Best TWAS P=3.85e-11 · Best GWAS P=1.31e-10 conditioned to 0.0288
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | HTR1D | 0.11 | 0.07 | enet | 21 | 0.09 | 1.1e-10 | -4.7 | 5.4 | 6.1e-08 | -0.78 | 0.43 | 0.57 | FALSE |
| 2 | GTEx | Brain Cortex | LUZP1 | 0.23 | 0.14 | lasso | 5 | 0.10 | 7.8e-04 | -6.4 | 6.4 | 1.7e-10 | -1.00 | 0.02 | 0.80 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | LUZP1 | 0.09 | 0.09 | lasso | 4 | 0.08 | 2.8e-06 | -6.4 | 6.4 | 1.7e-10 | -1.00 | 0.01 | 0.99 | FALSE |
| 4 | GTEx | Testis | LUZP1 | 0.17 | 0.09 | lasso | 4 | 0.08 | 2.6e-04 | -6.1 | -6.1 | 1.2e-09 | 0.55 | 0.04 | 0.87 | FALSE |
| 5 | The Cancer Genome Atlas | Colon Adenocarcinoma | HTR1D | 0.10 | 0.07 | enet | 7 | 0.08 | 3.8e-05 | -5.6 | 6.2 | 6.5e-10 | -0.94 | 0.02 | 0.98 | FALSE |
| 6 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | HTR1D | 0.24 | 0.12 | lasso | 4 | 0.12 | 1.2e-05 | -6.1 | 6.6 | 3.9e-11 | -0.76 | 0.02 | 0.97 | TRUE |
| 7 | The Cancer Genome Atlas | Rectum Adenocarcinoma | HTR1D | 0.19 | 0.12 | enet | 11 | 0.13 | 7.3e-04 | -6.4 | 5.9 | 3.3e-09 | -0.94 | 0.01 | 0.90 | FALSE |