[Hub]/) : Traits : Arm fat-free mass (left) : ← →

chr4:105,373,669-107,092,169

Best TWAS P=2.76e-19 · Best GWAS P=6.03e-22 conditioned to 6.68e-05

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex PPA2 0.08 0.03 bslmm 429 0.04 2.2e-05 -5.9 -6.4 1.2e-10 0.61 0.09 0.87 FALSE
2 GTEx Artery Aorta PPA2 0.11 -0.01 enet 24 0.01 1.6e-01 -9.0 -6.8 1.2e-11 0.58 0.08 0.28 FALSE
3 GTEx Brain Cerebellum PPA2 0.22 0.01 lasso 4 0.03 3.7e-02 -6.4 -5.2 2.6e-07 0.55 0.09 0.14 FALSE
4 GTEx Brain Cortex PPA2 0.14 0.09 lasso 9 0.09 1.6e-03 -7.6 -7.7 1.4e-14 0.79 0.08 0.44 FALSE
5 GTEx Cells Transformed fibroblasts PPA2 0.11 0.03 lasso 3 0.01 6.5e-02 -6.2 -6.7 1.6e-11 0.59 0.43 0.08 FALSE
6 GTEx Esophagus Gastroesophageal Junction PPA2 0.29 0.15 lasso 5 0.14 8.8e-06 -9.0 -9.0 2.8e-19 0.81 0.11 0.82 TRUE
7 GTEx Esophagus Mucosa PPA2 0.18 0.06 enet 14 0.12 2.5e-08 7.1 -7.9 2.5e-15 0.68 0.18 0.81 FALSE
8 GTEx Heart Atrial Appendage PPA2 0.15 0.05 lasso 7 0.06 7.4e-04 -7.9 -6.1 1.3e-09 0.70 0.24 0.36 FALSE
9 GTEx Muscle Skeletal PPA2 0.19 0.06 enet 28 0.11 8.7e-11 -7.7 -5.5 2.9e-08 0.67 0.77 0.23 FALSE
10 GTEx Nerve Tibial PPA2 0.13 0.07 enet 23 0.07 2.1e-05 -6.4 -6.3 3.0e-10 0.63 0.56 0.16 FALSE
11 GTEx Ovary PPA2 0.18 0.10 lasso 3 0.14 2.2e-04 -6.4 -7.7 1.0e-14 0.72 0.08 0.56 FALSE
12 GTEx Skin Sun Exposed Lower leg TET2 0.09 0.01 enet 18 0.02 3.6e-03 -9.3 -5.6 2.5e-08 0.58 0.04 0.77 FALSE
13 The Cancer Genome Atlas Thyroid Carcinoma PPA2 0.04 0.02 blup 84 0.04 6.1e-05 -7.7 -7.0 3.3e-12 0.74 0.14 0.66 FALSE