
Crohns Disease (2017)	0.7	1.4	3.2	-1.8	0.4	0.2	1.5
Irritable Bowel Disease (IBD)	0.7	1.7	5.2	-1.2	0.2	0.3	2.3
Ulcerative Colitis (UC)	0.5	0.8	3.2	-0.4	-0.1	-0.2	1.8
Major Depression (MDD)	1.0	1.3	3.2	0.7	1.0	-0.5	1.8
Reaction Time	2.7	5.1	13.2	0.2	-2.0	-1.8	-3.6
Verbal and Numeric Reasoning (VNR)	1.8	4.4	8.6	2.9	-0.7	-0.4	-2.9
Breast Cancer	0.8	1.8	3.7	-1.9	1.6	-0.7	0.7
Ovarian Cancer	1.3	1.7	4.2	0.4	1.6	-0.1	2.0
Prostate Cancer	0.4	0.6	1.9	0.6	0.0	1.4	-0.1
Age at First Birth	1.0	1.4	3.8	2.0	0.6	0.3	-1.2
Bipolar Disorder (2011)	0.5	0.5	0.7	-0.6	-0.8	-0.6	-0.7
Body Mass Index (BMI) (2010)	0.3	0.4	1.1	-0.0	-0.4	1.1	-0.6
Coronary Artery Disease (CAD)	0.6	0.8	1.7	0.6	-0.9	1.3	-0.5
Crohns Disease (2012)	0.8	1.3	3.1	0.2	0.8	1.7	1.2
Mean Putamen Volume	1.4	1.5	2.8	1.1	-1.2	-0.9	-1.7
Fasting Glucose	0.7	0.8	2.5	-0.4	1.6	0.1	0.7
HbA1C	0.3	0.3	0.8	0.2	0.5	0.9	-0.4
HDL Cholesterol	3.0	5.0	10.0	1.8	-3.2	0.3	-2.6
LDL Cholesterol	1.2	1.9	5.9	-1.3	0.3	-0.3	2.4
Lupus	0.4	0.6	1.1	1.0	1.1	0.0	-0.5
Neuroticism (2016)	1.2	1.7	4.1	0.3	-2.0	-0.4	-1.6
Primary Biliary Cirrhosis	0.9	1.3	3.4	-0.9	0.6	1.9	0.8
Rheumatoid Arthritis	1.8	2.5	4.4	1.4	-1.6	0.8	-2.1
Schizophrenia (2014)	0.5	1.2	2.6	-1.1	0.8	-0.4	1.6
Triglycerides	2.1	3.5	7.3	-0.8	2.3	0.7	2.7
Type 2 Diabetes (T2D) (2012)	1.0	1.1	3.2	0.3	-1.8	-0.9	-0.6
Ulcerative Colitis	0.5	0.8	2.7	0.6	0.1	0.1	1.6
Blood Eosinophil Count	0.9	7.3	9.1	-2.1	3.0	2.9	2.7
Blood Platelet Count	1.7	19.7	40.1	-3.6	3.1	4.0	6.3
Blood Red Count	0.2	2.3	6.5	-0.9	0.8	2.5	1.1
Blood White Count	0.8	5.8	22.1	-0.6	0.8	0.1	4.7
Heel T-Score	0.3	2.2	6.7	-2.6	-1.1	-0.0	-0.9
BMI	1.8	10.7	22.1	-3.5	2.6	1.2	4.7
Height	0.5	10.4	29.6	0.8	-1.9	2.8	-5.4
Waist Hip Ratio (WHR)	0.1	0.6	1.7	0.6	-0.6	0.1	1.3
Systolic Blood Pressure	0.4	2.1	7.7	-0.4	-2.8	-0.5	0.6
Smoking Status	1.3	3.0	5.9	0.5	2.0	1.4	2.4
Allergy or Eczema	0.4	1.1	1.6	-1.0	-1.3	-1.2	-0.6
Cardiovascular Disease	1.4	4.5	8.5	-1.1	-2.6	-2.9	1.3
Hypothyroidism (self reported)	0.8	1.8	6.0	-0.1	0.7	2.4	0.8
Respiratory disease	1.1	2.4	5.4	-1.7	1.0	0.7	2.3
Type 2 Diabetes (T2D) (2018)	1.0	2.0	6.7	0.0	1.0	-0.2	2.6
Lung FEV1/FVC ratio	0.5	2.6	4.1	1.5	-0.8	-1.9	-2.0
Lung FVC	1.7	8.6	24.1	-0.6	-3.0	0.9	-4.9
Neuroticism	0.2	0.4	1.0	0.8	-0.3	0.2	-1.0
Chronotype (morning person)	0.9	2.0	2.6	-1.4	-1.2	1.5	1.6
Hair Pigment	0.2	4.9	10.2	3.2	-1.2	-2.3	-1.6
Tanning	0.2	2.2	7.8	-2.8	-0.3	0.6	0.8
Hand grip strength (left)	0.2	0.4	0.6	-0.8	-0.7	0.4	-0.6
