Hub : Genes

ZNF503

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0770	0.0270	0.00031	0.001	0.027	0.027	0.025	0.017	2.2e-01	2.5e-04	2.6e-04	4.5e-04	3.6e-03
2	METSIM	Adipose	0.0381	0.0158	0.00100	0.001	0.018	0.008	0.020	0.002	2.3e-01	9.0e-04	2.0e-02	4.9e-04	1.2e-01
3	ROSMAP	Brain Pre-frontal Cortex	0.0541	0.0209	0.00062	0.043	0.042	0.029	0.044	0.038	2.5e-06	4.1e-06	1.0e-04	2.2e-06	1.0e-05
4	YFS	Blood	0.2980	0.0391	0.00000	0.140	0.148	0.162	0.161	0.154	2.2e-43	5.4e-46	1.1e-50	3.0e-50	4.4e-48

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	2.3	3.6	7.2	-2.7	-0.1	-2.5	1.0
Bipolar Disorder or Schizophrenia	0.5	1.3	2.5	-1.3	-0.5	-0.9	1.6
Depressed Affect (Nagel 2018)	0.9	1.9	3.4	1.8	0.6	1.1	-1.6
Depression (Nagel 2018)	2.1	3.1	5.7	1.0	-0.6	2.3	-2.4
Intelligence (Savage-Jansen 2018)	2.0	6.1	10.0	-1.8	3.2	-2.7	2.0
Neuroticism (Nagel 2018)	0.8	1.9	4.0	1.6	-0.2	2.0	-1.0
Schizophrenia (2018)	0.4	0.8	1.5	0.6	-0.6	0.9	1.2
Schizophrenia vs Biploar Disorder	1.1	1.4	1.8	1.3	0.9	1.3	1.2
Worry (Nagel 2018)	0.4	0.9	2.6	0.5	-0.6	1.6	-0.7
Alzheimer’s Disease (in mother)	0.3	0.3	0.9	0.4	0.2	0.6	-0.9
Alzheimer’s Disease (in father)	0.1	0.1	0.2	-0.3	-0.4	0.3	-0.5
Alzheimer’s Disease (including proxy)	0.7	1.1	1.8	0.8	0.0	1.4	-1.3
Crohns Disease (2017)	0.2	0.5	0.8	0.9	0.4	0.9	0.1
Irritable Bowel Disease (IBD)	0.1	0.3	0.9	-0.3	-0.4	0.0	-1.0
Ulcerative Colitis (UC)	0.4	0.7	1.0	-0.9	-0.8	-0.6	-1.0
Major Depression (MDD)	0.1	0.1	0.3	-0.5	-0.1	0.0	0.5
Reaction Time	0.6	1.1	4.0	0.5	-2.0	0.4	-0.0
Verbal and Numeric Reasoning (VNR)	2.2	5.2	10.7	-1.6	3.3	-2.1	1.8
Breast Cancer	0.9	2.2	4.0	2.0	-0.9	2.0	0.1
Ovarian Cancer	1.0	1.3	1.9	1.2	0.0	1.4	-1.3
Prostate Cancer	1.0	1.4	4.7	-0.8	2.2	-0.6	-0.2
Age at First Birth	1.2	1.7	4.4	-0.0	1.5	0.5	2.1
Bipolar Disorder (2011)	0.5	0.5	0.9	-0.9	0.4	-0.8	0.6
Body Mass Index (BMI) (2010)	4.0	5.5	11.2	3.3	-1.4	2.9	-0.7
Coronary Artery Disease (CAD)	0.7	0.9	2.6	0.4	0.9	1.6	-0.0
Crohns Disease (2012)	0.2	0.3	0.5	-0.7	-0.2	0.6	-0.6
Mean Putamen Volume	1.5	1.7	3.6	0.2	-1.7	1.9	-0.5
Fasting Glucose	0.5	0.5	1.1	-0.6	-0.7	-1.1	0.5
HbA1C	1.0	1.1	1.4	1.0	-1.1	0.9	1.2
HDL Cholesterol	1.1	1.8	3.7	0.6	1.2	1.9	-1.3
LDL Cholesterol	0.6	0.9	1.6	1.2	0.5	1.3	-0.4
Lupus	0.3	0.5	1.3	-0.7	-0.4	-1.1	0.0
Neuroticism (2016)	3.4	4.9	10.7	2.9	-0.5	3.3	0.5
Primary Biliary Cirrhosis	0.4	0.5	1.2	-1.1	0.6	-0.3	-0.7
Rheumatoid Arthritis	0.8	1.1	4.0	-0.3	-2.0	0.7	-0.2
Schizophrenia (2014)	0.9	1.9	7.6	0.1	-0.2	0.4	2.7
Triglycerides	1.4	2.3	3.6	-1.3	-1.0	-1.7	1.9
Type 2 Diabetes (T2D) (2012)	1.5	1.8	4.3	0.9	-2.1	1.1	-0.7
Ulcerative Colitis	1.2	1.7	2.7	-1.3	-1.5	-0.5	-1.7
