[Hub]/) : Traits : Arm fat-free mass (left) :

chr2:85,083,503-86,518,249

Best TWAS P=4.45e-13 · Best GWAS P=1.24e-10 conditioned to 0.0835

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex RNF181 0.07 0.02 bslmm 476 0.03 3.4e-04 5.1 5.3 1.3e-07 0.59 0.05 0.82 FALSE
2 GTEx Artery Aorta GGCX 0.23 0.22 lasso 6 0.23 5.5e-13 5.3 6.1 1.1e-09 0.74 0.67 0.33 FALSE
3 GTEx Artery Tibial GGCX 0.29 0.22 enet 14 0.24 6.3e-19 5.3 6.5 9.1e-11 0.69 0.79 0.20 FALSE
4 GTEx Brain Cerebellar Hemisphere GGCX 0.46 0.41 enet 16 0.48 5.3e-14 4.4 5.4 7.7e-08 0.72 0.84 0.16 FALSE
5 GTEx Brain Cerebellum GGCX 0.54 0.30 lasso 10 0.34 6.0e-11 5.2 6.1 7.8e-10 0.75 0.65 0.35 FALSE
6 GTEx Brain Cortex GGCX 0.38 0.17 enet 30 0.02 1.1e-01 4.4 5.3 9.4e-08 0.60 0.32 0.44 FALSE
7 GTEx Cells EBV-transformed lymphocytes GGCX 0.36 0.31 enet 18 0.29 4.5e-10 4.2 5.3 9.9e-08 0.71 0.77 0.23 FALSE
8 GTEx Colon Transverse GGCX 0.26 0.28 lasso 3 0.28 1.4e-13 5.2 5.8 6.4e-09 0.73 0.76 0.24 FALSE
9 GTEx Esophagus Gastroesophageal Junction GGCX 0.24 0.16 lasso 6 0.12 4.3e-05 5.2 5.7 1.5e-08 0.74 0.16 0.74 FALSE
10 GTEx Esophagus Mucosa GGCX 0.29 0.21 enet 30 0.27 5.8e-18 5.5 5.6 1.8e-08 0.62 0.69 0.31 FALSE
11 GTEx Esophagus Mucosa TMEM150A 0.10 0.05 enet 5 0.05 3.2e-04 5.2 -5.4 7.8e-08 -0.80 0.13 0.76 FALSE
12 GTEx Esophagus Muscularis GGCX 0.14 0.12 lasso 9 0.12 1.1e-07 5.3 6.1 1.0e-09 0.75 0.41 0.59 FALSE
13 GTEx Lung GGCX 0.17 0.17 lasso 2 0.18 2.3e-13 5.2 5.2 1.7e-07 0.72 0.85 0.15 FALSE
14 GTEx Muscle Skeletal GGCX 0.10 0.04 enet 11 0.02 2.7e-03 5.3 6.2 6.5e-10 0.78 0.12 0.88 FALSE
15 GTEx Nerve Tibial GGCX 0.38 0.30 lasso 7 0.33 6.5e-24 5.3 6.4 1.4e-10 0.72 0.82 0.18 FALSE
16 GTEx Pancreas VAMP5 0.29 0.09 enet 4 0.05 3.2e-03 6.3 -6.8 7.5e-12 -0.66 0.02 0.82 FALSE
17 GTEx Skin Not Sun Exposed Suprapubic GGCX 0.13 0.04 enet 11 0.06 3.9e-04 5.2 6.7 2.4e-11 0.64 0.10 0.76 FALSE
18 GTEx Skin Sun Exposed Lower leg GGCX 0.15 0.11 lasso 3 0.18 7.9e-15 5.2 6.7 1.8e-11 0.69 0.08 0.92 FALSE
19 GTEx Testis GGCX 0.38 0.36 enet 25 0.40 8.6e-19 5.2 6.3 3.5e-10 0.72 0.75 0.25 FALSE
20 GTEx Thyroid GGCX 0.30 0.17 enet 10 0.23 1.4e-17 5.2 6.3 2.2e-10 0.74 0.77 0.23 FALSE
21 GTEx Whole Blood GGCX 0.15 0.14 lasso 4 0.15 1.7e-13 5.2 5.7 1.2e-08 0.73 0.81 0.19 FALSE
22 NTR Blood VAMP5 0.04 0.01 enet 17 0.02 5.1e-08 6.2 -5.2 2.3e-07 -0.33 0.01 0.98 FALSE
23 YFS Blood VAMP8 0.15 0.15 enet 37 0.18 2.2e-55 5.5 -5.9 4.2e-09 -0.75 0.72 0.28 FALSE
24 The Cancer Genome Atlas Brain Lower Grade Glioma GGCX 0.05 0.05 lasso 1 0.04 1.2e-05 5.2 5.2 1.9e-07 0.72 0.63 0.23 FALSE
25 The Cancer Genome Atlas Lung Squamous Cell Carcinoma VAMP5 0.07 0.04 blup 44 0.05 2.1e-06 6.4 -5.6 2.8e-08 -0.49 0.01 0.98 FALSE
26 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma VAMP8 0.06 0.01 enet 15 0.02 2.1e-02 6.3 6.2 6.1e-10 0.45 0.01 0.83 FALSE
27 The Cancer Genome Atlas Prostate Adenocarcinoma GGCX 0.04 0.02 blup 44 0.02 2.7e-03 6.2 7.2 4.5e-13 0.72 0.02 0.96 TRUE
28 The Cancer Genome Atlas Soft Tissue Sarcoma GGCX 0.04 0.03 lasso 2 0.03 1.1e-02 5.5 5.5 4.3e-08 0.70 0.06 0.07 FALSE
29 The Cancer Genome Atlas Thyroid Carcinoma GGCX 0.03 0.03 enet 5 0.02 8.7e-03 4.7 5.2 2.5e-07 0.82 0.08 0.35 FALSE