Best TWAS P=1.13e-15 · Best GWAS P=5.63e-15 conditioned to 0.812
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | ZNF503 | 0.08 | 0.00 | blup | 366 | 0.03 | 2.5e-04 | 6.6 | 5.4 | 5.6e-08 | 0.19 | 0.36 | 0.03 | FALSE |
2 | GTEx | Adipose Subcutaneous | C10orf11 | 0.24 | 0.21 | lasso | 9 | 0.20 | 3.3e-16 | 6.8 | -7.4 | 1.2e-13 | -0.87 | 0.06 | 0.94 | FALSE |
3 | GTEx | Adipose Subcutaneous | DLG5 | 0.39 | 0.40 | lasso | 12 | 0.43 | 1.9e-38 | -5.2 | -5.2 | 1.7e-07 | 0.01 | 0.44 | 0.56 | FALSE |
4 | GTEx | Adipose Visceral Omentum | C10orf11 | 0.40 | 0.32 | enet | 11 | 0.27 | 2.2e-14 | 6.8 | -7.7 | 1.6e-14 | -0.89 | 0.03 | 0.97 | FALSE |
5 | GTEx | Adrenal Gland | C10orf11 | 0.24 | 0.22 | enet | 21 | 0.18 | 5.8e-07 | 6.8 | -6.6 | 4.0e-11 | -0.83 | 0.02 | 0.98 | FALSE |
6 | GTEx | Adrenal Gland | DLG5 | 0.22 | 0.14 | lasso | 6 | 0.11 | 8.5e-05 | -5.1 | -5.3 | 9.0e-08 | 0.02 | 0.28 | 0.54 | FALSE |
7 | GTEx | Artery Aorta | DLG5 | 0.26 | 0.19 | enet | 10 | 0.22 | 2.6e-12 | -4.9 | -5.5 | 3.4e-08 | 0.01 | 0.33 | 0.67 | FALSE |
8 | GTEx | Artery Aorta | RP13-39P12.3 | 0.14 | 0.13 | enet | 9 | 0.12 | 2.2e-07 | -4.9 | -5.2 | 1.7e-07 | 0.03 | 0.07 | 0.92 | FALSE |
9 | GTEx | Artery Coronary | DLG5 | 0.33 | 0.25 | lasso | 4 | 0.27 | 1.4e-09 | -5.3 | -5.3 | 1.4e-07 | 0.00 | 0.22 | 0.77 | FALSE |
10 | GTEx | Cells Transformed fibroblasts | DLG5 | 0.25 | 0.18 | lasso | 11 | 0.16 | 2.0e-12 | -5.1 | -5.4 | 5.4e-08 | 0.02 | 0.17 | 0.83 | FALSE |
11 | GTEx | Cells Transformed fibroblasts | RP13-39P12.3 | 0.19 | 0.13 | lasso | 7 | 0.15 | 4.5e-11 | -5.1 | -5.3 | 1.1e-07 | 0.00 | 0.33 | 0.66 | FALSE |
12 | GTEx | Colon Transverse | DLG5 | 0.23 | 0.17 | lasso | 8 | 0.19 | 1.4e-09 | -5.3 | -5.3 | 1.4e-07 | 0.00 | 0.40 | 0.60 | FALSE |
13 | GTEx | Esophagus Gastroesophageal Junction | DLG5 | 0.27 | 0.03 | enet | 13 | 0.06 | 3.9e-03 | -6.3 | -5.7 | 1.0e-08 | -0.06 | 0.00 | 0.98 | TRUE |
14 | GTEx | Esophagus Mucosa | DLG5 | 0.21 | 0.16 | lasso | 5 | 0.18 | 5.2e-12 | -5.2 | -5.2 | 2.4e-07 | 0.00 | 0.48 | 0.52 | FALSE |
