Best TWAS P=4.16e-11 · Best GWAS P=1.3e-11 conditioned to 0.00669
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | MGAT3 | 0.08 | 0.04 | lasso | 4 | 0.04 | 4.3e-04 | -5.4 | 5.3 | 9.4e-08 | 0.04 | 0.02 | 0.98 | FALSE |
2 | GTEx | Artery Aorta | APOBEC3G | 0.40 | 0.40 | lasso | 3 | 0.39 | 6.3e-23 | 5.0 | 5.3 | 1.2e-07 | 0.04 | 0.13 | 0.87 | FALSE |
3 | GTEx | Cells Transformed fibroblasts | APOBEC3G | 0.24 | 0.20 | enet | 11 | 0.24 | 9.4e-18 | 4.9 | 5.2 | 2.0e-07 | 0.05 | 0.15 | 0.84 | FALSE |
4 | GTEx | Heart Atrial Appendage | MGAT3 | 0.14 | 0.14 | lasso | 2 | 0.12 | 3.5e-06 | -5.6 | 5.6 | 2.6e-08 | 0.02 | 0.01 | 0.99 | TRUE |
5 | GTEx | Lung | COX5BP7 | 0.13 | 0.12 | lasso | 3 | 0.12 | 1.7e-09 | 5.1 | -5.3 | 1.2e-07 | -0.04 | 0.11 | 0.89 | FALSE |
6 | GTEx | Nerve Tibial | SYNGR1 | 0.26 | 0.18 | enet | 27 | 0.21 | 3.6e-15 | -4.9 | -5.5 | 3.9e-08 | -0.04 | 0.07 | 0.93 | FALSE |
7 | GTEx | Nerve Tibial | COX5BP7 | 0.44 | 0.25 | enet | 33 | 0.25 | 1.7e-17 | 3.7 | -5.2 | 2.4e-07 | -0.08 | 0.82 | 0.16 | FALSE |
8 | GTEx | Pituitary | APOBEC3G | 0.34 | 0.04 | enet | 11 | 0.11 | 1.2e-03 | 5.1 | 5.7 | 9.3e-09 | 0.04 | 0.09 | 0.44 | TRUE |
9 | GTEx | Skin Sun Exposed Lower leg | MGAT3 | 0.13 | 0.05 | lasso | 3 | 0.02 | 4.7e-03 | -5.6 | 5.6 | 2.7e-08 | 0.01 | 0.01 | 0.98 | FALSE |
10 | GTEx | Skin Sun Exposed Lower leg | APOBEC3G | 0.10 | 0.09 | lasso | 3 | 0.06 | 7.5e-06 | 5.0 | 5.3 | 1.4e-07 | 0.05 | 0.13 | 0.86 | FALSE |
11 | GTEx | Vagina | APOBEC3G | 0.23 | 0.07 | lasso | 5 | 0.06 | 1.8e-02 | 5.0 | 5.5 | 3.7e-08 | 0.05 | 0.09 | 0.26 | FALSE |
12 | NTR | Blood | SYNGR1 | 0.03 | 0.03 | enet | 6 | 0.03 | 1.0e-10 | 4.9 | 5.3 | 1.4e-07 | 0.01 | 0.20 | 0.79 | FALSE |
13 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TNRC6B | 0.02 | 0.01 | blup | 92 | 0.01 | 2.7e-03 | -5.5 | -6.0 | 1.5e-09 | 0.82 | 0.02 | 0.78 | FALSE |
14 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ADSL | 0.04 | 0.03 | enet | 6 | 0.03 | 1.6e-04 | -6.7 | -5.8 | 8.5e-09 | 0.86 | 0.00 | 0.94 | FALSE |
15 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | ADSL | 0.07 | 0.02 | blup | 33 | 0.05 | 5.2e-04 | -3.1 | -5.2 | 1.7e-07 | 0.67 | 0.07 | 0.49 | FALSE |
16 | The Cancer Genome Atlas | Lung Adenocarcinoma | ADSL | 0.03 | 0.00 | blup | 33 | 0.01 | 8.9e-03 | -6.5 | -6.0 | 2.2e-09 | 0.82 | 0.01 | 0.60 | FALSE |
17 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | ADSL | 0.06 | 0.02 | lasso | 2 | 0.03 | 6.6e-03 | -6.6 | -6.5 | 7.0e-11 | 0.97 | 0.00 | 0.80 | FALSE |
18 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | ADSL | 0.09 | 0.03 | lasso | 3 | 0.01 | 7.7e-02 | -6.7 | -6.6 | 4.2e-11 | 0.91 | 0.00 | 0.76 | TRUE |