TWAS hub - PSMG3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	ROSMAP	Brain Pre-frontal Cortex	0.1022	0.0353	0.00097	0.06	0.025	0.056	0.062	0.062	3.7e-08	0.00027	8.6e-08	2.3e-08	1.8e-08
2	YFS	Blood	0.0109	0.0051	0.00790	0.00	0.007	0.004	0.006	-0.001	4.4e-01	0.00150	2.0e-02	2.7e-03	8.9e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Illnesses of father: None of the above (group 1)	5.5	6.7	13.5	-0.0	3.7
Medication: Co-codamol	5.3	6.2	8.1	-2.9	-2.1
Smoking status: Previous	4.7	7.0	10.8	-1.8	-3.3
Past tobacco smoking	4.6	8.4	10.6	2.5	3.3
Ever smoked	4.3	7.6	9.2	-2.4	-3.0
Trunk fat percentage	3.9	15.4	27.1	-2.0	-5.2
Chronic bronchitis/emphysema (father)	3.9	4.6	8.6	2.9	0.8
Shortness of breath walking on level ground	3.8	4.5	9.0	-3.0	-0.1
Illnesses of father: Heart disease	3.7	5.2	10.1	-0.5	-3.2
Body fat percentage	3.5	14.0	23.5	-2.1	-4.9
Smoking Status	3.2	7.8	8.6	-2.6	-2.9
Illnesses of father: High blood pressure	3.2	4.0	7.2	-0.8	-2.7
Loneliness, isolation	3.1	4.2	6.8	1.3	2.6
Type 2 Diabetes (T2D) (2012)	2.9	3.4	6.8	0.0	2.6
Arm fat percentage (right)	2.8	10.9	14.4	-2.7	-3.8
Health satisfaction	2.8	3.6	3.8	-1.8	-1.9
Arm fat percentage (left)	2.8	11.1	16.9	-2.3	-4.1
Number of treatments/medications taken	2.7	4.9	6.2	-1.9	-2.5
Heart disease (mother)	2.7	3.3	3.6	-1.7	-1.9
Alcohol intake frequency.	2.7	6.4	11.2	-1.3	-3.3
Leg fat percentage (left)	2.7	9.6	14.3	-2.2	-3.8
Risk taking	2.7	4.0	4.7	1.8	2.2
Length of working week for main job	2.5	2.7	4.1	-1.1	-2.0
Cardiovascular Disease	2.4	7.8	15.5	0.1	-3.9
Happiness	2.4	2.9	4.9	-1.0	-2.2
Leg fat percentage (right)	2.4	8.7	12.4	-2.2	-3.5
Number of children fathered	2.4	2.7	5.3	0.2	2.3
Blood Platelet Count	2.3	26.4	52.9	0.2	-7.3
Eye problems/disorders: Diabetes related eye disease	2.3	2.5	4.4	2.1	0.7
Noisy workplace	2.3	2.9	5.0	-2.2	-0.9
Supplements: Vitamin C	2.3	2.7	4.9	2.2	0.7
Medication: Blood pressure	2.2	4.2	8.1	0.4	-2.9
Fasting Glucose	2.1	2.5	4.5	2.1	0.7
Prospective memory result	2.1	2.5	4.2	2.0	0.9
Illnesses of siblings: Diabetes	2.1	2.5	4.3	-0.9	-2.1
Alcohol drinker status: Previous	2.1	2.4	2.9	1.4	-1.7
High blood pressure	2.0	5.6	9.9	1.2	-3.1
Diverticular disease/diverticulitis (self-reported)	2.0	2.3	4.7	-2.2	0.1
Trunk fat mass	2.0	8.4	13.4	-1.9	-3.7
Illness, injury, bereavement, stress in last 2 years	2.0	2.4	3.2	1.8	1.3
Hypertension (Self-reported)	2.0	5.6	10.0	1.1	-3.2
Vascular/heart problems diagnosed by doctor	2.0	5.3	10.5	-0.4	3.2
Hair/balding pattern: Pattern 3	1.9	2.8	4.3	1.1	2.1
Number of live births	1.9	2.6	4.2	2.0	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	1.9	3.8	5.5	1.5	2.4
Breast Cancer	1.8	4.4	8.8	-0.0	-3.0
Multivitamins +/- minerals	1.8	2.3	4.6	-0.2	2.1
