Hub : Genes

RP5-821D11.7

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Lung 0.0835 0.0351 4.1e-04 0.024 NA 0.038 NA 0.032 6e-03 NA 6.6e-04 NA 1.7e-03
2 GTEx Testis 0.1480 0.0570 3.8e-06 0.163 NA 0.105 NA 0.115 1e-07 NA 2.2e-05 NA 9.0e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.2 0.3 0.6 0.8 0.2
Bipolar Disorder or Schizophrenia 1.1 2.7 5.3 2.3 -0.4
Depressed Affect (Nagel 2018) 4.9 10.3 18.4 1.4 -4.3
Depression (Nagel 2018) 0.4 0.7 0.8 0.7 -0.9
Intelligence (Savage-Jansen 2018) 3.6 11.0 13.4 -3.7 2.9
Neuroticism (Nagel 2018) 5.6 13.1 25.3 0.9 -5.0
Schizophrenia (2018) 1.7 3.5 6.5 2.5 -0.7
Schizophrenia vs Biploar Disorder 0.2 0.2 0.3 0.5 -0.4
Worry (Nagel 2018) 2.8 6.0 11.9 0.2 -3.4
Alzheimer’s Disease (in mother) 2.3 2.6 3.2 -1.8 -1.4
Alzheimer’s Disease (in father) 0.1 0.1 0.1 0.3 0.3
Alzheimer’s Disease (including proxy) 0.9 1.2 2.4 0.3 -1.5
Crohns Disease (2017) 2.3 5.1 8.3 1.3 -2.9
Irritable Bowel Disease (IBD) 0.9 2.2 3.6 0.9 -1.9
Ulcerative Colitis (UC) 0.1 0.1 0.2 0.2 -0.4
Major Depression (MDD) 0.0 0.0 0.1 -0.0 0.3
Reaction Time 1.6 3.1 5.7 -0.6 2.4
Verbal and Numeric Reasoning (VNR) 3.2 7.7 7.9 -2.8 2.7
Breast Cancer 1.3 3.1 4.7 2.2 -1.2
Ovarian Cancer 0.1 0.1 0.2 -0.4 -0.0
Prostate Cancer 2.3 3.2 4.2 -1.5 -2.0
Age at First Birth 2.6 3.8 5.6 -1.4 -2.4
Bipolar Disorder (2011) 0.8 0.7 1.4 1.2 0.3
Body Mass Index (BMI) (2010) 2.7 3.7 4.1 1.8 -2.0
Coronary Artery Disease (CAD) 0.3 0.3 0.6 -0.2 0.8
Crohns Disease (2012) 2.2 3.5 3.8 1.9 -1.8
Mean Putamen Volume 1.7 1.9 2.3 -1.2 -1.5
Fasting Glucose 1.5 1.7 3.1 0.6 -1.8
HbA1C 1.9 2.1 3.6 1.9 -0.8
HDL Cholesterol 0.2 0.4 0.8 -0.9 0.1
LDL Cholesterol 0.0 0.1 0.1 0.3 0.0
Lupus 0.0 0.0 0.0 0.1 -0.0
Neuroticism (2016) 3.2 4.6 9.2 0.1 -3.0
Primary Biliary Cirrhosis 1.5 2.1 4.2 0.0 -2.0
Rheumatoid Arthritis 1.4 1.9 3.5 -0.5 1.9
Schizophrenia (2014) 1.9 4.2 8.3 2.9 -0.4
Triglycerides 0.0 0.0 0.0 0.1 -0.1
Type 2 Diabetes (T2D) (2012) 0.2 0.2 0.4 -0.4 0.6
Ulcerative Colitis 0.1 0.1 0.2 0.4 0.3
Blood Eosinophil Count 3.8 29.2 57.2 -1.1 -7.6
Blood Platelet Count 1.2 13.6 21.0 -2.5 4.6
Blood Red Count 0.2 2.2 3.1 1.1 1.8
Blood White Count 0.0 0.1 0.2 0.2 0.4
Heel T-Score 2.5 19.5 29.3 -5.4 -3.1
BMI 1.8 10.6 14.2 3.8 -2.6
Height 1.0 20.0 32.8 5.7 -2.7
Waist Hip Ratio (WHR) 0.0 0.1 0.1 0.1 0.3
Systolic Blood Pressure 0.5 2.3 4.6 2.1 -0.3
Smoking Status 8.5 20.3 21.3 -4.4 4.6
Allergy or Eczema 5.2 13.8 26.0 1.2 -5.1
Cardiovascular Disease 0.6 2.0 3.5 0.8 -1.9
Hypothyroidism (self reported) 3.8 8.8 17.3 0.5 4.2
