Hub : Genes

SH3BP2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Tibial 0.1321 0.0464 4.0e-04 0.030 NA 0.053 NA 0.038 2.1e-03 NA 5.7e-05 NA 5.4e-04
2 GTEx Cells Transformed fibroblasts 0.1460 0.0430 7.1e-06 0.120 NA 0.130 NA 0.126 2.8e-09 NA 6.2e-10 NA 1.2e-09
3 NTR Blood 0.0352 0.0144 4.9e-03 0.008 0.008 0.005 0.009 0.008 7.3e-04 0.0011 7.0e-03 0.00064 1.3e-03
4 TCGA Soft Tissue Sarcoma 0.0800 0.0390 6.4e-03 0.029 0.018 0.003 NA 0.011 7.7e-03 0.0280 2.0e-01 NA 6.7e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.2 0.3 0.6 0.2 -0.8 -0.6 -0.2
Bipolar Disorder or Schizophrenia 0.3 0.7 1.1 -1.0 -0.7 -1.1 0.4
Depressed Affect (Nagel 2018) 0.3 0.5 1.2 1.1 0.3 0.9 0.1
Depression (Nagel 2018) 1.3 1.9 4.0 -1.6 0.6 0.8 2.0
Intelligence (Savage-Jansen 2018) 2.8 8.5 13.3 3.5 -1.3 -2.5 -3.6
Neuroticism (Nagel 2018) 0.5 1.2 3.6 0.9 -0.5 0.5 -1.9
Schizophrenia (2018) 0.4 0.9 2.3 -1.5 -0.3 -0.9 0.6
Schizophrenia vs Biploar Disorder 0.8 1.1 1.7 -1.3 1.1 -0.3 1.1
Worry (Nagel 2018) 0.5 1.0 2.9 0.7 -0.6 -0.3 -1.7
Alzheimer’s Disease (in mother) 1.7 2.0 5.2 -0.0 -1.6 -0.5 -2.3
Alzheimer’s Disease (in father) 2.2 2.4 4.3 -1.4 -2.1 -0.5 -1.7
Alzheimer’s Disease (including proxy) 1.2 1.8 3.1 -1.3 -1.8 -0.3 -1.5
Crohns Disease (2017) 0.7 1.4 3.2 -1.8 0.4 0.2 1.5
Irritable Bowel Disease (IBD) 0.7 1.7 5.2 -1.2 0.2 0.3 2.3
Ulcerative Colitis (UC) 0.5 0.8 3.2 -0.4 -0.1 -0.2 1.8
Major Depression (MDD) 1.0 1.3 3.2 0.7 1.0 -0.5 1.8
Reaction Time 2.7 5.1 13.2 0.2 -2.0 -1.8 -3.6
Verbal and Numeric Reasoning (VNR) 1.8 4.4 8.6 2.9 -0.7 -0.4 -2.9
Breast Cancer 0.8 1.8 3.7 -1.9 1.6 -0.7 0.7
Ovarian Cancer 1.3 1.7 4.2 0.4 1.6 -0.1 2.0
Prostate Cancer 0.4 0.6 1.9 0.6 0.0 1.4 -0.1
Age at First Birth 1.0 1.4 3.8 2.0 0.6 0.3 -1.2
Bipolar Disorder (2011) 0.5 0.5 0.7 -0.6 -0.8 -0.6 -0.7
Body Mass Index (BMI) (2010) 0.3 0.4 1.1 -0.0 -0.4 1.1 -0.6
Coronary Artery Disease (CAD) 0.6 0.8 1.7 0.6 -0.9 1.3 -0.5
Crohns Disease (2012) 0.8 1.3 3.1 0.2 0.8 1.7 1.2
Mean Putamen Volume 1.4 1.5 2.8 1.1 -1.2 -0.9 -1.7
Fasting Glucose 0.7 0.8 2.5 -0.4 1.6 0.1 0.7
HbA1C 0.3 0.3 0.8 0.2 0.5 0.9 -0.4
HDL Cholesterol 3.0 5.0 10.0 1.8 -3.2 0.3 -2.6
LDL Cholesterol 1.2 1.9 5.9 -1.3 0.3 -0.3 2.4
Lupus 0.4 0.6 1.1 1.0 1.1 0.0 -0.5
Neuroticism (2016) 1.2 1.7 4.1 0.3 -2.0 -0.4 -1.6
Primary Biliary Cirrhosis 0.9 1.3 3.4 -0.9 0.6 1.9 0.8
Rheumatoid Arthritis 1.8 2.5 4.4 1.4 -1.6 0.8 -2.1
Schizophrenia (2014) 0.5 1.2 2.6 -1.1 0.8 -0.4 1.6
Triglycerides 2.1 3.5 7.3 -0.8 2.3 0.7 2.7
Type 2 Diabetes (T2D) (2012) 1.0 1.1 3.2 0.3 -1.8 -0.9 -0.6
Ulcerative Colitis 0.5 0.8 2.7 0.6 0.1 0.1 1.6
Blood Eosinophil Count 0.9 7.3 9.1 -2.1 3.0 2.9 2.7
