Hub : Genes

POLR3H

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.2370 0.0550 0.0e+00 0.310 0.342 0.352 0.348 0.352 1.9e-38 5.3e-43 1.3e-44 6.1e-44 1.7e-44
2 GTEx Adipose Subcutaneous 0.1160 0.0410 1.3e-04 0.035 NA 0.063 NA 0.062 6.8e-04 NA 6.7e-06 NA 8.3e-06
3 GTEx Artery Aorta 0.1250 0.0610 4.2e-03 0.041 NA 0.037 NA 0.044 2.4e-03 NA 3.9e-03 NA 1.9e-03
4 GTEx Brain Cerebellar Hemisphere 0.0960 0.0500 9.4e-03 0.077 NA 0.062 NA 0.078 5.0e-03 NA 1.1e-02 NA 4.9e-03
5 GTEx Brain Cortex 0.2670 0.0980 4.3e-06 0.212 NA 0.142 NA 0.184 1.6e-06 NA 9.7e-05 NA 8.5e-06
6 GTEx Brain Frontal Cortex BA9 0.1258 0.0704 6.5e-03 0.089 NA 0.028 NA 0.039 2.4e-03 NA 6.0e-02 NA 3.4e-02
7 GTEx Brain Hippocampus 0.1622 0.0833 2.9e-03 0.112 NA 0.028 NA 0.052 1.4e-03 NA 7.3e-02 NA 2.4e-02
8 GTEx Brain Putamen basal ganglia 0.2300 0.1160 2.7e-03 0.058 NA 0.038 NA 0.032 1.7e-02 NA 4.5e-02 NA 6.0e-02
9 GTEx Breast Mammary Tissue 0.1550 0.0710 8.1e-03 0.019 NA 0.032 NA 0.012 3.7e-02 NA 9.0e-03 NA 7.8e-02
10 GTEx Breast Mammary Tissue (Female) 0.0928 0.0650 6.6e-02 -0.008 NA -0.010 NA -0.008 6.9e-01 NA 9.7e-01 NA 6.4e-01
11 GTEx Cells Transformed fibroblasts 0.1030 0.0430 2.7e-04 0.065 NA 0.024 NA 0.047 1.3e-05 NA 6.3e-03 NA 1.8e-04
12 GTEx Colon Sigmoid 0.2460 0.1090 3.2e-03 -0.004 NA 0.015 NA -0.007 5.0e-01 NA 9.1e-02 NA 6.5e-01
13 GTEx Muscle Skeletal 0.1685 0.0547 8.0e-07 0.118 NA 0.105 NA 0.109 1.3e-11 NA 1.8e-10 NA 8.0e-11
14 GTEx Nerve Tibial 0.0942 0.0431 1.3e-03 0.082 NA 0.045 NA 0.063 2.0e-06 NA 3.8e-04 NA 3.2e-05
15 GTEx Pancreas 0.1390 0.0720 2.4e-03 -0.002 NA 0.032 NA 0.016 3.9e-01 NA 1.7e-02 NA 6.6e-02
16 GTEx Testis 0.3190 0.0810 0.0e+00 0.512 NA 0.512 NA 0.511 5.7e-26 NA 5.6e-26 NA 6.9e-26
17 GTEx Thyroid 0.0610 0.0290 4.8e-03 0.018 NA 0.003 NA 0.001 1.6e-02 NA 1.9e-01 NA 2.7e-01
18 TCGA Head and Neck Squamous Cell Carcinoma 0.0438 0.0269 2.0e-05 0.038 0.035 0.029 NA 0.029 3.8e-05 6.8e-05 2.7e-04 NA 3.1e-04
19 TCGA Lung Adenocarcinoma 0.0259 0.0167 1.9e-03 0.014 0.006 -0.002 NA 0.001 8.3e-03 6.4e-02 9.6e-01 NA 2.5e-01
20 TCGA Prostate Adenocarcinoma 0.0426 0.0238 2.3e-05 0.048 0.052 0.036 NA 0.044 8.0e-06 3.4e-06 1.1e-04 NA 1.8e-05
21 TCGA Stomach Adenocarcinoma 0.0390 0.0330 3.0e-03 0.058 0.021 0.037 NA 0.042 4.9e-05 1.1e-02 1.1e-03 NA 4.8e-04
22 TCGA Testicular Germ Cell Tumors 0.0990 0.0680 8.6e-04 0.019 0.061 0.036 NA 0.036 6.9e-02 3.4e-03 2.0e-02 NA 2.0e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22
Bipolar Disorder (2018) 0.3 0.4 3.0 0.1 -1.2 0.2 0.2 0.4 0.3 0.2 -0.2 -0.2 0.9 0.2 1.7 0.3 -0.3 1.7 0.3 0.4 -0.1 0.2 0.1 0.0 0.0
Bipolar Disorder or Schizophrenia 0.9 2.3 9.5 0.7 0.4 1.8 1.4 1.4 1.3 1.3 0.4 -0.8 1.4 2.1 2.7 1.1 1.4 2.6 1.5 3.1 -0.5 -0.1 -0.1 -0.3 -1.5
Depressed Affect (Nagel 2018) 4.8 10.2 18.9 3.6 2.0 2.5 4.1 4.2 4.0 4.2 2.8 0.4 2.1 -0.1 -3.5 -1.1 0.3 -2.0 4.3 1.2 -4.0 -4.1 -3.8 -4.0 -4.3
Depression (Nagel 2018) 0.5 0.8 3.0 0.8 1.1 1.2 1.0 1.0 1.0 1.0 0.3 -0.2 0.9 0.2 -0.4 0.5 -0.3 0.4 1.2 1.7 -0.8 -0.9 -0.8 -0.9 -1.1
Intelligence (Savage-Jansen 2018) 2.0 6.3 14.1 -1.5 -3.0 -3.2 -2.8 -2.3 -2.7 -2.8 0.5 -1.5 -3.8 -3.2 1.9 -1.2 -2.4 -1.4 -3.0 -3.8 2.4 1.9 1.2 2.0 3.3
Neuroticism (Nagel 2018) 6.3 14.8 29.2 5.0 0.6 2.1 5.2 5.1 5.1 5.4 3.8 -0.8 1.2 -1.0 -3.1 -2.3 -0.5 -1.8 5.1 0.9 -5.0 -5.1 -5.0 -4.7 -5.1
Schizophrenia (2018) 1.3 2.7 13.3 0.9 1.4 2.2 1.6 1.4 1.5 1.6 0.6 -1.0 1.1 2.5 2.0 1.2 2.1 2.0 1.6 3.7 -0.6 -0.3 -0.3 -0.4 -1.9
Schizophrenia vs Biploar Disorder 0.3 0.4 2.4 0.4 1.0 0.7 0.7 0.4 0.6 0.7 0.6 -0.4 0.4 0.6 -0.5 0.2 0.6 -0.5 0.6 1.6 -0.5 -0.4 -0.3 -0.1 -0.6
Worry (Nagel 2018) 3.5 7.5 15.1 3.9 -0.8 0.3 3.5 3.4 3.5 3.8 2.6 -2.1 -0.1 -1.4 -1.8 -3.0 -1.4 -0.9 3.4 -0.0 -3.7 -3.7 -3.6 -3.2 -3.1
Alzheimer’s Disease (in mother) 2.6 3.0 6.2 2.3 -0.1 -0.1 2.5 2.3 2.5 2.4 0.4 -1.0 -1.9 -0.7 -1.6 -1.5 -0.1 -1.4 2.4 -0.9 -2.1 -1.9 -2.1 -1.7 -2.1
Alzheimer’s Disease (in father) 0.6 0.7 3.6 -0.1 1.6 1.3 0.5 0.4 0.5 0.4 0.2 -0.7 0.7 0.9 0.3 1.3 0.7 1.0 0.6 1.9 -0.0 0.2 0.2 0.4 -0.5
Alzheimer’s Disease (including proxy) 2.0 2.9 6.6 1.8 1.3 2.0 2.6 2.4 2.6 2.5 0.8 -0.6 0.1 0.7 -0.9 0.1 0.9 -0.5 2.6 1.5 -1.8 -1.4 -1.5 -1.4 -2.6
Crohns Disease (2017) 3.4 7.5 13.7 3.0 1.3 3.5 3.6 3.5 3.5 3.5 3.2 2.2 1.9 -1.0 -0.1 0.7 -0.8 -1.2 3.4 2.3 -2.8 -3.1 -3.2 -3.2 -3.7
Irritable Bowel Disease (IBD) 2.0 4.7 9.5 2.7 1.2 2.5 3.0 2.9 3.0 3.1 2.1 1.0 1.1 -0.8 -0.2 0.3 -0.9 -1.1 2.9 2.3 -2.3 -2.4 -2.5 -2.0 -2.9
Ulcerative Colitis (UC) 0.6 1.1 2.9 1.5 0.9 1.1 1.6 1.5 1.6 1.7 0.5 -0.2 -0.0 -0.3 -0.3 0.1 -0.4 -0.5 1.5 1.5 -1.0 -1.0 -1.2 -0.4 -1.3
Major Depression (MDD) 0.2 0.3 1.1 0.3 -1.0 -1.0 0.0 0.1 0.0 0.1 1.0 -1.0 -0.8 -0.3 0.1 -0.8 -0.3 -0.1 -0.1 -0.2 -0.5 -0.4 -0.3 0.2 0.3
Reaction Time 2.4 4.6 7.8 -2.6 0.6 -0.2 -2.4 -2.7 -2.5 -2.4 -2.7 1.0 -1.8 1.5 2.6 1.3 2.0 2.5 -2.8 -0.3 2.8 2.6 2.3 2.4 2.0
Verbal and Numeric Reasoning (VNR) 1.8 4.3 8.1 -1.6 -2.5 -1.7 -2.5 -2.3 -2.4 -2.5 0.1 -0.0 -2.7 -2.4 2.7 0.1 -1.8 -0.6 -2.8 -2.4 2.5 1.9 1.1 1.8 2.6
Breast Cancer 0.4 1.1 4.9 0.1 1.8 1.3 0.6 1.0 0.6 0.6 0.4 0.7 1.6 1.9 -0.3 0.6 2.2 -0.7 0.9 1.0 -0.6 -0.8 -0.3 -0.5 -1.2
Ovarian Cancer 0.2 0.3 0.9 -0.4 0.1 -0.9 -0.7 -0.6 -0.7 -0.7 -0.6 -0.7 -0.6 -0.6 -0.6 -0.5 -0.4 -0.6 -0.6 -0.8 0.5 0.1 0.0 -0.1 0.6
Prostate Cancer 2.7 3.8 7.0 2.5 -0.4 0.7 2.0 2.2 2.1 2.2 2.5 -1.6 -0.9 -1.8 -2.3 -1.4 -1.4 -2.6 2.0 -0.8 -1.9 -2.4 -2.6 -1.9 -2.0
Age at First Birth 3.1 4.5 9.1 3.0 -0.3 1.0 2.7 2.8 2.6 2.8 2.4 -0.2 -0.4 -1.3 -1.2 -1.4 -0.6 -2.2 2.7 -0.7 -2.2 -2.6 -3.0 -2.5 -2.7
Bipolar Disorder (2011) 0.5 0.4 2.0 -0.3 -0.3 0.9 -0.4 -0.2 -0.4 -0.3 -0.1 0.3 1.3 0.2 1.2 1.3 -0.4 0.8 -0.3 1.4 0.4 0.3 0.3 0.1 0.2
Body Mass Index (BMI) (2010) 1.5 2.0 5.0 1.1 1.2 1.4 1.6 1.8 1.6 1.6 1.2 1.4 2.2 0.5 -0.7 0.2 0.2 0.3 1.9 1.7 -1.5 -1.6 -1.3 -1.7 -2.0
Coronary Artery Disease (CAD) 0.3 0.4 2.6 0.0 -0.5 -0.4 -0.2 -0.3 -0.3 -0.1 -0.1 -1.3 -0.4 -0.0 -1.1 -0.3 0.2 -1.6 -0.3 -0.7 0.2 0.3 0.3 0.9 0.5
Crohns Disease (2012) 2.5 4.0 13.3 1.7 1.3 3.7 2.2 2.3 2.2 2.3 2.5 1.7 2.5 0.1 0.9 1.7 0.0 -0.0 2.3 2.8 -1.3 -1.5 -1.6 -1.9 -2.6
Mean Putamen Volume 0.7 0.9 2.4 1.0 -0.6 0.4 1.0 0.8 1.0 0.9 0.6 0.5 -0.3 -1.1 -1.0 0.1 -1.1 -1.6 0.9 -0.5 -1.3 -0.9 -0.6 -1.5 -0.8
Fasting Glucose 1.5 1.9 4.4 1.4 1.5 2.0 1.8 1.7 1.8 1.8 0.8 0.8 1.3 0.7 -0.9 0.6 0.9 -0.2 2.0 1.2 -1.0 -0.9 -0.9 -1.3 -2.1