Blood Eosinophil Count	0.0	0.2	0.6	0.3	-0.3	0.3	0.8
Blood Platelet Count	0.6	6.5	17.1	2.5	1.4	0.8	4.1
Blood Red Count	1.2	11.9	17.1	-4.0	-2.0	-4.1	-3.2
Blood White Count	0.2	1.7	5.7	0.0	-2.4	0.9	-0.4
Heel T-Score	1.4	11.5	38.9	-1.2	-6.2	-0.6	-2.2
BMI	1.4	8.2	17.9	4.2	-0.6	3.8	0.4
Height	0.2	3.9	8.0	1.5	-2.8	2.1	1.1
Waist Hip Ratio (WHR)	2.2	9.8	22.3	-4.0	-0.6	-4.7	-0.8
Systolic Blood Pressure	1.6	8.0	17.1	-3.5	-0.0	-4.1	1.5
Smoking Status	0.2	0.5	0.8	0.7	-0.6	0.9	-0.6
Allergy or Eczema	0.3	0.7	1.5	0.8	1.2	-0.1	0.9
Cardiovascular Disease	0.3	1.1	2.2	-0.1	-1.4	-0.0	1.5
Hypothyroidism (self reported)	0.2	0.5	1.3	-0.4	-0.7	-1.2	-0.1
Respiratory disease	0.3	0.6	1.3	0.6	0.7	0.3	1.2
Type 2 Diabetes (T2D) (2018)	2.0	3.7	8.2	-1.8	-1.7	-0.8	2.9
Lung FEV1/FVC ratio	1.4	7.2	14.0	-3.7	-1.6	-0.9	-3.4
Lung FVC	0.5	2.7	5.1	2.3	-0.1	1.3	2.1
Neuroticism	1.4	3.4	9.4	1.8	-0.1	3.1	-1.0
Chronotype (morning person)	0.6	1.5	4.7	-0.0	-1.1	0.1	2.2
Hair Pigment	0.1	1.4	3.5	0.0	0.6	-1.9	-1.4
Tanning	0.0	0.5	0.9	-1.0	-0.8	-0.6	0.2
Hand grip strength (left)	0.3	0.9	1.6	-0.8	0.9	-0.7	1.3
Number of treatments/medications taken	0.2	0.4	0.7	-0.7	-0.2	-0.5	0.8
Average weekly spirits intake	1.0	1.3	2.3	1.4	-1.5	0.3	-0.8
Sensitivity / hurt feelings	1.5	2.6	6.0	2.0	-0.4	2.4	0.2
Frequency of depressed mood in last 2 weeks	1.7	2.3	6.1	0.2	-1.2	2.5	-1.4
Hearing difficulty/problems: Yes	3.2	4.9	10.0	1.9	0.5	3.2	-2.4
Relative age of first facial hair	0.5	1.1	2.8	0.4	-0.7	1.7	0.9
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.8	0.8	-0.0	0.9	0.0
Ever used hormone-replacement therapy (HRT)	1.4	1.8	3.5	1.9	-0.7	1.6	-0.9
Ever had hysterectomy (womb removed)	0.8	1.0	2.4	-0.9	0.5	-1.6	-0.6
Systolic blood pressure, automated reading	1.8	5.2	11.8	-2.6	-0.5	-3.4	1.2
Eye problems/disorders: Diabetes related eye disease	2.4	2.7	9.1	0.3	-0.9	-0.9	3.0
Angina	0.8	1.1	1.4	1.0	1.1	1.2	-1.0
Medication for hormone replacement therapy	1.1	1.2	2.1	0.9	1.4	1.4	0.2
Vitamin and mineral supplements	0.6	0.9	2.5	0.2	-0.8	0.6	1.6
Supplements: Zinc	0.7	0.8	1.4	-0.9	0.5	-0.8	1.2
Medication: Co-codamol	0.3	0.3	1.0	-0.1	1.0	-0.3	-0.4
Medication: Metformin	0.7	1.0	3.7	-0.0	-0.5	0.3	1.9
Diabetes (father)	2.9	3.6	6.0	2.5	-1.1	1.8	2.0
Diabetes (mother)	2.1	2.7	6.9	1.8	-0.7	2.6	0.4
Severe depression (siblings)	0.8	0.9	2.5	-0.6	-1.6	-0.1	0.7
Pack years adult smoking proportion	0.4	0.6	1.4	0.6	0.8	0.2	1.2
Impedance of leg (right)	2.2	10.6	16.2	-3.5	1.7	-3.3	-4.0
Leg fat-free mass (left)	2.1	11.0	17.8	4.2	-2.1	4.1	2.1
Trunk fat percentage	1.0	3.8	6.5	2.6	1.2	1.5	-2.3
Hand grip strength (right)	0.3	0.8	1.4	-1.2	0.5	-0.9	0.9
