TWAS hub - MAD1L1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1370	0.0350	1.2e-06	0.024	0.049	0.075	0.058	0.067	5.2e-04	1.3e-06	1.7e-09	1.4e-07	1.6e-08
2	GTEx	Esophagus Muscularis	0.2210	0.0690	5.6e-04	0.013	NA	0.050	NA	0.025	5.3e-02	NA	5.6e-04	NA	1.1e-02
3	GTEx	Whole Blood	0.1500	0.0470	1.2e-04	0.013	NA	0.027	NA	0.023	2.1e-02	NA	1.4e-03	NA	2.9e-03
4	METSIM	Adipose	0.0681	0.0228	3.6e-05	0.001	0.031	0.033	0.030	0.017	2.5e-01	1.8e-05	9.8e-06	2.0e-05	1.2e-03
5	NTR	Blood	0.0509	0.0154	7.7e-06	0.019	0.019	0.020	0.021	0.018	5.7e-07	7.9e-07	2.4e-07	2.1e-07	1.3e-06
6	ROSMAP	Brain Pre-frontal Cortex	0.1054	0.0319	7.8e-05	0.026	0.050	0.051	0.059	0.067	2.6e-04	4.4e-07	3.1e-07	4.8e-08	4.7e-09
7	YFS	Blood	0.3890	0.0424	0.0e+00	0.056	0.176	0.188	0.175	0.165	6.7e-18	3.4e-55	2.6e-59	7.2e-55	1.0e-51
8	TCGA	Pheochromocytoma and Paraganglioma	0.2310	0.0960	3.3e-03	-0.007	0.025	0.012	NA	0.007	7.5e-01	3.5e-02	1.1e-01	NA	1.6e-01
9	TCGA	Prostate Adenocarcinoma	0.0929	0.0418	9.2e-04	0.011	0.036	0.014	NA	0.017	2.0e-02	1.1e-04	1.1e-02	NA	5.8e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9
Schizophrenia (2014)	4.1	9.1	34.3	-0.5	0.7	2.3	4.3	1.1	5.9	3.8	2.6	-0.9
Average weekly fortified wine intake	4.1	4.8	9.9	-2.6	-3.1	-3.1	-1.9	-0.3	-2.1	-2.7	0.4	1.4
Bipolar Disorder or Schizophrenia	3.6	8.8	35.6	-0.6	0.6	1.0	4.5	1.6	6.0	3.1	3.0	-0.3
Overall health rating	3.6	7.7	39.8	1.0	0.2	5.1	0.4	0.3	0.4	0.8	-0.6	-6.3
Seen doctor (GP) for nerves, anxiety, tension or depression	3.5	5.4	11.3	1.7	2.9	2.8	-1.2	3.0	1.6	3.4	-1.8	-1.3
Qualifications: nursing, teaching	3.3	5.2	18.0	-4.2	-3.5	-1.8	-1.3	-0.7	-0.8	-3.0	0.7	-0.8
Miserableness	3.2	5.6	16.7	2.6	1.2	3.4	-2.2	0.4	-0.7	0.6	-4.1	-2.9
Schizophrenia (2018)	3.0	6.2	21.9	-1.2	0.5	1.3	3.5	0.8	4.7	2.9	2.9	-0.9
Alcohol drinker status: Previous	3.0	3.4	9.4	-2.1	1.0	2.9	0.8	1.0	0.6	2.4	-0.3	-3.1
Medication: Metformin	2.9	4.0	18.4	-1.0	-1.5	2.6	-0.1	1.1	0.4	1.5	-2.1	-4.3
Number of incorrect matches in round	2.8	4.7	12.1	1.8	2.7	-0.8	-0.2	1.6	3.5	2.8	1.9	2.3
Qualifications: A levels/AS levels or equivalent	2.7	5.9	29.4	-5.4	-4.1	-1.6	1.2	0.9	0.1	0.1	1.2	-0.6
Average weekly spirits intake	2.6	3.2	13.2	1.2	1.5	0.8	1.8	0.0	3.6	1.5	2.0	1.5
Serious illness, injury or assault to yourself	2.6	3.1	12.9	-0.7	0.2	2.8	0.3	0.5	1.5	1.2	-1.7	-3.6
Financial difficulties in last 2 years	2.6	3.5	13.3	-0.3	1.8	2.5	-0.4	-0.4	-0.3	-0.0	-2.9	-3.7
Depression (Nagel 2018)	2.5	3.8	15.8	-0.1	-1.2	2.4	-0.8	1.3	-0.0	0.8	-4.0	-2.8
HbA1C	2.5	2.7	7.2	1.6	1.9	-0.3	1.7	0.1	2.7	1.7	-1.0	2.2
Ever highly irritable/argumentative for 2 days	2.5	3.0	11.6	1.0	1.2	1.6	-1.4	0.8	0.2	-0.1	-3.4	-2.7
Frequency of unenthusiasm / disinterest in last 2 weeks	2.4	3.2	12.3	0.3	-0.1	2.6	-0.1	0.4	0.5	1.2	-2.8	-3.5
Age at first live birth	2.4	4.2	13.3	-2.0	-3.6	-3.1	1.3	-1.0	-0.8	-1.9	0.3	1.9
Mouth/teeth dental problems: Loose teeth	2.4	2.9	8.7	-0.8	-1.6	1.3	-1.8	0.2	-0.6	-2.5	1.5	-2.9
Smoking Status	2.3	5.4	17.9	0.8	0.6	4.2	2.6	1.5	2.5	3.4	-1.2	-1.3
Commuting to job workplace: Car/motor vehicle	2.3	2.6	8.4	2.9	1.3	1.9	-0.6	-2.8	0.7	-0.9	0.4	0.2
Arm fat percentage (left)	2.3	9.0	36.6	-1.1	1.4	4.7	-1.8	1.7	-0.8	2.4	-2.7	-6.0
Irritability	2.3	3.9	11.0	1.6	0.6	3.3	-1.9	-0.8	-0.4	1.5	-2.4	-2.9
Unable to work because of sickness or disability	2.3	3.0	7.3	1.3	1.5	2.4	0.7	0.6	1.9	1.7	-1.5	-2.7
Schizophrenia vs Biploar Disorder	2.2	2.9	11.3	0.4	1.0	1.1	1.0	0.7	2.9	3.4	1.0	-1.2
Coronary Artery Disease (CAD)	2.2	2.7	11.1	0.6	1.5	1.1	1.8	-0.1	-0.9	-0.4	-2.2	-3.3
Seen a psychiatrist for nerves, anxiety, tension or depression	2.2	2.9	8.8	0.8	1.5	3.0	0.5	1.7	1.6	2.1	-1.1	-1.7
Chest pain or discomfort	2.2	3.2	6.8	-0.2	-1.4	1.6	-2.1	-2.2	-1.6	-2.1	-0.9	-2.6