Financial difficulties in last 2 years	1.8	2.4	2.9	-1.7	-1.4
Medication for cholesterol, blood pressure or diabetes	1.8	3.0	4.2	2.1	1.4
Friendships satisfaction	1.8	2.3	4.5	2.1	-0.3
Prostate Cancer	1.7	2.4	3.6	1.1	1.9
Hand grip strength (right)	1.7	4.6	8.1	2.8	1.1
Average weekly fortified wine intake	1.7	2.0	3.6	0.6	1.9
Falls in the last year	1.7	2.2	3.0	1.2	1.7
Whole body fat mass	1.7	7.1	10.2	-2.0	-3.2
Arm fat mass (left)	1.7	6.9	7.1	-2.6	-2.7
Impedance of whole body	1.7	8.8	16.3	1.1	-4.0
Taking other prescription medications	1.6	2.4	3.0	-1.7	-1.3
Time employed in main current job	1.6	1.8	3.0	1.7	0.8
Pulse wave Arterial Stiffness index	1.6	1.9	2.0	1.4	1.3
Arm fat mass (right)	1.6	6.7	6.8	-2.6	-2.6
Neck or shoulder pain in last month	1.6	2.2	4.1	-0.6	-2.0
Medication: Blood pressure	1.6	2.9	5.2	-0.8	-2.3
Number of self-reported non-cancer illnesses	1.6	2.8	5.4	-0.5	-2.3
Verbal and Numeric Reasoning (VNR)	1.5	3.5	6.8	0.5	2.6
Ovarian Cancer	1.5	2.0	4.0	2.0	-0.1
Type 2 Diabetes (T2D) (2018)	1.5	2.8	4.8	-2.2	-0.9
Average weekly spirits intake	1.5	1.9	3.5	0.5	-1.9
Age when periods started (menarche)	1.5	3.6	5.6	1.3	2.4
Worrier / anxious feelings	1.5	2.8	5.0	-0.7	-2.2
Chronic bronchitis/emphysema (mother)	1.5	1.8	3.5	-0.2	1.9
Wheeze or whistling in the chest in last year	1.5	2.7	2.8	1.6	-1.7
Townsend deprivation index at recruitment	1.4	2.0	2.6	-1.1	-1.6
Had other major operations	1.4	1.7	2.6	-0.9	-1.6
Impedance of arm (left)	1.4	6.7	12.9	0.7	-3.6
Trunk predicted mass	1.4	7.9	15.4	-0.6	3.9
Overall health rating	1.4	2.9	4.4	-2.1	-1.2
Diastolic blood pressure, automated reading	1.4	4.3	5.9	2.4	-1.6
Primary Biliary Cirrhosis	1.3	1.8	3.1	0.7	-1.8
Hearing difficulty/problems: Yes	1.3	1.9	3.0	-0.9	-1.7
Bilateral oophorectomy (both ovaries removed)	1.3	1.5	2.7	-1.6	0.5
Trunk fat-free mass	1.3	7.7	15.0	-0.6	3.9
Pulse wave peak to peak time	1.3	1.6	1.7	-1.3	-1.2
Medication: Aspirin	1.3	1.8	2.9	-0.8	-1.7
Smoking status: Current	1.3	2.1	4.2	-2.1	0.1
Ever depressed for a whole week	1.3	1.6	3.1	-1.8	0.2
Severe depression (siblings)	1.2	1.4	2.6	-1.6	-0.4
Serious illness, injury or assault to yourself	1.2	1.5	2.0	-1.4	-1.0
Impedance of leg (left)	1.2	6.0	11.0	1.0	-3.3
Impedance of arm (right)	1.2	5.4	10.9	0.0	-3.3
Hip circumference	1.2	5.3	7.2	-2.7	-1.8
Illnesses of mother	1.2	1.5	1.8	1.3	1.1
Ever highly irritable/argumentative for 2 days	1.2	1.4	2.2	-1.5	0.8
Medication: Amlodipine	1.2	1.7	3.5	-0.1	-1.9
Leg fat mass (right)	1.2	4.6	4.9	-2.1	-2.2
Long-standing illness, disability or infirmity	1.2	1.8	2.6	-1.6	-1.0
Mineral and other dietary supplements	1.2	1.7	2.2	1.5	1.1
Medication: Paracetamol	1.2	1.9	2.9	-0.9	-1.7
Number of operations (self-reported)	1.2	1.8	2.5	-1.6	-1.0