Townsend deprivation index at recruitment	0.4	0.5	1.1	0.6	0.8	0.0	-1.1
Current tobacco smoking	0.8	1.3	1.8	1.4	-0.3	1.3	-1.3
Average weekly fortified wine intake	0.4	0.5	1.1	0.3	-0.8	-0.3	1.1
Maternal smoking around birth	1.6	2.4	5.8	2.4	1.2	0.0	-1.5
Fed-up feelings	1.7	3.1	5.3	1.6	0.5	2.3	-2.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.8	2.3	6.1	0.6	0.0	2.5	-1.7
Relative age voice broke	0.5	0.8	1.1	-0.7	-1.0	1.1	0.7
Taking other prescription medications	0.4	0.6	1.8	0.1	-1.4	0.8	-0.1
Age when periods started (menarche)	1.2	3.0	4.9	0.9	2.1	1.5	-2.2
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	0.7	-0.4	0.8	-0.7	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.8	6.4	-0.4	-2.5	-0.2	-0.6
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	2.2	1.5	-0.6	1.4	0.1
Qualifications: CSEs or equivalent	1.5	2.0	4.3	1.5	-2.1	1.1	0.5
Serious illness, injury or assault to yourself	1.1	1.4	3.4	0.7	1.8	1.1	-0.5
High blood pressure	0.1	0.2	0.8	0.9	-0.3	-0.0	0.0
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.5	0.7	1.2	-0.6	0.8
Multivitamins +/- minerals	1.6	2.1	4.8	-1.1	1.4	-0.7	-2.2
Stomach or abdominal pain in last month	1.2	1.4	4.9	-0.6	-2.2	0.7	-0.3
Supplements: Glucosamine	0.6	0.8	1.8	0.2	0.4	1.3	-1.1
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	2.5	-0.8	-1.6	0.2	1.1
Medication: Atenolol	0.8	1.0	2.2	-1.5	-0.1	-1.1	0.7
Medication: Levothyroxine sodium	1.7	2.9	8.4	-1.6	-0.2	-2.9	-0.8
Sitting height	1.1	7.5	14.1	2.1	-3.2	1.0	3.8
Chronic bronchitis/emphysema (father)	0.2	0.3	0.6	0.4	-0.8	0.2	-0.5
High blood pressure (mother)	1.0	1.5	3.5	-0.9	-1.9	-0.7	1.1
Body mass index (BMI)	1.8	7.7	16.6	4.1	0.4	3.8	0.3
Impedance of leg (left)	1.8	8.6	11.2	-2.9	2.0	-3.3	-3.3
Leg predicted mass (left)	2.1	11.2	17.7	4.2	-2.1	4.2	2.2
Trunk fat mass	1.2	5.4	13.4	3.7	0.5	2.6	-1.1
Waist circumference	0.9	3.1	8.0	2.8	0.6	2.1	0.2
Number of incorrect matches in round	0.4	0.7	1.6	-0.6	-0.8	-1.2	-0.4
Past tobacco smoking	0.1	0.2	0.6	0.5	-0.0	0.8	0.2
Alcohol usually taken with meals	0.8	1.4	2.9	-1.3	-0.7	-0.7	1.7
Nervous feelings	0.5	0.9	2.1	0.0	-0.6	1.0	-1.5
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.8	6.0	0.4	-0.8	2.5	-0.6
Hearing difficulty/problems with background noise	3.6	5.7	14.2	1.5	-0.4	2.5	-3.8
Hair/balding pattern: Pattern 2	6.4	8.2	19.3	-4.4	-0.6	-3.4	1.2
Had menopause	0.4	0.5	0.9	0.2	0.5	1.0	-0.9
Had other major operations	0.2	0.2	0.7	-0.8	-0.2	0.3	0.4
Forced vital capacity (FVC)	0.2	0.8	1.7	0.2	-1.1	-0.4	1.3
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.9	6.5	-0.1	-2.5	0.2	-1.1
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.7	-0.3	1.3	0.3	-0.9