Medication: Gliclazide	2.2	2.5	12.3	-0.0	-0.0	2.0	-0.7	1.4	0.6	0.1	-1.9	-3.5
Age started oral contraceptive pill	2.2	2.7	10.4	-0.6	-0.6	-3.2	-2.2	1.2	-1.0	-1.2	0.6	2.0
Alzheimer’s Disease (in mother)	2.1	2.5	5.9	-0.7	0.2	2.3	1.8	1.9	1.4	2.4	0.1	-1.4
Townsend deprivation index at recruitment	2.1	2.9	5.2	0.1	2.3	1.6	1.6	-0.2	1.6	2.0	-2.2	-2.1
Arm fat percentage (right)	2.1	8.3	31.5	-1.0	1.6	4.6	-1.8	1.3	-0.9	2.3	-2.8	-5.6
Depression (self-reported)	2.1	2.5	4.7	0.6	-0.3	2.1	-0.1	1.4	1.7	1.8	-2.1	-2.2
Mouth/teeth dental problems: Bleeding gums	2.1	2.7	12.5	1.5	0.2	2.6	-0.1	-1.6	-0.2	0.8	-0.1	-3.5
Headache pain in last month	2.1	3.5	10.3	-0.3	-0.9	1.0	-3.2	-0.9	-1.9	-1.3	-2.6	-2.6
Diabetes diagnosed by doctor	2.1	3.4	14.2	-1.1	-0.5	2.3	-0.4	1.1	-0.9	0.7	-2.7	-3.8
Number of self-reported non-cancer illnesses	2.1	3.7	13.1	-0.3	-0.4	2.7	-2.3	0.9	0.4	1.0	-2.3	-3.6
Frequency of tiredness / lethargy in last 2 weeks	2.0	3.3	11.6	0.4	-0.7	2.8	-1.5	-0.0	-0.6	-0.2	-2.6	-3.4
Qualifications: College or University degree	2.0	6.4	25.6	-5.1	-4.1	-3.2	0.7	-0.3	0.5	-1.1	1.4	0.5
Medication: Blood pressure	2.0	3.6	10.8	-1.1	1.1	2.5	1.2	0.2	0.5	1.7	-3.0	-3.3
Mood swings	2.0	3.7	13.9	1.3	0.9	3.7	-0.9	0.8	0.4	0.1	-2.1	-3.3
Bipolar Disorder (2018)	1.9	2.9	13.6	0.4	-0.1	0.1	2.5	1.6	3.7	1.3	1.2	0.6
Depressed Affect (Nagel 2018)	1.9	3.9	11.2	1.5	0.5	2.9	-3.4	0.3	-1.1	0.5	-2.2	-2.6
Neuroticism (Nagel 2018)	1.9	4.4	10.9	1.6	0.8	3.3	-2.7	1.7	-0.1	1.9	-2.4	-2.4
Reaction Time	1.9	3.7	10.6	0.2	1.9	0.6	2.9	-0.3	3.3	2.7	1.0	1.3
Age at First Birth	1.9	2.8	8.5	-2.8	-1.9	-2.9	-0.8	0.6	-0.5	-0.9	0.0	1.8
Type 2 Diabetes (T2D) (2012)	1.9	2.2	6.2	0.9	-2.5	2.0	-1.8	0.8	-0.4	-0.8	-1.4	-1.5
Trunk fat percentage	1.9	7.7	24.0	-1.0	1.4	4.7	-2.1	1.7	0.2	3.0	-1.8	-4.9
Past tobacco smoking	1.9	3.5	6.1	1.5	-0.0	-2.4	-2.3	-2.2	-1.4	-2.5	2.0	1.0
Diabetes (self-reported)	1.9	2.9	11.2	-0.3	0.1	2.6	-0.4	0.4	-0.5	0.5	-2.7	-3.3
Qualifications: O levels/GCSEs or equivalent	1.9	3.0	10.1	-1.6	-3.2	-1.1	0.2	-1.7	0.1	-1.9	1.2	-2.3
Body fat percentage	1.9	7.5	24.5	-1.0	1.6	4.5	-1.9	1.6	-0.3	2.9	-2.1	-5.0
Heart disease (mother)	1.9	2.3	7.3	-1.1	1.1	2.7	1.6	1.0	0.7	0.5	-1.4	-2.2
Illnesses of father: None of the above (group 1)	1.9	2.3	8.2	-2.5	-2.9	-0.9	-1.3	0.0	-1.4	-1.3	-0.2	0.3
Commuting to job workplace: Public transport	1.9	2.3	6.6	-1.9	-0.3	0.2	1.9	1.8	1.2	2.6	0.5	-1.2
Hearing difficulty/problems: Yes	1.8	2.7	10.7	-0.2	-0.0	3.3	-1.6	1.5	1.0	0.7	0.6	-2.6
Fed-up feelings	1.8	3.3	6.9	2.6	0.9	1.5	-2.4	-1.8	-2.0	-1.0	-1.1	-2.1
Body mass index (BMI)	1.8	7.5	30.5	-0.8	0.5	3.8	-1.8	1.3	-1.4	1.1	-3.6	-5.5
Medication: Simvastatin	1.8	2.6	6.2	-0.3	0.2	1.8	-0.5	2.4	1.4	1.5	-2.5	-1.9
Serious illness, injury or assault of a close relative in last 2 years	1.8	2.1	5.5	-1.3	-0.3	2.3	0.6	0.6	1.6	1.6	-0.5	-2.3
Lung cancer (father)	1.8	2.1	6.7	-0.6	-1.6	-0.4	-2.6	-1.0	-1.7	-1.7	-1.4	-0.8
Illness, injury, bereavement, stress in last 2 years	1.8	2.3	8.3	0.9	-1.4	-1.7	0.1	2.0	-1.5	-0.7	-0.2	2.9
Ever had stillbirth, spontaneous miscarriage or termination	1.8	1.9	5.8	2.2	1.7	-0.2	1.4	-0.8	0.8	-0.1	-2.4	-0.1
Osteoarthritis (self-reported)	1.8	2.3	5.7	2.4	0.3	0.9	-0.7	0.6	2.3	2.3	1.8	0.3
Arm fat mass (left)	1.8	7.5	28.2	-0.9	0.1	3.7	-2.8	1.3	-1.4	1.8	-3.2	-5.3
Crohns Disease (2012)	1.7	2.8	7.8	0.8	0.6	2.8	1.8	1.7	2.3	0.3	-0.8	-1.9
Rheumatoid Arthritis	1.7	2.4	9.5	3.1	2.0	1.7	-0.0	-1.4	-0.2	1.8	-0.0	0.3
Cardiovascular Disease	1.7	5.6	18.8	0.9	0.6	4.3	1.1	1.4	1.7	-0.2	-2.5	-4.3
Number of treatments/medications taken	1.7	3.1	7.5	1.0	0.5	2.5	-2.6	0.8	0.6	-0.4	-2.7	-2.1
Hand grip strength (right)	1.7	4.6	12.0	-1.8	-2.5	-3.5	-1.5	-1.0	-1.1	-3.4	-0.2	1.9