HbA1C 0.5 0.6 2.5 -0.1 1.1 0.8 0.5 0.4 0.5 0.5 0.1 0.2 1.3 1.6 0.5 0.4 1.5 0.9 0.4 0.7 -0.5 -0.4 0.0 -0.3 -0.8
HDL Cholesterol 0.3 0.5 2.4 0.4 -0.4 -1.5 -0.3 -0.3 -0.2 -0.2 -1.3 -1.0 -0.8 -0.1 -0.9 -1.6 -0.4 -0.0 -0.1 -1.0 -0.1 -0.0 0.0 0.1 0.3
LDL Cholesterol 0.0 0.0 0.3 0.1 -0.4 -0.0 0.1 -0.2 -0.2 0.1 -0.1 0.1 -0.1 -0.0 0.5 -0.1 -0.4 0.1 -0.2 0.3 0.1 0.1 0.1 -0.1 0.0
Lupus 0.4 0.7 2.0 0.8 0.4 0.3 1.1 1.1 1.1 1.2 0.1 -0.7 0.0 0.4 -0.8 -0.5 0.7 -0.5 1.0 -0.1 -1.4 -1.2 -1.0 -0.2 -0.9
Neuroticism (2016) 3.5 5.1 10.0 3.0 -1.3 0.9 3.0 2.3 2.5 3.0 1.8 -1.3 0.3 -1.7 -1.8 -1.8 -1.6 -1.9 2.5 -0.6 -2.8 -3.2 -3.1 -3.1 -2.6
Primary Biliary Cirrhosis 2.9 4.1 7.7 2.2 1.4 2.3 2.7 2.6 2.7 2.7 1.5 -0.3 1.0 -0.7 -1.6 0.1 -0.8 -1.2 2.8 1.8 -2.2 -2.4 -2.6 -2.1 -2.7
Rheumatoid Arthritis 1.0 1.3 4.1 -1.2 -0.4 -0.4 -1.4 -1.7 -1.5 -1.3 -2.0 0.5 -1.0 0.1 1.3 0.7 0.2 0.6 -1.7 -0.6 1.4 1.0 0.9 1.3 1.3
Schizophrenia (2014) 1.4 3.1 18.4 0.2 1.6 2.5 1.1 1.0 1.0 1.0 0.5 -0.5 1.8 2.9 2.6 2.1 2.2 2.5 1.2 4.3 -0.0 0.2 0.2 -0.1 -1.5
Triglycerides 0.3 0.5 2.3 0.3 -1.1 0.9 0.3 0.4 0.5 0.3 0.9 0.5 -0.2 -1.5 0.7 0.2 -1.3 -0.6 0.0 -0.4 -0.2 -0.5 -0.8 -0.5 -0.3
Type 2 Diabetes (T2D) (2012) 0.5 0.6 1.6 -0.9 -0.3 -0.7 -1.3 -1.0 -0.9 -1.2 -0.7 -0.0 -0.8 0.1 -0.7 -0.2 0.2 -0.6 -1.0 -0.5 0.7 0.8 1.0 0.5 0.9
Ulcerative Colitis 0.2 0.2 0.7 0.5 0.6 0.8 0.6 0.7 0.7 0.8 -0.1 0.2 0.4 0.3 0.3 0.5 0.5 0.1 0.5 0.8 -0.2 -0.2 -0.2 0.5 -0.4
Blood Eosinophil Count 6.8 52.1 98.2 9.7 1.2 3.4 9.7 9.7 9.7 9.9 7.5 -0.5 -0.7 -4.3 -4.3 -4.2 -3.4 -6.0 9.6 1.5 -8.9 -9.3 -9.9 -7.9 -8.9
Blood Platelet Count 1.3 15.0 28.9 -4.5 -1.6 -3.9 -5.1 -4.7 -5.2 -5.1 -5.2 -1.2 -2.4 0.2 2.6 0.3 -0.3 2.6 -4.8 -1.9 4.2 4.7 5.0 4.7 5.4
Blood Red Count 0.3 2.4 5.9 -1.7 1.9 -0.5 -1.8 -1.4 -1.7 -1.7 -1.1 0.4 0.5 1.7 1.4 1.1 1.7 2.4 -1.4 1.6 1.8 1.7 1.7 2.0 1.5
Blood White Count 0.1 0.9 4.6 0.1 1.6 -2.0 -0.5 -0.6 -0.6 -0.4 -0.7 -2.1 -0.7 0.6 -1.1 -1.4 -0.1 -0.8 -0.3 1.2 -0.0 -0.2 -0.1 0.5 0.8
Heel T-Score 1.9 15.4 28.3 5.3 -1.9 0.0 4.7 4.3 4.7 4.8 3.3 -2.1 -4.2 -5.3 -1.5 -3.9 -4.1 -3.4 4.1 -2.4 -3.7 -4.2 -5.2 -4.4 -3.7
BMI 0.7 4.3 16.6 1.3 1.2 2.5 1.7 2.1 1.8 1.8 1.4 3.8 4.1 1.3 -1.3 1.2 1.1 -0.4 1.9 1.8 -2.6 -2.6 -1.6 -2.0 -2.3
Height 1.0 19.2 82.6 -0.1 5.7 9.1 1.8 2.8 1.9 1.9 2.6 6.5 7.4 3.8 2.6 7.2 4.3 3.5 2.6 7.2 0.5 -0.7 -1.1 -2.1 -4.3
Waist Hip Ratio (WHR) 0.2 0.8 5.5 -0.2 2.3 1.5 -0.1 -0.1 -0.2 0.1 0.3 0.6 0.1 0.1 -0.2 1.4 0.6 -0.8 -0.1 2.3 0.7 0.1 -0.3 0.1 -0.2
Systolic Blood Pressure 0.2 0.8 5.2 -0.4 0.6 0.6 -0.3 -0.3 -0.4 -0.2 -0.3 -0.9 1.6 1.6 0.1 1.0 0.8 1.5 -0.1 2.3 0.7 0.8 0.8 -0.0 -0.1
Smoking Status 5.9 14.1 31.4 -3.0 -3.2 -5.6 -4.2 -4.4 -4.2 -4.3 -2.9 -4.8 -5.1 -2.2 0.2 -2.1 -2.5 -0.7 -4.4 -4.1 3.0 3.2 3.1 4.1 5.4
Allergy or Eczema 6.8 17.8 33.8 5.2 0.7 3.5 5.6 5.6 5.6 5.7 4.8 0.7 2.2 -1.7 -3.2 -1.2 -1.3 -3.0 5.4 1.3 -4.5 -5.1 -5.6 -5.4 -5.8
Cardiovascular Disease 0.7 2.2 4.7 1.5 0.0 0.6 1.9 1.9 1.9 1.9 1.3 -0.7 1.0 -0.1 -2.0 -0.5 -0.4 -1.3 2.0 1.1 -2.2 -1.9 -1.5 -1.7 -1.7
Hypothyroidism (self reported) 5.9 13.6 22.9 -4.7 0.6 -0.6 -4.5 -4.5 -4.5 -4.7 -4.5 1.7 -1.0 2.4 4.8 3.1 2.2 3.8 -4.3 1.0 4.8 4.3 4.2 4.2 4.0
Respiratory disease 8.8 19.7 38.1 5.0 2.7 4.5 6.1 6.0 6.1 6.0 4.3 2.0 2.6 -1.0 -3.3 -0.1 -0.5 -2.8 6.0 2.3 -5.1 -5.1 -5.2 -5.2 -6.2
Type 2 Diabetes (T2D) (2018) 1.4 2.7 7.3 1.3 0.8 2.4 2.0 1.9 1.9 2.0 1.4 1.4 2.7 0.7 -1.1 0.9 0.8 -0.6 2.0 1.4 -1.8 -1.8 -1.4 -1.5 -2.2
Lung FEV1/FVC ratio 0.9 4.5 11.1 2.5 -0.6 0.5 2.6 2.9 2.6 2.8 2.8 -0.8 1.5 0.5 -2.3 -1.9 0.3 -1.3 2.8 0.0 -3.3 -2.9 -2.2 -1.5 -2.4
Lung FVC 1.1 5.5 10.3 -2.1 -1.4 -3.2 -2.5 -2.3 -2.5 -2.7 -1.9 -2.5 -2.9 -0.0 2.6 -0.9 0.2 1.1 -2.4 -3.0 2.5 2.8 2.5 3.0 2.9
Neuroticism 3.9 9.5 19.3 4.2 0.1 1.3 4.1 4.0 4.1 4.4 2.8 -1.2 0.8 -1.1 -2.6 -2.3 -0.9 -1.4 3.9 0.7 -4.2 -4.1 -4.0 -3.5 -3.9
Chronotype (morning person) 2.5 5.8 20.0 1.3 1.3 4.0 2.1 2.1 2.1 2.2 2.1 4.5 4.2 1.8 0.1 2.1 1.8 0.2 2.0 2.5 -1.4 -2.0 -1.8 -2.4 -3.3
Hair Pigment 0.3 8.6 16.7 -3.7 -0.2 -1.9 -3.7 -3.9 -3.7 -3.9 -3.3 -0.7 -1.4 0.7 1.9 1.2 0.6 1.1 -3.8 -1.3 3.8 4.1 4.0 3.9 3.8
Tanning 0.3 3.3 6.4 -2.4 -0.3 -0.9 -2.3 -2.1 -2.4 -2.4 -2.5 -0.2 -1.4 0.4 0.8 0.9 0.5 1.3 -2.3 -0.9 2.5 2.2 1.9 2.5 2.3
Hand grip strength (left) 1.2 3.2 8.3 -2.0 1.5 0.5 -2.2 -1.7 -2.2 -2.0 -0.9 0.5 2.9 2.3 1.1 1.9 1.2 1.8 -1.6 2.3 2.0 1.6 1.7 1.7 1.7
Number of treatments/medications taken 1.6 2.9 6.4 1.2 2.4 1.9 1.9 1.9 1.8 2.0 0.8 0.7 2.0 2.0 0.0 0.4 2.3 0.5 2.2 2.5 -1.5 -1.5 -1.4 -0.9 -2.3
Average weekly spirits intake 4.0 5.0 9.5 -2.8 0.5 -0.6 -3.0 -3.0 -3.0 -2.9 -2.5 -0.1 0.1 1.4 1.5 1.6 1.5 1.0 -2.9 0.3 3.0 2.8 2.7 3.1 2.8
Sensitivity / hurt feelings 1.2 2.0 4.6 2.0 -0.9 1.5 1.9 1.8 1.9 2.1 1.7 0.1 0.1 -1.2 -0.2 -0.2 -0.7 -0.4 1.6 -0.2 -1.4 -1.5 -1.8 -1.7 -2.0
Frequency of depressed mood in last 2 weeks 1.0 1.4 2.7 1.4 0.7 1.5 1.4 1.5 1.4 1.5 0.8 0.1 0.8 -0.3 -0.5 0.2 -0.4 -0.3 1.5 1.2 -1.0 -1.4 -1.6 -1.5 -1.6
Hearing difficulty/problems: Yes 0.7 1.1 2.9 -1.3 0.4 -0.0 -1.5 -1.4 -1.5 -1.4 -0.8 0.1 -0.5 0.5 0.5 1.0 0.9 0.2 -1.5 -0.1 1.7 1.2 1.0 1.2 1.2
Relative age of first facial hair 2.8 5.7 11.0 2.9 0.3 -0.0 2.7 2.8 2.7 2.8 2.5 -0.8 -0.4 -1.8 -2.9 -2.1 -1.3 -2.7 2.7 -1.1 -3.3 -3.3 -3.1 -3.0 -2.5
Other serious medical condition/disability diagnosed by doctor 0.1 0.1 0.7 0.1 -0.1 0.7 0.2 0.1 0.2 0.3 -0.1 0.8 -0.7 0.1 0.7 0.3 0.6 0.1 0.1 -0.1 0.1 -0.1 -0.2 -0.2 -0.4
Ever used hormone-replacement therapy (HRT) 0.4 0.5 2.2 -0.3 1.5 0.9 0.1 0.3 0.1 0.1 0.2 0.2 1.5 1.2 -0.1 0.6 1.0 0.1 0.5 1.3 0.2 -0.0 -0.1 0.3 -0.4
Ever had hysterectomy (womb removed) 0.4 0.5 1.9 0.8 -0.4 -0.1 0.6 0.6 0.6 0.6 0.5 -0.2 -0.2 -0.7 -1.4 -0.6 -0.5 -0.8 0.6 -0.4 -0.6 -0.7 -0.7 -1.4 -0.6
Systolic blood pressure, automated reading 0.6 1.7 9.8 -0.8 1.7 0.4 -0.3 -0.4 -0.3 -0.4 -1.1 -0.3 1.9 3.1 -0.4 1.0 2.4 1.8 0.1 2.7 0.4 0.7 1.0 0.5 -0.1
Eye problems/disorders: Diabetes related eye disease 0.6 0.6 3.6 0.6 -0.1 0.4 0.8 1.0 0.8 0.8 0.5 0.4 1.9 0.6 -0.5 -0.2 0.4 0.1 1.0 0.6 -0.9 -0.9 -0.7 -1.0 -1.0
Angina 2.0 2.6 8.5 0.0 2.6 2.5 1.1 1.0 1.1 1.0 -0.2 1.6 1.9 2.6 1.1 1.9 2.9 1.6 1.3 2.5 -0.2 -0.2 -0.2 -0.0 -1.7
Medication for hormone replacement therapy 0.3 0.3 0.6 -0.7 0.6 0.0 -0.6 -0.6 -0.7 -0.7 -0.4 -0.4 0.6 0.8 -0.3 0.5 0.3 0.3 -0.4 0.8 0.7 0.6 0.6 0.7 0.7
Vitamin and mineral supplements 1.7 2.3 9.7 -1.0 -1.4 -3.1 -1.7 -1.6 -1.6 -1.7 -1.4 -1.6 -1.9 -0.5 -0.3 -1.6 -0.8 -0.0 -1.6 -1.9 0.9 1.0 1.1 1.1 2.2