Qualifications: None of the above	0.5	1.1	2.7	0.9	-1.6	-0.2	-0.9
Financial difficulties in last 2 years	2.5	3.4	7.9	1.6	-1.4	2.8	-0.9
Mouth/teeth dental problems	0.6	0.8	2.2	-1.0	0.3	-1.5	-0.2
Heart attack	1.0	1.2	1.7	0.8	-1.3	1.0	-1.2
Allergy	0.7	1.5	2.8	-0.9	-1.4	0.7	-1.7
Pain all over the body in last month	0.5	0.5	1.4	0.3	0.4	1.2	0.5
Diabetes (self-reported)	0.8	1.3	2.6	-1.6	-0.5	-0.2	1.6
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.8	0.9	-0.2	0.1	-0.4
Medication: Ramipril	2.0	2.6	5.9	1.7	-0.7	2.4	-1.1
Medication: Simvastatin	0.3	0.4	1.1	-0.3	-0.2	-1.0	-0.5
Fluid intelligence score	2.8	5.9	7.9	-2.8	2.7	-2.6	1.2
Illnesses of siblings	0.0	0.0	0.1	0.0	-0.3	0.2	0.2
Neuroticism score	1.3	2.7	7.2	1.6	-0.0	2.7	-0.9
Weight	2.0	10.0	21.8	4.7	-0.8	4.1	0.8
Impedance of arm (right)	4.2	19.6	27.4	-5.0	2.3	-5.2	-4.6
Arm fat percentage (right)	0.7	2.7	4.1	2.0	1.3	1.3	-1.8
Trunk fat-free mass	3.1	17.8	26.3	4.8	-3.2	5.1	3.4
Hip circumference	2.3	9.9	21.8	4.7	0.3	4.2	0.3
Time employed in main current job	3.5	4.1	9.5	3.1	-0.5	2.5	0.5
Alcohol intake versus 10 years previously	2.4	3.6	7.0	-2.5	1.1	-2.6	0.3
Father’s age at death	0.6	0.8	2.7	-0.6	-0.2	-0.4	1.6
Worrier / anxious feelings	1.6	3.0	6.1	1.9	0.5	2.5	1.4
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.4	7.6	1.4	0.0	2.8	0.3
Falls in the last year	2.6	3.6	5.8	2.0	0.5	2.4	-2.0
Hair/balding pattern: Pattern 3	1.9	2.9	10.0	3.2	0.2	1.2	-0.1
Number of live births	0.7	1.0	2.1	1.4	1.2	-0.7	0.2
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	2.4	-0.5	-1.5	-0.3	0.0
Pulse rate	0.7	1.1	2.1	1.2	-0.9	1.5	-0.1
Happiness	2.1	2.6	7.3	1.0	0.3	1.4	-2.7
Noisy workplace	0.5	0.7	1.5	-0.6	0.7	-1.2	-0.7
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.4	0.4	1.2	0.9	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.4	0.1	0.5	0.6	-0.2
Mouth/teeth dental problems: Dentures	0.8	1.4	2.3	1.5	-1.1	1.4	-0.0
Asthma	0.6	1.1	1.7	1.1	1.2	0.5	1.3
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.5	0.7	0.7	0.2	-0.3
Medication: Cholesterol lowering	0.2	0.3	0.7	0.6	-0.9	0.3	-0.3
Depression (self-reported)	1.6	1.9	6.0	0.9	-0.7	2.4	0.7
Medication: Lansoprazole	1.0	1.1	3.2	1.8	-0.1	1.0	0.6
Prospective memory result	1.7	2.1	3.0	1.7	1.3	1.3	1.4
Lung cancer (father)	1.3	1.5	2.2	1.2	-1.2	1.5	-0.8
Illnesses of mother	0.1	0.2	0.4	-0.5	-0.3	-0.1	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	1.2	0.2	-0.9	1.1	0.5
Pulse wave Arterial Stiffness index	1.8	2.1	5.2	-1.6	0.6	-2.3	0.5
Impedance of arm (left)	3.3	15.3	21.9	-4.5	2.0	-4.7	-3.9
Arm fat mass (right)	1.5	6.2	13.6	3.7	0.1	3.3	-0.6