Maternal smoking around birth	1.7	2.4	7.9	0.5	1.0	2.8	1.1	0.7	0.6	1.7	-0.2	-2.7
Pulse rate	1.7	2.8	8.7	-1.4	-1.5	0.2	-2.3	-1.0	-1.7	-3.0	0.7	-1.7
Happiness	1.7	2.1	4.8	0.9	2.0	1.9	2.2	-0.3	1.8	1.3	0.5	0.2
Arm fat mass (right)	1.7	6.9	25.1	-1.1	0.3	3.7	-2.8	1.1	-1.5	1.5	-2.9	-5.0
Mean time to correctly identify matches	1.7	3.3	13.8	0.3	1.6	0.0	1.6	0.5	3.7	2.1	1.5	1.9
Illnesses of siblings: Diabetes	1.7	2.1	5.6	-0.2	0.1	2.2	2.0	-0.1	1.1	0.5	-1.6	-2.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.7	3.7	10.3	-2.8	-0.4	-3.2	0.8	-1.1	-3.0	-1.1	-1.3	1.0
Medication: Blood pressure	1.7	3.3	15.2	-0.1	0.5	3.0	0.4	3.9	0.8	0.2	-1.0	-1.8
Medication: Atorvastatin	1.7	2.1	5.6	1.3	-1.5	1.3	0.6	-1.7	-0.1	-1.3	-1.5	-2.4
Breast Cancer	1.6	3.7	8.8	-1.3	0.8	2.1	2.5	2.1	2.3	3.0	-0.0	-1.5
Type 2 Diabetes (T2D) (2018)	1.6	3.0	14.1	-0.3	0.2	2.3	-0.6	0.5	0.4	0.5	-2.6	-3.8
Lung FVC	1.6	8.3	31.9	-2.6	-1.8	-3.5	-1.2	-0.8	-5.7	-2.3	-3.1	1.8
Taking other prescription medications	1.6	2.4	8.7	1.1	0.5	2.6	-2.1	0.3	-0.1	0.2	-0.6	-3.0
Impedance of leg (left)	1.6	7.6	23.5	1.9	3.7	-0.9	1.9	-0.9	2.7	1.1	3.7	4.8
Trunk fat mass	1.6	6.7	22.5	-1.3	0.0	3.9	-3.0	1.2	-0.5	2.5	-2.1	-4.7
Illnesses of mother	1.6	2.0	9.1	1.1	-0.7	-3.0	-1.2	-0.4	-0.4	-1.3	0.4	1.9
Forced vital capacity (FVC), Best measure	1.6	6.0	12.9	-2.3	-3.2	-3.2	-2.0	-1.4	-3.6	-2.2	-1.5	1.4
Whole body fat mass	1.6	6.7	23.6	-1.2	0.3	3.7	-2.7	1.2	-0.9	2.4	-2.5	-4.9
Ever smoked	1.6	2.8	7.0	-1.6	0.6	2.6	2.1	1.2	1.4	1.9	-1.5	-1.1
Fractured/broken bones in last 5 years	1.6	2.1	4.6	2.1	1.7	1.0	-0.4	1.3	0.7	2.1	-1.1	1.5
Prostate Cancer	1.5	2.1	6.3	1.0	-1.5	-1.0	-2.5	1.0	-1.6	-1.8	-0.9	0.6
Hypothyroidism (self reported)	1.5	3.4	11.2	-0.5	0.9	1.2	2.7	1.1	1.4	3.3	-1.8	-1.7
Diabetes (father)	1.5	1.9	6.5	1.6	0.6	1.4	2.5	-0.1	1.4	0.0	-0.1	-1.9
Sitting height	1.5	10.8	36.2	-0.5	-4.8	-3.3	-6.0	-2.7	-2.3	-2.1	0.8	3.0
Forced vital capacity (FVC)	1.5	6.0	14.8	-2.3	-3.3	-2.5	-1.8	-2.3	-3.8	-2.0	-1.4	1.1
Qualifications: None of the above	1.5	3.2	9.2	2.7	3.0	1.9	-0.6	0.8	0.7	2.1	-0.0	1.8
Neuroticism score	1.5	3.1	8.6	1.1	0.7	2.7	-1.7	0.6	-0.8	0.4	-2.6	-2.9
Medication: Cholesterol lowering	1.5	2.4	7.9	-0.5	0.0	0.8	1.0	1.2	1.1	1.8	-2.8	-2.3
Birth weight	1.5	3.3	10.2	-0.8	-0.9	-3.2	-2.2	0.0	-2.2	-0.1	0.6	2.8
Health satisfaction	1.5	2.0	9.7	0.2	-0.1	3.1	1.3	-0.8	1.1	-0.2	0.7	-1.9
Medication for pain relief, constipation, heartburn	1.5	2.6	7.8	-0.5	-0.1	-1.8	2.6	0.8	-0.3	1.2	1.7	2.8
Medication: Aspirin	1.5	1.9	4.9	0.0	0.5	1.4	-1.5	1.9	-0.8	-0.5	-2.2	-1.8
Pain type(s) experienced in last month: Hip pain	1.5	1.9	5.4	1.3	1.0	2.1	0.6	0.7	2.3	0.2	1.3	-1.3
Average weekly beer plus cider intake	1.5	2.2	6.2	-0.4	0.8	2.3	2.5	1.3	1.2	1.2	-0.7	-1.6
Myopia	1.5	2.1	5.7	-2.4	-0.4	-1.0	2.0	-0.9	-0.3	-1.5	1.9	1.2
BMI	1.4	7.9	27.5	-1.6	-0.3	3.5	-0.7	0.9	-1.2	0.8	-5.0	-5.2
Eye problems/disorders: Diabetes related eye disease	1.4	1.5	5.4	0.9	-0.5	2.3	-0.3	0.3	1.0	1.8	-0.5	-1.5
Leg fat-free mass (left)	1.4	7.6	16.5	-1.9	-4.0	0.7	-4.0	0.1	-2.4	0.1	-3.1	-4.1
Medication: Atenolol	1.4	1.8	8.8	0.3	0.3	1.6	1.3	3.0	0.5	0.5	-0.6	-1.4
Leg predicted mass (left)	1.4	7.5	16.5	-1.9	-4.1	0.7	-4.0	0.2	-2.3	0.2	-3.1	-4.0
Hearing difficulty/problems with background noise	1.4	2.3	7.3	-0.5	-0.6	2.1	-2.6	1.3	-0.1	-0.2	0.4	-2.7
Hip circumference	1.4	6.0	20.5	-0.3	-1.4	3.0	-2.9	0.8	-0.9	1.3	-3.3	-4.5
Noisy workplace	1.4	1.7	5.4	1.6	2.3	1.5	-0.5	1.4	1.2	1.1	0.3	0.6
Pulse wave Arterial Stiffness index	1.4	1.7	4.3	-1.0	-1.8	-0.0	-1.9	-0.5	-2.1	-1.3	-0.8	-0.5
Length of working week for main job	1.4	1.5	5.6	-0.7	-0.4	1.2	-0.2	-1.4	-0.9	0.1	-1.8	-2.4
Exposure to tobacco smoke at home	1.4	1.6	5.8	1.3	0.2	1.6	0.6	0.3	2.4	1.7	-0.8	0.3
Birth weight of first child	1.4	2.6	5.6	-0.5	-2.1	-2.3	-1.0	-2.4	-1.0	-0.7	0.9	2.1
