Best TWAS P=9.04e-17 · Best GWAS P=6.19e-15 conditioned to 0.206
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | AMZ1 | 0.19 | 0.12 | enet | 22 | 0.13 | 5.7e-16 | 5.8 | 6.6 | 3.3e-11 | -0.43 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Artery Tibial | GNA12 | 0.24 | 0.13 | enet | 20 | 0.22 | 3.5e-17 | -7.5 | -5.9 | 3.4e-09 | 0.84 | 0.03 | 0.97 | FALSE |
| 3 | GTEx | Cells EBV-transformed lymphocytes | GNA12 | 0.46 | 0.51 | lasso | 5 | 0.50 | 7.9e-19 | -7.8 | -7.7 | 1.9e-14 | 0.99 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | GNA12 | 0.21 | 0.11 | lasso | 11 | 0.15 | 1.7e-11 | -7.4 | -5.5 | 4.6e-08 | 0.86 | 0.03 | 0.97 | FALSE |
| 5 | GTEx | Colon Sigmoid | GNA12 | 0.14 | 0.05 | lasso | 3 | 0.03 | 3.6e-02 | -3.2 | -5.7 | 1.1e-08 | 0.87 | 0.03 | 0.90 | FALSE |
| 6 | GTEx | Esophagus Gastroesophageal Junction | GNA12 | 0.20 | 0.12 | lasso | 6 | 0.12 | 3.4e-05 | -3.5 | -5.9 | 4.6e-09 | 0.86 | 0.03 | 0.95 | FALSE |
| 7 | GTEx | Esophagus Mucosa | GNA12 | 0.16 | 0.13 | lasso | 3 | 0.13 | 3.0e-09 | -6.6 | -5.7 | 1.1e-08 | 0.87 | 0.06 | 0.94 | FALSE |
| 8 | GTEx | Esophagus Muscularis | GNA12 | 0.32 | 0.31 | lasso | 3 | 0.34 | 2.1e-21 | -7.5 | -7.3 | 4.0e-13 | 0.94 | 0.02 | 0.98 | FALSE |
| 9 | GTEx | Nerve Tibial | GNA12 | 0.31 | 0.34 | lasso | 7 | 0.36 | 9.6e-27 | -3.5 | -5.2 | 1.6e-07 | 0.86 | 0.79 | 0.21 | FALSE |
| 10 | GTEx | Skin Sun Exposed Lower leg | GNA12 | 0.17 | 0.16 | lasso | 3 | 0.18 | 1.3e-14 | -3.6 | -5.4 | 8.4e-08 | 0.87 | 0.17 | 0.83 | FALSE |
| 11 | GTEx | Whole Blood | GNA12 | 0.09 | 0.01 | enet | 4 | 0.00 | 3.3e-01 | -7.4 | -7.7 | 1.5e-14 | 0.94 | 0.02 | 0.92 | FALSE |
| 12 | NTR | Blood | GNA12 | 0.07 | 0.03 | bslmm | 597 | 0.06 | 1.3e-17 | -4.4 | -5.4 | 6.8e-08 | 0.63 | 0.92 | 0.08 | FALSE |
| 13 | ROSMAP | Brain Pre-frontal Cortex | AMZ1 | 0.09 | 0.05 | lasso | 6 | 0.04 | 2.4e-06 | -7.5 | 8.3 | 9.0e-17 | -0.90 | 0.05 | 0.95 | TRUE |
| 14 | YFS | Blood | GNA12 | 0.23 | 0.15 | bslmm | 570 | 0.25 | 4.5e-82 | 5.3 | -5.9 | 4.2e-09 | 0.52 | 1.00 | 0.00 | FALSE |
| 15 | YFS | Blood | PSMG3 | 0.01 | 0.00 | blup | 331 | 0.01 | 1.5e-03 | 2.4 | -5.2 | 2.0e-07 | -0.04 | 0.08 | 0.02 | TRUE |
| 16 | The Cancer Genome Atlas | Esophageal Carcinoma | AMZ1 | 0.18 | 0.05 | blup | 69 | 0.05 | 1.4e-02 | 4.7 | -7.4 | 1.7e-13 | 0.71 | 0.01 | 0.71 | FALSE |
| 17 | The Cancer Genome Atlas | Brain Lower Grade Glioma | AMZ1 | 0.04 | 0.04 | lasso | 3 | 0.02 | 1.3e-03 | 4.7 | 5.2 | 1.8e-07 | -0.60 | 0.04 | 0.90 | FALSE |
| 18 | The Cancer Genome Atlas | Lung Adenocarcinoma | GNA12 | 0.03 | 0.01 | enet | 7 | 0.02 | 1.5e-03 | 2.5 | -6.0 | 2.7e-09 | 0.78 | 0.05 | 0.76 | FALSE |