Blood Platelet Count 1.7 19.7 40.1 -3.6 3.1 4.0 6.3
Blood Red Count 0.2 2.3 6.5 -0.9 0.8 2.5 1.1
Blood White Count 0.8 5.8 22.1 -0.6 0.8 0.1 4.7
Heel T-Score 0.3 2.2 6.7 -2.6 -1.1 -0.0 -0.9
BMI 1.8 10.7 22.1 -3.5 2.6 1.2 4.7
Height 0.5 10.4 29.6 0.8 -1.9 2.8 -5.4
Waist Hip Ratio (WHR) 0.1 0.6 1.7 0.6 -0.6 0.1 1.3
Systolic Blood Pressure 0.4 2.1 7.7 -0.4 -2.8 -0.5 0.6
Smoking Status 1.3 3.0 5.9 0.5 2.0 1.4 2.4
Allergy or Eczema 0.4 1.1 1.6 -1.0 -1.3 -1.2 -0.6
Cardiovascular Disease 1.4 4.5 8.5 -1.1 -2.6 -2.9 1.3
Hypothyroidism (self reported) 0.8 1.8 6.0 -0.1 0.7 2.4 0.8
Respiratory disease 1.1 2.4 5.4 -1.7 1.0 0.7 2.3
Type 2 Diabetes (T2D) (2018) 1.0 2.0 6.7 0.0 1.0 -0.2 2.6
Lung FEV1/FVC ratio 0.5 2.6 4.1 1.5 -0.8 -1.9 -2.0
Lung FVC 1.7 8.6 24.1 -0.6 -3.0 0.9 -4.9
Neuroticism 0.2 0.4 1.0 0.8 -0.3 0.2 -1.0
Chronotype (morning person) 0.9 2.0 2.6 -1.4 -1.2 1.5 1.6
Hair Pigment 0.2 4.9 10.2 3.2 -1.2 -2.3 -1.6
Tanning 0.2 2.2 7.8 -2.8 -0.3 0.6 0.8
Hand grip strength (left) 0.2 0.4 0.6 -0.8 -0.7 0.4 -0.6
Number of treatments/medications taken 0.2 0.4 0.8 0.9 0.3 -0.1 0.7
Average weekly spirits intake 2.3 2.8 6.1 1.0 2.5 0.8 1.9
Sensitivity / hurt feelings 0.0 0.1 0.2 -0.2 -0.1 0.2 0.5
Frequency of depressed mood in last 2 weeks 0.4 0.5 1.0 -1.0 -0.3 -0.4 0.9
Hearing difficulty/problems: Yes 1.3 1.9 4.8 -0.5 -1.6 -2.2 0.3
Relative age of first facial hair 0.9 1.8 4.3 1.6 -0.5 -0.5 -2.1
Other serious medical condition/disability diagnosed by doctor 0.1 0.2 0.4 -0.0 0.4 -0.4 0.6
Ever used hormone-replacement therapy (HRT) 1.7 2.2 5.6 0.1 1.5 2.4 0.9
Ever had hysterectomy (womb removed) 0.8 0.9 2.1 -1.4 -0.3 1.1 0.7
Systolic blood pressure, automated reading 0.5 1.4 1.7 -1.2 -1.3 1.1 1.2
Eye problems/disorders: Diabetes related eye disease 0.9 1.0 3.2 0.2 0.9 -0.2 1.8
Angina 1.3 1.8 6.3 0.1 -0.2 0.9 2.5
Medication for hormone replacement therapy 0.4 0.4 1.0 -1.0 -0.6 -0.4 0.4
Vitamin and mineral supplements 1.2 1.6 4.3 -0.9 0.6 -1.0 2.1
Supplements: Zinc 1.2 1.3 3.5 1.9 -0.7 0.0 -1.2
Medication: Co-codamol 1.1 1.3 2.7 -1.6 -0.3 -1.4 0.5
Medication: Metformin 0.1 0.2 0.5 0.5 0.1 0.2 0.7
Diabetes (father) 0.9 1.1 2.9 -0.4 1.2 -0.3 1.7
Diabetes (mother) 4.7 6.0 12.7 0.1 3.6 0.7 3.3
Severe depression (siblings) 1.9 2.1 5.8 2.4 -1.1 -0.6 -1.1
Pack years adult smoking proportion 2.4 3.6 12.0 -0.9 0.8 1.0 3.5
Impedance of leg (right) 0.4 2.0 4.8 0.7 -1.1 -1.2 -2.2
Leg fat-free mass (left) 0.6 2.9 3.7 -1.7 1.5 1.9 1.6
Trunk fat percentage 2.3 9.1 24.3 -2.7 2.2 0.3 4.9
Hand grip strength (right) 0.4 1.1 2.0 -0.5 -1.4 0.6 -1.4
Townsend deprivation index at recruitment 2.5 3.5 8.3 -2.9 0.5 1.0 2.2