Number of treatments/medications taken	0.2	0.4	0.8	0.9	0.3	-0.1	0.7
Average weekly spirits intake	2.3	2.8	6.1	1.0	2.5	0.8	1.9
Sensitivity / hurt feelings	0.0	0.1	0.2	-0.2	-0.1	0.2	0.5
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.0	-1.0	-0.3	-0.4	0.9
Hearing difficulty/problems: Yes	1.3	1.9	4.8	-0.5	-1.6	-2.2	0.3
Relative age of first facial hair	0.9	1.8	4.3	1.6	-0.5	-0.5	-2.1
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.4	-0.0	0.4	-0.4	0.6
Ever used hormone-replacement therapy (HRT)	1.7	2.2	5.6	0.1	1.5	2.4	0.9
Ever had hysterectomy (womb removed)	0.8	0.9	2.1	-1.4	-0.3	1.1	0.7
Systolic blood pressure, automated reading	0.5	1.4	1.7	-1.2	-1.3	1.1	1.2
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	3.2	0.2	0.9	-0.2	1.8
Angina	1.3	1.8	6.3	0.1	-0.2	0.9	2.5
Medication for hormone replacement therapy	0.4	0.4	1.0	-1.0	-0.6	-0.4	0.4
Vitamin and mineral supplements	1.2	1.6	4.3	-0.9	0.6	-1.0	2.1
Supplements: Zinc	1.2	1.3	3.5	1.9	-0.7	0.0	-1.2
Medication: Co-codamol	1.1	1.3	2.7	-1.6	-0.3	-1.4	0.5
Medication: Metformin	0.1	0.2	0.5	0.5	0.1	0.2	0.7
Diabetes (father)	0.9	1.1	2.9	-0.4	1.2	-0.3	1.7
Diabetes (mother)	4.7	6.0	12.7	0.1	3.6	0.7	3.3
Severe depression (siblings)	1.9	2.1	5.8	2.4	-1.1	-0.6	-1.1
Pack years adult smoking proportion	2.4	3.6	12.0	-0.9	0.8	1.0	3.5
Impedance of leg (right)	0.4	2.0	4.8	0.7	-1.1	-1.2	-2.2
Leg fat-free mass (left)	0.6	2.9	3.7	-1.7	1.5	1.9	1.6
Trunk fat percentage	2.3	9.1	24.3	-2.7	2.2	0.3	4.9
Hand grip strength (right)	0.4	1.1	2.0	-0.5	-1.4	0.6	-1.4
Townsend deprivation index at recruitment	2.5	3.5	8.3	-2.9	0.5	1.0	2.2
Current tobacco smoking	2.0	3.3	8.4	-0.2	2.1	0.6	2.9
Average weekly fortified wine intake	0.8	0.9	1.7	0.9	1.3	-0.6	0.8
Maternal smoking around birth	2.4	3.5	7.2	-2.3	-1.1	-2.7	-0.4
Fed-up feelings	0.4	0.8	1.8	1.3	0.5	1.1	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	4.1	-1.5	0.1	0.3	2.0
Relative age voice broke	0.8	1.2	3.9	-0.2	-0.1	-0.9	-2.0
Taking other prescription medications	0.9	1.4	3.3	-0.6	0.9	1.0	1.8
Age when periods started (menarche)	1.0	2.5	7.2	1.3	-0.7	-0.7	-2.7
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.4	-0.9	-0.3	1.2	1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	5.2	-2.3	0.0	-0.4	0.4
Tinnitus: Yes, but not now, but have in the past	1.6	1.7	4.0	-1.3	1.0	2.0	0.1
Qualifications: CSEs or equivalent	2.0	2.6	5.2	-2.3	0.3	1.8	1.3
Serious illness, injury or assault to yourself	1.2	1.4	4.3	0.7	0.5	-0.8	2.1
High blood pressure	1.7	4.9	13.8	-0.5	-3.7	-2.2	-0.7