Supplements: Zinc 1.6 1.7 7.3 1.3 -0.8 -0.1 1.1 1.2 1.2 1.2 1.3 -0.8 -0.0 -1.4 -2.7 -1.1 -1.2 -2.5 1.2 -1.0 -1.4 -1.1 -1.0 -1.3 -0.9
Medication: Co-codamol 1.6 1.8 3.4 -1.3 -0.6 -1.2 -1.9 -1.8 -1.8 -1.7 -1.8 -0.9 -1.4 0.1 1.7 -0.5 0.4 1.3 -1.8 -1.0 1.6 1.0 0.9 1.3 1.6
Medication: Metformin 0.2 0.3 1.0 -0.6 -0.4 0.5 -0.2 -0.4 -0.2 -0.2 -0.9 1.0 0.6 0.7 -0.1 0.8 0.8 0.2 -0.2 -0.2 0.2 0.2 0.3 0.6 0.1
Diabetes (father) 0.6 0.8 3.1 0.1 0.7 1.8 0.7 0.6 0.6 0.7 0.6 1.6 1.1 0.9 -0.1 1.3 1.0 0.1 0.5 1.4 -0.6 -0.6 -0.3 -0.4 -0.9
Diabetes (mother) 3.3 4.2 8.5 -2.5 1.1 -1.0 -2.4 -2.5 -2.4 -2.4 -2.9 -0.2 -0.7 2.4 0.8 1.2 2.2 1.5 -2.3 0.9 2.3 2.5 2.7 2.6 2.2
Severe depression (siblings) 0.2 0.2 0.9 0.4 0.1 0.4 0.4 0.4 0.5 0.4 -0.0 0.1 0.3 -0.0 0.4 0.3 -0.4 0.4 0.5 0.4 -0.5 -0.5 -0.4 -1.0 -0.5
Pack years adult smoking proportion 1.8 2.8 6.2 -2.5 -0.0 -0.3 -2.0 -2.1 -2.0 -2.2 -1.9 0.4 0.0 0.8 0.9 1.8 0.4 0.7 -1.9 0.4 2.2 2.3 2.3 2.4 2.1
Impedance of leg (right) 1.3 6.4 13.1 3.6 0.5 1.3 3.6 3.2 3.6 3.6 2.5 -0.7 -1.5 -2.9 -1.8 -1.2 -2.4 -1.7 3.3 0.4 -2.5 -2.1 -2.8 -2.7 -3.0
Leg fat-free mass (left) 0.7 3.8 21.5 0.4 1.2 3.2 1.0 1.5 1.0 1.1 1.7 3.2 4.6 2.1 0.2 2.2 2.0 0.9 1.3 2.1 -1.2 -1.7 -1.1 -1.7 -2.1
Trunk fat percentage 4.8 19.4 38.2 5.4 0.4 2.3 5.6 5.7 5.6 5.7 4.9 0.4 2.4 -1.5 -4.5 -2.0 -1.0 -3.2 5.6 0.8 -6.2 -6.0 -5.3 -5.5 -5.5
Hand grip strength (right) 1.0 2.7 7.8 -1.9 1.2 1.2 -1.8 -1.3 -1.7 -1.7 -0.4 1.1 2.8 2.1 0.9 2.4 1.0 1.4 -1.3 2.6 1.8 1.5 1.7 1.5 1.2
Townsend deprivation index at recruitment 0.7 1.0 3.7 0.3 -1.8 -0.4 -0.1 -0.1 -0.1 -0.0 1.3 -1.5 -1.5 -1.4 -0.2 -0.8 -1.3 -1.8 -0.3 -1.9 -0.2 -0.5 -0.4 0.2 0.5
Current tobacco smoking 8.7 14.3 33.9 -4.0 -1.9 -5.0 -4.9 -4.9 -4.9 -5.0 -3.3 -3.2 -3.2 -0.4 0.7 -0.8 -0.9 -0.4 -4.7 -2.7 3.9 4.3 4.3 4.6 5.8
Average weekly fortified wine intake 0.6 0.7 2.8 0.9 -0.3 0.1 0.7 0.7 0.7 0.7 0.6 0.0 -1.5 -1.7 -1.0 -0.5 -1.1 -1.1 0.6 -1.3 -0.4 -0.6 -1.0 -0.7 -0.5
Maternal smoking around birth 7.7 11.2 20.3 -4.4 0.9 -1.8 -4.5 -4.3 -4.5 -4.5 -3.8 -0.7 -0.4 2.3 2.4 1.6 1.9 2.9 -4.2 0.4 4.0 3.9 4.0 4.3 4.3
Fed-up feelings 4.4 7.9 15.3 3.1 1.8 2.4 3.5 3.7 3.5 3.7 3.0 0.6 2.0 -0.3 -3.0 -0.6 0.2 -1.9 3.7 0.7 -3.4 -3.5 -3.3 -3.7 -3.9
Frequency of unenthusiasm / disinterest in last 2 weeks 2.1 2.8 5.8 2.0 -0.1 1.3 2.0 2.1 2.1 2.2 1.9 -0.6 0.6 -1.0 -1.8 -0.5 -1.3 -1.1 2.1 0.5 -2.1 -2.4 -2.2 -1.9 -1.9
Relative age voice broke 1.1 1.7 3.1 1.6 0.8 1.1 1.6 1.7 1.6 1.6 1.0 0.0 0.6 -0.7 -1.6 -0.2 -0.8 -1.4 1.8 0.6 -1.5 -1.6 -1.6 -1.5 -1.6
Taking other prescription medications 2.4 3.7 7.8 2.3 0.8 1.1 2.7 2.7 2.6 2.7 1.1 -0.4 0.2 0.1 -1.2 -1.1 0.5 -0.8 2.8 0.5 -2.4 -2.7 -2.8 -2.1 -2.8
Age when periods started (menarche) 0.8 2.0 9.7 -0.3 -1.4 -2.5 -1.1 -1.1 -1.0 -1.1 -0.7 -2.5 -3.1 -1.2 -0.0 -1.7 -1.4 -0.4 -1.2 -1.1 0.7 0.9 0.8 0.9 1.7
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.8 -0.4 0.5 0.7 0.0 0.2 -0.0 -0.1 -0.0 0.3 0.7 0.7 -0.6 0.9 0.7 0.7 0.1 0.4 0.2 0.3 0.3 -0.0 -0.2
Heel bone mineral density (BMD) T-score, automated (left) 2.5 5.8 10.2 3.1 -1.5 -0.6 2.5 2.4 2.5 2.7 2.3 -2.2 -2.4 -3.1 -1.4 -2.9 -2.6 -2.4 2.2 -1.6 -2.5 -2.8 -3.2 -2.2 -1.7
Tinnitus: Yes, but not now, but have in the past 0.5 0.5 1.9 -1.0 0.6 -0.4 -0.7 -0.6 -0.7 -0.8 -1.0 -0.1 0.0 1.3 0.0 0.4 1.4 0.5 -0.6 0.3 0.4 0.7 1.0 1.0 0.6
Qualifications: CSEs or equivalent 1.3 1.7 5.0 1.6 0.5 0.6 1.5 1.2 1.4 1.5 0.8 -0.0 1.1 -0.4 -2.1 -0.6 -0.7 -1.1 1.5 -0.1 -1.5 -1.6 -1.6 -2.2 -1.6
Serious illness, injury or assault to yourself 1.7 2.0 7.7 1.0 1.2 2.8 1.4 1.3 1.5 1.5 1.2 2.3 1.3 0.2 0.4 1.5 0.8 0.0 1.3 1.1 -0.8 -1.4 -1.5 -1.7 -2.0
High blood pressure 0.2 0.4 1.8 0.3 0.7 -0.4 0.5 0.5 0.4 0.5 -0.3 -0.7 0.2 1.3 -0.9 -0.7 1.2 -0.6 0.7 0.6 -0.7 -0.7 -0.4 -0.4 -0.5
Hayfever, allergic rhinitis or eczema 5.6 12.2 23.0 4.2 0.8 3.2 4.4 4.5 4.5 4.5 4.0 1.0 2.2 -1.4 -2.9 -0.8 -1.0 -2.6 4.4 0.8 -3.5 -4.3 -4.7 -4.7 -4.8
Multivitamins +/- minerals 1.5 1.9 7.4 1.0 1.2 2.7 1.5 1.3 1.4 1.6 1.5 1.3 2.2 0.6 -0.1 1.2 0.6 -0.4 1.4 2.0 -1.0 -1.0 -0.9 -1.1 -1.9
Stomach or abdominal pain in last month 0.6 0.8 6.5 -0.8 0.5 -0.2 -0.4 -0.6 -0.5 -0.6 -0.8 -0.2 -0.4 0.2 2.6 0.6 -0.3 2.3 -0.4 1.1 0.4 0.2 0.2 0.5 0.6
Supplements: Glucosamine 0.7 0.9 2.2 -1.1 -0.2 -0.8 -1.1 -1.2 -1.1 -1.1 -0.3 -0.2 -1.2 -0.0 0.4 0.3 0.6 -0.3 -1.3 -1.3 1.1 1.2 1.1 1.5 1.3
Diverticular disease/diverticulitis (self-reported) 1.6 1.9 3.7 -1.6 -0.4 -1.0 -1.9 -1.8 -1.8 -1.9 -1.3 0.5 -0.3 0.2 1.9 0.5 -0.1 1.3 -1.9 -0.2 1.6 1.7 1.7 1.4 1.8
Medication: Atenolol 3.5 4.4 8.1 -2.6 1.0 0.8 -2.0 -2.1 -2.1 -2.1 -1.3 1.3 1.1 2.8 2.5 2.3 2.8 2.7 -2.1 1.7 2.4 2.3 2.3 2.3 1.4
Medication: Levothyroxine sodium 5.6 9.5 17.0 -3.7 0.5 -0.3 -3.7 -3.8 -3.7 -3.7 -3.9 1.6 -1.0 2.1 4.1 2.6 2.0 3.3 -3.7 1.1 4.0 3.6 3.5 3.4 3.1
Sitting height 0.7 4.7 18.5 -0.9 2.2 4.3 -0.3 0.4 -0.2 -0.3 1.2 3.7 4.3 1.5 2.0 4.2 1.3 2.7 0.2 2.9 1.1 0.6 0.6 -0.4 -1.1
Chronic bronchitis/emphysema (father) 1.5 1.8 6.6 -1.2 2.5 0.9 -1.0 -0.9 -0.9 -1.0 -1.6 0.7 1.9 1.9 0.4 1.4 1.4 1.7 -0.7 2.6 0.8 0.6 0.9 0.5 0.5
High blood pressure (mother) 0.3 0.4 1.8 -0.6 1.0 0.4 -0.2 -0.3 -0.2 -0.3 -0.1 0.6 1.1 1.3 0.6 0.7 0.8 0.5 -0.1 1.2 0.2 0.4 0.6 0.4 0.1
Body mass index (BMI) 0.5 2.1 8.2 1.0 0.2 1.1 1.3 1.5 1.3 1.3 1.2 1.7 2.9 1.3 -1.2 0.1 1.1 -0.6 1.4 0.9 -2.2 -2.3 -1.4 -1.5 -1.6
Impedance of leg (left) 1.3 6.4 12.6 3.5 0.5 1.4 3.5 3.2 3.5 3.5 2.5 -0.9 -1.2 -2.7 -2.0 -1.3 -2.4 -1.7 3.4 0.7 -2.5 -2.2 -2.9 -2.9 -2.9
Leg predicted mass (left) 0.8 4.0 21.9 0.4 1.2 3.3 1.0 1.6 1.1 1.2 1.8 3.2 4.7 2.0 0.2 2.2 2.0 0.8 1.4 2.1 -1.2 -1.8 -1.2 -1.8 -2.2
Trunk fat mass 3.0 12.7 24.4 3.9 0.8 2.9 4.4 4.7 4.4 4.5 4.0 1.6 3.3 -0.2 -3.2 -0.6 0.1 -1.9 4.5 1.5 -4.9 -4.9 -4.3 -4.4 -4.7
Waist circumference 1.1 3.9 8.2 1.6 1.0 2.1 2.1 2.4 2.1 2.2 1.9 1.8 2.7 1.2 -1.3 0.4 1.4 -0.7 2.2 1.7 -2.5 -2.9 -2.3 -2.2 -2.6
Number of incorrect matches in round 0.8 1.3 2.7 1.3 -0.2 0.4 1.5 1.4 1.5 1.5 -0.1 0.6 1.0 0.9 -1.1 -1.1 1.0 0.4 1.5 -0.3 -1.6 -1.3 -1.0 -1.3 -1.6
Past tobacco smoking 0.8 1.5 7.5 -0.9 1.5 0.9 -0.5 -0.3 -0.5 -0.5 -0.2 1.8 2.7 2.0 0.7 1.3 1.4 1.0 -0.1 1.8 0.8 1.1 1.4 0.5 0.2
Alcohol usually taken with meals 0.6 1.0 3.7 0.3 0.6 1.6 0.8 1.1 0.8 0.7 1.6 1.2 1.9 0.0 0.8 1.0 -0.2 0.3 0.9 1.8 -0.5 -0.4 -0.4 -0.5 -1.0
Nervous feelings 1.5 2.8 6.2 2.5 -1.2 -0.2 1.9 1.7 1.9 2.1 1.3 -2.0 -1.9 -1.5 -0.2 -2.3 -1.1 -0.5 1.5 -0.7 -1.6 -2.1 -2.5 -1.5 -1.6