Leg fat mass (left)	1.2	4.7	5.0	-2.1	-2.2
Alzheimer’s Disease (in father)	1.1	1.2	1.4	-0.9	-1.2
Vitamin and mineral supplements	1.1	1.5	2.9	-0.3	-1.7
Diabetes (mother)	1.1	1.4	1.6	-1.3	1.1
Body mass index (BMI)	1.1	4.9	4.9	-2.2	-2.2
Alcohol intake versus 10 years previously	1.1	1.7	3.4	-0.1	-1.9
Pulse rate	1.1	1.9	3.1	1.8	0.8
Birth weight	1.1	2.4	4.8	-2.2	-0.1
High blood pressure (siblings)	1.1	1.6	1.7	-1.2	-1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	2.6	-1.6	0.0
Handedness (chirality/laterality): Left-handed	1.1	1.3	2.5	1.6	-0.3
Medication: Gliclazide	1.1	1.3	1.3	-1.2	-1.1
Impedance of leg (right)	1.0	4.9	8.9	0.9	-3.0
Stomach or abdominal pain in last month	1.0	1.3	2.4	-1.5	0.4
Medication: Atenolol	1.0	1.3	2.5	-0.3	-1.6
Hair/balding pattern: Pattern 2	1.0	1.2	2.2	1.5	0.5
Pain type(s) experienced in last month: Hip pain	1.0	1.3	2.2	-1.5	-0.6
Ever had prostate specific antigen (PSA) test	1.0	1.1	1.8	0.6	1.4
HbA1C	0.9	1.0	1.5	-1.2	0.7
HDL Cholesterol	0.9	1.5	3.1	0.0	1.8
Schizophrenia (2014)	0.9	1.9	2.0	-1.4	-1.4
Sitting height	0.9	6.1	10.0	1.5	3.2
Waist circumference	0.9	3.3	4.3	-2.1	-1.5
Had menopause	0.9	1.1	2.1	-1.4	-0.4
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.0	-1.4	-0.5
Lung cancer (father)	0.9	1.1	2.1	0.3	1.4
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	2.2	0.1	1.5
Age at first live birth	0.9	1.5	3.0	0.3	1.7
Medication for pain relief, constipation, heartburn	0.9	1.6	3.1	0.3	1.8
Number of full sisters	0.9	1.1	2.0	-1.4	-0.4
Whole body fat-free mass	0.9	5.1	9.9	-0.5	3.1
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	1.6	1.3	1.1
Whole body water mass	0.9	5.3	10.1	-0.7	3.2
Fractured/broken bones in last 5 years	0.9	1.1	2.2	1.5	-0.1
Unable to work because of sickness or disability	0.9	1.1	2.2	-0.2	-1.5
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.0	-1.4	-0.3
Pain experienced in last month	0.9	1.5	2.0	1.4	1.0
Basal cell carcinoma (self-reported)	0.9	1.0	2.0	0.1	1.4
Intelligence (Savage-Jansen 2018)	0.8	2.5	4.8	0.3	2.2
Schizophrenia (2018)	0.8	1.6	2.1	-1.0	-1.5
Alzheimer’s Disease (in mother)	0.8	0.9	1.8	0.3	-1.3
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	1.9	-0.4	-1.4
Ever had hysterectomy (womb removed)	0.8	0.9	1.8	-1.3	-0.1
Medication: Metformin	0.8	1.1	1.5	-1.2	-0.8
High blood pressure (mother)	0.8	1.2	2.0	0.6	-1.4
Father’s age at death	0.8	1.0	2.0	-0.1	-1.4
Asthma	0.8	1.7	3.3	0.2	-1.8
Medication: Cholesterol lowering	0.8	1.2	2.4	-1.6	-0.2
Comparative body size at age 10	0.8	2.1	3.8	-0.6	-2.0
Mood swings	0.8	1.4	1.6	1.1	-1.3
Medication: Aspirin	0.8	1.1	1.9	-0.4	-1.4
Average weekly champagne plus white wine intake	0.8	1.0	1.9	0.4	1.4
Ever taken oral contraceptive pill	0.8	0.9	1.6	1.3	0.4
