Best TWAS P=7.79e-09 · Best GWAS P=5.31e-14 conditioned to 1.35e-07
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | CYP2D6 | 0.26 | 0.10 | enet | 34 | 0.20 | 1.2e-16 | -3.6 | -5.6 | 2.5e-08 | 0.45 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Breast Mammary Tissue (Male) | CYP2D6 | 0.34 | -0.01 | lasso | 6 | 0.00 | 3.2e-01 | 4.5 | -5.1 | 2.8e-07 | 0.36 | 0.11 | 0.10 | FALSE |
| 3 | GTEx | Breast Mammary Tissue (Female) | POLR3H | 0.09 | -0.01 | lasso | 6 | -0.01 | 6.4e-01 | -5.1 | 5.2 | 1.6e-07 | -0.46 | 0.04 | 0.06 | FALSE |
| 4 | GTEx | Lung | RP5-821D11.7 | 0.08 | 0.02 | enet | 21 | 0.04 | 6.6e-04 | 3.7 | 5.7 | 1.3e-08 | -0.40 | 0.53 | 0.04 | FALSE |
| 5 | GTEx | Spleen | CCDC134 | 0.23 | 0.00 | enet | 14 | 0.09 | 2.7e-03 | -5.1 | 5.4 | 6.2e-08 | -0.40 | 0.07 | 0.07 | FALSE |
| 6 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | WBP2NL | 0.06 | 0.04 | blup | 140 | 0.03 | 9.6e-05 | -5.1 | 5.8 | 7.8e-09 | -0.53 | 0.58 | 0.24 | TRUE |
| 7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | WBP2NL | 0.10 | 0.04 | blup | 140 | 0.05 | 1.8e-06 | -3.6 | 5.6 | 2.5e-08 | -0.40 | 0.98 | 0.00 | FALSE |