Best TWAS P=6.32e-10 · Best GWAS P=1.12e-09 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | PSMB7 | 0.08 | 0.04 | lasso | 6 | 0.04 | 3.4e-04 | 4.4 | -5.5 | 4.4e-08 | 0.02 | 0.02 | 0.97 | TRUE |
| 2 | GTEx | Artery Aorta | PSMB7 | 0.15 | 0.03 | enet | 16 | 0.05 | 1.4e-03 | -4.3 | -5.2 | 1.9e-07 | 0.14 | 0.06 | 0.72 | FALSE |
| 3 | GTEx | Artery Tibial | GAPVD1 | 0.11 | 0.16 | enet | 19 | 0.16 | 6.4e-13 | -5.7 | -6.2 | 6.4e-10 | 0.94 | 0.02 | 0.98 | FALSE |
| 4 | GTEx | Brain Cerebellum | PRPS1P2 | 0.09 | 0.08 | enet | 16 | 0.04 | 2.8e-02 | -6.0 | 5.3 | 1.3e-07 | -0.84 | 0.05 | 0.79 | FALSE |
| 5 | GTEx | Breast Mammary Tissue | PSMB7 | 0.11 | 0.03 | lasso | 7 | 0.04 | 4.7e-03 | 5.6 | -5.5 | 4.4e-08 | 0.06 | 0.04 | 0.85 | FALSE |
| 6 | GTEx | Breast Mammary Tissue (Female) | PPP6C | 0.14 | 0.04 | lasso | 4 | 0.04 | 3.1e-02 | 5.0 | -5.3 | 1.2e-07 | 0.74 | 0.08 | 0.80 | FALSE |
| 7 | GTEx | Colon Sigmoid | PSMB7 | 0.15 | 0.10 | lasso | 3 | 0.09 | 3.3e-04 | 5.3 | -5.4 | 6.1e-08 | 0.05 | 0.04 | 0.92 | FALSE |
| 8 | GTEx | Esophagus Mucosa | PPP6C | 0.07 | 0.07 | enet | 21 | 0.08 | 7.1e-06 | 5.0 | -5.2 | 2.4e-07 | 0.67 | 0.85 | 0.14 | FALSE |
| 9 | GTEx | Esophagus Mucosa | PRPS1P2 | 0.07 | 0.08 | lasso | 3 | 0.07 | 1.5e-05 | 5.0 | 5.2 | 1.7e-07 | -0.67 | 0.47 | 0.45 | FALSE |
| 10 | GTEx | Esophagus Muscularis | OLFML2A | 0.08 | 0.00 | enet | 27 | 0.00 | 4.9e-01 | 4.8 | 5.5 | 3.4e-08 | -0.50 | 0.08 | 0.23 | FALSE |
| 11 | GTEx | Muscle Skeletal | GAPVD1 | 0.13 | 0.10 | lasso | 3 | 0.09 | 4.7e-09 | -6.0 | 6.1 | 1.4e-09 | -0.95 | 0.02 | 0.98 | FALSE |
| 12 | GTEx | Nerve Tibial | GAPVD1 | 0.17 | 0.08 | lasso | 10 | 0.10 | 9.3e-08 | 5.0 | -6.0 | 2.2e-09 | 0.84 | 0.13 | 0.87 | FALSE |
| 13 | GTEx | Thyroid | NEK6 | 0.20 | 0.21 | lasso | 4 | 0.20 | 1.3e-15 | 5.0 | -5.2 | 2.1e-07 | 0.05 | 0.42 | 0.58 | FALSE |
| 14 | GTEx | Thyroid | GAPVD1 | 0.05 | 0.05 | enet | 13 | 0.01 | 6.6e-02 | -6.0 | -6.2 | 6.3e-10 | 0.96 | 0.02 | 0.98 | TRUE |
| 15 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GAPVD1 | 0.02 | 0.04 | enet | 4 | 0.01 | 9.8e-03 | -6.1 | 6.1 | 9.9e-10 | -0.97 | 0.02 | 0.90 | FALSE |
| 16 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PSMB7 | 0.03 | 0.04 | lasso | 4 | 0.04 | 1.2e-04 | 5.3 | -5.4 | 8.4e-08 | 0.03 | 0.03 | 0.93 | FALSE |
| 17 | The Cancer Genome Atlas | Thyroid Carcinoma | PSMB7 | 0.06 | 0.06 | lasso | 4 | 0.04 | 3.7e-05 | 5.4 | -5.4 | 6.1e-08 | 0.07 | 0.07 | 0.93 | FALSE |