Respiratory disease 7.3 16.2 29.3 1.7 -5.4
Type 2 Diabetes (T2D) (2018) 2.4 4.5 5.7 2.4 -1.8
Lung FEV1/FVC ratio 0.6 2.8 3.8 1.4 -1.9
Lung FVC 1.8 9.1 10.3 -2.8 3.2
Neuroticism 3.1 7.5 14.9 0.4 -3.9
Chronotype (morning person) 6.2 14.3 19.0 4.4 -3.1
Hair Pigment 0.3 8.1 15.0 -1.1 3.9
Tanning 0.3 4.1 7.9 -0.6 2.8
Hand grip strength (left) 3.0 8.0 13.2 3.6 1.6
Number of treatments/medications taken 1.7 3.0 4.7 2.2 -1.1
Average weekly spirits intake 3.8 4.7 9.4 0.1 3.1
Sensitivity / hurt feelings 0.7 1.1 2.1 -0.3 -1.5
Frequency of depressed mood in last 2 weeks 0.9 1.3 2.1 0.7 -1.4
Hearing difficulty/problems: Yes 0.8 1.2 1.9 -0.6 1.4
Relative age of first facial hair 2.1 4.3 7.9 -0.8 -2.8
Other serious medical condition/disability diagnosed by doctor 0.0 0.0 0.0 0.1 -0.1
Ever used hormone-replacement therapy (HRT) 1.0 1.2 2.4 1.6 0.1
Ever had hysterectomy (womb removed) 0.7 0.8 1.5 -0.3 -1.2
Systolic blood pressure, automated reading 0.9 2.7 5.3 2.3 -0.1
Eye problems/disorders: Diabetes related eye disease 2.2 2.4 3.1 1.8 -1.3
Angina 2.4 3.2 6.1 2.5 -0.5
Medication for hormone replacement therapy 0.5 0.5 0.7 0.6 0.9
Vitamin and mineral supplements 1.5 2.0 2.3 -1.3 1.5
Supplements: Zinc 1.4 1.5 2.4 -0.8 -1.5
Medication: Co-codamol 1.4 1.6 3.1 -0.3 1.8
Medication: Metformin 0.3 0.5 0.8 0.9 0.4
Diabetes (father) 1.4 1.7 3.1 1.8 -0.6
Diabetes (mother) 2.1 2.6 4.8 0.7 2.2
Severe depression (siblings) 0.5 0.6 1.2 0.0 -1.1
Pack years adult smoking proportion 1.8 2.7 5.3 -0.3 2.3
Impedance of leg (right) 1.3 6.4 6.5 -2.6 -2.5
Leg fat-free mass (left) 2.2 11.9 19.3 4.4 -2.1
Trunk fat percentage 4.3 17.1 33.2 1.0 -5.8
Hand grip strength (right) 2.4 6.6 11.6 3.4 1.3
Townsend deprivation index at recruitment 0.9 1.3 2.4 -1.6 0.3
Current tobacco smoking 9.8 16.1 24.0 -2.9 4.9
Average weekly fortified wine intake 1.0 1.1 2.1 -1.5 -0.4
Maternal smoking around birth 6.9 10.0 18.3 1.3 4.3
Fed-up feelings 5.0 9.1 16.4 1.3 -4.1
Frequency of unenthusiasm / disinterest in last 2 weeks 1.5 2.0 3.6 0.5 -1.9
Relative age voice broke 0.4 0.7 1.3 -0.2 -1.1
Taking other prescription medications 1.7 2.5 4.7 0.6 -2.2
Age when periods started (menarche) 1.3 3.1 5.0 -2.2 1.1
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 1.0 1.0 -0.1
Heel bone mineral density (BMD) T-score, automated (left) 2.4 5.5 8.8 -3.0 -1.5
Tinnitus: Yes, but not now, but have in the past 0.2 0.3 0.4 0.3 0.7
Qualifications: CSEs or equivalent 2.0 2.6 4.8 0.6 -2.2
Serious illness, injury or assault to yourself 1.7 2.0 2.3 1.3 -1.5