Hayfever, allergic rhinitis or eczema	0.5	1.1	3.7	0.2	-0.7	-1.9	-0.1
Multivitamins +/- minerals	1.0	1.3	3.7	0.2	0.1	1.9	-1.2
Stomach or abdominal pain in last month	2.6	3.2	8.0	-1.0	1.8	0.7	2.8
Supplements: Glucosamine	2.2	2.9	8.9	0.5	-1.6	0.2	-3.0
Diverticular disease/diverticulitis (self-reported)	1.9	2.2	6.3	-0.7	0.9	1.2	2.5
Medication: Atenolol	1.0	1.2	3.1	0.7	0.7	0.9	1.8
Medication: Levothyroxine sodium	1.2	2.0	3.8	-1.2	0.9	2.0	1.4
Sitting height	0.5	3.3	7.7	-0.5	-0.1	2.3	-2.8
Chronic bronchitis/emphysema (father)	2.3	2.7	5.2	-1.3	2.3	0.9	1.7
High blood pressure (mother)	0.3	0.4	1.2	1.1	-0.4	-0.3	0.4
Body mass index (BMI)	3.6	15.3	33.6	-4.2	2.6	1.8	5.8
Impedance of leg (left)	0.4	1.9	3.0	0.9	-1.0	-1.7	-1.7
Leg predicted mass (left)	0.5	2.8	3.4	-1.7	1.4	1.8	1.6
Trunk fat mass	1.8	7.7	17.9	-3.0	1.9	0.9	4.2
Waist circumference	2.0	7.1	15.4	-2.5	1.7	2.0	3.9
Number of incorrect matches in round	1.0	1.6	4.6	0.6	-0.8	0.9	-2.2
Past tobacco smoking	0.6	1.0	3.9	-2.0	-0.3	0.4	-0.1
Alcohol usually taken with meals	1.4	2.3	6.2	0.9	0.2	-1.5	-2.5
Nervous feelings	0.7	1.2	3.6	-0.2	-1.1	0.4	-1.9
Frequency of tenseness / restlessness in last 2 weeks	2.0	3.2	8.1	-2.9	-0.4	-0.4	2.1
Hearing difficulty/problems with background noise	1.8	2.9	4.5	-1.7	-1.8	-2.1	-1.0
Hair/balding pattern: Pattern 2	1.0	1.3	2.1	0.4	0.9	1.4	1.5
Had menopause	0.5	0.7	1.6	0.1	1.3	0.7	-0.8
Had other major operations	0.3	0.3	0.9	-0.0	-1.0	-0.3	-0.6
Forced vital capacity (FVC)	1.4	5.3	16.0	0.4	-2.1	0.8	-4.0
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.9	5.2	-2.3	-0.8	-1.2	-0.3
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.4	-0.9	-0.4	-1.2	0.4
Qualifications: None of the above	4.3	9.2	21.3	-2.3	1.9	2.5	4.6
Financial difficulties in last 2 years	1.8	2.4	6.5	-0.4	1.5	0.8	2.5
Mouth/teeth dental problems	1.0	1.6	4.0	-0.7	-1.3	-0.2	-2.0
Heart attack	2.1	2.7	6.4	2.0	0.7	-0.2	2.5
Allergy	0.5	1.0	2.7	0.2	-0.4	1.6	-1.1
Pain all over the body in last month	1.0	1.1	1.6	-1.1	0.0	-1.2	1.2
Diabetes (self-reported)	0.6	0.9	2.9	-0.8	0.1	-0.2	1.7
Hayfever/allergic rhinitis (self-reported)	2.9	3.8	7.2	2.7	2.1	1.4	1.2
Medication: Ramipril	2.7	3.4	7.7	-0.4	-2.4	-2.8	-0.2
Medication: Simvastatin	1.3	1.9	4.8	-1.5	-2.2	-0.9	-0.0
Fluid intelligence score	0.9	1.9	5.2	2.3	-0.8	-0.2	-1.3
Illnesses of siblings	0.7	0.9	3.2	-0.1	0.4	0.6	-1.8
Neuroticism score	0.2	0.4	0.6	0.1	-0.7	-0.8	-0.6
Weight	1.5	7.2	10.2	-3.2	2.0	2.1	3.2