Frequency of tenseness / restlessness in last 2 weeks 1.9 3.0 6.1 2.4 -0.3 1.1 2.1 2.1 2.2 2.4 1.3 -0.4 -0.8 -2.0 -0.9 -0.9 -1.9 -1.1 2.0 -0.2 -2.0 -2.3 -2.5 -1.7 -1.9
Hearing difficulty/problems with background noise 0.4 0.6 1.6 -0.8 -0.3 -0.0 -1.1 -1.2 -1.1 -0.9 -0.9 -0.4 -0.4 0.2 -0.3 0.5 0.5 -0.3 -1.3 -0.2 1.2 0.9 0.8 1.0 1.0
Hair/balding pattern: Pattern 2 0.6 0.8 5.5 -0.6 1.7 1.0 -0.7 -0.5 -0.7 -0.5 -0.3 0.7 1.2 1.3 0.4 1.1 0.8 0.7 -0.5 2.3 0.6 0.1 0.2 0.3 0.2
Had menopause 0.2 0.2 0.8 -0.4 0.3 -0.9 -0.5 -0.4 -0.5 -0.6 0.2 -0.1 -0.1 0.6 0.4 -0.4 0.7 -0.5 -0.3 -0.5 0.4 0.2 0.1 0.5 0.6
Had other major operations 0.7 0.8 3.2 0.4 -1.6 -0.7 0.0 0.0 0.1 0.2 0.4 -0.8 -1.1 -1.6 -1.2 -1.0 -0.9 -1.8 -0.2 -1.6 -0.4 -0.5 -0.6 0.0 0.2
Forced vital capacity (FVC) 0.2 0.9 2.6 0.9 0.6 1.4 1.1 1.6 1.3 1.1 1.6 0.4 0.9 -0.4 1.1 0.6 -0.2 0.6 1.3 0.1 -0.5 -0.3 -0.6 -0.7 -1.4
Heel bone mineral density (BMD) T-score, automated (right) 1.9 4.4 8.0 2.8 -1.8 -0.4 2.4 2.2 2.4 2.5 1.7 -1.9 -2.5 -2.7 -0.5 -2.4 -2.2 -1.3 1.9 -1.7 -2.1 -2.3 -2.7 -2.0 -1.6
Ever unenthusiastic/disinterested for a whole week 1.5 1.8 6.2 0.3 2.5 2.1 0.9 1.4 1.0 1.0 0.5 0.6 1.6 1.7 -0.4 1.3 2.2 1.2 1.3 2.1 -0.3 -0.5 -0.5 -0.1 -1.6
Qualifications: None of the above 0.3 0.7 4.8 -0.9 0.2 -1.0 -0.8 -1.2 -0.8 -0.9 -2.2 -0.1 -0.3 1.1 -0.1 -0.1 0.5 0.2 -1.0 0.5 0.2 0.6 1.1 0.9 0.9
Financial difficulties in last 2 years 0.2 0.3 1.7 0.3 -0.1 0.2 -0.1 -0.2 -0.1 -0.0 -0.0 0.2 -0.8 -1.2 -0.3 -0.0 -1.2 -1.3 -0.2 -0.7 0.1 -0.2 -0.3 -0.5 0.1
Mouth/teeth dental problems 0.8 1.2 4.5 1.0 -1.1 1.0 1.4 1.2 1.4 1.2 2.1 0.3 0.9 -1.1 -0.7 0.5 -1.3 -1.1 1.1 0.1 -1.1 -0.8 -0.8 -0.8 -1.1
Heart attack 0.6 0.8 2.5 -0.2 1.1 1.2 0.5 0.4 0.5 0.3 -0.4 1.3 0.8 1.1 1.6 1.2 1.1 1.5 0.6 1.5 -0.1 -0.1 -0.1 0.2 -0.6
Allergy 8.0 18.4 36.6 -4.9 -2.1 -4.6 -5.5 -5.5 -5.5 -5.6 -4.2 -1.9 -3.2 1.0 3.5 0.2 0.5 2.9 -5.5 -2.1 4.4 5.2 5.6 5.6 6.0
Pain all over the body in last month 0.2 0.2 0.8 -0.6 0.2 0.3 -0.4 -0.4 -0.4 -0.4 -0.3 -0.4 0.4 0.1 0.2 0.6 0.1 0.5 -0.4 0.4 0.4 0.7 0.9 0.4 0.4
Diabetes (self-reported) 0.7 1.0 4.4 0.3 0.8 1.9 0.8 0.8 0.8 0.9 0.1 1.4 2.1 1.2 -0.4 1.0 1.4 0.0 0.9 1.0 -0.6 -0.8 -0.7 -0.5 -1.2
Hayfever/allergic rhinitis (self-reported) 2.7 3.5 8.3 1.8 2.2 1.9 2.4 2.4 2.4 2.4 1.4 0.1 1.2 0.2 -2.0 0.0 0.5 -0.5 2.6 1.3 -1.9 -2.0 -2.1 -2.4 -2.9
Medication: Ramipril 0.2 0.3 2.0 0.1 0.9 0.5 0.3 0.3 0.2 0.4 -0.2 0.3 1.2 0.8 0.2 0.1 0.5 0.3 0.5 1.4 -0.2 -0.3 -0.2 0.1 -0.2
Medication: Simvastatin 1.9 2.8 5.8 -2.2 0.6 -0.5 -1.8 -1.9 -1.9 -1.8 -2.3 0.5 0.7 2.4 1.7 0.9 2.3 2.3 -1.7 0.7 1.6 1.4 1.6 1.8 1.5
Fluid intelligence score 1.2 2.4 7.4 -1.4 -1.8 -1.0 -1.9 -1.7 -1.8 -1.9 0.3 -0.1 -1.7 -1.6 2.7 0.4 -1.3 0.3 -2.2 -1.2 1.9 1.4 0.8 1.6 1.9
Illnesses of siblings 1.1 1.5 8.8 0.6 -2.0 -1.1 -0.4 -0.3 -0.3 -0.3 0.8 -0.3 -0.8 -2.7 -1.1 -1.1 -3.0 -1.9 -0.5 -1.4 -0.1 -0.2 -0.3 -0.8 0.7
Neuroticism score 4.2 8.7 17.5 4.0 -0.1 1.8 3.8 4.0 3.9 4.2 2.9 -0.8 0.9 -1.2 -2.1 -1.8 -0.8 -1.1 3.7 0.3 -3.7 -4.0 -4.0 -3.6 -3.9
Weight 1.2 6.1 19.6 1.8 1.2 3.3 2.3 2.9 2.4 2.5 2.4 2.8 4.4 1.5 -1.1 1.2 1.5 -0.0 2.6 2.3 -2.7 -3.1 -2.4 -2.7 -3.2
Impedance of arm (right) 5.8 27.2 48.7 6.9 0.4 1.4 7.0 6.5 6.9 6.9 5.7 -2.8 -2.1 -4.8 -5.0 -4.0 -3.7 -4.5 6.5 -1.1 -6.0 -5.6 -6.3 -6.0 -5.9
Arm fat percentage (right) 3.0 11.9 26.1 4.0 0.5 1.8 4.5 4.5 4.4 4.5 3.7 0.7 2.2 -0.5 -3.6 -1.6 -0.2 -2.6 4.4 0.6 -5.1 -4.9 -4.1 -4.1 -4.4
Trunk fat-free mass 1.9 10.8 32.4 -2.9 2.5 4.0 -1.9 -1.2 -1.8 -1.8 -1.2 5.3 5.7 4.8 3.7 5.3 4.2 4.3 -1.3 4.2 2.2 1.4 1.9 1.1 0.1
Hip circumference 1.4 6.0 14.1 2.6 -0.8 1.6 2.9 3.2 2.9 2.9 2.7 1.1 2.5 -0.2 -1.9 -0.7 -0.2 -0.8 2.9 0.4 -3.6 -3.8 -3.1 -3.3 -3.1
Time employed in main current job 0.3 0.3 2.4 0.4 -1.6 -0.7 0.3 0.2 0.3 0.3 0.2 -0.1 -0.5 0.4 0.8 -0.8 0.3 0.6 0.2 -0.8 -0.4 -0.4 -0.4 -0.3 -0.3
Alcohol intake versus 10 years previously 0.7 1.0 4.2 0.1 2.0 1.4 0.7 0.4 0.6 0.6 -0.2 1.2 1.4 1.3 -0.9 0.9 1.4 0.7 0.6 1.3 -0.7 -0.7 -0.4 -0.9 -1.2
Father’s age at death 0.5 0.6 2.1 0.0 -1.1 -1.2 -0.6 -0.8 -0.6 -0.5 -0.4 -0.7 -1.4 -1.2 0.5 -0.8 -1.3 -0.1 -0.7 -1.1 0.5 -0.1 -0.4 0.0 1.0
Worrier / anxious feelings 3.6 6.8 13.2 3.5 -0.1 1.9 3.4 3.4 3.4 3.6 2.4 -0.2 0.9 -0.5 -1.8 -1.3 -0.4 -0.8 3.3 0.9 -3.2 -3.6 -3.6 -3.5 -3.6
Frequency of tiredness / lethargy in last 2 weeks 4.2 6.9 14.0 2.9 1.9 2.7 3.1 3.5 3.2 3.4 2.6 0.5 2.5 0.4 -1.6 -0.3 0.7 -0.6 3.4 1.8 -2.9 -3.4 -3.2 -3.6 -3.7
Falls in the last year 0.1 0.1 0.3 0.2 -0.1 0.6 0.0 0.2 0.1 0.2 -0.4 0.5 -0.0 -0.0 -0.3 0.3 0.2 0.2 0.1 0.4 0.4 0.2 -0.1 -0.2 -0.2
Hair/balding pattern: Pattern 3 0.2 0.2 1.7 -0.2 -0.0 -0.7 -0.1 -0.1 -0.1 -0.2 -0.4 -1.3 -0.2 0.5 -0.8 -0.8 0.8 0.4 -0.1 -0.6 -0.1 0.1 0.3 0.3 0.2
Number of live births 0.5 0.7 5.0 0.8 0.3 -0.8 0.5 0.5 0.5 0.5 0.4 -2.2 -0.4 -0.5 -1.4 -1.3 -0.8 -0.4 0.6 -0.2 -0.6 -0.8 -0.9 -1.0 -0.3
Forced expiratory volume in 1-second (FEV1) 0.7 2.5 6.2 1.8 0.7 1.9 2.0 2.5 2.1 2.1 2.4 0.4 1.6 -0.3 0.3 0.2 -0.1 -0.0 2.3 0.4 -1.6 -1.3 -1.4 -1.4 -2.3
Pulse rate 0.4 0.6 3.1 0.5 -0.0 -1.8 -0.0 0.4 0.1 0.1 0.2 -1.6 -1.3 -0.6 -0.9 -1.6 -0.6 -0.3 0.2 -0.9 -0.6 -0.5 -0.3 -0.0 0.3
Happiness 3.2 3.9 12.9 -0.2 3.2 3.6 0.6 0.9 0.6 0.8 0.6 2.3 2.9 2.7 1.5 2.7 2.9 1.6 1.0 3.6 0.2 -0.6 -0.6 -0.8 -1.8
Noisy workplace 0.7 0.8 5.4 -0.6 1.7 0.0 -0.0 -0.1 0.0 -0.2 -1.6 0.3 0.8 2.3 -0.8 0.2 2.1 0.6 0.2 0.7 -0.0 0.1 0.4 0.4 -0.2
Qualifications: A levels/AS levels or equivalent 1.3 2.8 11.3 0.7 -2.9 -2.1 -0.2 -0.1 -0.2 -0.1 0.7 -1.3 -3.4 -3.2 -0.0 -2.0 -3.0 -1.2 -0.4 -2.8 -0.0 -0.1 -0.6 0.6 1.1
Serious illness, injury or assault of a close relative in last 2 years 5.5 6.3 11.0 -2.9 1.2 -0.3 -3.2 -3.2 -3.1 -3.2 -2.6 1.0 -0.2 1.2 2.9 2.2 0.8 3.2 -3.1 1.5 3.3 2.9 2.6 2.8 2.9
Mouth/teeth dental problems: Dentures 3.0 5.1 8.1 -2.8 2.7 -0.1 -2.6 -2.4 -2.5 -2.6 -2.8 -0.1 0.3 2.8 2.0 1.6 2.6 1.7 -2.1 1.6 2.7 2.7 2.8 2.4 2.0
Asthma 7.3 14.3 25.7 4.5 1.4 3.5 5.0 5.0 5.1 5.1 4.0 0.8 1.4 -1.9 -3.4 -0.7 -1.3 -3.3 4.9 1.3 -4.4 -4.5 -4.6 -4.5 -5.0
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.3 1.7 0.2 0.6 0.9 0.2 0.4 0.2 0.3 0.1 1.1 0.8 -0.1 0.7 0.8 -0.2 0.1 0.4 1.3 0.1 0.2 0.1 0.1 -0.2
Medication: Cholesterol lowering 1.6 2.4 7.8 -1.6 0.9 1.0 -0.9 -1.1 -1.0 -1.0 -1.6 2.0 2.0 2.8 1.8 1.8 2.8 2.1 -0.9 1.5 1.2 1.1 1.2 1.2 0.3
Depression (self-reported) 1.1 1.4 3.0 1.7 0.0 0.9 1.4 1.6 1.4 1.6 1.7 -0.1 0.6 -0.4 0.2 -0.6 -0.5 -0.4 1.5 0.8 -1.2 -1.5 -1.6 -1.3 -1.5