Trunk predicted mass	3.1	17.6	26.1	4.8	-3.1	5.1	3.3
Standing height	0.5	4.7	9.0	2.2	-3.0	2.1	0.9
Length of working week for main job	0.5	0.6	1.3	1.1	-0.7	0.5	0.4
Exposure to tobacco smoke at home	0.9	1.1	2.4	0.0	-1.5	0.4	-1.3
Breastfed as a baby	1.3	1.6	5.7	-0.3	0.5	-0.4	2.4
Tense / ‘highly strung’	1.2	1.9	3.6	1.4	-1.0	1.9	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	2.1	1.3	-0.9	0.6	-1.5
Hair/balding pattern: Pattern 4	3.7	9.0	20.8	2.6	4.6	2.5	-1.4
Birth weight of first child	0.4	0.8	2.2	1.5	0.1	0.4	0.9
Peak expiratory flow (PEF)	1.2	2.7	5.3	-0.9	-2.3	-0.6	-2.1
Pulse wave reflection index	2.2	2.7	5.5	-2.0	1.2	-2.3	-0.3
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.8	-0.0	-0.9	0.5	0.2
Loud music exposure frequency	0.7	0.8	1.3	-0.9	-0.4	-0.9	1.1
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.6	-0.4	-0.6	-0.4	1.3
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	3.6	-0.2	0.6	1.2	-1.9
Blood clot in the leg (DVT)	1.4	1.8	5.5	-0.0	-2.4	-0.0	-1.3
Medication: Paracetamol	0.2	0.3	1.1	0.4	0.4	-1.0	0.1
Headache pain in last month	1.3	2.3	4.7	2.0	-0.1	2.2	-0.6
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	3.3	-1.6	0.3	-1.8	-0.2
Glaucoma (self-reported)	0.1	0.1	0.2	0.1	-0.4	0.5	0.1
Gout (self-reported)	0.2	0.3	0.6	0.0	-0.8	-0.1	0.7
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	2.7	-0.5	-0.2	-1.6	-0.1
Medication: Amlodipine	0.5	0.7	1.8	-0.7	-0.3	-0.5	1.4
Medication: Ventolin 100micrograms inhaler	0.6	0.7	1.7	1.3	0.4	1.0	-0.1
Birth weight	0.9	1.9	2.6	1.6	1.4	0.6	1.6
Chronic bronchitis/emphysema (mother)	1.0	1.2	3.8	-0.2	2.0	-1.0	0.1
High blood pressure (siblings)	0.2	0.2	0.6	-0.4	0.3	-0.8	0.3
Forced vital capacity (FVC), Best measure	0.5	2.0	4.1	1.0	-1.1	1.3	2.0
Body fat percentage	1.0	4.1	8.0	2.8	1.5	1.5	-1.9
Leg fat percentage (right)	1.4	4.9	9.0	3.0	1.9	1.9	-1.8
Arm fat-free mass (right)	3.8	19.5	30.6	5.5	-3.0	5.4	3.1
Exposure to tobacco smoke outside home	0.6	0.8	1.5	1.2	0.8	0.6	0.7
Comparative body size at age 10	1.5	4.2	9.4	2.4	-0.7	3.1	1.0
Number of full brothers	0.1	0.1	0.3	0.6	-0.1	-0.2	0.1
Worry too long after embarrassment	0.7	1.2	2.0	1.4	0.6	1.4	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	1.7	1.1	-0.2	1.3	-0.1
Wheeze or whistling in the chest in last year	3.2	5.8	14.3	3.8	1.2	2.7	-0.1
Number of children fathered	1.1	1.3	3.2	0.3	-1.8	0.2	1.3
Reason for reducing amount of alcohol drunk: Health precaution	2.2	2.6	4.6	-0.2	2.1	-1.3	2.0
Age at first live birth	2.7	4.8	8.2	2.0	0.9	2.5	2.9
Pulse wave peak to peak time	2.1	2.5	5.9	1.8	-0.8	2.4	-0.4
Health satisfaction	0.4	0.5	0.9	0.2	0.6	0.9	-1.0