Current tobacco smoking 2.0 3.3 8.4 -0.2 2.1 0.6 2.9
Average weekly fortified wine intake 0.8 0.9 1.7 0.9 1.3 -0.6 0.8
Maternal smoking around birth 2.4 3.5 7.2 -2.3 -1.1 -2.7 -0.4
Fed-up feelings 0.4 0.8 1.8 1.3 0.5 1.1 0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 1.2 1.6 4.1 -1.5 0.1 0.3 2.0
Relative age voice broke 0.8 1.2 3.9 -0.2 -0.1 -0.9 -2.0
Taking other prescription medications 0.9 1.4 3.3 -0.6 0.9 1.0 1.8
Age when periods started (menarche) 1.0 2.5 7.2 1.3 -0.7 -0.7 -2.7
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 1.4 -0.9 -0.3 1.2 1.0
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.4 5.2 -2.3 0.0 -0.4 0.4
Tinnitus: Yes, but not now, but have in the past 1.6 1.7 4.0 -1.3 1.0 2.0 0.1
Qualifications: CSEs or equivalent 2.0 2.6 5.2 -2.3 0.3 1.8 1.3
Serious illness, injury or assault to yourself 1.2 1.4 4.3 0.7 0.5 -0.8 2.1
High blood pressure 1.7 4.9 13.8 -0.5 -3.7 -2.2 -0.7
Hayfever, allergic rhinitis or eczema 0.5 1.1 3.7 0.2 -0.7 -1.9 -0.1
Multivitamins +/- minerals 1.0 1.3 3.7 0.2 0.1 1.9 -1.2
Stomach or abdominal pain in last month 2.6 3.2 8.0 -1.0 1.8 0.7 2.8
Supplements: Glucosamine 2.2 2.9 8.9 0.5 -1.6 0.2 -3.0
Diverticular disease/diverticulitis (self-reported) 1.9 2.2 6.3 -0.7 0.9 1.2 2.5
Medication: Atenolol 1.0 1.2 3.1 0.7 0.7 0.9 1.8
Medication: Levothyroxine sodium 1.2 2.0 3.8 -1.2 0.9 2.0 1.4
Sitting height 0.5 3.3 7.7 -0.5 -0.1 2.3 -2.8
Chronic bronchitis/emphysema (father) 2.3 2.7 5.2 -1.3 2.3 0.9 1.7
High blood pressure (mother) 0.3 0.4 1.2 1.1 -0.4 -0.3 0.4
Body mass index (BMI) 3.6 15.3 33.6 -4.2 2.6 1.8 5.8
Impedance of leg (left) 0.4 1.9 3.0 0.9 -1.0 -1.7 -1.7
Leg predicted mass (left) 0.5 2.8 3.4 -1.7 1.4 1.8 1.6
Trunk fat mass 1.8 7.7 17.9 -3.0 1.9 0.9 4.2
Waist circumference 2.0 7.1 15.4 -2.5 1.7 2.0 3.9
Number of incorrect matches in round 1.0 1.6 4.6 0.6 -0.8 0.9 -2.2
Past tobacco smoking 0.6 1.0 3.9 -2.0 -0.3 0.4 -0.1
Alcohol usually taken with meals 1.4 2.3 6.2 0.9 0.2 -1.5 -2.5
Nervous feelings 0.7 1.2 3.6 -0.2 -1.1 0.4 -1.9
Frequency of tenseness / restlessness in last 2 weeks 2.0 3.2 8.1 -2.9 -0.4 -0.4 2.1
Hearing difficulty/problems with background noise 1.8 2.9 4.5 -1.7 -1.8 -2.1 -1.0
Hair/balding pattern: Pattern 2 1.0 1.3 2.1 0.4 0.9 1.4 1.5
Had menopause 0.5 0.7 1.6 0.1 1.3 0.7 -0.8
Had other major operations 0.3 0.3 0.9 -0.0 -1.0 -0.3 -0.6
Forced vital capacity (FVC) 1.4 5.3 16.0 0.4 -2.1 0.8 -4.0
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.9 5.2 -2.3 -0.8 -1.2 -0.3
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 1.4 -0.9 -0.4 -1.2 0.4