15 | GTEx | Esophagus Muscularis | C10orf11 | 0.45 | 0.39 | enet | 42 | 0.38 | 5.1e-24 | 6.8 | -8.0 | 1.1e-15 | -0.84 | 0.25 | 0.75 | TRUE |
16 | GTEx | Heart Atrial Appendage | DLG5 | 0.32 | 0.23 | lasso | 4 | 0.24 | 3.9e-11 | -5.0 | -5.1 | 2.8e-07 | 0.02 | 0.48 | 0.52 | FALSE |
17 | GTEx | Lung | C10orf11 | 0.30 | 0.26 | lasso | 5 | 0.24 | 2.0e-18 | 6.8 | -7.4 | 1.0e-13 | -0.87 | 0.06 | 0.94 | FALSE |
18 | GTEx | Lung | DLG5 | 0.41 | 0.38 | lasso | 8 | 0.37 | 7.9e-30 | -5.1 | -5.2 | 1.5e-07 | 0.01 | 0.54 | 0.46 | FALSE |
19 | GTEx | Nerve Tibial | DLG5 | 0.51 | 0.44 | lasso | 6 | 0.50 | 1.4e-39 | -5.2 | -5.6 | 1.9e-08 | 0.01 | 0.45 | 0.55 | FALSE |
20 | GTEx | Nerve Tibial | RP13-39P12.3 | 0.31 | 0.25 | lasso | 7 | 0.36 | 1.3e-26 | -5.1 | -5.4 | 7.0e-08 | 0.00 | 0.24 | 0.76 | FALSE |
21 | GTEx | Ovary | DLG5 | 0.62 | 0.38 | lasso | 6 | 0.40 | 5.3e-11 | -5.1 | -5.4 | 5.3e-08 | 0.01 | 0.51 | 0.48 | FALSE |
22 | GTEx | Ovary | RP13-39P12.3 | 0.42 | 0.29 | lasso | 5 | 0.33 | 7.5e-09 | -5.1 | -5.4 | 7.4e-08 | 0.01 | 0.43 | 0.45 | FALSE |
23 | GTEx | Pituitary | DLG5 | 0.45 | 0.36 | lasso | 11 | 0.31 | 1.9e-08 | -5.1 | -5.3 | 8.9e-08 | 0.02 | 0.06 | 0.93 | FALSE |
24 | GTEx | Pituitary | RP13-39P12.3 | 0.38 | 0.22 | lasso | 11 | 0.17 | 3.8e-05 | -5.1 | -5.4 | 7.0e-08 | 0.02 | 0.03 | 0.93 | FALSE |
25 | GTEx | Spleen | DLG5 | 0.51 | 0.46 | lasso | 4 | 0.44 | 1.1e-12 | -5.2 | -5.2 | 2.2e-07 | 0.01 | 0.40 | 0.60 | FALSE |
26 | GTEx | Thyroid | C10orf11 | 0.38 | 0.21 | lasso | 9 | 0.25 | 6.7e-19 | 6.3 | -7.6 | 4.1e-14 | -0.80 | 0.14 | 0.86 | FALSE |
27 | GTEx | Thyroid | RP13-39P12.3 | 0.28 | 0.30 | lasso | 8 | 0.29 | 3.3e-22 | -5.1 | -5.1 | 2.7e-07 | 0.02 | 0.57 | 0.43 | FALSE |
28 | METSIM | Adipose | C10orf11 | 0.11 | 0.10 | enet | 14 | 0.10 | 1.1e-14 | 6.3 | -6.6 | 3.1e-11 | -0.78 | 0.52 | 0.48 | FALSE |
29 | ROSMAP | Brain Pre-frontal Cortex | ZNF503 | 0.05 | 0.04 | bslmm | 342 | 0.04 | 2.2e-06 | 6.1 | 5.5 | 2.9e-08 | 0.15 | 0.96 | 0.01 | TRUE |
30 | ROSMAP | Brain Pre-frontal Cortex | ZNF503-AS2 | 0.07 | 0.06 | lasso | 2 | 0.06 | 2.2e-08 | 6.1 | 6.3 | 2.1e-10 | 0.29 | 0.99 | 0.01 | FALSE |