Shortness of breath walking on level ground	2.8	3.4	7.0	1.9	1.1	1.2	-2.6
Qualifications: College or University degree	0.0	0.1	0.2	-0.4	0.5	-0.3	-0.1
Eye problems/disorders: None of the above	0.5	0.6	1.6	0.7	-0.3	1.3	-0.5
Mouth/teeth dental problems: Loose teeth	1.8	2.1	3.8	2.0	1.4	1.6	0.6
Emphysema/chronic bronchitis	0.6	0.7	0.9	1.0	0.8	0.7	0.7
Medication for pain relief, constipation, heartburn	0.0	0.1	0.2	-0.5	-0.2	0.0	0.1
Neck or shoulder pain in last month	0.3	0.5	1.5	0.6	-0.1	1.2	-0.3
Medication: Blood pressure	1.6	2.8	6.1	2.5	-0.1	2.2	-0.4
Angina (self-reported)	0.9	1.2	1.5	0.9	1.0	1.1	-1.2
Migraine (self-reported)	1.5	1.8	5.2	-1.0	0.8	-2.3	0.6
Medication: Ibuprofen	0.2	0.2	0.6	0.4	-0.0	0.0	-0.8
Medication: Allopurinol	0.1	0.2	0.6	-0.3	-0.8	-0.1	0.1
Medication: Omeprazole	0.8	0.9	1.9	-0.6	1.1	-0.4	-1.4
Medication: Seretide 50 evohaler	0.5	0.6	1.2	1.1	-0.4	0.9	-0.4
Mean time to correctly identify matches	0.9	1.7	6.6	0.5	-2.6	0.1	-0.3
Heart disease (mother)	0.3	0.4	1.4	-0.4	-0.2	-0.3	1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.6	3.4	-1.1	1.0	-1.8	-0.8
Whole body fat mass	1.5	6.2	15.0	3.9	0.6	2.9	-0.8
Leg fat mass (right)	1.6	6.4	15.5	3.9	0.8	3.0	-0.5
Arm predicted mass (right)	3.9	19.9	31.6	5.6	-2.8	5.5	3.1
Pulse rate, automated reading	0.3	0.8	1.6	-1.3	1.0	-0.7	-0.4
Alcohol intake frequency.	0.4	1.0	2.8	-0.7	1.7	-0.8	0.0
Comparative height size at age 10	0.6	3.1	9.7	1.1	-3.1	1.0	0.8
Number of full sisters	0.5	0.6	1.1	-0.9	-1.0	-0.8	0.2
Suffer from ‘nerves’	0.3	0.5	1.2	-0.3	-0.3	1.1	-0.8
Overall health rating	0.3	0.7	1.9	0.7	-0.3	1.4	-0.5
Chest pain or discomfort	0.7	1.0	1.8	0.4	-0.1	1.3	-1.4
Had major operations	2.4	2.8	5.3	-2.3	-1.4	-1.4	-1.4
Age at last live birth	2.2	3.2	6.3	2.5	0.7	2.2	0.9
Family relationship satisfaction	0.7	0.9	3.3	-0.1	0.4	-0.1	-1.8
Leg pain on walking	0.4	0.5	0.9	0.3	0.8	-0.4	-1.0
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.8	-0.9	-0.0	0.0	-0.0
Commuting to job workplace: Car/motor vehicle	1.7	2.0	4.0	2.0	0.8	1.8	0.3
Illness, injury, bereavement, stress in last 2 years	1.7	2.1	7.4	-1.0	-0.4	-2.7	-0.1
Medication: Aspirin	0.1	0.1	0.3	-0.2	0.4	-0.2	0.6
Supplements: Vitamin C	0.6	0.7	2.4	0.5	0.1	-0.4	1.5
Knee pain experienced in last month	0.7	1.0	2.2	0.9	-0.6	1.5	-0.8
Hypertension (Self-reported)	0.2	0.7	1.8	1.3	-0.6	0.5	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.2	2.6	6.0	1.4	0.8	1.3	-2.5
Illnesses of father: Heart disease	0.3	0.4	0.7	-0.8	-0.8	-0.2	0.2
Illnesses of siblings: Diabetes	0.4	0.5	1.3	0.5	0.3	0.6	1.1
Smoking status: Previous	0.8	1.2	2.4	-1.5	0.2	-1.6	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	1.7	3.6	6.6	0.6	-2.6	2.4	-1.3