Leg fat percentage (right)	1.4	4.9	16.4	-0.8	1.7	3.4	-1.5	1.5	-1.0	1.6	-2.1	-4.1
Alcohol intake frequency.	1.4	3.3	12.5	1.1	3.5	2.0	0.6	0.5	0.4	0.6	-1.3	-3.1
Leg fat-free mass (right)	1.4	7.4	17.1	-2.0	-4.1	0.5	-4.1	-0.2	-2.3	-0.4	-2.7	-3.9
Medication: Aspirin	1.4	1.9	5.7	0.1	0.1	1.5	-1.4	1.6	-0.9	-0.7	-2.4	-1.6
Leg predicted mass (right)	1.4	7.3	17.1	-1.9	-4.1	0.6	-4.1	-0.3	-2.2	-0.4	-2.8	-3.9
Guilty feelings	1.4	2.0	5.4	0.0	0.2	2.2	-0.6	1.0	0.0	1.4	-2.3	-2.2
Ever had prostate specific antigen (PSA) test	1.4	1.6	6.0	-0.9	-2.4	-1.2	-0.6	-0.3	-0.1	0.1	0.7	2.5
Primary Biliary Cirrhosis	1.3	1.9	7.5	1.0	-0.3	2.2	1.2	0.3	1.3	-0.1	0.2	-2.7
Impedance of leg (right)	1.3	6.1	19.7	2.0	3.4	-0.8	1.9	-0.5	2.1	1.7	2.9	4.4
Current tobacco smoking	1.3	2.1	7.6	0.9	1.6	2.8	1.3	0.2	1.8	1.3	-0.4	-1.1
Weight	1.3	6.2	19.6	-1.2	-2.0	2.3	-3.7	0.4	-1.7	0.9	-2.6	-4.4
Trunk fat-free mass	1.3	7.5	22.2	-1.6	-4.7	-2.5	-4.5	-1.1	-3.1	-1.6	-1.7	-0.2
Trunk predicted mass	1.3	7.5	21.9	-1.6	-4.7	-2.5	-4.4	-1.1	-3.2	-1.5	-1.8	-0.3
Blood clot in the leg (DVT)	1.3	1.7	7.0	0.9	1.0	-0.7	-0.3	-2.6	0.4	1.9	1.4	0.0
Medication: Amlodipine	1.3	1.8	5.0	0.1	1.5	2.0	1.4	2.2	0.9	-0.5	-1.1	-1.0
Leg fat mass (right)	1.3	4.9	17.4	-0.7	0.4	3.0	-2.4	0.9	-1.3	1.5	-2.5	-4.2
Knee pain experienced in last month	1.3	2.0	5.5	0.2	2.1	2.3	0.2	-0.0	1.4	0.8	1.3	-1.9
Average weekly red wine intake	1.3	2.0	9.6	-3.1	-1.0	-2.0	0.4	1.3	-0.1	-0.0	1.2	-0.3
Smoking status: Current	1.3	2.0	6.5	0.7	1.3	2.6	1.4	0.6	2.1	1.3	-0.1	-1.1
Medication: Bendroflumethiazide	1.3	2.0	6.4	-1.1	-0.9	1.5	-0.5	1.7	-0.9	-0.7	-2.5	-1.7
Illnesses of father: High blood pressure	1.3	1.6	4.0	0.3	0.4	2.0	1.5	0.7	0.8	1.5	0.8	-2.0
Leg fat percentage (left)	1.3	4.8	16.2	-0.9	1.9	3.6	-1.6	1.4	-0.7	1.4	-1.8	-4.0
Intelligence (Savage-Jansen 2018)	1.2	3.7	11.1	-2.7	-1.2	-1.9	-2.3	0.1	-3.3	-1.9	-0.2	-0.9
Neuroticism	1.2	2.9	6.9	1.2	0.3	2.6	-2.2	0.9	-0.6	0.6	-2.4	-2.2
Ever had hysterectomy (womb removed)	1.2	1.3	5.4	0.1	-0.1	-0.6	-1.7	-0.7	0.4	-1.6	2.3	-0.0
Systolic blood pressure, automated reading	1.2	3.6	12.5	-2.1	-1.8	2.4	1.4	1.8	0.8	-0.3	0.4	-3.5
Severe depression (siblings)	1.2	1.3	5.1	-0.1	-0.4	1.6	0.7	-1.0	2.3	0.5	0.5	-1.5
Waist circumference	1.2	4.5	18.4	-0.3	-0.2	2.6	-2.2	1.5	-1.1	1.0	-2.4	-4.3
Falls in the last year	1.2	1.7	8.0	0.2	0.3	2.8	-0.5	0.6	0.9	0.6	-0.8	-2.1
Forced expiratory volume in 1-second (FEV1)	1.2	4.0	12.2	-2.2	-2.0	-2.0	-1.1	-2.6	-3.5	-1.4	-0.8	0.5
Asthma	1.2	2.5	13.3	0.1	0.3	1.4	0.1	-1.1	-0.5	-0.8	-3.6	-2.1
Prospective memory result	1.2	1.5	5.2	0.8	1.3	-0.2	0.7	0.4	2.3	1.1	0.1	2.0
Number of full brothers	1.2	1.4	4.3	1.7	1.2	2.1	1.4	-1.0	0.9	0.4	-0.2	0.3
Pulse wave peak to peak time	1.2	1.4	4.1	1.2	1.5	-0.1	1.4	0.4	2.0	1.1	1.0	0.6
Comparative height size at age 10	1.2	6.7	19.4	1.3	-3.4	-1.3	-3.4	-2.0	1.7	0.4	4.4	2.8
Illnesses of father: Heart disease	1.2	1.6	6.1	2.5	2.3	1.0	0.0	-0.1	0.7	1.2	0.0	-0.6
Whole body fat-free mass	1.2	7.0	20.5	-1.8	-4.5	-1.3	-4.4	-0.6	-2.9	-0.9	-2.3	-1.8
Medication for cholesterol	1.2	1.8	6.6	0.6	-0.7	-2.1	0.3	-2.6	-0.6	-0.3	1.5	1.3
Asthma (self-reported)	1.2	2.4	12.8	-0.2	0.2	1.2	0.0	-1.4	-0.3	-0.7	-3.6	-2.1
Whole body water mass	1.2	6.7	20.0	-1.7	-4.5	-1.3	-4.3	-0.7	-2.8	-0.9	-2.3	-1.7
Leg fat mass (left)	1.2	4.8	17.3	-0.8	0.4	3.0	-2.5	0.9	-1.1	1.4	-2.3	-4.2
Verbal and Numeric Reasoning (VNR)	1.1	2.6	9.7	-0.1	-0.6	-2.2	-2.2	-0.9	-3.1	-1.7	-0.6	0.1
Hand grip strength (left)	1.1	2.8	9.9	-2.0	-1.8	-2.2	-1.1	-0.2	-1.1	-3.1	0.3	1.0
Vitamin and mineral supplements	1.1	1.5	7.4	1.1	-0.1	1.2	0.1	0.6	-0.8	0.1	-1.6	-2.7
Multivitamins +/- minerals	1.1	1.3	4.5	-0.7	-0.4	-1.1	-0.6	-0.6	1.0	-0.1	2.0	2.1