Impedance of arm (right)	1.1	5.2	7.5	2.7	-0.4	-2.7	-2.4
Arm fat percentage (right)	3.0	11.7	30.8	-2.9	2.7	0.5	5.5
Trunk fat-free mass	0.4	2.5	5.9	-1.9	0.4	2.4	-0.7
Hip circumference	1.3	5.7	7.0	-2.6	2.2	2.0	2.6
Time employed in main current job	0.2	0.2	0.3	0.6	0.2	0.5	0.4
Alcohol intake versus 10 years previously	0.8	1.3	2.4	-1.4	-0.4	1.5	0.7
Father’s age at death	1.4	1.8	6.0	0.9	0.4	0.6	-2.4
Worrier / anxious feelings	0.2	0.4	1.2	0.5	0.0	-0.6	-1.1
Frequency of tiredness / lethargy in last 2 weeks	1.9	3.1	9.2	-1.6	0.7	0.3	3.0
Falls in the last year	1.4	1.9	5.1	-1.1	0.4	-1.1	2.2
Hair/balding pattern: Pattern 3	1.7	2.6	3.1	-1.8	-1.6	-1.7	-1.4
Number of live births	0.9	1.3	2.7	-0.3	-0.4	1.6	-1.5
Forced expiratory volume in 1-second (FEV1)	1.4	4.8	13.7	0.6	-2.3	0.2	-3.7
Pulse rate	0.5	0.9	2.0	1.0	0.0	1.4	0.8
Happiness	0.6	0.7	1.4	-0.8	1.2	0.9	0.3
Noisy workplace	2.4	3.0	7.9	-1.3	0.8	1.3	2.8
Qualifications: A levels/AS levels or equivalent	2.1	4.7	7.8	2.0	-1.3	-2.3	-2.8
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	1.4	1.2	-0.7	-1.1	0.7
Mouth/teeth dental problems: Dentures	0.7	1.1	2.7	-0.9	-0.2	0.9	1.7
Asthma	0.9	1.7	4.1	-1.2	1.0	0.6	2.0
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.5	-0.2	-0.8	-1.2	0.3
Medication: Cholesterol lowering	1.2	1.9	2.7	-0.7	-1.6	-1.6	1.4
Depression (self-reported)	0.4	0.5	1.8	1.3	0.0	0.0	0.4
Medication: Lansoprazole	1.8	2.1	4.5	-2.1	0.5	-1.9	0.1
Prospective memory result	0.3	0.3	0.8	-0.2	-0.3	0.6	-0.9
Lung cancer (father)	1.0	1.2	2.2	1.5	1.5	0.5	0.2
Illnesses of mother	1.4	1.7	4.0	-2.0	-1.2	-0.9	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	2.1	6.7	18.1	0.8	-2.9	-0.1	-4.2
Pulse wave Arterial Stiffness index	0.5	0.6	1.7	-0.7	-0.6	1.3	0.0
Impedance of arm (left)	1.1	5.1	9.8	3.1	-0.5	-2.6	-1.9
Arm fat mass (right)	2.9	12.0	27.1	-3.6	2.5	1.3	5.2
Trunk predicted mass	0.4	2.5	5.9	-1.8	0.4	2.4	-0.8
Standing height	0.8	7.7	26.1	1.6	-1.1	1.0	-5.1
Length of working week for main job	0.3	0.4	0.8	-0.9	-0.4	-0.1	0.7
Exposure to tobacco smoke at home	1.1	1.2	3.0	-1.7	1.2	0.0	0.7
Breastfed as a baby	0.4	0.5	1.2	0.6	0.1	-0.8	-1.1
Tense / ‘highly strung’	0.6	0.9	2.9	-1.7	-0.1	-0.2	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.7	0.0	-0.0	-0.4	0.8
Hair/balding pattern: Pattern 4	0.2	0.4	0.8	-0.5	0.9	0.4	0.5
Birth weight of first child	1.0	1.8	3.2	-1.3	1.5	1.8	0.0
Peak expiratory flow (PEF)	0.9	2.1	5.6	-0.5	-1.4	0.8	-2.4
Pulse wave reflection index	0.4	0.5	1.7	-1.3	0.2	0.3	0.4