Irritable Bowel Disease (IBD)	0.7	1.7	1.8	-1.3	-1.2
Age at First Birth	0.7	1.0	1.0	1.0	1.0
Crohns Disease (2012)	0.7	1.2	2.2	-0.4	-1.5
BMI	0.7	4.3	4.5	-2.1	-2.0
Allergy	0.7	1.7	3.4	0.1	1.8
Illnesses of siblings	0.7	1.0	1.5	0.8	1.2
Qualifications: A levels/AS levels or equivalent	0.7	1.6	2.8	1.7	-0.7
Depression (self-reported)	0.7	0.8	1.5	-1.2	-0.2
Medication: Lansoprazole	0.7	0.8	1.5	-1.2	0.1
Hair/balding pattern: Pattern 4	0.7	1.7	3.0	-0.7	-1.7
Glaucoma (self-reported)	0.7	0.9	1.6	-1.3	-0.4
Number of full brothers	0.7	0.9	1.7	-0.2	-1.3
Medication: Omeprazole	0.7	0.8	1.6	-1.3	-0.2
Pulse rate, automated reading	0.7	2.3	3.1	1.2	1.8
Family relationship satisfaction	0.7	0.9	1.0	1.0	0.9
Osteoporosis (self-reported)	0.7	0.9	1.7	-1.3	-0.0
Wears glasses or contact lenses	0.7	0.8	1.4	-1.2	-0.3
Commuting to job workplace: Public transport	0.7	0.9	1.7	0.1	-1.3
Eye problems/disorders: Glaucoma	0.7	0.8	1.6	-1.3	-0.0
Arm fat-free mass (left)	0.7	3.4	4.7	-1.4	2.2
Alzheimer’s Disease (including proxy)	0.6	0.9	1.8	-0.3	-1.3
Crohns Disease (2017)	0.6	1.2	1.5	-1.2	-1.0
Blood White Count	0.6	4.7	7.6	1.4	-2.8
Systolic Blood Pressure	0.6	3.1	3.5	1.7	-1.9
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	2.3	0.7	1.5
Medication: Ramipril	0.6	0.8	1.0	-1.0	-0.8
Medication: Paracetamol	0.6	1.1	2.1	0.2	-1.4
Medication: Ventolin 100micrograms inhaler	0.6	0.7	1.3	-0.4	-1.1
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	1.0	-1.0	0.7
Commuting to job workplace: Walk	0.6	0.7	1.4	1.2	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.3	0.1	1.1
Financial situation satisfaction	0.6	0.8	1.2	-0.6	-1.1
Tinnitus: Yes, now most or all of the time	0.6	0.8	0.9	1.0	-0.8
Supplements: Calcium	0.6	0.6	1.0	-1.0	0.5
Arm predicted mass (left)	0.6	2.9	5.2	-0.8	2.3
Depressed Affect (Nagel 2018)	0.5	1.0	1.9	1.4	0.4
Heel T-Score	0.5	4.3	8.5	0.3	2.9
Height	0.5	9.2	16.1	1.5	4.0
Hypothyroidism (self reported)	0.5	1.2	2.0	-0.6	-1.4
Hand grip strength (left)	0.5	1.4	2.7	1.6	-0.2
Current tobacco smoking	0.5	0.9	1.8	-1.3	0.0
Alcohol usually taken with meals	0.5	0.8	0.9	-0.8	-1.0
Pain all over the body in last month	0.5	0.5	1.1	-1.0	0.1
Medication: Simvastatin	0.5	0.7	1.4	-1.2	-0.2
Fluid intelligence score	0.5	0.9	1.8	-0.2	1.4
Weight	0.5	2.3	4.0	-2.0	-0.8
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.7	0.2	-1.3
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	1.5	1.2	0.3
Eye problems/disorders: None of the above	0.5	0.6	1.0	-1.0	-0.3
Medication: Seretide 50 evohaler	0.5	0.5	0.6	0.7	0.8
Arm predicted mass (right)	0.5	2.7	4.8	-0.7	2.2
Had major operations	0.5	0.6	1.2	-0.2	1.1
Leg fat-free mass (right)	0.5	2.5	4.6	-0.6	2.1
Asthma (self-reported)	0.5	1.1	2.1	0.2	-1.4
