Best TWAS P=1.07e-10 · Best GWAS P=1.59e-09 conditioned to 0.002
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Visceral Omentum | DCAF4 | 0.23 | 0.07 | enet | 30 | 0.13 | 4.3e-07 | 4.7 | 6.0 | 2.5e-09 | 0.48 | 0.16 | 0.82 | FALSE |
2 | GTEx | Breast Mammary Tissue | DCAF4 | 0.24 | 0.10 | lasso | 6 | 0.18 | 1.2e-09 | 4.8 | 5.3 | 9.1e-08 | 0.54 | 0.31 | 0.67 | FALSE |
3 | GTEx | Colon Sigmoid | DCAF4 | 0.30 | 0.10 | lasso | 9 | 0.11 | 1.3e-04 | 5.4 | 6.4 | 1.8e-10 | 0.74 | 0.01 | 0.93 | FALSE |
4 | GTEx | Colon Transverse | DCAF4 | 0.26 | 0.27 | lasso | 10 | 0.27 | 2.7e-13 | 4.8 | 5.2 | 1.6e-07 | 0.54 | 0.40 | 0.60 | FALSE |
5 | GTEx | Esophagus Gastroesophageal Junction | DCAF4 | 0.18 | 0.01 | enet | 10 | 0.06 | 3.0e-03 | 5.4 | 6.5 | 1.1e-10 | 0.53 | 0.07 | 0.50 | TRUE |
6 | GTEx | Esophagus Mucosa | ZFYVE1 | 0.10 | 0.00 | lasso | 7 | 0.00 | 2.0e-01 | 5.4 | 6.2 | 7.3e-10 | 0.61 | 0.10 | 0.67 | FALSE |
7 | GTEx | Pancreas | DCAF4 | 0.20 | 0.15 | lasso | 4 | 0.14 | 2.4e-06 | 5.4 | 5.4 | 8.7e-08 | 0.60 | 0.06 | 0.88 | FALSE |
8 | GTEx | Spleen | DCAF4 | 0.47 | 0.12 | enet | 10 | 0.19 | 1.5e-05 | 4.8 | 6.2 | 7.5e-10 | 0.63 | 0.11 | 0.84 | FALSE |
9 | GTEx | Spleen | NUMB | 0.46 | -0.01 | enet | 28 | 0.09 | 3.2e-03 | 1.4 | 5.6 | 2.7e-08 | 0.48 | 0.08 | 0.27 | FALSE |
10 | NTR | Blood | DCAF4 | 0.04 | 0.03 | lasso | 6 | 0.03 | 6.5e-09 | 5.4 | 5.5 | 3.9e-08 | 0.60 | 0.06 | 0.94 | FALSE |
11 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | DCAF4 | 0.04 | 0.02 | blup | 83 | 0.03 | 1.2e-04 | 4.4 | 5.2 | 1.7e-07 | 0.55 | 0.02 | 0.95 | FALSE |
12 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | DPF3 | 0.18 | 0.18 | lasso | 7 | 0.22 | 1.6e-24 | 5.0 | 5.7 | 1.0e-08 | 0.91 | 0.00 | 1.00 | FALSE |
13 | The Cancer Genome Atlas | Thyroid Carcinoma | DPF3 | 0.10 | 0.02 | blup | 210 | 0.07 | 1.9e-07 | -3.0 | -5.6 | 2.0e-08 | -0.53 | 0.76 | 0.18 | FALSE |