Ever highly irritable/argumentative for 2 days	0.8	0.9	1.9	-1.4	0.6	-1.2	0.1
Loud music exposure frequency	2.6	2.9	7.2	-2.7	1.2	-0.0	1.7
Qualifications: O levels/GCSEs or equivalent	2.2	3.6	7.8	2.5	-0.0	-0.4	-2.8
Mouth/teeth dental problems: Bleeding gums	1.5	1.9	5.9	2.4	0.3	-0.6	1.1
Blood clot in the leg (DVT)	1.2	1.6	4.1	-2.0	-0.6	-0.6	1.2
Medication: Paracetamol	1.0	1.7	4.2	-0.8	2.0	0.3	1.4
Headache pain in last month	2.3	4.0	8.2	-1.9	2.0	0.7	2.9
Medication for cholesterol, blood pressure or diabetes	1.8	2.9	6.1	1.2	2.5	1.8	-1.0
Glaucoma (self-reported)	1.4	1.7	3.5	1.1	1.9	1.4	-0.2
Gout (self-reported)	1.3	1.7	3.5	-1.2	-1.9	-0.7	-1.2
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	5.7	-0.9	0.1	2.4	0.3
Medication: Amlodipine	2.9	4.1	13.3	-0.6	-3.6	-1.6	-0.3
Medication: Ventolin 100micrograms inhaler	1.0	1.3	2.9	0.1	1.7	1.1	1.0
Birth weight	0.5	1.1	2.3	0.7	-0.5	1.1	-1.5
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.3	0.4	-0.3	-0.5	0.2
High blood pressure (siblings)	0.3	0.5	1.4	0.1	-0.7	-0.1	1.2
Forced vital capacity (FVC), Best measure	1.9	7.0	21.2	0.3	-2.6	0.3	-4.6
Body fat percentage	2.6	10.4	27.0	-3.0	2.3	0.6	5.2
Leg fat percentage (right)	3.4	12.2	25.7	-3.8	2.4	1.8	5.1
Arm fat-free mass (right)	0.5	2.7	4.8	-2.2	0.7	2.2	0.9
Exposure to tobacco smoke outside home	1.6	2.2	4.5	-1.1	1.1	1.4	2.1
Comparative body size at age 10	0.8	2.1	5.6	-1.3	0.7	0.9	2.4
Number of full brothers	0.9	1.2	2.5	-1.6	-1.5	0.1	-0.1
Worry too long after embarrassment	2.6	4.4	13.6	0.8	-1.9	-0.0	-3.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	3.2	1.8	0.0	-1.3	0.9
Wheeze or whistling in the chest in last year	2.1	3.8	9.9	-1.3	1.9	0.4	3.2
Number of children fathered	1.4	1.6	2.4	-1.5	-1.4	-0.6	-1.4
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.2	-0.8	-1.1	0.2	-1.0
Age at first live birth	1.7	3.1	7.1	2.0	-0.1	-1.1	-2.7
Pulse wave peak to peak time	0.5	0.5	1.0	0.8	0.6	-1.0	-0.3
Health satisfaction	2.2	2.9	8.2	0.2	1.8	-0.3	2.9
Shortness of breath walking on level ground	3.8	4.5	11.4	-1.2	2.2	0.3	3.4
Qualifications: College or University degree	2.8	9.0	20.0	2.3	-1.1	-3.0	-4.5
Eye problems/disorders: None of the above	0.9	1.0	2.1	-1.5	-0.4	-1.3	0.1
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.1	-0.0	0.4	-0.2	-0.1
Emphysema/chronic bronchitis	1.2	1.4	2.6	-1.1	1.6	-0.5	1.2
Medication for pain relief, constipation, heartburn	0.3	0.5	1.0	1.0	-0.2	0.8	-0.7
Neck or shoulder pain in last month	0.8	1.1	2.5	-1.6	-0.2	1.3	0.6