Qualifications: None of the above 4.3 9.2 21.3 -2.3 1.9 2.5 4.6
Financial difficulties in last 2 years 1.8 2.4 6.5 -0.4 1.5 0.8 2.5
Mouth/teeth dental problems 1.0 1.6 4.0 -0.7 -1.3 -0.2 -2.0
Heart attack 2.1 2.7 6.4 2.0 0.7 -0.2 2.5
Allergy 0.5 1.0 2.7 0.2 -0.4 1.6 -1.1
Pain all over the body in last month 1.0 1.1 1.6 -1.1 0.0 -1.2 1.2
Diabetes (self-reported) 0.6 0.9 2.9 -0.8 0.1 -0.2 1.7
Hayfever/allergic rhinitis (self-reported) 2.9 3.8 7.2 2.7 2.1 1.4 1.2
Medication: Ramipril 2.7 3.4 7.7 -0.4 -2.4 -2.8 -0.2
Medication: Simvastatin 1.3 1.9 4.8 -1.5 -2.2 -0.9 -0.0
Fluid intelligence score 0.9 1.9 5.2 2.3 -0.8 -0.2 -1.3
Illnesses of siblings 0.7 0.9 3.2 -0.1 0.4 0.6 -1.8
Neuroticism score 0.2 0.4 0.6 0.1 -0.7 -0.8 -0.6
Weight 1.5 7.2 10.2 -3.2 2.0 2.1 3.2
Impedance of arm (right) 1.1 5.2 7.5 2.7 -0.4 -2.7 -2.4
Arm fat percentage (right) 3.0 11.7 30.8 -2.9 2.7 0.5 5.5
Trunk fat-free mass 0.4 2.5 5.9 -1.9 0.4 2.4 -0.7
Hip circumference 1.3 5.7 7.0 -2.6 2.2 2.0 2.6
Time employed in main current job 0.2 0.2 0.3 0.6 0.2 0.5 0.4
Alcohol intake versus 10 years previously 0.8 1.3 2.4 -1.4 -0.4 1.5 0.7
Father’s age at death 1.4 1.8 6.0 0.9 0.4 0.6 -2.4
Worrier / anxious feelings 0.2 0.4 1.2 0.5 0.0 -0.6 -1.1
Frequency of tiredness / lethargy in last 2 weeks 1.9 3.1 9.2 -1.6 0.7 0.3 3.0
Falls in the last year 1.4 1.9 5.1 -1.1 0.4 -1.1 2.2
Hair/balding pattern: Pattern 3 1.7 2.6 3.1 -1.8 -1.6 -1.7 -1.4
Number of live births 0.9 1.3 2.7 -0.3 -0.4 1.6 -1.5
Forced expiratory volume in 1-second (FEV1) 1.4 4.8 13.7 0.6 -2.3 0.2 -3.7
Pulse rate 0.5 0.9 2.0 1.0 0.0 1.4 0.8
Happiness 0.6 0.7 1.4 -0.8 1.2 0.9 0.3
Noisy workplace 2.4 3.0 7.9 -1.3 0.8 1.3 2.8
Qualifications: A levels/AS levels or equivalent 2.1 4.7 7.8 2.0 -1.3 -2.3 -2.8
Serious illness, injury or assault of a close relative in last 2 years 0.8 0.9 1.4 1.2 -0.7 -1.1 0.7
Mouth/teeth dental problems: Dentures 0.7 1.1 2.7 -0.9 -0.2 0.9 1.7
Asthma 0.9 1.7 4.1 -1.2 1.0 0.6 2.0
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.6 1.5 -0.2 -0.8 -1.2 0.3
Medication: Cholesterol lowering 1.2 1.9 2.7 -0.7 -1.6 -1.6 1.4
Depression (self-reported) 0.4 0.5 1.8 1.3 0.0 0.0 0.4
Medication: Lansoprazole 1.8 2.1 4.5 -2.1 0.5 -1.9 0.1
Prospective memory result 0.3 0.3 0.8 -0.2 -0.3 0.6 -0.9
Lung cancer (father) 1.0 1.2 2.2 1.5 1.5 0.5 0.2
Illnesses of mother 1.4 1.7 4.0 -2.0 -1.2 -0.9 -0.8
Forced expiratory volume in 1-second (FEV1), Best measure 2.1 6.7 18.1 0.8 -2.9 -0.1 -4.2
Pulse wave Arterial Stiffness index 0.5 0.6 1.7 -0.7 -0.6 1.3 0.0
Impedance of arm (left) 1.1 5.1 9.8 3.1 -0.5 -2.6 -1.9
Arm fat mass (right) 2.9 12.0 27.1 -3.6 2.5 1.3 5.2