Leg predicted mass (right)	0.5	2.6	4.9	-0.5	2.2
Mother’s age at death	0.5	0.6	0.8	0.6	-0.9
Medication: Lisinopril	0.5	0.7	1.2	-1.1	-0.3
Medication: Atorvastatin	0.5	0.6	1.2	0.1	1.1
Basal metabolic rate	0.5	2.7	4.6	-0.9	2.1
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.1	-1.1	-0.2
Bipolar Disorder or Schizophrenia	0.4	0.9	1.5	-0.5	-1.2
Ulcerative Colitis	0.4	0.6	1.1	0.2	-1.1
Blood Eosinophil Count	0.4	3.0	5.4	2.3	0.8
Respiratory disease	0.4	1.0	1.9	0.1	-1.4
Lung FEV1/FVC ratio	0.4	2.1	3.4	-1.9	-0.9
Systolic blood pressure, automated reading	0.4	1.2	2.0	1.4	-0.6
Medication for hormone replacement therapy	0.4	0.4	0.7	0.2	0.9
Leg fat-free mass (left)	0.4	2.2	4.0	-0.7	2.0
Maternal smoking around birth	0.4	0.6	1.2	-1.1	-0.1
Fed-up feelings	0.4	0.7	1.1	0.5	1.1
Qualifications: CSEs or equivalent	0.4	0.6	1.0	-1.0	-0.3
Leg predicted mass (left)	0.4	2.4	4.2	-0.7	2.0
Number of incorrect matches in round	0.4	0.7	1.0	0.7	-1.0
Standing height	0.4	4.4	8.5	0.4	2.9
Tense / ‘highly strung’	0.4	0.7	1.2	-0.4	1.1
Peak expiratory flow (PEF)	0.4	0.9	1.7	-0.2	-1.3
Pulse wave reflection index	0.4	0.5	0.6	0.7	0.8
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.0	-0.3	-1.0
Arm fat-free mass (right)	0.4	2.1	4.0	-0.4	2.0
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.0	-0.0	-1.0
Emphysema/chronic bronchitis	0.4	0.5	0.6	0.5	-0.8
Medication: Allopurinol	0.4	0.5	0.6	-0.6	0.8
Average weekly red wine intake	0.4	0.6	1.0	1.0	-0.5
Diabetes diagnosed by doctor	0.4	0.7	0.8	-0.9	-0.8
Medication for cholesterol	0.4	0.7	0.9	-0.6	1.0
Alcohol drinker status: Never	0.4	0.5	0.9	-1.0	-0.2
Age started oral contraceptive pill	0.4	0.5	1.0	1.0	-0.3
Neuroticism (Nagel 2018)	0.3	0.7	1.5	1.2	-0.1
Schizophrenia vs Biploar Disorder	0.3	0.4	0.8	0.0	-0.9
LDL Cholesterol	0.3	0.4	0.9	0.0	0.9
Rheumatoid Arthritis	0.3	0.4	0.7	0.2	-0.8
Hair Pigment	0.3	8.4	13.3	1.9	-3.6
Tanning	0.3	4.2	7.4	-2.7	-1.0
Sensitivity / hurt feelings	0.3	0.6	1.1	0.2	-1.1
Diabetes (father)	0.3	0.4	0.5	-0.5	-0.7
Hayfever, allergic rhinitis or eczema	0.3	0.6	0.6	0.7	-0.7
Qualifications: None of the above	0.3	0.6	1.2	0.1	-1.1
Heart attack	0.3	0.3	0.6	-0.8	-0.2
Diabetes (self-reported)	0.3	0.4	0.6	-0.6	-0.8
Breastfed as a baby	0.3	0.4	0.6	-0.8	0.4
Blood clot in the leg (DVT)	0.3	0.4	0.4	0.7	-0.6
Gout (self-reported)	0.3	0.3	0.7	-0.0	0.8
Qualifications: College or University degree	0.3	0.9	1.7	1.3	-0.2
Migraine (self-reported)	0.3	0.3	0.5	0.4	-0.7
Leg pain on walking	0.3	0.4	0.6	0.3	0.8
Ever had bowel cancer screening	0.3	0.4	0.7	0.8	-0.1
Qualifications: nursing, teaching	0.3	0.5	1.0	-1.0	0.2
Guilty feelings	0.3	0.4	0.6	0.8	0.4
High cholesterol (Self-reported)	0.3	0.6	0.6	0.8	0.8