High blood pressure 0.2 0.6 1.0 1.0 -0.4
Hayfever, allergic rhinitis or eczema 4.8 10.4 18.8 1.4 -4.3
Multivitamins +/- minerals 1.6 2.0 2.0 1.4 -1.4
Stomach or abdominal pain in last month 0.4 0.5 0.7 0.5 0.8
Supplements: Glucosamine 1.5 1.9 2.6 -1.1 1.6
Diverticular disease/diverticulitis (self-reported) 0.9 1.0 2.0 0.2 1.4
Medication: Atenolol 4.0 5.0 5.1 2.2 2.3
Medication: Levothyroxine sodium 3.3 5.6 11.0 0.3 3.3
Sitting height 0.5 3.5 6.2 2.5 -0.9
Chronic bronchitis/emphysema (father) 2.6 3.0 6.0 2.4 0.2
High blood pressure (mother) 1.0 1.4 2.8 1.7 0.3
Body mass index (BMI) 1.6 6.6 9.5 3.1 -2.0
Impedance of leg (left) 1.2 6.0 6.7 -2.3 -2.6
Leg predicted mass (left) 2.3 12.1 19.4 4.4 -2.2
Trunk fat mass 3.4 14.5 23.2 2.4 -4.8
Waist circumference 1.9 6.8 7.5 2.7 -2.5
Number of incorrect matches in round 1.2 1.9 2.1 1.3 -1.4
Past tobacco smoking 1.5 2.8 5.6 2.4 0.1
Alcohol usually taken with meals 0.7 1.1 1.9 1.4 -0.6
Nervous feelings 1.1 2.1 2.1 -1.5 -1.5
Frequency of tenseness / restlessness in last 2 weeks 1.1 1.7 2.5 -1.0 -1.6
Hearing difficulty/problems with background noise 0.5 0.9 1.5 -0.5 1.2
Hair/balding pattern: Pattern 2 1.7 2.2 4.3 2.1 0.2
Had menopause 0.2 0.3 0.5 -0.1 0.7
Had other major operations 1.1 1.4 2.6 -1.6 0.3
Forced vital capacity (FVC) 0.1 0.4 0.7 -0.3 -0.8
Heel bone mineral density (BMD) T-score, automated (right) 1.6 3.6 5.9 -2.4 -1.2
Ever unenthusiastic/disinterested for a whole week 0.9 1.0 1.8 1.3 -0.6
Qualifications: None of the above 0.1 0.2 0.3 0.5 0.4
Financial difficulties in last 2 years 0.2 0.3 0.6 -0.8 -0.2
Mouth/teeth dental problems 0.2 0.3 0.6 -0.1 -0.8
Heart attack 0.5 0.6 1.1 1.1 0.2
Allergy 7.9 18.1 30.6 -2.4 5.5
Pain all over the body in last month 0.0 0.0 0.0 0.0 -0.0
Diabetes (self-reported) 1.5 2.3 4.0 2.0 -0.7
Hayfever/allergic rhinitis (self-reported) 3.4 4.5 7.6 1.2 -2.8
Medication: Ramipril 0.5 0.6 1.2 1.1 -0.1
Medication: Simvastatin 2.3 3.4 3.4 1.8 1.8
Fluid intelligence score 2.0 4.1 5.6 -1.6 2.4
Illnesses of siblings 1.4 1.9 3.6 -1.9 -0.5
Neuroticism score 3.6 7.6 14.6 0.8 -3.8
Weight 2.7 13.2 16.2 4.0 -3.2
Impedance of arm (right) 5.0 23.5 30.4 -4.1 -5.5
Arm fat percentage (right) 2.8 11.2 20.4 1.4 -4.5
Trunk fat-free mass 3.4 19.4 38.7 6.2 0.4
Hip circumference 2.2 9.4 12.6 2.5 -3.5
Time employed in main current job 0.0 0.0 0.1 -0.1 -0.3
Alcohol intake versus 10 years previously 0.9 1.3 1.4 1.1 -1.2
Father’s age at death 1.6 2.2 3.7 -1.9 0.8
Worrier / anxious feelings 3.9 7.4 13.1 1.3 -3.6
Frequency of tiredness / lethargy in last 2 weeks 6.7 10.9 15.7 2.5 -4.0