Heart attack	1.1	1.5	3.7	1.9	1.6	0.4	0.1	0.7	0.4	1.8	-1.6	-0.6
Number of live births	1.1	1.6	6.1	1.5	2.5	1.7	-0.2	1.1	0.6	0.6	1.0	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.6	10.2	-2.1	-2.5	-2.1	-1.0	-1.5	-3.2	-1.5	-1.1	0.4
Loud music exposure frequency	1.1	1.2	3.0	0.7	-0.4	0.4	0.8	-1.7	1.3	-0.9	1.6	-1.2
Medication for cholesterol, blood pressure or diabetes	1.1	1.9	4.9	0.4	-1.0	-1.3	-1.3	0.1	-0.8	-1.4	2.2	2.2
Chronic bronchitis/emphysema (mother)	1.1	1.3	3.5	0.7	1.9	1.0	0.6	0.1	0.7	1.8	-0.4	-1.5
Arm fat-free mass (right)	1.1	5.4	17.9	-1.2	-3.7	-1.2	-4.2	-0.1	-2.7	-0.8	-2.2	-1.3
Migraine (self-reported)	1.1	1.3	6.4	-0.2	-0.3	1.3	-1.0	0.7	0.6	0.7	-2.5	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	4.7	-2.2	-0.6	0.2	0.0	-0.5	-1.0	1.0	-0.7	-2.0
Age at last live birth	1.1	1.7	5.3	-2.2	-2.3	-1.4	-0.2	-0.4	-1.1	-0.4	-1.0	-0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.2	5.1	-0.7	-1.7	1.2	-0.9	-0.1	-0.2	-0.4	0.0	-2.3
Long-standing illness, disability or infirmity	1.1	1.7	9.4	-0.1	-0.6	1.9	-0.9	-0.4	-0.6	-0.5	0.1	-3.1
Basal metabolic rate	1.1	6.2	18.7	-1.5	-3.9	-0.2	-4.3	-0.3	-2.6	-0.4	-2.6	-2.5
Cholesterol lowering medication	1.1	1.7	4.5	0.7	0.3	2.1	-0.8	1.6	0.5	-0.1	-2.1	-1.4
Heart attack/myocardial infarction (self-reported)	1.1	1.4	4.2	2.0	1.6	0.3	-0.0	0.8	0.6	1.6	-1.4	-0.6
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	6.7	0.7	0.9	-0.7	-0.5	-2.6	0.2	1.4	1.4	0.1
Alzheimer’s Disease (in father)	1.0	1.0	5.7	0.2	-0.4	-0.6	-0.8	-2.4	0.1	-0.4	0.0	-1.5
Fasting Glucose	1.0	1.2	3.5	-0.4	-1.0	0.3	-1.4	-0.7	-1.9	-1.8	0.1	-0.3
LDL Cholesterol	1.0	1.6	6.9	0.4	2.6	-0.7	0.7	1.4	-0.2	1.8	-0.9	0.8
Age when periods started (menarche)	1.0	2.5	10.6	-0.2	-0.3	-1.6	-0.2	-1.2	-2.7	-0.0	-3.2	0.7
High blood pressure	1.0	2.9	11.6	-0.1	0.7	3.4	1.2	0.9	0.8	0.2	-1.1	-3.1
Medication: Ramipril	1.0	1.3	4.6	-0.4	0.6	1.2	-1.0	0.8	1.0	2.1	-1.6	-0.4
Breastfed as a baby	1.0	1.3	4.4	0.3	-0.4	-0.3	0.7	0.2	2.1	-0.0	1.5	2.0
Exposure to tobacco smoke outside home	1.0	1.3	3.7	-0.6	0.2	1.6	0.8	0.0	0.8	1.7	-1.0	-1.9
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	3.7	1.3	0.8	0.0	0.5	-0.1	1.4	0.8	1.9	1.4
Arm predicted mass (right)	1.0	4.9	16.2	-1.1	-3.8	-1.0	-4.0	-0.2	-2.3	-0.8	-2.1	-1.1
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.1	5.0	2.2	0.2	1.0	1.0	0.8	1.2	-0.1	-0.4	1.0
Smoking status: Previous	1.0	1.5	3.7	-0.7	-0.2	1.0	1.6	1.7	0.4	1.9	-1.5	-0.2
Ever had bowel cancer screening	1.0	1.2	3.4	-0.7	-1.8	0.3	-1.1	1.3	0.6	1.3	-1.2	0.4
Financial situation satisfaction	1.0	1.3	3.2	1.4	0.7	1.8	0.1	-0.1	-0.7	0.7	-1.4	-1.6
Arm fat-free mass (left)	1.0	5.3	16.2	-1.0	-3.5	-0.8	-4.0	-0.3	-2.8	-0.8	-2.7	-1.2
Vascular/heart problems diagnosed by doctor	1.0	2.6	9.9	0.6	-0.6	-2.9	-0.6	-1.5	-0.1	-0.6	1.2	3.1
Impedance of whole body	1.0	5.0	10.0	1.0	3.1	1.0	1.8	-0.2	3.0	2.3	3.2	2.2
Arm predicted mass (left)	1.0	5.2	15.5	-1.0	-3.6	-0.8	-3.9	-0.3	-2.7	-0.5	-2.7	-1.4
Neuroticism (2016)	0.9	1.3	5.3	1.5	0.7	0.4	-2.3	0.3	-0.2	0.5	-1.3	1.1
Systolic Blood Pressure	0.9	4.3	11.4	-0.6	0.1	3.4	3.2	2.4	1.3	0.2	-0.7	-3.0
Respiratory disease	0.9	2.1	8.0	-0.8	-0.4	0.6	0.2	-1.7	-0.3	-1.3	-2.8	-2.3
Frequency of depressed mood in last 2 weeks	0.9	1.3	4.7	-0.3	0.2	1.3	-0.7	0.1	0.5	0.0	-2.2	-2.1
Pack years adult smoking proportion	0.9	1.3	5.1	1.4	2.2	1.4	0.3	-0.6	1.2	1.1	0.2	0.3
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	2.9	0.3	0.8	-1.4	-1.7	-0.4	-1.3	-0.9	0.5	0.8
Supplements: Glucosamine	0.9	1.1	3.3	-1.1	-0.6	0.4	0.0	0.3	1.8	0.5	1.8	1.3
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	3.2	0.7	1.8	-0.2	-1.6	0.2	0.6	0.1	0.7	1.6
Chronic bronchitis/emphysema (father)	0.9	1.1	3.0	1.3	0.4	0.8	-1.0	-0.1	-1.5	-0.6	-1.7	0.9