Trunk predicted mass 0.4 2.5 5.9 -1.8 0.4 2.4 -0.8
Standing height 0.8 7.7 26.1 1.6 -1.1 1.0 -5.1
Length of working week for main job 0.3 0.4 0.8 -0.9 -0.4 -0.1 0.7
Exposure to tobacco smoke at home 1.1 1.2 3.0 -1.7 1.2 0.0 0.7
Breastfed as a baby 0.4 0.5 1.2 0.6 0.1 -0.8 -1.1
Tense / ‘highly strung’ 0.6 0.9 2.9 -1.7 -0.1 -0.2 0.8
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.2 0.7 0.0 -0.0 -0.4 0.8
Hair/balding pattern: Pattern 4 0.2 0.4 0.8 -0.5 0.9 0.4 0.5
Birth weight of first child 1.0 1.8 3.2 -1.3 1.5 1.8 0.0
Peak expiratory flow (PEF) 0.9 2.1 5.6 -0.5 -1.4 0.8 -2.4
Pulse wave reflection index 0.4 0.5 1.7 -1.3 0.2 0.3 0.4
Ever highly irritable/argumentative for 2 days 0.8 0.9 1.9 -1.4 0.6 -1.2 0.1
Loud music exposure frequency 2.6 2.9 7.2 -2.7 1.2 -0.0 1.7
Qualifications: O levels/GCSEs or equivalent 2.2 3.6 7.8 2.5 -0.0 -0.4 -2.8
Mouth/teeth dental problems: Bleeding gums 1.5 1.9 5.9 2.4 0.3 -0.6 1.1
Blood clot in the leg (DVT) 1.2 1.6 4.1 -2.0 -0.6 -0.6 1.2
Medication: Paracetamol 1.0 1.7 4.2 -0.8 2.0 0.3 1.4
Headache pain in last month 2.3 4.0 8.2 -1.9 2.0 0.7 2.9
Medication for cholesterol, blood pressure or diabetes 1.8 2.9 6.1 1.2 2.5 1.8 -1.0
Glaucoma (self-reported) 1.4 1.7 3.5 1.1 1.9 1.4 -0.2
Gout (self-reported) 1.3 1.7 3.5 -1.2 -1.9 -0.7 -1.2
Hypothyroidism/myxoedema (self-reported) 0.8 1.6 5.7 -0.9 0.1 2.4 0.3
Medication: Amlodipine 2.9 4.1 13.3 -0.6 -3.6 -1.6 -0.3
Medication: Ventolin 100micrograms inhaler 1.0 1.3 2.9 0.1 1.7 1.1 1.0
Birth weight 0.5 1.1 2.3 0.7 -0.5 1.1 -1.5
Chronic bronchitis/emphysema (mother) 0.1 0.1 0.3 0.4 -0.3 -0.5 0.2
High blood pressure (siblings) 0.3 0.5 1.4 0.1 -0.7 -0.1 1.2
Forced vital capacity (FVC), Best measure 1.9 7.0 21.2 0.3 -2.6 0.3 -4.6
Body fat percentage 2.6 10.4 27.0 -3.0 2.3 0.6 5.2
Leg fat percentage (right) 3.4 12.2 25.7 -3.8 2.4 1.8 5.1
Arm fat-free mass (right) 0.5 2.7 4.8 -2.2 0.7 2.2 0.9
Exposure to tobacco smoke outside home 1.6 2.2 4.5 -1.1 1.1 1.4 2.1
Comparative body size at age 10 0.8 2.1 5.6 -1.3 0.7 0.9 2.4
Number of full brothers 0.9 1.2 2.5 -1.6 -1.5 0.1 -0.1
Worry too long after embarrassment 2.6 4.4 13.6 0.8 -1.9 -0.0 -3.7
Seen a psychiatrist for nerves, anxiety, tension or depression 1.1 1.4 3.2 1.8 0.0 -1.3 0.9
Wheeze or whistling in the chest in last year 2.1 3.8 9.9 -1.3 1.9 0.4 3.2
Number of children fathered 1.4 1.6 2.4 -1.5 -1.4 -0.6 -1.4
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 1.2 -0.8 -1.1 0.2 -1.0
Age at first live birth 1.7 3.1 7.1 2.0 -0.1 -1.1 -2.7
Pulse wave peak to peak time 0.5 0.5 1.0 0.8 0.6 -1.0 -0.3
Health satisfaction 2.2 2.9 8.2 0.2 1.8 -0.3 2.9