Falls in the last year 0.0 0.0 0.0 -0.0 0.1
Hair/balding pattern: Pattern 3 0.1 0.1 0.1 0.3 0.3
Number of live births 0.2 0.3 0.5 -0.2 -0.7
Forced expiratory volume in 1-second (FEV1) 0.4 1.4 2.6 0.4 -1.6
Pulse rate 0.2 0.3 0.6 -0.8 -0.2
Happiness 4.3 5.2 9.4 3.1 -1.0
Noisy workplace 1.2 1.5 2.9 1.7 -0.2
Qualifications: A levels/AS levels or equivalent 3.4 7.5 13.2 -3.6 1.3
Serious illness, injury or assault of a close relative in last 2 years 4.6 5.3 10.4 0.4 3.2
Mouth/teeth dental problems: Dentures 1.4 2.3 4.0 0.8 2.0
Asthma 5.4 10.7 21.4 0.2 -4.6
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.1 0.2 0.5 0.2
Medication: Cholesterol lowering 2.9 4.5 7.7 2.8 1.1
Depression (self-reported) 0.9 1.1 1.2 1.0 -1.1
Medication: Lansoprazole 1.0 1.1 2.2 1.5 0.0
Prospective memory result 1.4 1.8 3.5 0.1 -1.9
Lung cancer (father) 0.5 0.6 1.2 0.3 1.1
Illnesses of mother 2.5 3.1 4.7 -2.2 1.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.4 2.9 0.1 -1.7
Pulse wave Arterial Stiffness index 3.6 4.2 7.8 2.8 -0.8
Impedance of arm (left) 5.5 25.3 37.0 -3.7 -6.1
Arm fat mass (right) 3.0 12.3 15.2 3.1 -3.9
Trunk predicted mass 3.5 19.7 39.3 6.3 0.4
Standing height 0.9 9.0 9.7 2.9 -3.1
Length of working week for main job 1.1 1.2 2.1 1.5 0.6
Exposure to tobacco smoke at home 0.4 0.4 0.7 -0.8 0.4
Breastfed as a baby 1.7 2.1 4.0 -0.4 -2.0
Tense / ‘highly strung’ 4.4 7.3 13.5 1.0 -3.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 0.9 1.0 -0.4
Hair/balding pattern: Pattern 4 1.6 3.9 5.3 -2.3 1.6
Birth weight of first child 2.5 4.5 8.4 2.9 -0.7
Peak expiratory flow (PEF) 0.7 1.6 2.0 1.1 -1.4
Pulse wave reflection index 2.3 2.8 5.6 2.4 -0.3
Ever highly irritable/argumentative for 2 days 0.6 0.7 1.3 1.1 -0.4
Loud music exposure frequency 1.5 1.6 3.1 -1.8 0.3
Qualifications: O levels/GCSEs or equivalent 0.4 0.6 1.1 -1.1 0.2
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 1.5 1.2 -0.3
Blood clot in the leg (DVT) 1.3 1.7 3.3 1.8 0.1
Medication: Paracetamol 1.0 1.6 2.7 1.6 -0.7
Headache pain in last month 3.7 6.3 11.8 3.4 -0.9
Medication for cholesterol, blood pressure or diabetes 0.8 1.3 2.5 -1.6 -0.4
Glaucoma (self-reported) 2.4 2.8 3.7 -1.9 -1.4
Gout (self-reported) 1.1 1.5 2.8 0.5 -1.7
Hypothyroidism/myxoedema (self-reported) 2.9 5.7 10.2 1.0 3.2
Medication: Amlodipine 0.4 0.6 1.1 -0.4 1.0
Medication: Ventolin 100micrograms inhaler 5.7 7.3 14.4 -0.5 -3.8
Birth weight 1.4 3.0 4.9 2.2 1.0
Chronic bronchitis/emphysema (mother) 0.7 0.8 1.1 1.1 -0.8