Alcohol usually taken with meals	0.9	1.5	5.3	-2.3	-1.0	-0.3	-0.5	0.8	-1.6	0.2	-0.2	-1.9
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	3.4	-1.2	0.9	1.5	-1.6	-0.3	-0.4	0.7	-1.2	-1.9
Fluid intelligence score	0.9	1.9	8.9	-0.9	-1.0	-1.5	-0.5	-1.0	-3.0	-1.4	-1.0	-0.5
Standing height	0.9	8.7	30.9	-1.0	-5.6	-3.2	-4.7	-1.9	-0.7	-0.4	1.9	2.4
Medication: Paracetamol	0.9	1.4	7.8	-1.2	-0.1	0.2	-2.8	-0.7	0.3	-0.1	0.4	-1.7
Neck or shoulder pain in last month	0.9	1.3	3.7	1.4	1.4	1.9	-0.7	0.1	1.6	0.6	-0.0	-0.7
Hypertension (Self-reported)	0.9	2.5	9.8	-0.2	-0.0	3.0	0.8	0.9	0.8	-0.2	-1.2	-3.1
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	4.6	-0.9	-1.8	-2.2	0.0	-0.4	-0.5	-1.7	0.5	-0.0
Tinnitus: Yes, now most or all of the time	0.9	1.0	2.6	1.5	-0.8	0.8	0.6	1.1	1.6	-1.0	0.3	0.9
Number of operations (self-reported)	0.9	1.3	6.3	1.3	0.6	2.5	-1.0	-1.0	-0.7	0.5	-0.4	-0.8
Risk taking	0.9	1.3	4.9	-2.2	-0.7	-1.4	-1.4	-0.0	-0.3	-0.9	-0.1	1.2
Diastolic blood pressure, automated reading	0.9	2.8	11.5	-2.0	-0.2	2.7	1.2	0.5	0.7	-0.2	-0.2	-3.4
Pain experienced in last month	0.9	1.5	3.1	-1.7	-1.3	-1.8	1.3	1.0	-1.1	0.0	-1.0	0.8
Ulcerative Colitis	0.8	1.2	6.4	0.2	-0.9	1.2	0.3	-1.2	-0.1	-0.5	2.5	-0.6
Chronotype (morning person)	0.8	1.8	4.6	1.5	2.1	-1.5	-1.7	-0.6	-1.0	-0.4	-1.3	0.9
Sensitivity / hurt feelings	0.8	1.4	4.2	0.9	1.0	2.0	-1.1	0.4	0.2	0.7	-1.8	-1.4
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	6.6	1.4	2.6	0.1	-0.4	0.0	0.2	-0.8	-0.5	-0.1
Alcohol intake versus 10 years previously	0.8	1.2	5.9	1.1	0.8	0.8	-0.3	1.1	-0.2	-0.2	-2.4	-1.2
Hair/balding pattern: Pattern 3	0.8	1.3	4.5	0.5	0.2	-1.3	0.3	-1.3	-0.1	-0.4	2.1	1.7
Impedance of arm (left)	0.8	3.5	7.8	-0.0	2.0	1.8	1.4	0.3	2.8	2.6	2.8	0.1
Gout (self-reported)	0.8	1.1	4.0	-0.6	-1.6	2.0	0.4	0.8	-0.0	-0.3	0.2	-1.5
Shortness of breath walking on level ground	0.8	1.0	3.6	0.6	-0.0	1.5	0.2	-1.1	-1.0	-0.4	-0.4	-1.9
Eye problems/disorders: None of the above	0.8	1.0	4.0	-2.0	0.4	-1.0	1.0	0.9	-1.0	-0.5	0.6	-0.3
Medication: Ibuprofen	0.8	0.9	2.7	1.6	-0.9	1.2	-1.0	-0.4	0.4	-0.6	-1.0	-0.8
Had major operations	0.8	0.9	3.1	-0.8	0.0	1.1	-1.8	0.5	-1.4	1.1	-0.0	-0.0
Handedness (chirality/laterality): Left-handed	0.8	0.9	2.4	1.0	1.0	1.5	0.9	0.3	0.9	1.2	-0.9	-0.1
Friendships satisfaction	0.8	1.0	3.7	-1.2	0.3	-0.2	-0.8	-0.3	-0.7	-0.6	1.9	1.5
Mineral and other dietary supplements	0.8	1.1	4.2	0.2	-1.0	-0.4	0.3	0.3	-0.8	-0.9	-1.7	-2.1
Osteoporosis (self-reported)	0.8	0.9	2.7	-0.1	-1.3	1.2	-0.6	-0.1	1.5	0.5	0.1	-1.6
Wears glasses or contact lenses	0.8	1.0	2.6	-1.1	-1.6	-0.7	-0.9	-0.2	-1.4	-0.5	-0.6	-1.1
Hearing aid user	0.8	0.9	3.2	-0.2	0.4	-1.1	-0.9	-0.5	-0.0	-1.8	1.3	0.7
Medication: Paracetamol	0.8	1.2	5.9	-0.8	0.4	-0.3	-2.4	-1.3	0.4	-0.5	0.5	-1.5
Basal cell carcinoma (self-reported)	0.8	0.9	2.2	0.9	-0.4	-0.9	-1.2	0.5	-1.1	-1.5	-0.5	1.0
Ovarian Cancer	0.7	0.9	4.8	-1.1	-2.2	0.2	0.7	0.8	0.2	0.7	0.4	-0.7
Body Mass Index (BMI) (2010)	0.7	1.0	6.2	-1.1	-2.5	0.0	0.1	0.0	-0.2	-1.1	0.4	-0.3
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	4.0	-0.4	0.2	0.8	0.1	-0.0	2.0	1.4	1.2	-0.3
Ever used hormone-replacement therapy (HRT)	0.7	0.8	3.2	0.5	0.0	0.6	-0.4	1.4	1.3	1.8	-0.1	0.0
Supplements: Zinc	0.7	0.8	4.0	-2.0	-0.5	-0.6	-0.7	0.3	-0.4	-1.0	0.3	-0.6
Medication: Co-codamol	0.7	0.8	2.1	0.2	-0.9	0.9	-0.7	-0.5	0.4	-1.4	1.5	-0.7
Relative age voice broke	0.7	1.1	4.7	-1.1	-2.2	-0.5	0.2	-0.5	-1.3	-1.1	0.2	0.1
Tinnitus: Yes, but not now, but have in the past	0.7	0.8	1.9	0.5	-0.1	-0.3	-1.3	-0.7	-1.4	-1.2	1.0	-0.5
Qualifications: CSEs or equivalent	0.7	0.9	2.3	1.5	0.8	0.8	1.1	-0.7	1.1	-0.2	-0.2	-1.3
Medication: Levothyroxine sodium	0.7	1.1	3.0	-0.0	-0.1	0.8	1.5	-0.4	0.0	0.9	-1.7	-1.7