Shortness of breath walking on level ground 3.8 4.5 11.4 -1.2 2.2 0.3 3.4
Qualifications: College or University degree 2.8 9.0 20.0 2.3 -1.1 -3.0 -4.5
Eye problems/disorders: None of the above 0.9 1.0 2.1 -1.5 -0.4 -1.3 0.1
Mouth/teeth dental problems: Loose teeth 0.0 0.0 0.1 -0.0 0.4 -0.2 -0.1
Emphysema/chronic bronchitis 1.2 1.4 2.6 -1.1 1.6 -0.5 1.2
Medication for pain relief, constipation, heartburn 0.3 0.5 1.0 1.0 -0.2 0.8 -0.7
Neck or shoulder pain in last month 0.8 1.1 2.5 -1.6 -0.2 1.3 0.6
Medication: Blood pressure 1.4 2.5 6.4 -1.0 -2.5 -1.5 -0.5
Angina (self-reported) 1.5 1.9 6.5 -0.1 -0.0 1.1 2.5
Migraine (self-reported) 0.3 0.4 0.7 -0.8 -0.7 -0.5 0.4
Medication: Ibuprofen 0.8 1.0 2.7 -0.4 -0.9 -1.6 0.5
Medication: Allopurinol 3.6 4.8 10.4 -0.2 -3.2 -1.8 -2.4
Medication: Omeprazole 0.5 0.6 1.5 -0.3 -0.5 1.2 0.9
Medication: Seretide 50 evohaler 2.0 2.3 5.0 2.2 1.4 1.5 -0.4
Mean time to correctly identify matches 3.6 6.8 19.9 0.8 -2.3 -1.1 -4.5
Heart disease (mother) 1.9 2.3 6.0 2.4 0.7 1.6 -0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 0.9 1.8 -0.9 0.4 0.9 1.4
Whole body fat mass 2.4 10.0 22.5 -3.4 2.1 1.3 4.7
Leg fat mass (right) 2.9 11.3 22.2 -3.8 2.2 1.9 4.7
Arm predicted mass (right) 0.6 3.0 5.7 -2.0 0.9 2.4 1.3
Pulse rate, automated reading 2.0 6.5 16.8 1.0 2.8 0.4 4.1
Alcohol intake frequency. 2.5 5.9 10.8 -3.3 0.6 1.6 3.2
Comparative height size at age 10 0.8 4.3 8.4 -0.5 -2.0 2.1 -2.9
Number of full sisters 3.1 3.7 8.9 -0.7 1.8 1.5 3.0
Suffer from ‘nerves’ 1.5 2.3 4.9 -0.1 -1.7 -1.2 -2.2
Overall health rating 4.2 9.0 30.1 -1.3 2.0 -0.2 5.5
Chest pain or discomfort 2.7 3.9 13.4 -0.9 1.1 0.0 3.7
Had major operations 2.1 2.5 8.4 0.8 0.9 -2.9 -0.3
Age at last live birth 1.6 2.3 6.9 1.4 -0.3 -0.6 -2.6
Family relationship satisfaction 0.9 1.1 2.5 1.1 0.7 -1.6 -0.4
Leg pain on walking 2.7 3.4 8.5 -2.9 0.3 -0.4 2.2
Qualifications: NVQ or HND or HNC or equivalent 2.6 3.1 6.7 -1.6 -1.1 -2.6 1.4
Commuting to job workplace: Car/motor vehicle 2.8 3.1 6.8 -1.6 1.5 1.0 2.6
Illness, injury, bereavement, stress in last 2 years 0.9 1.2 3.6 0.8 0.3 0.5 -1.9
Medication: Aspirin 0.6 0.8 2.5 -0.6 0.5 -0.5 1.6
Supplements: Vitamin C 1.2 1.4 2.9 1.4 -0.8 -0.1 -1.7
Knee pain experienced in last month 1.8 2.8 6.3 0.3 2.1 -0.5 2.5
Hypertension (Self-reported) 1.7 4.8 12.5 -0.3 -3.5 -2.5 -0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.2 0.5 -0.5 0.4 0.7 0.1
Illnesses of father: Heart disease 1.1 1.5 3.4 0.5 -1.1 -1.8 1.1
Illnesses of siblings: Diabetes 2.4 3.0 6.6 -1.6 1.3 1.0 2.6
Smoking status: Previous 0.8 1.1 3.2 1.8 -0.8 0.2 -0.8