Medication: Blood pressure	1.4	2.5	6.4	-1.0	-2.5	-1.5	-0.5
Angina (self-reported)	1.5	1.9	6.5	-0.1	-0.0	1.1	2.5
Migraine (self-reported)	0.3	0.4	0.7	-0.8	-0.7	-0.5	0.4
Medication: Ibuprofen	0.8	1.0	2.7	-0.4	-0.9	-1.6	0.5
Medication: Allopurinol	3.6	4.8	10.4	-0.2	-3.2	-1.8	-2.4
Medication: Omeprazole	0.5	0.6	1.5	-0.3	-0.5	1.2	0.9
Medication: Seretide 50 evohaler	2.0	2.3	5.0	2.2	1.4	1.5	-0.4
Mean time to correctly identify matches	3.6	6.8	19.9	0.8	-2.3	-1.1	-4.5
Heart disease (mother)	1.9	2.3	6.0	2.4	0.7	1.6	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	1.8	-0.9	0.4	0.9	1.4
Whole body fat mass	2.4	10.0	22.5	-3.4	2.1	1.3	4.7
Leg fat mass (right)	2.9	11.3	22.2	-3.8	2.2	1.9	4.7
Arm predicted mass (right)	0.6	3.0	5.7	-2.0	0.9	2.4	1.3
Pulse rate, automated reading	2.0	6.5	16.8	1.0	2.8	0.4	4.1
Alcohol intake frequency.	2.5	5.9	10.8	-3.3	0.6	1.6	3.2
Comparative height size at age 10	0.8	4.3	8.4	-0.5	-2.0	2.1	-2.9
Number of full sisters	3.1	3.7	8.9	-0.7	1.8	1.5	3.0
Suffer from ‘nerves’	1.5	2.3	4.9	-0.1	-1.7	-1.2	-2.2
Overall health rating	4.2	9.0	30.1	-1.3	2.0	-0.2	5.5
Chest pain or discomfort	2.7	3.9	13.4	-0.9	1.1	0.0	3.7
Had major operations	2.1	2.5	8.4	0.8	0.9	-2.9	-0.3
Age at last live birth	1.6	2.3	6.9	1.4	-0.3	-0.6	-2.6
Family relationship satisfaction	0.9	1.1	2.5	1.1	0.7	-1.6	-0.4
Leg pain on walking	2.7	3.4	8.5	-2.9	0.3	-0.4	2.2
Qualifications: NVQ or HND or HNC or equivalent	2.6	3.1	6.7	-1.6	-1.1	-2.6	1.4
Commuting to job workplace: Car/motor vehicle	2.8	3.1	6.8	-1.6	1.5	1.0	2.6
Illness, injury, bereavement, stress in last 2 years	0.9	1.2	3.6	0.8	0.3	0.5	-1.9
Medication: Aspirin	0.6	0.8	2.5	-0.6	0.5	-0.5	1.6
Supplements: Vitamin C	1.2	1.4	2.9	1.4	-0.8	-0.1	-1.7
Knee pain experienced in last month	1.8	2.8	6.3	0.3	2.1	-0.5	2.5
Hypertension (Self-reported)	1.7	4.8	12.5	-0.3	-3.5	-2.5	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.5	-0.5	0.4	0.7	0.1
Illnesses of father: Heart disease	1.1	1.5	3.4	0.5	-1.1	-1.8	1.1
Illnesses of siblings: Diabetes	2.4	3.0	6.6	-1.6	1.3	1.0	2.6
Smoking status: Previous	0.8	1.1	3.2	1.8	-0.8	0.2	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.4	0.1	1.2	0.7	0.3
Whole body fat-free mass	0.4	2.3	5.0	-1.8	0.9	2.2	0.4
Leg fat-free mass (right)	0.4	2.2	2.3	-1.4	1.4	1.5	1.5
Arm fat percentage (left)	3.0	12.0	33.1	-2.8	2.6	0.2	5.8
Average weekly red wine intake	2.4	3.5	10.5	3.2	1.0	-1.6	-0.4
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.2	1.0	1.1	0.7	-0.4