Mouth/teeth dental problems	0.7	1.1	6.1	-0.1	-0.8	-1.2	1.1	0.2	0.3	0.2	0.4	2.5
Illnesses of siblings	0.7	1.0	1.8	-1.3	-1.2	-1.3	-1.2	0.7	-0.9	-0.6	0.6	1.0
Impedance of arm (right)	0.7	3.2	6.7	-0.4	2.0	1.9	1.4	-0.5	2.5	2.6	2.4	0.2
Mouth/teeth dental problems: Dentures	0.7	1.3	3.8	0.6	1.9	1.7	-1.1	1.0	1.2	0.6	0.4	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.6	1.6	-0.6	1.2	-1.1	-0.6	0.8	-0.6	-0.6	-0.8
Tense / ‘highly strung’	0.7	1.1	5.3	0.2	0.6	0.4	-2.3	1.5	-0.0	0.5	-1.2	-0.7
High blood pressure (siblings)	0.7	1.0	2.8	1.3	0.7	1.1	1.7	-0.9	0.7	-0.1	1.1	-0.6
Medication: Allopurinol	0.7	0.9	3.9	-0.0	-1.4	1.2	-0.5	-0.6	-0.3	-0.4	0.5	-2.0
Family relationship satisfaction	0.7	0.9	4.8	-0.6	-0.1	-0.5	-1.0	1.2	-0.3	0.4	0.4	2.2
Alcohol drinker status: Never	0.7	0.8	1.7	-1.2	0.6	-0.1	-1.3	0.3	-0.5	-1.3	-0.2	-1.2
Commuting to job workplace: Cycle	0.7	0.8	2.8	-0.9	-0.9	-1.7	0.2	0.4	0.2	-0.8	-0.8	1.4
Pack years of smoking	0.7	1.1	3.4	1.3	1.8	0.5	-0.0	-0.5	1.1	0.9	0.9	1.2
Crohns Disease (2017)	0.6	1.2	3.5	-0.9	0.3	1.4	0.2	1.9	1.7	0.1	-0.3	-1.2
Lung FEV1/FVC ratio	0.6	3.0	6.8	-0.3	0.5	2.5	2.2	-0.7	2.6	2.0	0.8	-1.9
High blood pressure (mother)	0.6	0.8	1.6	0.7	1.1	1.3	0.7	-1.0	1.0	1.0	-0.1	-0.3
Pain all over the body in last month	0.6	0.6	1.4	1.1	0.5	0.6	0.1	-0.8	0.5	1.2	1.0	0.6
Worrier / anxious feelings	0.6	1.1	4.8	0.6	0.9	1.0	-1.1	1.2	-0.0	0.5	-2.2	-0.8
Pulse wave reflection index	0.6	0.7	2.9	0.4	0.5	0.4	1.4	-0.3	0.6	0.7	-1.7	0.5
Medication: Ventolin 100micrograms inhaler	0.6	0.8	3.3	0.0	0.9	-0.1	0.4	0.1	-0.2	-1.8	-1.8	-0.3
Worry too long after embarrassment	0.6	1.1	2.3	1.0	0.1	1.5	-0.6	1.3	-0.2	1.2	-1.0	-1.3
Wheeze or whistling in the chest in last year	0.6	1.0	5.7	-0.1	0.1	1.2	-1.0	-0.7	-0.1	-0.0	-0.7	-2.4
Pulse rate, automated reading	0.6	1.8	7.0	-0.7	-1.6	-0.2	-2.6	-1.2	-0.8	-1.8	0.3	-1.2
Leg pain on walking	0.6	0.8	1.7	-0.5	0.4	0.9	1.1	0.8	1.3	0.5	0.6	-1.2
Commuting to job workplace: Walk	0.6	0.7	1.6	-0.0	-1.2	-1.1	0.6	1.3	0.3	0.1	-0.4	0.9
Back pain experienced in last month	0.6	0.9	4.8	-0.5	0.3	1.7	-0.2	0.1	0.2	-0.1	0.5	-2.2
Breast cancer (self-reported)	0.6	0.7	1.9	1.4	0.8	-0.3	1.0	-0.6	-0.9	0.9	0.9	0.4
Ever taken oral contraceptive pill	0.6	0.6	1.7	-0.0	-0.6	0.5	0.4	-0.9	-0.9	-0.2	-1.2	-1.3
Supplements: Fish oil (including cod liver oil)	0.6	0.8	3.3	-0.1	0.2	0.6	-0.7	0.4	0.2	1.6	-0.0	1.8
High cholesterol (Self-reported)	0.6	1.0	2.5	1.2	0.9	1.1	0.2	0.6	1.5	-0.5	-1.6	-0.4
Ulcerative Colitis (UC)	0.5	1.0	3.5	0.3	-0.4	1.4	1.1	-1.9	-0.0	-0.6	1.1	-0.5
Lupus	0.5	0.7	3.2	-0.2	-0.3	-0.5	-0.1	0.6	1.8	-0.2	0.9	1.2
Blood Red Count	0.5	5.2	24.4	-1.4	0.7	2.1	-0.2	-0.9	-2.6	-1.3	-4.9	-2.5
Heel T-Score	0.5	4.3	10.9	-2.2	-2.3	-3.2	0.2	-0.4	-2.0	-3.3	-0.3	1.8
Height	0.5	8.8	32.5	0.6	-5.7	-1.9	-4.7	-3.2	0.4	-0.1	2.5	2.0
Angina	0.5	0.7	2.5	0.6	1.1	0.4	0.2	0.1	-0.9	1.6	-1.1	-0.1
Medication for hormone replacement therapy	0.5	0.5	1.5	-0.9	1.2	0.3	0.0	-0.4	-1.0	0.8	0.6	-0.4
Allergy	0.5	1.1	4.1	0.2	-0.5	-1.1	-0.6	0.3	0.3	-0.5	1.9	2.0
Father’s age at death	0.5	0.7	2.5	-0.5	1.6	-0.4	-0.4	-1.1	-0.1	1.3	0.6	0.4
Medication: Lansoprazole	0.5	0.5	2.1	-0.5	-0.3	0.5	-0.3	1.0	0.0	-0.2	-1.0	-1.5
Hair/balding pattern: Pattern 4	0.5	1.2	3.1	1.2	0.8	1.3	-0.1	1.3	1.8	1.0	0.1	-1.1
Glaucoma (self-reported)	0.5	0.6	1.3	-1.1	-0.2	-0.9	-0.4	-0.6	-0.9	-0.1	0.8	-0.9
Comparative body size at age 10	0.5	1.3	3.5	-1.1	-1.1	-0.5	-1.0	1.6	-0.4	1.4	-1.9	-0.6
Number of children fathered	0.5	0.6	2.2	-0.2	-0.5	0.4	0.4	-0.2	-0.1	-1.5	0.3	-1.4
Angina (self-reported)	0.5	0.6	2.1	0.5	1.1	0.4	0.3	0.1	-0.8	1.4	-1.0	-0.1
Medication: Omeprazole	0.5	0.6	1.4	0.9	-0.9	0.3	-0.0	-1.2	1.2	0.2	-0.6	-0.4
Medication: Seretide 50 evohaler	0.5	0.6	1.7	-0.2	0.6	-0.0	-0.9	-0.6	-0.6	-0.4	-1.1	-1.3