Medication: Lansoprazole 0.8 0.9 4.0 0.4 1.1 1.4 0.8 0.9 0.8 0.8 0.0 0.4 1.4 1.2 0.9 0.7 1.2 1.0 0.9 2.0 -0.4 -0.6 -0.7 -0.1 -1.0
Prospective memory result 1.2 1.5 3.7 1.5 0.0 0.4 1.4 1.3 1.4 1.5 -0.1 0.8 -0.1 -0.3 -1.9 -0.8 -0.2 -1.9 1.4 -0.7 -1.5 -1.6 -1.4 -1.7 -1.6
Lung cancer (father) 1.6 1.9 3.7 -1.6 1.3 -0.4 -1.6 -1.6 -1.6 -1.6 -1.9 0.2 -0.7 1.5 1.0 0.8 1.8 1.2 -1.4 0.1 1.7 1.7 1.7 1.5 1.2
Illnesses of mother 1.2 1.5 3.3 -0.9 -1.4 -0.9 -1.4 -1.5 -1.4 -1.4 -0.9 -0.1 -1.5 -1.7 0.5 0.1 -1.8 -0.2 -1.7 -0.9 1.4 1.4 1.1 1.0 1.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.7 2.3 5.8 1.6 0.7 2.1 2.0 2.4 2.1 2.0 2.4 0.3 1.8 -0.3 0.3 0.6 -0.2 0.2 2.2 0.5 -1.5 -1.1 -1.0 -1.3 -2.2
Pulse wave Arterial Stiffness index 1.9 2.2 9.8 -0.5 2.5 1.8 0.1 0.3 0.1 0.0 0.3 1.8 3.1 2.3 -0.0 2.0 2.2 1.3 0.6 2.9 0.2 0.1 0.2 -0.4 -0.9
Impedance of arm (left) 6.5 30.0 54.0 7.2 0.6 2.0 7.3 6.9 7.3 7.3 6.1 -2.5 -1.3 -4.8 -5.5 -3.7 -3.7 -4.7 6.9 -0.7 -6.4 -5.9 -6.4 -6.4 -6.4
Arm fat mass (right) 2.0 8.3 15.6 2.8 0.9 2.7 3.4 3.7 3.4 3.5 3.1 2.1 3.6 0.8 -2.1 0.1 0.9 -1.1 3.5 1.7 -3.9 -4.0 -3.2 -3.4 -3.9
Trunk predicted mass 1.9 10.7 32.5 -2.8 2.5 4.0 -1.9 -1.1 -1.8 -1.8 -1.2 5.3 5.7 4.8 3.7 5.2 4.3 4.4 -1.3 4.2 2.2 1.4 1.9 1.1 0.0
Standing height 0.9 8.5 32.0 1.7 2.7 5.7 2.6 3.3 2.7 2.7 2.9 3.2 4.3 1.0 0.5 3.2 1.3 1.5 3.1 3.8 -1.2 -2.0 -2.2 -2.9 -3.9
Length of working week for main job 1.3 1.5 7.0 -0.8 1.4 1.9 -0.7 -0.5 -0.7 -0.4 -0.5 2.6 1.9 1.5 0.6 2.1 1.8 0.2 -0.5 1.2 1.1 0.7 0.7 0.6 -0.1
Exposure to tobacco smoke at home 0.3 0.4 2.1 -0.2 -1.2 -0.8 -0.4 -0.5 -0.4 -0.4 0.1 -0.6 -0.7 -0.9 0.1 -0.3 -1.5 0.1 -0.5 -0.4 0.4 0.7 0.5 0.3 0.7
Breastfed as a baby 2.4 3.0 6.0 2.2 1.4 2.0 2.1 2.2 2.1 2.2 1.9 0.0 0.7 -0.7 -1.6 -0.0 -0.2 -1.6 2.2 0.7 -1.2 -1.9 -2.5 -2.2 -2.3
Tense / ‘highly strung’ 5.0 8.2 15.5 3.8 0.3 1.6 3.7 3.9 3.8 3.9 3.0 -0.5 1.4 -1.2 -2.2 -2.0 -0.7 -1.6 3.6 0.1 -3.6 -3.9 -3.9 -3.3 -3.8
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 2.3 0.6 0.5 1.5 0.5 0.8 0.6 0.9 0.7 0.1 0.7 0.5 0.7 0.7 0.8 0.8 0.6 1.0 -0.2 -0.5 -0.7 -0.2 -0.9
Hair/balding pattern: Pattern 4 1.1 2.7 10.4 -0.5 -2.6 -2.4 -1.4 -1.8 -1.5 -1.3 -1.2 -1.0 -3.0 -1.3 0.2 -1.3 -1.1 -0.6 -1.7 -3.2 1.3 1.0 0.6 1.1 1.9
Birth weight of first child 0.4 0.8 6.5 -0.2 0.8 0.1 0.1 0.5 0.2 0.0 0.6 -0.0 2.6 1.8 0.8 -0.1 1.2 1.4 0.5 1.2 -0.4 -0.1 0.4 0.0 -0.4
Peak expiratory flow (PEF) 0.8 1.9 4.1 1.6 0.7 1.6 1.7 2.0 1.7 1.7 2.0 0.3 1.8 -0.1 -0.6 0.1 -0.3 -1.0 2.0 0.7 -1.5 -1.4 -1.2 -1.2 -1.9
Pulse wave reflection index 1.4 1.7 8.3 -0.7 1.2 1.7 -0.3 -0.2 -0.3 -0.3 0.1 2.5 2.9 1.6 1.2 2.2 1.4 1.4 -0.1 1.9 0.7 0.8 0.8 -0.2 -0.4
Ever highly irritable/argumentative for 2 days 1.0 1.2 5.0 -0.2 2.2 1.7 0.5 0.9 0.6 0.5 0.1 0.8 1.6 1.4 0.4 1.2 1.5 1.5 0.9 1.8 -0.2 -0.3 -0.1 -0.1 -0.9
Loud music exposure frequency 0.6 0.6 3.4 0.5 -0.9 -0.3 0.3 0.1 0.3 0.2 -0.6 0.6 -1.9 -1.8 0.9 -0.2 -1.6 -0.5 0.0 -0.7 0.1 -0.1 -0.5 -0.5 -0.0
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 1.8 0.0 -0.6 0.4 0.2 0.2 0.2 0.0 1.3 -0.0 -0.5 -1.2 0.4 0.6 -1.0 -0.2 0.1 -0.4 0.0 0.0 -0.2 0.0 0.1
Mouth/teeth dental problems: Bleeding gums 0.2 0.2 1.6 0.1 -0.0 -0.2 0.2 0.4 0.2 0.3 -0.7 0.5 0.4 0.5 -0.2 -0.1 0.6 1.3 0.2 0.5 -0.5 -0.4 -0.2 -0.3 -0.2
Blood clot in the leg (DVT) 0.4 0.5 2.2 -0.6 0.0 0.0 -0.6 -0.4 -0.6 -0.5 -0.4 0.6 1.5 1.4 0.7 0.1 1.3 1.0 -0.5 0.2 0.4 0.3 0.5 0.4 0.3
Medication: Paracetamol 0.6 1.1 3.9 0.5 1.1 1.6 0.8 1.1 0.8 0.9 0.4 -0.0 2.0 1.5 0.6 0.6 0.9 0.7 1.2 2.0 -0.7 -0.6 -0.3 -0.4 -1.2
Headache pain in last month 2.3 3.9 16.0 -0.5 4.0 2.6 0.3 0.6 0.3 0.3 -0.1 1.4 3.6 3.4 0.8 2.3 3.4 2.4 0.9 3.1 0.1 -0.1 0.3 -0.5 -1.4
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 2.1 0.4 0.3 0.2 0.2 0.2 0.2 0.2 0.5 -1.0 -0.7 -1.4 -0.6 0.1 -1.4 -0.6 0.2 -0.2 -0.1 -0.1 -0.3 -0.4 0.1
Glaucoma (self-reported) 3.5 4.1 8.6 2.9 -0.9 -0.4 2.3 2.2 2.4 2.5 1.7 -1.2 -1.8 -2.2 -1.7 -2.3 -1.9 -1.6 2.1 -0.8 -2.3 -2.5 -2.9 -2.0 -1.8
Gout (self-reported) 0.9 1.2 3.0 1.3 0.7 0.8 1.4 1.2 1.4 1.4 1.3 -0.1 0.8 -0.0 -0.1 -0.4 -0.1 -0.5 1.3 0.6 -1.2 -1.4 -1.4 -1.7 -1.5
Hypothyroidism/myxoedema (self-reported) 5.6 10.9 18.4 -4.3 1.2 0.3 -3.9 -3.8 -3.9 -4.0 -4.0 2.1 -0.2 2.6 4.0 3.4 2.6 3.8 -3.8 1.5 4.3 3.7 3.6 3.4 3.1
Medication: Amlodipine 1.1 1.6 3.0 -1.3 -0.5 -1.5 -1.7 -1.5 -1.7 -1.6 -1.5 -1.0 -1.0 0.8 0.5 -0.2 0.6 0.7 -1.5 -0.8 1.3 1.4 1.6 1.3 1.6
Medication: Ventolin 100micrograms inhaler 7.4 9.5 16.6 3.7 0.7 2.4 4.1 4.0 4.1 4.1 3.8 0.1 0.6 -2.1 -2.4 -0.8 -1.7 -2.8 3.9 0.7 -3.5 -3.7 -3.9 -3.8 -3.8
Birth weight 0.9 2.0 7.1 -1.5 1.9 -0.4 -1.3 -0.9 -1.2 -1.3 -1.3 -0.2 1.7 2.3 1.5 0.4 2.0 2.7 -0.8 1.5 0.9 0.9 1.2 1.5 1.0
Chronic bronchitis/emphysema (mother) 0.4 0.5 2.0 -0.3 1.2 1.1 0.1 0.3 0.1 0.1 -0.0 1.3 1.4 0.7 -0.2 1.1 0.9 0.4 0.4 0.8 -0.3 -0.5 -0.1 -0.2 -0.4
High blood pressure (siblings) 0.6 0.8 4.0 -0.5 0.8 0.1 -0.1 -0.1 -0.1 -0.1 -0.8 0.1 0.4 2.0 1.7 0.3 1.8 2.0 0.0 1.0 0.3 0.4 0.5 0.9 0.1
Forced vital capacity (FVC), Best measure 0.1 0.5 2.0 0.5 0.4 1.3 0.7 1.0 0.8 0.6 1.4 0.1 0.8 -0.6 1.1 1.0 -0.4 0.6 0.8 0.0 -0.0 0.3 0.0 -0.3 -0.9
Body fat percentage 3.8 14.9 32.1 4.7 0.1 1.6 4.9 5.0 4.9 5.0 4.1 0.3 2.0 -1.2 -4.2 -2.1 -0.8 -2.9 4.9 0.5 -5.7 -5.4 -4.7 -4.6 -4.7
Leg fat percentage (right) 1.4 5.2 13.9 2.7 -0.3 0.4 2.9 2.8 2.8 2.9 2.4 0.5 1.3 -0.4 -2.7 -1.6 -0.2 -1.8 2.8 0.1 -3.7 -3.4 -2.8 -2.5 -2.7
Arm fat-free mass (right) 1.6 8.2 31.9 -2.4 2.0 3.5 -1.6 -0.9 -1.6 -1.5 -0.7 5.1 5.6 4.2 3.0 4.5 3.6 3.5 -1.0 3.7 1.5 0.7 1.4 0.6 -0.1
Exposure to tobacco smoke outside home 1.0 1.3 2.7 -1.0 0.3 -0.8 -1.6 -1.6 -1.6 -1.4 -1.5 0.7 -1.2 -0.3 1.2 0.3 -0.1 0.4 -1.6 -0.1 1.6 1.4 1.1 0.9 1.4
Comparative body size at age 10 1.7 4.6 12.4 -2.3 -2.3 -3.5 -2.7 -2.5 -2.7 -2.9 -2.2 -1.1 -0.7 1.1 0.7 -1.2 0.2 1.5 -2.5 -2.1 1.3 1.8 2.4 2.6 3.1
Number of full brothers 0.3 0.4 2.1 0.1 -0.6 -0.8 -0.4 -0.5 -0.4 -0.3 -0.7 -0.4 -1.0 -1.2 -0.4 -0.6 -1.1 -0.4 -0.6 -1.4 0.3 0.0 -0.2 -0.3 0.5
Worry too long after embarrassment 0.5 0.9 2.1 1.3 -0.1 1.3 1.3 1.2 1.3 1.5 0.7 -0.9 -0.4 -0.4 -0.3 -0.0 -0.1 0.2 1.2 0.3 -0.8 -1.1 -1.3 -1.1 -1.4
Seen a psychiatrist for nerves, anxiety, tension or depression 2.7 3.5 7.6 2.6 0.8 1.6 2.5 2.7 2.5 2.7 1.9 -1.0 0.7 -0.7 -1.3 -0.7 -0.6 -0.6 2.6 1.3 -2.0 -2.0 -2.2 -2.0 -2.4