High blood pressure (siblings) 0.9 1.4 2.3 1.5 0.6
Forced vital capacity (FVC), Best measure 0.1 0.4 0.5 -0.7 -0.6
Body fat percentage 3.3 13.0 24.9 1.1 -5.0
Leg fat percentage (right) 1.3 4.8 8.1 1.3 -2.8
Arm fat-free mass (right) 3.6 18.5 37.0 6.1 -0.1
Exposure to tobacco smoke outside home 0.9 1.1 1.5 -0.9 1.2
Comparative body size at age 10 1.2 3.2 5.7 0.9 2.4
Number of full brothers 0.3 0.4 0.9 -0.9 -0.0
Worry too long after embarrassment 0.4 0.6 1.3 -0.1 -1.1
Seen a psychiatrist for nerves, anxiety, tension or depression 1.7 2.2 4.4 -0.1 -2.1
Wheeze or whistling in the chest in last year 2.0 3.5 6.9 0.4 -2.6
Number of children fathered 2.5 2.8 4.2 1.2 2.0
Reason for reducing amount of alcohol drunk: Health precaution 0.1 0.1 0.1 0.3 0.4
Age at first live birth 1.0 1.8 3.1 -1.8 -0.7
Pulse wave peak to peak time 2.9 3.4 6.5 -2.5 0.5
Health satisfaction 2.0 2.6 5.2 2.3 -0.2
Shortness of breath walking on level ground 0.3 0.4 0.5 0.4 -0.7
Qualifications: College or University degree 2.0 6.3 12.2 -3.5 0.6
Eye problems/disorders: None of the above 0.2 0.3 0.4 -0.4 0.6
Mouth/teeth dental problems: Loose teeth 4.5 5.4 9.8 -1.0 3.1
Emphysema/chronic bronchitis 0.4 0.5 0.7 0.8 0.5
Medication for pain relief, constipation, heartburn 1.0 1.8 2.9 -1.7 0.8
Neck or shoulder pain in last month 0.3 0.5 1.0 1.0 -0.0
Medication: Blood pressure 0.1 0.1 0.2 0.5 0.1
Angina (self-reported) 2.3 3.0 5.9 2.4 -0.2
Migraine (self-reported) 1.1 1.4 1.6 1.1 -1.3
Medication: Ibuprofen 0.0 0.0 0.0 0.2 0.0
Medication: Allopurinol 2.4 3.2 5.6 0.9 -2.4
Medication: Omeprazole 0.1 0.1 0.1 -0.1 -0.3
Medication: Seretide 50 evohaler 1.0 1.2 2.4 0.1 -1.5
Mean time to correctly identify matches 4.0 7.7 13.0 -1.5 3.6
Heart disease (mother) 1.7 2.0 3.9 2.0 -0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.2 0.3 -0.6 -0.0
Whole body fat mass 2.9 12.0 18.0 2.5 -4.2
Leg fat mass (right) 1.9 7.5 8.2 2.6 -2.9
Arm predicted mass (right) 3.9 19.8 39.5 6.3 0.3
Pulse rate, automated reading 0.1 0.5 0.9 -0.9 -0.2
Alcohol intake frequency. 2.9 6.8 9.4 2.0 -3.1
Comparative height size at age 10 0.4 2.2 4.3 2.1 -0.0
Number of full sisters 2.3 2.8 5.5 0.0 2.4
Suffer from ‘nerves’ 0.6 1.0 1.9 0.3 -1.4
Overall health rating 1.8 3.9 5.0 2.2 -1.7
Chest pain or discomfort 2.3 3.3 5.6 2.4 -1.0
Had major operations 0.9 1.0 1.3 0.8 1.2
Age at last live birth 2.2 3.2 4.7 -2.2 -1.3
Family relationship satisfaction 2.8 3.5 6.1 2.5 -0.9
Leg pain on walking 0.3 0.4 0.7 -0.1 0.9
Qualifications: NVQ or HND or HNC or equivalent 4.6 5.5 6.6 2.6 2.1