Whole body fat-free mass	2.9	16.7	24.7	4.9	-3.0	5.0	3.0
Leg fat-free mass (right)	2.4	12.6	20.2	4.5	-2.3	4.3	2.6
Arm fat percentage (left)	0.8	3.2	5.6	2.4	1.4	1.7	-1.5
Average weekly red wine intake	0.9	1.4	2.1	0.2	-1.2	1.4	-1.4
Handedness (chirality/laterality): Left-handed	2.6	3.2	7.2	-2.7	0.2	-1.5	-1.8
Mood swings	0.5	0.9	2.6	0.3	-0.0	1.0	-1.6
Loneliness, isolation	2.8	3.9	9.0	2.1	1.0	3.0	-1.0
Long-standing illness, disability or infirmity	0.8	1.2	2.0	0.9	-1.4	1.4	-0.2
Ever had bowel cancer screening	0.2	0.2	0.6	0.8	-0.3	0.2	-0.5
Diabetes diagnosed by doctor	0.7	1.2	3.6	-1.0	-0.1	0.1	1.9
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	3.6	0.5	0.2	0.2	-1.9
Friendships satisfaction	0.9	1.2	4.0	-0.4	0.5	-0.5	-2.0
Qualifications: nursing, teaching	0.3	0.5	1.3	-0.3	1.1	0.4	0.6
Commuting to job workplace: Walk	0.3	0.3	0.9	-0.1	-0.9	-0.4	-0.3
Eye problems/disorders: Cataract	0.8	0.9	2.1	-0.7	1.4	-0.7	0.8
Mouth/teeth dental problems: Mouth ulcers	1.3	2.1	4.6	1.7	0.5	2.1	0.8
Medication for cholesterol	0.7	1.0	1.4	1.2	-0.6	1.2	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	1.8	0.2	-1.3	-0.1	-1.1
Back pain experienced in last month	3.1	4.5	6.8	2.5	-2.2	2.6	0.3
Mineral and other dietary supplements	0.3	0.3	1.1	0.2	-1.0	-0.1	-0.5
Breast cancer (self-reported)	1.8	2.2	3.2	1.6	0.8	1.8	-1.6
Asthma (self-reported)	0.4	0.8	1.5	1.1	0.7	0.4	1.2
Osteoporosis (self-reported)	0.0	0.0	0.1	-0.3	-0.1	-0.3	-0.1
Osteoarthritis (self-reported)	0.4	0.5	1.0	-1.0	-0.9	-0.5	-0.2
Medication: Aspirin	0.1	0.1	0.2	-0.4	0.2	-0.1	0.3
Medication: Gliclazide	0.6	0.7	1.3	-0.9	-0.7	-1.1	-0.2
Illnesses of father: None of the above (group 1)	0.0	0.0	0.1	0.0	0.1	0.1	0.3
Smoking status: Current	1.1	1.8	2.7	1.6	-0.4	1.6	-1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.7	0.5	-0.7	0.9	-0.4
Whole body water mass	3.0	17.1	25.0	5.0	-3.0	5.0	3.2
Leg predicted mass (right)	2.3	12.2	19.0	4.4	-2.3	4.2	2.6
Arm fat mass (left)	1.6	6.5	14.3	3.8	0.0	3.4	-0.4
Number of self-reported non-cancer illnesses	1.1	2.0	6.4	0.1	-1.0	-0.6	2.5
Average weekly champagne plus white wine intake	0.2	0.2	0.7	0.9	-0.0	0.1	0.4
Miserableness	0.4	0.7	2.1	0.4	0.2	0.6	-1.5
Guilty feelings	2.1	3.1	7.7	2.1	0.6	2.8	0.3
Wears glasses or contact lenses	1.0	1.2	3.6	-0.8	-1.9	-0.5	-0.5
Ever taken oral contraceptive pill	0.8	0.9	2.2	-0.8	0.8	-1.5	-0.4
Hearing aid user	0.6	0.7	2.0	0.3	-0.8	1.4	0.5
Mother’s age at death	1.6	2.0	4.2	-0.9	0.1	-2.0	1.7
Financial situation satisfaction	0.7	0.9	1.9	0.8	0.4	1.4	-0.9
Tinnitus: Yes, now most or all of the time	1.1	1.3	2.7	1.6	0.2	1.5	-0.4