Wheeze or whistling in the chest in last year 1.9 3.4 7.8 2.1 0.5 1.4 2.4 2.2 2.4 2.4 2.1 -0.3 0.6 -0.7 -1.4 -0.5 -0.4 -1.5 2.3 0.5 -1.9 -2.3 -2.5 -2.8 -2.6
Number of children fathered 3.2 3.6 6.9 -2.3 0.5 -0.5 -2.2 -2.2 -2.1 -2.2 -2.0 0.5 0.5 2.3 1.7 1.4 1.7 2.5 -2.1 0.9 1.9 2.3 2.6 2.5 1.9
Reason for reducing amount of alcohol drunk: Health precaution 0.1 0.2 1.5 -0.2 -0.9 -0.3 -0.1 -0.3 -0.1 -0.2 -0.3 -0.2 -0.2 0.4 1.2 -0.1 0.1 0.7 -0.2 -0.2 0.4 0.2 0.0 0.1 0.1
Age at first live birth 1.4 2.5 5.5 1.8 -1.6 -1.1 1.1 1.5 1.2 1.3 1.9 -1.8 -0.9 -2.2 -1.7 -2.3 -1.8 -2.4 1.2 -1.4 -1.8 -1.7 -1.6 -0.7 -0.5
Pulse wave peak to peak time 1.7 2.0 7.8 0.7 -2.5 -1.6 0.1 -0.1 0.1 0.2 0.1 -1.8 -2.8 -2.2 0.0 -2.0 -2.2 -1.2 -0.4 -2.7 -0.4 -0.3 -0.4 0.1 0.7
Health satisfaction 2.6 3.3 10.1 -1.0 2.3 3.2 -0.4 -0.3 -0.3 -0.2 -0.8 2.4 2.4 2.8 1.8 3.0 3.0 2.0 -0.3 3.0 0.9 0.6 0.7 0.2 -0.7
Shortness of breath walking on level ground 0.9 1.1 3.8 0.5 2.0 1.5 0.9 0.8 0.8 0.9 -0.6 1.2 0.5 1.5 0.1 1.0 1.8 0.8 1.0 1.6 -0.3 -0.3 -0.4 -0.8 -1.4
Qualifications: College or University degree 0.9 2.9 14.0 0.9 -2.3 -1.6 -0.1 0.2 -0.0 0.1 1.7 -2.3 -2.5 -3.7 -0.5 -1.8 -3.2 -2.2 -0.2 -2.5 -0.3 -0.7 -1.2 0.0 0.8
Eye problems/disorders: None of the above 0.6 0.7 1.8 -0.8 0.3 0.3 -0.8 -1.0 -0.8 -0.9 -1.2 0.4 -0.9 -0.1 0.7 1.1 -0.5 0.3 -0.9 0.8 1.2 1.3 1.2 0.3 0.8
Mouth/teeth dental problems: Loose teeth 3.9 4.6 9.4 -2.5 -0.7 -1.8 -2.8 -3.1 -2.8 -2.8 -2.5 -0.7 -1.8 0.5 1.8 0.4 0.3 1.3 -2.9 -0.9 2.5 2.4 2.3 2.7 2.9
Emphysema/chronic bronchitis 0.3 0.3 1.7 -0.7 0.6 0.1 -0.5 -0.5 -0.6 -0.5 -1.3 0.7 -0.0 0.2 0.6 0.6 0.3 0.9 -0.6 0.7 0.5 0.4 0.4 0.4 0.5
Medication for pain relief, constipation, heartburn 1.1 1.9 7.6 -0.8 -1.5 -1.9 -1.6 -1.6 -1.5 -1.5 -0.6 -0.5 -2.1 -1.2 -0.7 -0.9 -0.8 -1.0 -1.9 -2.8 1.2 0.9 0.7 0.6 1.6
Neck or shoulder pain in last month 0.7 0.9 3.6 -0.3 1.4 1.7 0.0 0.1 0.0 0.0 0.2 0.6 1.5 1.3 1.2 1.3 1.4 1.5 0.2 1.9 0.3 0.1 0.1 0.1 -0.4
Medication: Blood pressure 0.1 0.2 0.8 0.3 -0.8 -0.7 0.4 0.3 0.4 0.4 0.0 0.3 -0.3 0.8 0.6 -0.9 0.9 0.2 0.3 -0.5 -0.4 -0.2 -0.1 0.1 -0.3
Angina (self-reported) 1.8 2.3 8.5 -0.2 2.5 2.2 0.9 0.8 0.9 0.8 -0.5 1.6 1.6 2.6 1.1 1.9 2.9 1.7 1.0 2.5 -0.0 0.0 0.0 0.2 -1.4
Migraine (self-reported) 1.0 1.2 3.5 1.1 1.6 0.9 0.9 1.3 0.9 1.0 1.1 -1.1 1.9 0.6 -1.6 -0.1 0.4 0.1 1.4 1.3 -0.8 -1.0 -0.9 -1.0 -1.2
Medication: Ibuprofen 0.4 0.4 1.8 0.4 1.2 1.0 0.6 0.7 0.5 0.6 0.0 1.1 0.6 -0.1 0.7 0.6 0.0 0.2 0.8 1.3 -0.2 0.0 -0.1 -0.2 -0.6
Medication: Allopurinol 1.9 2.6 6.0 1.5 1.3 2.2 1.9 1.7 1.8 1.9 1.9 1.3 1.2 -0.0 -0.4 0.6 0.3 -0.7 1.8 1.2 -1.3 -1.9 -2.1 -2.5 -2.4
Medication: Omeprazole 0.3 0.4 0.9 0.4 0.8 0.4 0.8 0.6 0.8 0.7 0.2 -0.2 -0.7 -0.3 1.0 0.0 -0.2 0.8 0.8 0.7 -0.4 -0.6 -0.9 -0.4 -0.8
Medication: Seretide 50 evohaler 1.4 1.6 3.0 1.5 0.2 1.5 1.6 1.4 1.6 1.7 0.7 1.6 0.3 -0.4 -1.0 0.0 -0.3 -1.3 1.4 1.0 -1.4 -1.3 -1.3 -1.6 -1.7
Mean time to correctly identify matches 4.2 8.1 14.1 -3.5 -0.1 -1.2 -3.4 -3.7 -3.5 -3.4 -3.5 0.6 -2.6 1.5 2.8 1.0 2.2 2.4 -3.8 -1.0 3.7 3.5 3.1 3.6 3.1
Heart disease (mother) 0.7 0.9 3.1 0.3 1.2 0.8 0.9 0.9 0.9 0.9 0.2 0.9 1.8 1.7 -0.0 0.3 1.7 0.2 1.1 0.9 -0.7 -0.7 -0.7 -0.5 -1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.4 1.1 0.9 -0.2 -0.3 0.5 0.2 0.5 0.6 0.2 -1.0 -0.8 -0.5 -1.0 -1.0 -0.8 -1.0 0.4 -0.0 -0.6 -0.7 -0.7 -0.6 -0.3
Whole body fat mass 2.3 9.8 19.7 3.4 0.6 2.5 3.8 4.1 3.8 3.9 3.5 1.5 3.1 0.1 -2.7 -0.5 0.3 -1.7 3.9 1.3 -4.4 -4.4 -3.7 -3.8 -4.1
Leg fat mass (right) 1.2 4.5 9.8 2.1 0.1 1.6 2.4 2.7 2.5 2.5 2.3 1.6 2.6 0.4 -2.0 -0.2 0.5 -1.1 2.5 0.9 -3.1 -3.1 -2.4 -2.4 -2.7
Arm predicted mass (right) 1.8 9.0 31.8 -2.7 2.0 3.4 -2.0 -1.2 -1.9 -1.8 -1.0 5.0 5.6 4.5 3.2 4.7 3.8 3.8 -1.3 3.8 1.8 1.1 1.7 0.9 0.3
Pulse rate, automated reading 0.2 0.8 4.6 0.3 -0.1 -2.1 -0.5 0.0 -0.4 -0.2 -0.8 -1.1 -1.8 0.1 -0.7 -1.9 0.5 -0.3 -0.1 -1.3 -0.4 -0.4 0.1 0.1 0.6
Alcohol intake frequency. 2.9 6.8 16.8 2.7 1.7 2.5 3.7 3.5 3.6 3.7 1.8 1.7 2.2 1.2 -0.7 -0.1 1.5 0.4 3.6 2.0 -3.3 -2.8 -2.4 -2.7 -4.1
Comparative height size at age 10 0.7 4.0 14.1 -1.3 2.3 3.3 -0.7 -0.3 -0.7 -0.5 -0.8 3.6 3.3 2.1 1.5 3.8 2.4 2.8 -0.4 2.5 1.4 1.1 1.2 0.4 -0.3
Number of full sisters 3.1 3.7 8.3 -2.0 0.7 -1.5 -2.6 -2.8 -2.7 -2.5 -2.9 -0.8 -0.9 1.2 1.4 0.5 0.4 1.5 -2.4 0.8 2.5 2.1 1.8 2.1 2.7
Suffer from ‘nerves’ 0.8 1.3 6.0 1.5 -0.6 -0.5 1.1 1.1 1.2 1.4 1.0 -2.4 -0.5 -0.2 -1.0 -1.7 -0.2 0.5 1.0 -0.4 -1.3 -1.4 -1.4 -1.2 -0.9
Overall health rating 1.0 2.1 5.0 0.6 1.9 2.2 1.2 1.1 1.2 1.3 0.1 2.0 1.7 1.8 0.3 1.2 1.9 1.3 1.1 2.0 -1.0 -1.2 -1.0 -1.4 -1.9
Chest pain or discomfort 2.0 3.0 8.2 0.1 2.7 2.9 1.0 1.2 1.0 1.1 0.1 1.6 2.3 2.3 1.2 2.2 2.6 2.1 1.3 2.7 0.1 -0.3 -0.6 -1.0 -1.9
Had major operations 1.8 2.1 5.6 -1.5 1.7 0.5 -1.3 -1.2 -1.3 -1.2 -2.2 0.6 -0.0 2.1 1.3 1.6 2.4 1.9 -1.0 1.2 1.8 1.5 1.3 1.4 0.7
Age at last live birth 3.4 5.0 10.6 2.5 -2.3 -1.2 1.8 2.1 1.8 1.9 2.7 -2.8 -1.4 -2.9 -2.6 -2.7 -2.4 -3.3 1.7 -2.3 -2.4 -2.2 -2.1 -1.5 -0.9
Family relationship satisfaction 2.4 3.0 11.9 0.0 2.2 3.1 0.7 1.0 0.7 0.8 0.9 2.2 2.7 2.3 1.2 2.1 2.5 1.2 0.9 3.5 -0.1 -0.7 -0.8 -0.8 -1.7
Leg pain on walking 0.1 0.1 0.8 -0.5 -0.1 -0.3 -0.2 -0.4 -0.2 -0.3 -0.2 -0.3 -0.4 0.1 -0.0 0.2 0.1 -0.4 -0.4 -0.1 0.1 0.6 0.7 0.9 0.4
Qualifications: NVQ or HND or HNC or equivalent 4.4 5.3 9.1 -2.7 1.3 -0.2 -2.5 -2.4 -2.4 -2.4 -1.8 1.1 0.8 3.0 3.0 2.0 2.8 2.9 -2.4 1.4 2.5 2.8 3.0 2.5 2.0
Commuting to job workplace: Car/motor vehicle 2.6 3.0 6.4 -1.8 2.3 1.6 -1.4 -1.3 -1.4 -1.3 -1.5 2.0 1.8 2.3 1.3 2.5 2.1 2.3 -1.1 2.2 1.9 1.6 1.6 0.7 0.5
Illness, injury, bereavement, stress in last 2 years 3.2 3.9 11.6 1.6 -2.8 -2.6 1.2 1.0 1.1 1.1 1.6 -2.9 -1.9 -2.2 -2.5 -3.4 -2.1 -2.3 0.9 -2.9 -1.9 -1.3 -1.2 -0.5 -0.2
Medication: Aspirin 0.7 0.9 2.9 -1.2 0.5 -0.2 -0.6 -0.8 -0.7 -0.7 -0.9 -0.1 0.1 1.4 1.4 0.7 1.4 1.0 -0.7 0.8 0.8 1.0 1.0 1.7 0.8
Supplements: Vitamin C 0.4 0.4 1.8 -0.5 0.8 1.1 -0.2 -0.3 -0.2 -0.2 -0.4 1.3 0.8 0.6 0.0 1.3 0.7 0.3 -0.2 0.9 0.5 0.5 0.5 -0.2 -0.2
Knee pain experienced in last month 0.2 0.4 1.2 -0.7 0.8 -0.1 -0.5 -0.5 -0.5 -0.5 -0.8 0.5 0.7 0.9 0.4 0.4 1.1 0.8 -0.6 0.5 0.2 0.4 0.7 0.1 0.3
Hypertension (Self-reported) 0.2 0.7 1.2 0.7 0.8 -0.3 0.9 0.8 0.8 0.9 0.0 -0.8 0.2 1.1 -1.0 -0.9 1.0 -0.8 1.1 0.7 -1.1 -1.1 -0.8 -0.7 -0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.5 3.3 -0.6 1.8 0.5 -0.2 -0.2 -0.1 -0.3 -0.9 0.5 0.6 0.6 0.3 0.8 0.6 1.0 -0.0 1.6 0.4 0.4 0.3 0.5 -0.0