Commuting to job workplace: Car/motor vehicle 3.2 3.7 7.1 2.7 0.5
Illness, injury, bereavement, stress in last 2 years 2.8 3.5 6.8 -2.6 -0.4
Medication: Aspirin 1.2 1.6 2.9 0.6 1.7
Supplements: Vitamin C 0.1 0.1 0.2 0.2 -0.4
Knee pain experienced in last month 0.7 1.0 2.0 1.4 0.1
Hypertension (Self-reported) 0.2 0.6 0.7 0.8 -0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.1 0.4 0.4
Illnesses of father: Heart disease 1.3 1.9 3.7 1.9 0.2
Illnesses of siblings: Diabetes 1.2 1.5 2.8 1.7 0.5
Smoking status: Previous 0.7 1.0 1.0 -1.0 -1.0
Forced expiratory volume in 1-second (FEV1), predicted 2.1 4.5 5.3 1.9 -2.3
Whole body fat-free mass 3.0 17.3 34.2 5.9 -0.6
Leg fat-free mass (right) 2.2 12.0 20.3 4.5 -1.9
Arm fat percentage (left) 3.2 12.7 22.7 1.6 -4.8
Average weekly red wine intake 2.1 3.0 5.9 0.5 2.4
Handedness (chirality/laterality): Left-handed 0.3 0.4 0.4 -0.6 0.6
Mood swings 5.4 9.8 17.8 1.3 -4.2
Loneliness, isolation 1.9 2.6 4.1 1.0 -2.0
Long-standing illness, disability or infirmity 1.9 2.9 5.3 2.3 -0.6
Ever had bowel cancer screening 0.0 0.0 0.0 0.0 0.2
Diabetes diagnosed by doctor 1.3 2.1 3.2 1.8 -1.0
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 0.7 -0.8 -0.2
Friendships satisfaction 3.7 4.6 9.1 3.0 0.0
Qualifications: nursing, teaching 0.6 0.9 1.4 -0.6 -1.2
Commuting to job workplace: Walk 0.3 0.4 0.4 -0.6 0.6
Eye problems/disorders: Cataract 0.3 0.3 0.4 -0.5 -0.6
Mouth/teeth dental problems: Mouth ulcers 0.6 1.0 1.7 -1.3 -0.6
Medication for cholesterol 0.5 0.8 1.2 -0.6 -1.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.1 0.1 0.3 0.3
Back pain experienced in last month 0.8 1.2 2.3 1.5 0.2
Mineral and other dietary supplements 0.3 0.5 0.5 -0.7 -0.7
Breast cancer (self-reported) 0.5 0.6 1.1 -1.1 0.1
Asthma (self-reported) 6.2 12.4 24.6 0.4 -5.0
Osteoporosis (self-reported) 1.4 1.7 3.1 1.8 -0.5
Osteoarthritis (self-reported) 0.1 0.2 0.4 0.6 -0.1
Medication: Aspirin 1.2 1.5 2.8 0.5 1.7
Medication: Gliclazide 0.4 0.5 0.8 0.4 0.9
Illnesses of father: None of the above (group 1) 2.4 3.0 3.7 -1.9 1.5
Smoking status: Current 9.1 14.4 19.2 -3.1 4.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.3 2.1 -1.4 -0.6
Whole body water mass 3.0 16.8 33.5 5.8 -0.4
Leg predicted mass (right) 2.3 12.1 20.4 4.5 -1.9
Arm fat mass (left) 3.3 13.4 15.7 3.3 -4.0
Number of self-reported non-cancer illnesses 5.4 9.4 11.4 3.4 -2.7
Average weekly champagne plus white wine intake 1.7 2.4 4.7 2.2 -0.3
Miserableness 1.6 2.8 5.6 -0.2 -2.4
Guilty feelings 2.1 3.2 5.3 1.1 -2.3