Commuting to job workplace: Public transport	0.1	0.1	0.1	-0.3	-0.3	0.4	-0.2
Eye problems/disorders: Glaucoma	0.5	0.6	1.2	-0.2	-1.1	-0.4	1.0
Medication: Blood pressure	0.7	1.3	2.8	-1.1	-0.4	-1.7	1.0
Pain type(s) experienced in last month: Hip pain	1.4	1.8	4.7	1.1	0.4	2.2	-1.1
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.4	-0.4	0.6	-0.4	0.6
High cholesterol (Self-reported)	0.2	0.3	1.0	1.0	0.0	-0.1	-0.6
Medication: Bendroflumethiazide	0.4	0.7	1.4	1.2	-0.4	0.8	0.7
Medication: Paracetamol	0.1	0.1	0.2	0.4	0.3	-0.4	-0.1
Medication: Lisinopril	0.4	0.5	1.2	-0.2	-0.2	-1.1	0.9
Medication: Atorvastatin	2.1	2.6	6.1	2.5	-0.4	2.0	0.2
Illnesses of father: High blood pressure	1.0	1.2	3.6	1.9	-0.8	0.8	0.1
Alcohol drinker status: Never	1.0	1.2	2.4	0.7	-0.7	1.5	-1.2
Ever smoked	0.1	0.1	0.3	-0.3	-0.1	-0.5	0.0
Basal metabolic rate	2.7	15.1	24.4	4.9	-2.5	4.9	2.5
Leg fat percentage (left)	1.6	5.7	12.0	3.5	2.1	2.2	-1.2
Arm fat-free mass (left)	3.8	19.1	30.8	5.4	-2.9	5.5	2.8
Number of operations (self-reported)	0.7	1.0	2.1	-1.5	-0.4	-0.5	-1.2
Average weekly beer plus cider intake	0.2	0.2	0.5	-0.7	0.1	0.0	-0.7
Irritability	1.1	1.9	5.3	0.8	-1.3	2.3	0.3
Risk taking	0.4	0.6	1.0	0.3	-0.8	1.0	-0.9
Ever had prostate specific antigen (PSA) test	1.8	2.0	5.0	2.2	0.9	1.4	0.7
Fractured/broken bones in last 5 years	0.9	1.1	4.2	-0.5	0.3	2.0	-0.3
Age started oral contraceptive pill	0.6	0.7	1.2	1.1	-0.6	1.0	0.4
Diastolic blood pressure, automated reading	1.0	3.2	7.2	-2.3	-0.4	-2.7	-0.3
Ever depressed for a whole week	0.6	0.8	1.6	-0.6	1.3	-1.0	-0.1
Unable to work because of sickness or disability	2.0	2.5	6.8	-2.6	-0.8	-1.4	-0.9
Commuting to job workplace: Cycle	1.6	1.9	3.8	-1.6	-0.5	-2.0	0.9
Myopia	0.5	0.8	2.0	0.1	0.8	1.4	-0.6
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.7	-0.9	0.4	-0.3	0.4
Cholesterol lowering medication	0.4	0.6	1.4	0.0	0.1	-1.1	-1.2
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	2.3	-0.6	1.5	-0.6	-0.5
Pain experienced in last month	1.3	2.2	5.0	-2.2	0.5	-1.8	0.6
Supplements: Calcium	0.9	1.0	2.5	0.2	-0.0	1.6	-1.3
Basal cell carcinoma (self-reported)	1.5	1.8	3.6	-0.7	1.9	-1.3	1.3
Heart attack/myocardial infarction (self-reported)	0.8	1.0	1.3	0.8	-1.1	1.1	-0.9
Deep venous thrombosis (DVT) (self-reported)	1.4	1.8	5.0	-0.2	-2.2	0.1	-1.5
Heart disease (siblings)	0.6	0.8	1.8	0.8	-0.1	0.9	-1.3
Alcohol drinker status: Previous	0.6	0.6	1.9	0.5	1.4	-0.6	0.2
Pack years of smoking	0.3	0.4	0.7	0.7	0.7	0.2	0.9
Impedance of whole body	3.2	16.3	23.0	-4.3	2.0	-4.8	-4.4
Leg fat mass (left)	1.9	7.2	17.9	4.2	1.0	3.2	-0.2
Arm predicted mass (left)	3.6	18.3	29.7	5.5	-2.9	5.4	2.4