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.5 1.4 0.1 1.2 0.7 0.3
Whole body fat-free mass 0.4 2.3 5.0 -1.8 0.9 2.2 0.4
Leg fat-free mass (right) 0.4 2.2 2.3 -1.4 1.4 1.5 1.5
Arm fat percentage (left) 3.0 12.0 33.1 -2.8 2.6 0.2 5.8
Average weekly red wine intake 2.4 3.5 10.5 3.2 1.0 -1.6 -0.4
Handedness (chirality/laterality): Left-handed 0.6 0.7 1.2 1.0 1.1 0.7 -0.4
Mood swings 0.7 1.2 3.8 -1.0 0.4 0.1 2.0
Loneliness, isolation 1.1 1.6 2.8 -0.9 -1.7 -1.4 0.9
Long-standing illness, disability or infirmity 0.7 1.1 2.9 -0.8 0.5 0.9 1.7
Ever had bowel cancer screening 0.3 0.4 0.7 -0.6 0.2 0.6 -0.9
Diabetes diagnosed by doctor 0.4 0.7 2.9 0.1 -0.1 -0.0 1.7
Ever had stillbirth, spontaneous miscarriage or termination 1.5 1.6 3.9 -0.1 1.1 2.0 1.2
Friendships satisfaction 0.5 0.6 0.8 -0.9 0.8 -0.1 0.9
Qualifications: nursing, teaching 1.1 1.7 4.1 1.3 -0.8 -0.5 -2.0
Commuting to job workplace: Walk 3.2 3.4 7.6 0.5 -2.0 -2.8 -1.4
Eye problems/disorders: Cataract 2.2 2.6 6.8 1.0 -2.6 0.5 -1.6
Mouth/teeth dental problems: Mouth ulcers 0.5 0.8 2.2 0.9 1.5 0.4 0.2
Medication for cholesterol 0.8 1.2 4.3 -0.5 2.1 0.5 -0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.4 1.7 3.9 -1.3 1.0 -0.0 2.0
Back pain experienced in last month 1.4 2.0 6.0 -0.6 1.3 0.3 2.5
Mineral and other dietary supplements 1.9 2.6 8.0 -0.4 0.8 -1.2 2.8
Breast cancer (self-reported) 1.4 1.6 2.0 -1.1 -1.4 -1.2 -1.4
Asthma (self-reported) 0.7 1.4 3.5 -1.3 0.7 0.2 1.9
Osteoporosis (self-reported) 2.4 2.9 7.0 2.6 1.1 -1.9 0.2
Osteoarthritis (self-reported) 0.4 0.6 1.2 0.8 -0.3 -1.1 0.5
Medication: Aspirin 0.4 0.5 1.5 -0.4 0.1 -0.7 1.2
Medication: Gliclazide 0.9 1.1 2.4 0.4 0.2 -1.6 1.3
Illnesses of father: None of the above (group 1) 0.2 0.3 0.6 0.0 -0.2 0.8 -0.7
Smoking status: Current 2.0 3.1 6.4 -0.2 2.3 0.8 2.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.1 4.4 8.9 -0.3 -2.9 0.3 -3.0
Whole body water mass 0.4 2.2 4.5 -1.7 1.0 2.1 0.6
Leg predicted mass (right) 0.4 2.1 2.5 -1.4 1.4 1.5 1.6
Arm fat mass (left) 2.7 11.0 26.3 -3.3 2.3 1.3 5.1
Number of self-reported non-cancer illnesses 0.6 1.0 3.4 0.7 -0.1 0.2 1.9
Average weekly champagne plus white wine intake 1.5 2.1 7.4 -0.5 -0.0 -0.8 -2.7
Miserableness 0.5 1.0 2.3 1.5 -1.0 -0.7 -0.3
Guilty feelings 1.4 2.1 6.6 -0.5 -0.8 -0.9 -2.6
Wears glasses or contact lenses 5.1 5.8 14.3 2.2 -2.0 -0.4 -3.8
Ever taken oral contraceptive pill 2.7 3.0 5.5 2.3 -0.2 -2.2 -1.3
Hearing aid user 0.5 0.6 1.0 -0.9 -0.7 -0.0 1.0
Mother’s age at death 3.0 3.8 13.0 1.0 -0.8 -0.6 -3.6
Financial situation satisfaction 1.1 1.3 3.6 -1.9 0.7 -0.3 1.1
Tinnitus: Yes, now most or all of the time 0.5 0.6 1.8 1.3 -0.5 -0.4 -0.0