Wears glasses or contact lenses 0.2 0.2 0.4 0.2 -0.6
Ever taken oral contraceptive pill 1.0 1.1 1.3 -1.2 1.0
Hearing aid user 0.1 0.1 0.1 0.4 -0.0
Mother’s age at death 0.7 0.9 1.6 -1.3 0.4
Financial situation satisfaction 1.1 1.4 1.6 1.3 -1.1
Tinnitus: Yes, now most or all of the time 1.0 1.2 1.8 -1.3 0.8
Commuting to job workplace: Public transport 4.5 5.4 8.1 -2.9 1.6
Eye problems/disorders: Glaucoma 2.0 2.3 2.5 -1.6 -1.5
Medication: Blood pressure 0.2 0.5 0.8 0.9 0.4
Pain type(s) experienced in last month: Hip pain 1.6 2.0 3.4 0.8 1.8
Supplements: Fish oil (including cod liver oil) 1.1 1.4 2.4 1.5 -0.7
High cholesterol (Self-reported) 1.2 2.0 2.5 1.3 1.6
Medication: Bendroflumethiazide 0.3 0.4 0.9 -0.9 -0.2
Medication: Paracetamol 0.6 1.0 1.7 1.3 -0.5
Medication: Lisinopril 0.6 0.8 1.4 1.2 -0.4
Medication: Atorvastatin 0.5 0.7 1.3 1.1 -0.2
Illnesses of father: High blood pressure 1.3 1.7 3.2 -0.4 -1.8
Alcohol drinker status: Never 1.3 1.5 3.0 0.2 -1.7
Ever smoked 3.2 5.5 11.0 -3.3 0.3
Basal metabolic rate 2.9 16.1 30.2 5.5 -1.4
Leg fat percentage (left) 1.4 4.9 7.9 1.4 -2.8
Arm fat-free mass (left) 3.3 16.8 33.6 5.8 0.1
Number of operations (self-reported) 0.4 0.6 1.1 -0.2 1.0
Average weekly beer plus cider intake 1.1 1.6 2.5 -0.9 1.6
Irritability 4.6 7.8 14.5 1.0 -3.8
Risk taking 1.0 1.5 2.6 -1.6 0.6
Ever had prostate specific antigen (PSA) test 0.9 1.0 1.1 0.9 1.0
Fractured/broken bones in last 5 years 0.7 1.0 1.7 0.4 -1.3
Age started oral contraceptive pill 0.9 1.1 1.3 -1.1 -1.0
Diastolic blood pressure, automated reading 1.8 5.5 8.2 2.9 -1.6
Ever depressed for a whole week 0.1 0.1 0.2 0.4 0.1
Unable to work because of sickness or disability 0.7 0.9 1.2 0.7 1.1
Commuting to job workplace: Cycle 0.5 0.7 1.0 -1.0 -0.6
Myopia 8.1 11.8 15.6 -4.0 2.8
Vascular/heart problems diagnosed by doctor 0.5 1.4 2.9 -1.7 -0.1
Cholesterol lowering medication 1.3 1.9 3.3 1.8 0.8
Medication: Omeprazole (e.g. Zanprol) 0.6 0.7 1.4 -0.0 -1.2
Pain experienced in last month 2.8 4.6 6.2 -2.5 -1.7
Supplements: Calcium 2.9 3.2 3.5 1.7 -1.9
Basal cell carcinoma (self-reported) 6.2 7.4 13.1 -1.3 -3.6
Heart attack/myocardial infarction (self-reported) 0.8 1.0 2.0 1.4 0.2
Deep venous thrombosis (DVT) (self-reported) 1.5 2.0 3.8 1.9 0.4
Heart disease (siblings) 0.7 0.8 1.7 1.3 0.1
Alcohol drinker status: Previous 0.8 0.9 1.7 0.3 1.3
Pack years of smoking 2.2 3.2 6.2 -0.6 2.5
Impedance of whole body 4.0 20.5 27.7 -3.6 -5.3
Leg fat mass (left) 1.9 7.3 7.8 2.6 -2.8
Arm predicted mass (left) 3.2 16.2 32.4 5.7 0.0