Best TWAS P=2.48e-15 · Best GWAS P=3.52e-15 conditioned to 0.619
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | ZNF503 | 0.08 | 0.00 | blup | 366 | 0.03 | 2.5e-04 | 6.5 | 5.5 | 5.0e-08 | 0.19 | 0.36 | 0.02 | TRUE |
2 | GTEx | Adipose Subcutaneous | C10orf11 | 0.24 | 0.21 | lasso | 9 | 0.20 | 3.3e-16 | 6.8 | -7.4 | 1.4e-13 | -0.87 | 0.07 | 0.93 | FALSE |
3 | GTEx | Adipose Visceral Omentum | C10orf11 | 0.40 | 0.32 | enet | 11 | 0.27 | 2.2e-14 | 6.8 | -7.6 | 2.2e-14 | -0.89 | 0.04 | 0.96 | FALSE |
4 | GTEx | Adrenal Gland | C10orf11 | 0.24 | 0.22 | enet | 21 | 0.18 | 5.8e-07 | 6.8 | -6.5 | 8.6e-11 | -0.83 | 0.02 | 0.98 | FALSE |
5 | GTEx | Artery Aorta | DLG5 | 0.26 | 0.19 | enet | 10 | 0.22 | 2.6e-12 | -4.7 | -5.2 | 1.7e-07 | 0.01 | 0.30 | 0.69 | FALSE |
6 | GTEx | Esophagus Gastroesophageal Junction | DLG5 | 0.27 | 0.03 | enet | 13 | 0.06 | 3.9e-03 | -6.1 | -5.2 | 1.7e-07 | -0.06 | 0.00 | 0.98 | FALSE |
7 | GTEx | Esophagus Muscularis | C10orf11 | 0.45 | 0.39 | enet | 42 | 0.38 | 5.1e-24 | 6.8 | -7.9 | 2.5e-15 | -0.84 | 0.27 | 0.73 | TRUE |
8 | GTEx | Lung | C10orf11 | 0.30 | 0.26 | lasso | 5 | 0.24 | 2.0e-18 | 6.8 | -7.4 | 1.1e-13 | -0.87 | 0.06 | 0.94 | FALSE |
9 | GTEx | Nerve Tibial | DLG5 | 0.51 | 0.44 | lasso | 6 | 0.50 | 1.4e-39 | -4.9 | -5.3 | 9.5e-08 | 0.01 | 0.38 | 0.61 | TRUE |
10 | GTEx | Ovary | DLG5 | 0.62 | 0.38 | lasso | 6 | 0.40 | 5.3e-11 | -4.8 | -5.1 | 3.1e-07 | 0.01 | 0.48 | 0.51 | FALSE |
11 | GTEx | Thyroid | C10orf11 | 0.38 | 0.21 | lasso | 9 | 0.25 | 6.7e-19 | 6.3 | -7.5 | 5.0e-14 | -0.80 | 0.15 | 0.85 | FALSE |
12 | METSIM | Adipose | C10orf11 | 0.11 | 0.10 | enet | 14 | 0.10 | 1.1e-14 | 6.3 | -6.6 | 3.2e-11 | -0.78 | 0.56 | 0.44 | FALSE |
13 | ROSMAP | Brain Pre-frontal Cortex | ZNF503 | 0.05 | 0.04 | bslmm | 342 | 0.04 | 2.2e-06 | 6.2 | 5.4 | 5.9e-08 | 0.15 | 0.96 | 0.00 | FALSE |
14 | ROSMAP | Brain Pre-frontal Cortex | ZNF503-AS2 | 0.07 | 0.06 | lasso | 2 | 0.06 | 2.2e-08 | 6.2 | 6.4 | 2.0e-10 | 0.29 | 1.00 | 0.00 | FALSE |