Commuting to job workplace: Public transport 3.2 3.8 7.9 0.8 -1.8 -2.8 -2.0
Eye problems/disorders: Glaucoma 1.3 1.5 3.2 1.1 1.8 1.0 0.6
Medication: Blood pressure 1.3 2.5 5.8 1.0 -2.4 -1.8 0.1
Pain type(s) experienced in last month: Hip pain 0.1 0.2 0.3 -0.4 -0.6 0.4 0.2
Supplements: Fish oil (including cod liver oil) 1.4 1.8 6.1 0.3 -0.2 1.1 -2.5
High cholesterol (Self-reported) 0.5 0.9 1.4 -1.2 -1.1 1.0 0.5
Medication: Bendroflumethiazide 0.6 0.9 2.3 -0.8 -0.8 -1.5 0.3
Medication: Paracetamol 1.0 1.5 4.5 -0.5 2.1 -0.2 1.1
Medication: Lisinopril 0.6 0.8 2.8 0.1 -1.7 -0.3 -0.6
Medication: Atorvastatin 3.3 4.1 11.8 2.0 0.7 3.4 0.3
Illnesses of father: High blood pressure 0.4 0.5 1.3 -0.3 -0.9 -0.2 -1.1
Alcohol drinker status: Never 2.4 2.9 11.3 -3.4 -0.2 -0.3 0.5
Ever smoked 0.8 1.3 3.0 1.5 0.3 -1.7 -0.2
Basal metabolic rate 0.6 3.2 5.2 -2.3 1.3 2.1 1.3
Leg fat percentage (left) 3.3 12.1 27.9 -3.7 2.2 1.4 5.3
Arm fat-free mass (left) 0.9 4.3 7.2 -2.7 1.0 2.6 1.5
Number of operations (self-reported) 0.3 0.4 0.8 -0.2 0.9 -0.2 0.8
Average weekly beer plus cider intake 0.0 0.1 0.1 0.3 -0.2 0.4 0.2
Irritability 0.2 0.4 0.7 -0.4 0.7 -0.2 0.9
Risk taking 0.5 0.7 1.5 -1.0 0.4 0.2 1.2
Ever had prostate specific antigen (PSA) test 3.1 3.6 13.1 0.7 -0.7 -0.6 -3.6
Fractured/broken bones in last 5 years 0.6 0.7 1.9 0.0 1.4 0.1 1.0
Age started oral contraceptive pill 1.0 1.2 2.6 0.1 -0.7 1.6 -1.3
Diastolic blood pressure, automated reading 1.4 4.2 9.9 -1.4 1.7 1.5 3.1
Ever depressed for a whole week 0.8 1.0 2.1 1.2 1.5 -0.2 0.5
Unable to work because of sickness or disability 2.2 2.9 9.2 -1.2 0.8 -0.5 3.0
Commuting to job workplace: Cycle 2.3 2.8 4.1 -1.2 -1.6 -1.8 -2.0
Myopia 0.3 0.5 1.7 0.1 1.3 0.2 -0.2
Vascular/heart problems diagnosed by doctor 1.6 4.5 12.4 0.4 3.5 2.3 -0.3
Cholesterol lowering medication 0.8 1.2 3.7 0.9 0.4 1.9 0.2
Medication: Omeprazole (e.g. Zanprol) 0.8 0.9 1.9 -0.9 -1.0 1.4 0.4
Pain experienced in last month 1.2 1.9 2.7 0.1 -1.6 -1.6 -1.6
Supplements: Calcium 1.4 1.6 3.9 1.2 -0.0 1.0 -2.0
Basal cell carcinoma (self-reported) 0.8 1.0 1.9 -1.1 -0.8 -1.4 -0.6
Heart attack/myocardial infarction (self-reported) 1.9 2.4 5.0 2.1 0.2 -0.5 2.2
Deep venous thrombosis (DVT) (self-reported) 0.8 1.0 2.5 -1.6 -0.8 -0.8 0.7
Heart disease (siblings) 0.5 0.6 1.3 0.3 -0.8 1.1 0.6
Alcohol drinker status: Previous 1.2 1.4 3.2 -1.8 -0.4 -0.4 1.4
Pack years of smoking 1.7 2.5 7.8 -0.8 0.3 1.2 2.8
Impedance of whole body 0.9 4.6 6.7 2.4 -1.0 -2.6 -2.2
Leg fat mass (left) 2.9 11.2 23.7 -3.7 2.1 1.6 4.9
Arm predicted mass (left) 0.7 3.3 5.8 -2.4 1.0 2.1 1.4