Loneliness, isolation	0.5	0.7	2.1	-0.6	0.0	0.4	-0.9	-0.5	-0.3	1.2	-1.0	-1.5
Mother’s age at death	0.5	0.6	1.0	-1.0	-0.7	-0.9	-0.3	-0.9	-1.0	0.3	0.8	0.7
Medication: Lisinopril	0.5	0.6	1.9	-0.3	-0.1	-0.5	-0.9	-0.5	-1.2	-1.4	-0.6	-0.8
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.6	0.3	-0.3	0.2	-0.0	-1.0	0.7	-0.6	-1.3	-1.1
Heart disease (siblings)	0.5	0.6	3.1	0.8	1.8	0.6	0.2	-0.2	0.8	0.5	-0.8	0.1
Bipolar Disorder (2011)	0.4	0.4	1.7	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.3	1.2
Mean Putamen Volume	0.4	0.4	1.8	0.3	0.5	0.4	-0.2	0.0	0.6	1.3	0.1	-1.0
HDL Cholesterol	0.4	0.7	3.3	0.4	1.0	0.7	-0.1	-0.1	0.3	0.9	-1.8	-0.1
Triglycerides	0.4	0.7	1.6	0.3	-0.8	-1.0	0.8	0.6	0.4	-0.3	1.3	1.2
Blood Platelet Count	0.4	4.5	17.4	-1.3	-0.7	-0.0	-1.1	0.4	-3.0	-4.2	-2.7	-2.0
Relative age of first facial hair	0.4	0.7	1.6	-1.1	-0.6	0.8	1.3	0.6	0.1	1.0	0.3	-1.1
Diabetes (mother)	0.4	0.6	2.1	-0.5	1.4	0.7	-0.2	-0.1	-0.5	-0.5	1.3	0.3
Stomach or abdominal pain in last month	0.4	0.6	1.2	-0.6	-0.5	0.4	-1.0	-1.1	0.0	-1.0	-0.3	-1.0
Nervous feelings	0.4	0.7	2.6	0.3	0.6	0.1	-1.1	1.6	0.5	-0.3	-1.0	0.7
Time employed in main current job	0.4	0.5	1.7	-0.5	-0.7	0.3	-0.5	-0.5	-0.7	1.3	-0.6	-0.5
Peak expiratory flow (PEF)	0.4	1.0	3.1	-1.1	-0.2	-0.9	-0.2	-1.8	-1.3	0.3	-1.0	0.8
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	3.6	-0.0	0.4	0.0	0.8	-0.2	-0.1	1.9	-1.5	-0.7
Number of full sisters	0.4	0.4	1.8	-0.4	0.6	0.5	-1.4	0.4	0.1	0.7	0.8	0.1
Suffer from ‘nerves’	0.4	0.6	2.5	1.0	0.6	0.9	0.1	0.7	1.6	0.3	0.3	-0.2
Eye problems/disorders: Cataract	0.4	0.5	1.2	0.5	-0.6	1.1	0.5	-0.4	0.9	0.3	-0.8	-0.7
Worry (Nagel 2018)	0.3	0.7	1.6	0.8	-0.3	1.3	-1.0	1.1	0.5	0.8	-0.8	-0.6
Alzheimer’s Disease (including proxy)	0.3	0.4	2.5	-0.6	-0.3	0.0	0.5	0.2	0.4	1.6	0.3	-0.6
Irritable Bowel Disease (IBD)	0.3	0.7	3.2	-0.3	-0.2	1.8	0.8	-0.2	0.9	-0.1	0.7	-1.0
Blood White Count	0.3	2.3	4.4	1.4	2.1	0.9	0.7	-1.1	-1.2	-2.1	-2.0	-1.4
Hayfever, allergic rhinitis or eczema	0.3	0.7	2.2	-1.0	0.3	1.0	0.2	1.5	-0.2	-0.1	-0.8	-1.2
Had menopause	0.3	0.4	1.4	0.2	-0.3	-0.0	0.1	1.2	0.1	1.2	0.3	-0.3
Had other major operations	0.3	0.4	1.3	0.9	0.6	1.1	-0.0	-0.6	0.0	-0.0	-0.6	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	2.0	0.3	0.5	-0.2	0.4	0.9	0.2	1.4	-0.8	1.0
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	1.7	1.3	-0.1	-0.1	0.5	0.3	0.8	0.3	-0.2	0.6
Supplements: Vitamin C	0.3	0.4	0.9	-0.7	-0.9	-0.4	0.2	-1.0	0.1	-0.7	0.1	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	2.1	1.2	-1.4	-0.3	-0.8	-0.0	0.0	-0.1	-0.7	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	1.3	-0.2	0.1	0.5	-1.1	0.4	-0.3	-0.7	0.6	-0.4
Average weekly champagne plus white wine intake	0.3	0.4	2.5	-0.3	-0.6	0.2	-0.2	0.0	-0.0	1.6	-0.3	-0.1
Blood Eosinophil Count	0.2	1.5	8.6	0.8	2.9	-0.6	0.3	-0.7	-0.8	-0.6	-0.9	1.3
Waist Hip Ratio (WHR)	0.2	0.9	3.7	1.4	1.9	-0.3	0.8	0.9	0.7	0.2	0.7	0.5
Allergy or Eczema	0.2	0.4	1.6	-0.9	0.2	0.7	-0.4	0.6	-0.2	-0.0	-0.7	-1.3
Hair/balding pattern: Pattern 2	0.2	0.2	0.7	0.1	-0.2	-0.2	-0.1	0.7	-0.6	-0.3	-0.8	0.5
Emphysema/chronic bronchitis	0.2	0.2	0.8	0.3	-0.1	0.3	-0.1	0.3	-0.9	0.3	0.9	0.5
Eye problems/disorders: Glaucoma	0.2	0.3	1.2	-0.3	1.1	-0.1	-0.1	-0.1	-0.2	0.6	0.6	-0.5
Ever depressed for a whole week	0.2	0.2	0.3	0.5	-0.5	0.4	-0.4	-0.5	0.5	-0.2	-0.5	-0.5
Major Depression (MDD)	0.1	0.2	1.2	0.0	0.0	0.0	0.0	0.0	0.0	0.0	-1.1	-0.6
Tanning	0.1	1.5	3.9	1.0	1.2	2.0	1.0	0.9	1.4	1.7	-0.4	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	1.0	0.1	0.1	-0.1	0.2	1.0	0.1	0.9	-0.1	0.7
Supplements: Calcium	0.1	0.1	0.4	0.1	-0.2	0.3	0.6	0.3	0.1	0.2	-0.0	-0.6
Hair Pigment	0.0	0.9	2.8	-1.1	1.7	-0.6	0.6	1.0	0.3	1.3	-0.3	0.7

Hub : Genes

MAD1L1

Models

Trait associations