Mood swings	0.7	1.2	3.8	-1.0	0.4	0.1	2.0
Loneliness, isolation	1.1	1.6	2.8	-0.9	-1.7	-1.4	0.9
Long-standing illness, disability or infirmity	0.7	1.1	2.9	-0.8	0.5	0.9	1.7
Ever had bowel cancer screening	0.3	0.4	0.7	-0.6	0.2	0.6	-0.9
Diabetes diagnosed by doctor	0.4	0.7	2.9	0.1	-0.1	-0.0	1.7
Ever had stillbirth, spontaneous miscarriage or termination	1.5	1.6	3.9	-0.1	1.1	2.0	1.2
Friendships satisfaction	0.5	0.6	0.8	-0.9	0.8	-0.1	0.9
Qualifications: nursing, teaching	1.1	1.7	4.1	1.3	-0.8	-0.5	-2.0
Commuting to job workplace: Walk	3.2	3.4	7.6	0.5	-2.0	-2.8	-1.4
Eye problems/disorders: Cataract	2.2	2.6	6.8	1.0	-2.6	0.5	-1.6
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	2.2	0.9	1.5	0.4	0.2
Medication for cholesterol	0.8	1.2	4.3	-0.5	2.1	0.5	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.7	3.9	-1.3	1.0	-0.0	2.0
Back pain experienced in last month	1.4	2.0	6.0	-0.6	1.3	0.3	2.5
Mineral and other dietary supplements	1.9	2.6	8.0	-0.4	0.8	-1.2	2.8
Breast cancer (self-reported)	1.4	1.6	2.0	-1.1	-1.4	-1.2	-1.4
Asthma (self-reported)	0.7	1.4	3.5	-1.3	0.7	0.2	1.9
Osteoporosis (self-reported)	2.4	2.9	7.0	2.6	1.1	-1.9	0.2
Osteoarthritis (self-reported)	0.4	0.6	1.2	0.8	-0.3	-1.1	0.5
Medication: Aspirin	0.4	0.5	1.5	-0.4	0.1	-0.7	1.2
Medication: Gliclazide	0.9	1.1	2.4	0.4	0.2	-1.6	1.3
Illnesses of father: None of the above (group 1)	0.2	0.3	0.6	0.0	-0.2	0.8	-0.7
Smoking status: Current	2.0	3.1	6.4	-0.2	2.3	0.8	2.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.1	4.4	8.9	-0.3	-2.9	0.3	-3.0
Whole body water mass	0.4	2.2	4.5	-1.7	1.0	2.1	0.6
Leg predicted mass (right)	0.4	2.1	2.5	-1.4	1.4	1.5	1.6
Arm fat mass (left)	2.7	11.0	26.3	-3.3	2.3	1.3	5.1
Number of self-reported non-cancer illnesses	0.6	1.0	3.4	0.7	-0.1	0.2	1.9
Average weekly champagne plus white wine intake	1.5	2.1	7.4	-0.5	-0.0	-0.8	-2.7
Miserableness	0.5	1.0	2.3	1.5	-1.0	-0.7	-0.3
Guilty feelings	1.4	2.1	6.6	-0.5	-0.8	-0.9	-2.6
Wears glasses or contact lenses	5.1	5.8	14.3	2.2	-2.0	-0.4	-3.8
Ever taken oral contraceptive pill	2.7	3.0	5.5	2.3	-0.2	-2.2	-1.3
Hearing aid user	0.5	0.6	1.0	-0.9	-0.7	-0.0	1.0
Mother’s age at death	3.0	3.8	13.0	1.0	-0.8	-0.6	-3.6
Financial situation satisfaction	1.1	1.3	3.6	-1.9	0.7	-0.3	1.1
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.8	1.3	-0.5	-0.4	-0.0
Commuting to job workplace: Public transport	3.2	3.8	7.9	0.8	-1.8	-2.8	-2.0
Eye problems/disorders: Glaucoma	1.3	1.5	3.2	1.1	1.8	1.0	0.6