Illnesses of father: Heart disease 1.1 1.6 5.8 -0.7 0.7 2.0 -0.0 -0.1 -0.1 -0.1 -0.6 2.4 1.6 1.7 1.4 2.2 1.8 1.7 -0.1 1.8 0.7 0.7 0.6 0.4 -0.6
Illnesses of siblings: Diabetes 1.6 2.0 8.9 -1.2 1.9 0.8 -0.6 -0.7 -0.6 -0.6 -1.3 1.3 1.6 2.7 1.0 1.3 3.0 2.1 -0.5 1.4 0.6 1.1 1.7 1.1 0.1
Smoking status: Previous 0.8 1.1 3.1 1.3 -0.6 0.2 1.1 1.1 1.2 1.2 0.5 -0.8 -1.2 -1.2 -0.9 -0.8 -0.5 -0.2 0.8 -1.0 -1.3 -1.6 -1.8 -1.2 -1.2
Forced expiratory volume in 1-second (FEV1), predicted 1.7 3.4 12.3 1.2 1.3 3.5 1.7 2.0 1.8 1.8 2.2 2.5 3.1 -0.2 0.1 2.1 -0.0 0.3 1.8 1.8 -1.3 -1.5 -1.4 -2.2 -2.2
Whole body fat-free mass 1.2 7.0 31.2 -1.7 2.0 3.8 -0.9 -0.2 -0.9 -0.8 -0.1 4.7 5.6 3.9 2.5 4.2 3.5 3.2 -0.4 3.5 1.0 0.2 0.8 0.0 -0.7
Leg fat-free mass (right) 0.7 3.6 22.2 0.1 1.2 3.1 0.7 1.3 0.7 0.8 1.5 3.0 4.7 2.3 0.4 2.3 2.0 1.1 1.1 2.2 -0.9 -1.6 -1.0 -1.6 -1.8
Arm fat percentage (left) 3.2 12.8 27.5 4.1 0.6 2.0 4.6 4.6 4.5 4.6 3.9 0.8 2.5 -0.5 -3.8 -1.4 -0.1 -2.7 4.5 0.7 -5.2 -5.0 -4.2 -4.3 -4.6
Average weekly red wine intake 2.4 3.5 7.0 -2.4 0.2 -0.6 -2.6 -2.2 -2.6 -2.5 -1.5 0.3 0.3 1.0 2.0 1.2 1.0 1.0 -2.3 0.1 2.5 2.4 2.4 2.6 2.3
Handedness (chirality/laterality): Left-handed 0.2 0.2 1.2 -0.1 -0.3 -0.7 -0.5 -0.2 -0.4 -0.4 -0.4 -0.7 -0.5 -0.8 0.0 -0.5 -1.1 -0.2 -0.3 0.1 0.3 0.4 0.3 0.4 0.7
Mood swings 6.2 11.1 20.8 4.3 0.6 2.1 4.2 4.4 4.2 4.6 3.1 -1.1 1.9 -0.8 -3.5 -1.8 -0.6 -2.5 4.4 0.9 -4.2 -4.4 -4.3 -4.0 -4.2
Loneliness, isolation 1.2 1.7 4.1 1.3 1.1 1.1 1.5 1.5 1.5 1.6 1.1 0.8 1.0 -0.1 -1.1 -0.4 0.3 -0.6 1.5 0.1 -1.4 -1.8 -1.8 -2.0 -1.9
Long-standing illness, disability or infirmity 0.9 1.3 4.0 -0.1 1.2 2.0 0.4 0.4 0.4 0.5 0.1 1.5 1.7 1.8 1.4 1.5 1.8 1.7 0.5 1.8 0.1 -0.3 -0.3 -0.4 -1.0
Ever had bowel cancer screening 0.2 0.3 1.3 0.1 0.6 -0.9 0.1 0.0 0.1 0.1 -1.1 -0.7 -0.5 0.7 -0.8 -0.9 0.5 0.0 0.3 0.2 -0.7 -0.4 -0.0 0.5 0.1
Diabetes diagnosed by doctor 0.6 1.0 3.6 0.6 0.2 1.7 1.0 0.9 1.0 1.2 0.2 1.3 1.9 1.0 -0.6 0.7 1.3 -0.1 1.0 0.6 -0.8 -1.1 -0.9 -0.7 -1.3
Ever had stillbirth, spontaneous miscarriage or termination 1.1 1.2 3.9 0.8 -2.0 -0.7 0.5 0.5 0.4 0.6 1.1 -0.2 -0.9 -1.8 -0.9 -1.2 -1.5 -1.7 0.1 -1.9 -0.9 -1.0 -1.0 -0.5 0.1
Friendships satisfaction 3.3 4.1 13.5 -1.3 2.9 3.0 -0.8 -0.5 -0.8 -0.6 -0.6 2.5 2.4 3.3 2.1 2.9 3.2 2.0 -0.4 3.7 1.6 0.8 0.8 0.1 -0.5
Qualifications: nursing, teaching 1.2 1.9 4.3 1.5 0.0 0.4 1.5 1.7 1.5 1.5 2.1 -0.5 0.3 -1.5 -1.6 -0.7 -1.2 -1.5 1.5 -0.3 -1.9 -2.0 -1.9 -1.1 -1.3
Commuting to job workplace: Walk 0.4 0.4 2.2 0.3 -1.0 -0.7 0.1 0.1 0.1 0.1 0.7 -1.5 -0.9 -1.0 0.6 -0.8 -1.0 0.0 0.1 -0.7 -0.1 -0.4 -0.6 0.5 0.3
Eye problems/disorders: Cataract 1.2 1.4 3.1 1.3 -1.1 -0.7 1.2 1.4 1.1 1.3 1.3 -1.2 0.0 -0.6 -1.3 -1.7 -0.0 -0.9 1.2 -1.6 -1.8 -1.6 -1.4 -0.4 -0.7
Mouth/teeth dental problems: Mouth ulcers 0.7 1.0 3.1 1.2 -1.7 -0.7 0.7 0.6 0.6 0.8 0.4 -0.8 -1.5 -1.4 -0.3 -1.8 -1.2 -1.0 0.5 -1.5 -0.8 -0.8 -1.0 -0.7 -0.4
Medication for cholesterol 0.4 0.6 2.1 1.0 -0.8 -0.3 0.7 0.8 0.8 0.7 0.5 0.5 -0.7 -1.5 -0.2 -0.7 -1.3 -0.5 0.6 -1.2 -0.6 -0.6 -0.8 -1.1 -0.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.1 0.5 0.4 -0.2 -0.2 0.0 0.1 0.0 0.2 0.1 -0.5 0.1 0.3 -0.1 -0.7 -0.1 0.1 0.2 0.4 -0.2 -0.2 -0.3 0.0 0.1
Back pain experienced in last month 0.4 0.5 2.0 -0.4 0.7 1.1 -0.1 0.1 -0.1 -0.1 -0.1 0.7 1.3 1.1 0.9 1.1 0.9 1.2 0.1 1.4 0.4 0.1 0.1 0.0 -0.2
Mineral and other dietary supplements 0.9 1.2 3.2 1.1 -1.6 -1.1 0.4 0.6 0.4 0.5 0.7 0.1 -1.0 -1.7 -0.6 -1.8 -1.7 -1.4 0.4 -1.7 -0.9 -1.4 -1.5 -1.0 -0.1
Breast cancer (self-reported) 0.6 0.7 3.2 0.4 -0.6 -1.0 -0.1 -0.2 -0.1 0.1 0.4 -1.6 -1.0 -1.0 -1.8 -1.2 -0.4 -1.2 -0.4 -1.5 -0.2 -0.6 -0.8 -0.2 0.3
Asthma (self-reported) 7.7 15.4 27.4 4.6 1.4 3.5 5.2 5.2 5.2 5.2 4.3 1.0 1.6 -1.9 -3.6 -0.8 -1.3 -3.4 5.1 1.1 -4.6 -4.7 -4.7 -4.8 -5.2
Osteoporosis (self-reported) 0.6 0.7 3.3 0.5 1.5 0.6 0.5 0.6 0.5 0.6 0.0 0.4 1.7 1.2 0.2 0.2 0.8 0.7 0.8 1.8 -0.5 -0.6 -0.6 -0.2 -0.7
Osteoarthritis (self-reported) 0.3 0.4 1.9 -0.1 0.8 0.6 0.2 -0.0 0.2 0.2 -1.0 1.4 0.2 0.6 1.0 0.7 1.1 0.5 0.0 0.6 -0.1 -0.2 -0.1 0.3 -0.5
Medication: Aspirin 0.8 1.1 3.1 -1.2 1.1 -0.2 -0.7 -0.9 -0.8 -0.8 -1.2 -0.1 0.1 1.8 1.2 0.7 1.8 1.1 -0.7 1.1 0.9 1.1 1.1 1.6 0.8
Medication: Gliclazide 0.3 0.4 1.5 -0.7 -0.4 -0.5 -0.7 -0.9 -0.8 -0.7 -1.2 0.0 -0.1 0.5 0.1 0.1 0.1 0.4 -0.7 0.2 0.4 0.2 0.4 0.9 0.9
Illnesses of father: None of the above (group 1) 2.1 2.6 9.5 -0.9 -2.0 -2.9 -1.5 -1.4 -1.5 -1.6 -0.4 -1.9 -2.1 -1.1 0.3 -2.0 -0.9 -0.6 -1.5 -3.1 1.1 1.2 1.0 1.4 1.9
Smoking status: Current 7.0 11.1 26.6 -3.2 -2.1 -4.8 -4.1 -4.2 -4.1 -4.2 -2.7 -3.5 -3.3 -0.8 0.3 -1.2 -1.4 -0.9 -4.0 -2.7 3.2 3.6 3.6 4.1 5.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.7 4.7 1.5 -1.0 -1.5 1.1 1.3 1.2 1.0 1.7 -1.9 -0.7 -1.5 -0.9 -2.2 -1.4 -1.2 1.1 -1.9 -1.4 -0.8 -0.7 -0.6 -0.5
Whole body water mass 1.2 7.0 29.8 -1.9 1.9 3.7 -1.1 -0.3 -1.0 -0.9 -0.3 4.7 5.5 4.0 2.6 4.2 3.6 3.2 -0.5 3.5 1.1 0.3 0.9 0.2 -0.6
Leg predicted mass (right) 0.7 3.6 22.4 0.1 1.2 3.2 0.7 1.3 0.7 0.8 1.5 3.0 4.7 2.2 0.4 2.3 2.0 1.1 1.1 2.2 -0.9 -1.6 -1.0 -1.6 -1.8
Arm fat mass (left) 2.1 8.6 15.6 2.7 1.2 3.0 3.4 3.7 3.4 3.5 3.0 2.3 3.9 1.0 -2.1 0.5 1.1 -1.0 3.5 2.0 -3.9 -3.9 -3.1 -3.4 -3.9
Number of self-reported non-cancer illnesses 4.3 7.4 20.2 1.9 2.7 4.5 3.2 3.1 3.2 3.2 1.4 3.0 3.4 2.0 -0.3 1.9 2.6 0.3 3.2 2.9 -2.3 -2.4 -2.2 -2.2 -4.0
Average weekly champagne plus white wine intake 1.5 2.1 8.5 -0.7 1.4 2.3 0.2 0.3 0.2 0.0 -0.2 2.9 2.3 1.3 1.9 2.2 1.4 2.2 0.2 2.4 0.5 0.4 0.3 -0.2 -0.9
Miserableness 2.5 4.3 11.2 2.5 0.4 -0.5 2.4 2.4 2.3 2.5 1.6 -1.8 0.0 -0.9 -3.3 -2.3 -0.9 -2.0 2.5 -0.5 -2.9 -2.7 -2.4 -2.1 -2.0
Guilty feelings 1.4 2.0 5.8 2.0 0.4 1.0 1.6 1.7 1.6 1.9 1.4 -0.1 0.6 0.1 -0.3 -0.9 0.2 0.2 1.6 0.9 -1.5 -2.1 -2.2 -2.4 -2.1
Wears glasses or contact lenses 0.2 0.3 2.1 0.3 -0.2 -0.2 0.2 0.7 0.3 0.3 0.7 -0.5 0.9 -0.1 -1.4 -0.6 0.0 0.1 0.5 -0.2 -0.9 -0.6 -0.2 -0.1 -0.2
Ever taken oral contraceptive pill 1.2 1.3 2.1 -1.1 -1.1 -1.1 -1.4 -1.4 -1.3 -1.4 -1.3 -0.1 -1.2 -0.8 0.3 0.0 -0.9 -0.6 -1.5 -1.2 1.5 1.4 1.1 0.9 1.5
Hearing aid user 0.3 0.4 1.2 -0.7 0.8 -1.1 -0.9 -0.6 -0.8 -0.8 -0.1 -0.1 0.5 0.8 -1.0 -0.3 0.6 0.3 -0.6 -0.1 0.2 0.3 0.6 0.2 0.7
Mother’s age at death 0.3 0.4 1.4 -0.3 -0.4 -1.1 -0.5 -0.6 -0.6 -0.6 0.1 -0.6 -0.9 -0.7 0.6 -0.5 -0.5 -0.6 -0.5 -1.2 0.5 0.5 0.4 0.5 0.8
Financial situation satisfaction 1.1 1.4 5.3 0.1 2.3 2.3 0.5 0.7 0.5 0.6 0.3 1.6 1.9 1.0 0.5 1.6 1.3 0.4 0.8 2.1 -0.0 -0.2 -0.2 -0.9 -1.1
Tinnitus: Yes, now most or all of the time 0.3 0.3 1.7 -0.1 -0.9 -0.3 -0.2 -0.2 -0.2 -0.2 0.4 -1.3 -1.0 -0.9 -0.5 -0.2 -0.9 -0.2 -0.3 -0.3 0.2 0.5 0.4 0.8 0.6
Commuting to job workplace: Public transport 2.0 2.4 10.9 -0.5 -1.6 -2.7 -0.8 -1.0 -0.9 -1.1 -1.2 -2.6 -3.3 -1.6 -0.1 -1.6 -1.5 -1.0 -1.0 -2.4 0.7 0.9 0.5 1.2 1.6
Eye problems/disorders: Glaucoma 2.8 3.3 6.8 2.6 -0.4 -0.6 2.2 2.0 2.2 2.2 1.2 -1.5 -1.6 -1.7 -1.1 -2.3 -1.6 -0.8 2.1 -0.5 -2.1 -2.2 -2.6 -2.0 -1.8
Medication: Blood pressure 0.1 0.3 2.1 -0.1 0.8 0.1 0.2 0.0 0.1 0.1 -0.4 -0.2 0.4 1.4 0.1 0.2 1.4 -0.1 0.3 0.9 -0.2 -0.2 -0.0 0.3 -0.2
Pain type(s) experienced in last month: Hip pain 1.3 1.6 3.7 -1.6 0.5 0.1 -1.2 -1.1 -1.2 -1.3 -1.8 0.2 -0.3 1.2 1.9 1.2 1.4 1.6 -1.1 0.5 1.5 1.4 1.3 1.8 1.0
Supplements: Fish oil (including cod liver oil) 1.4 1.8 9.1 -0.3 3.0 1.5 0.6 0.4 0.5 0.4 0.0 -0.1 1.9 2.3 -0.3 1.4 1.9 1.1 0.8 2.9 -0.3 0.3 0.7 -0.1 -1.0
High cholesterol (Self-reported) 1.0 1.8 3.6 -1.9 -0.0 -0.1 -1.6 -1.8 -1.7 -1.5 -1.6 -0.0 0.4 1.8 0.7 1.1 1.6 1.0 -1.6 0.8 1.5 1.2 1.4 1.6 1.3
Medication: Bendroflumethiazide 1.3 2.0 6.6 1.3 -0.6 -1.8 1.3 1.0 1.2 1.2 0.8 -1.9 -1.8 -0.6 -1.8 -2.6 -0.3 -2.3 1.1 -1.8 -1.7 -1.3 -1.2 -0.3 -0.6
Medication: Paracetamol 0.5 0.8 3.7 0.3 1.1 1.2 0.6 0.9 0.6 0.7 0.5 -0.3 1.6 1.1 0.8 0.4 0.6 0.8 1.1 1.9 -0.5 -0.3 -0.1 -0.2 -0.8
Medication: Lisinopril 0.3 0.4 1.1 0.3 0.3 0.3 0.6 0.6 0.6 0.6 0.6 0.5 0.5 0.9 0.7 0.2 1.0 -0.5 0.6 -0.1 -0.5 -0.8 -0.9 -0.6 -0.8
Medication: Atorvastatin 0.2 0.2 0.7 0.2 -0.2 0.6 0.3 0.3 0.4 0.4 0.7 0.0 0.8 0.7 -0.3 0.3 0.8 -0.5 0.3 0.3 -0.3 -0.4 -0.3 0.2 -0.4
Illnesses of father: High blood pressure 2.1 2.6 4.7 2.0 -0.5 2.1 2.1 1.9 2.0 2.2 1.6 1.7 0.1 -1.2 -0.1 0.6 -1.0 -1.0 1.9 0.3 -1.5 -1.8 -2.0 -2.2 -2.2
Alcohol drinker status: Never 1.2 1.5 3.3 1.5 0.4 0.0 1.5 1.7 1.5 1.6 1.1 -0.1 0.7 0.0 -1.2 -1.1 0.2 -0.7 1.8 0.3 -1.8 -1.5 -1.2 -1.4 -1.6
Ever smoked 1.3 2.3 11.6 0.7 -1.6 -1.9 -0.0 -0.1 0.0 0.0 -0.0 -2.4 -3.4 -2.6 -1.0 -1.8 -2.0 -1.5 -0.3 -2.6 -0.4 -0.8 -1.2 -0.2 0.5
Basal metabolic rate 1.0 5.7 29.8 -0.8 1.8 3.9 0.1 0.7 0.1 0.2 0.7 4.4 5.5 3.4 1.5 3.6 3.0 2.4 0.5 3.2 -0.1 -0.7 -0.1 -0.8 -1.5
Leg fat percentage (left) 1.5 5.3 13.7 2.7 -0.2 0.5 2.8 2.8 2.8 2.8 2.4 0.4 1.4 -0.3 -2.8 -1.6 -0.2 -1.9 2.8 0.2 -3.7 -3.5 -2.8 -2.5 -2.6
Arm fat-free mass (left) 1.5 7.6 28.7 -2.2 1.8 3.3 -1.5 -0.8 -1.4 -1.4 -0.8 4.7 5.4 4.2 2.8 4.2 3.6 3.7 -0.9 3.6 1.4 0.7 1.4 0.7 -0.1
Number of operations (self-reported) 0.4 0.6 1.9 -0.7 0.3 -0.7 -0.9 -0.9 -0.9 -0.8 -1.4 -0.4 -0.9 0.6 -0.1 -0.0 1.1 -0.3 -0.9 -0.0 0.9 0.7 0.6 1.0 0.8
Average weekly beer plus cider intake 1.5 2.2 4.8 -1.5 0.4 -1.8 -2.0 -2.1 -2.0 -2.0 -1.8 -1.1 -1.2 0.3 0.0 0.0 0.1 0.0 -1.9 -0.4 1.7 1.8 1.8 1.4 2.2
Irritability 5.5 9.3 16.5 3.8 0.5 1.7 3.8 4.1 3.8 4.0 3.7 -0.7 2.0 -1.1 -2.5 -1.6 -1.1 -2.2 4.0 1.0 -4.0 -4.1 -3.8 -3.7 -3.7
Risk taking 0.8 1.1 6.7 0.4 -1.2 -1.1 0.0 0.1 0.1 0.1 0.5 -1.2 -1.3 -1.6 -1.9 -1.1 -1.4 -2.6 -0.0 -1.6 -0.2 -0.0 -0.2 0.1 0.4
Ever had prostate specific antigen (PSA) test 0.8 0.9 2.0 -1.2 0.4 0.7 -0.9 -0.8 -0.9 -0.9 -0.8 1.2 0.8 1.1 0.5 1.3 1.0 0.8 -0.8 1.4 0.8 0.8 0.9 1.1 0.7
Fractured/broken bones in last 5 years 0.7 0.9 2.3 0.9 0.1 1.2 0.8 0.8 0.8 0.9 1.2 1.1 1.2 -0.9 -1.3 0.5 -1.0 -1.5 0.8 0.4 -0.7 -0.8 -0.9 -1.3 -1.0
Age started oral contraceptive pill 0.8 1.0 2.8 1.3 -1.1 -0.5 1.1 1.1 1.1 1.2 1.7 -0.2 -0.4 -0.3 -1.0 -1.4 0.1 -1.7 0.9 -1.1 -1.2 -0.9 -0.8 -0.7 -0.8
Diastolic blood pressure, automated reading 0.5 1.6 6.1 0.6 1.6 0.7 0.8 1.2 0.9 0.9 0.6 0.2 2.5 2.3 -0.3 0.2 1.6 1.2 1.4 2.0 -1.2 -1.0 -0.4 -1.1 -1.2
Ever depressed for a whole week 0.6 0.8 3.6 -0.1 1.9 0.8 0.2 0.6 0.3 0.3 -0.8 -0.0 0.6 1.5 -0.1 0.5 1.8 1.6 0.6 1.6 0.1 0.1 0.1 0.3 -0.7
Unable to work because of sickness or disability 1.2 1.6 3.1 -1.3 0.9 -0.5 -1.4 -1.4 -1.4 -1.4 -1.8 -0.3 0.1 1.4 1.2 0.5 1.0 1.7 -1.2 0.8 1.6 1.7 1.7 1.2 1.2
Commuting to job workplace: Cycle 1.0 1.2 3.4 1.2 -1.0 -1.0 0.8 0.9 0.8 0.8 0.5 -0.8 -1.0 -1.3 -1.3 -1.8 -1.2 -1.0 0.9 -1.4 -1.3 -1.3 -1.1 -0.8 -0.3
Myopia 2.6 3.7 14.6 -0.8 -2.0 -2.5 -1.6 -1.7 -1.6 -1.7 -1.7 -1.5 -3.8 -2.5 0.2 -1.0 -2.5 -0.7 -1.8 -2.3 1.4 1.5 1.1 2.1 2.7
Vascular/heart problems diagnosed by doctor 0.3 0.7 5.4 0.3 -1.4 -0.1 -0.1 -0.0 -0.0 -0.1 0.8 -0.0 -0.8 -2.3 0.1 -0.1 -2.2 -0.4 -0.3 -1.3 0.0 -0.0 -0.3 -0.2 0.3
Cholesterol lowering medication 0.8 1.2 4.3 -1.2 1.1 0.8 -0.7 -0.8 -0.8 -0.7 -0.6 -0.4 1.3 2.1 0.5 1.2 2.0 1.6 -0.7 1.5 0.9 0.7 0.8 1.1 0.4
Medication: Omeprazole (e.g. Zanprol) 1.1 1.4 3.3 1.3 0.7 0.9 1.5 1.5 1.5 1.5 1.4 -0.2 -0.3 -0.9 0.3 -0.4 -0.6 0.0 1.5 0.8 -1.0 -1.5 -1.8 -1.5 -1.6
Pain experienced in last month 2.9 4.9 9.7 2.6 -2.1 -1.8 1.8 1.6 1.8 1.8 1.7 -1.9 -1.9 -3.0 -2.5 -3.1 -3.1 -3.1 1.6 -2.5 -2.0 -1.8 -2.0 -2.1 -1.0
Supplements: Calcium 3.2 3.6 7.7 1.8 1.6 2.3 2.6 2.5 2.6 2.6 1.5 1.2 1.8 0.5 -1.2 0.4 1.1 -1.2 2.6 1.2 -1.9 -1.7 -2.0 -1.6 -2.8
Basal cell carcinoma (self-reported) 10.2 12.2 23.6 4.6 -0.8 -0.2 3.9 4.0 4.0 4.1 3.3 -2.7 -0.7 -2.6 -3.4 -3.9 -2.6 -3.4 4.0 -1.5 -4.5 -4.9 -4.9 -3.8 -3.3
Heart attack/myocardial infarction (self-reported) 0.9 1.2 3.9 -0.2 1.6 1.5 0.5 0.4 0.5 0.4 -0.4 1.6 1.1 1.3 1.7 1.5 1.3 1.5 0.6 2.0 -0.0 -0.1 -0.2 0.3 -0.7
Deep venous thrombosis (DVT) (self-reported) 0.6 0.8 2.6 -0.8 -0.2 -0.1 -1.0 -0.8 -1.0 -0.9 -0.6 0.4 1.2 1.6 1.1 0.2 1.4 1.2 -0.9 0.1 0.9 0.7 0.8 0.8 0.7
Heart disease (siblings) 0.3 0.4 2.3 -0.3 1.1 0.5 0.2 0.3 0.2 0.1 -0.4 -0.4 0.7 1.0 0.5 0.6 0.7 1.0 0.3 1.5 0.2 -0.0 -0.3 0.2 -0.3
Alcohol drinker status: Previous 0.6 0.7 2.3 -0.5 1.0 -0.7 -0.6 -0.6 -0.6 -0.5 -1.5 -0.6 -0.5 1.2 1.5 -0.7 1.3 1.5 -0.4 0.6 0.6 0.4 0.3 0.8 0.5
Pack years of smoking 2.3 3.4 7.5 -2.7 0.0 -0.8 -2.2 -2.3 -2.2 -2.5 -2.3 0.3 -0.4 1.0 0.8 1.6 0.8 0.8 -2.1 0.1 2.3 2.5 2.5 2.6 2.2
Impedance of whole body 4.6 23.3 42.2 6.5 0.4 1.8 6.5 6.1 6.5 6.5 5.2 -2.1 -1.7 -4.7 -4.5 -3.2 -3.7 -4.0 6.1 -0.3 -5.5 -5.1 -5.7 -5.7 -5.6
Leg fat mass (left) 1.1 4.3 9.7 2.0 0.0 1.6 2.4 2.6 2.4 2.4 2.2 1.5 2.6 0.5 -2.0 -0.2 0.5 -1.1 2.4 0.9 -3.1 -3.1 -2.4 -2.4 -2.6
Arm predicted mass (left) 1.5 7.5 27.5 -2.2 1.9 3.4 -1.4 -0.7 -1.3 -1.3 -0.8 4.6 5.2 4.2 2.9 4.3 3.7 3.5 -0.9 3.6 1.4 0.7 1.3 0.7 -0.1