Medication: Blood pressure	1.3	2.5	5.8	1.0	-2.4	-1.8	0.1
Pain type(s) experienced in last month: Hip pain	0.1	0.2	0.3	-0.4	-0.6	0.4	0.2
Supplements: Fish oil (including cod liver oil)	1.4	1.8	6.1	0.3	-0.2	1.1	-2.5
High cholesterol (Self-reported)	0.5	0.9	1.4	-1.2	-1.1	1.0	0.5
Medication: Bendroflumethiazide	0.6	0.9	2.3	-0.8	-0.8	-1.5	0.3
Medication: Paracetamol	1.0	1.5	4.5	-0.5	2.1	-0.2	1.1
Medication: Lisinopril	0.6	0.8	2.8	0.1	-1.7	-0.3	-0.6
Medication: Atorvastatin	3.3	4.1	11.8	2.0	0.7	3.4	0.3
Illnesses of father: High blood pressure	0.4	0.5	1.3	-0.3	-0.9	-0.2	-1.1
Alcohol drinker status: Never	2.4	2.9	11.3	-3.4	-0.2	-0.3	0.5
Ever smoked	0.8	1.3	3.0	1.5	0.3	-1.7	-0.2
Basal metabolic rate	0.6	3.2	5.2	-2.3	1.3	2.1	1.3
Leg fat percentage (left)	3.3	12.1	27.9	-3.7	2.2	1.4	5.3
Arm fat-free mass (left)	0.9	4.3	7.2	-2.7	1.0	2.6	1.5
Number of operations (self-reported)	0.3	0.4	0.8	-0.2	0.9	-0.2	0.8
Average weekly beer plus cider intake	0.0	0.1	0.1	0.3	-0.2	0.4	0.2
Irritability	0.2	0.4	0.7	-0.4	0.7	-0.2	0.9
Risk taking	0.5	0.7	1.5	-1.0	0.4	0.2	1.2
Ever had prostate specific antigen (PSA) test	3.1	3.6	13.1	0.7	-0.7	-0.6	-3.6
Fractured/broken bones in last 5 years	0.6	0.7	1.9	0.0	1.4	0.1	1.0
Age started oral contraceptive pill	1.0	1.2	2.6	0.1	-0.7	1.6	-1.3
Diastolic blood pressure, automated reading	1.4	4.2	9.9	-1.4	1.7	1.5	3.1
Ever depressed for a whole week	0.8	1.0	2.1	1.2	1.5	-0.2	0.5
Unable to work because of sickness or disability	2.2	2.9	9.2	-1.2	0.8	-0.5	3.0
Commuting to job workplace: Cycle	2.3	2.8	4.1	-1.2	-1.6	-1.8	-2.0
Myopia	0.3	0.5	1.7	0.1	1.3	0.2	-0.2
Vascular/heart problems diagnosed by doctor	1.6	4.5	12.4	0.4	3.5	2.3	-0.3
Cholesterol lowering medication	0.8	1.2	3.7	0.9	0.4	1.9	0.2
Medication: Omeprazole (e.g. Zanprol)	0.8	0.9	1.9	-0.9	-1.0	1.4	0.4
Pain experienced in last month	1.2	1.9	2.7	0.1	-1.6	-1.6	-1.6
Supplements: Calcium	1.4	1.6	3.9	1.2	-0.0	1.0	-2.0
Basal cell carcinoma (self-reported)	0.8	1.0	1.9	-1.1	-0.8	-1.4	-0.6
Heart attack/myocardial infarction (self-reported)	1.9	2.4	5.0	2.1	0.2	-0.5	2.2
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	2.5	-1.6	-0.8	-0.8	0.7
Heart disease (siblings)	0.5	0.6	1.3	0.3	-0.8	1.1	0.6
Alcohol drinker status: Previous	1.2	1.4	3.2	-1.8	-0.4	-0.4	1.4
Pack years of smoking	1.7	2.5	7.8	-0.8	0.3	1.2	2.8
Impedance of whole body	0.9	4.6	6.7	2.4	-1.0	-2.6	-2.2
Leg fat mass (left)	2.9	11.2	23.7	-3.7	2.1	1.6	4.9
Arm predicted mass (left)	0.7	3.3	5.8	-2.4	1.0	2.1	1.4