Average weekly beer plus cider intake	0.3	0.5	1.0	-1.0	-0.0
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	0.5	0.5	-0.7
Heart disease (siblings)	0.3	0.4	0.7	-0.1	0.8
Worry (Nagel 2018)	0.2	0.5	0.9	1.0	-0.3
Ulcerative Colitis (UC)	0.2	0.4	0.6	-0.5	-0.8
Reaction Time	0.2	0.4	0.8	0.9	0.2
Chronotype (morning person)	0.2	0.4	0.8	0.2	0.9
Relative age of first facial hair	0.2	0.5	0.7	-0.8	-0.5
Supplements: Zinc	0.2	0.3	0.5	0.2	0.7
Pack years adult smoking proportion	0.2	0.2	0.3	0.5	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.5	0.7	0.6
Supplements: Glucosamine	0.2	0.2	0.3	-0.5	-0.4
Nervous feelings	0.2	0.3	0.6	0.8	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.3	-0.5	0.6
Hearing difficulty/problems with background noise	0.2	0.3	0.6	-0.8	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.3	0.2	-0.6
Exposure to tobacco smoke at home	0.2	0.3	0.5	0.2	-0.7
Loud music exposure frequency	0.2	0.2	0.3	-0.6	-0.2
Headache pain in last month	0.2	0.3	0.6	-0.3	-0.8
Forced vital capacity (FVC), Best measure	0.2	0.8	1.5	1.2	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.4	0.2	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.6	-0.8	0.1
Suffer from ‘nerves’	0.2	0.3	0.4	-0.6	0.5
Knee pain experienced in last month	0.2	0.3	0.6	-0.8	0.1
Miserableness	0.2	0.3	0.3	0.5	-0.6
Hearing aid user	0.2	0.2	0.4	-0.2	-0.6
Medication: Bendroflumethiazide	0.2	0.3	0.5	-0.3	-0.7
Commuting to job workplace: Cycle	0.2	0.2	0.5	0.0	0.7
Myopia	0.2	0.3	0.6	-0.3	0.8
Pack years of smoking	0.2	0.3	0.5	0.2	0.7
Depression (Nagel 2018)	0.1	0.2	0.3	0.5	0.2
Lupus	0.1	0.1	0.2	0.3	0.4
Neuroticism (2016)	0.1	0.1	0.1	0.4	0.1
Triglycerides	0.1	0.1	0.2	0.0	-0.4
Blood Red Count	0.1	0.8	1.6	1.3	0.1
Waist Hip Ratio (WHR)	0.1	0.3	0.6	0.7	-0.1
Lung FVC	0.1	0.6	1.1	-1.0	-0.4
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.2	0.0	0.4
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.3	-0.1	-0.5
Angina	0.1	0.1	0.2	0.1	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.2	0.4	-0.4
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	0.2	-0.5
Medication: Levothyroxine sodium	0.1	0.2	0.4	0.6	-0.3
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.2	0.2	-0.5
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	0.7	0.1	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.2	-0.4	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	0.8	0.9	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.2	0.5	-0.2
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.3	0.1	-0.5
Exposure to tobacco smoke outside home	0.1	0.2	0.2	-0.4	-0.4
Worry too long after embarrassment	0.1	0.1	0.2	0.4	-0.2
Angina (self-reported)	0.1	0.1	0.1	0.3	-0.3
Mean time to correctly identify matches	0.1	0.1	0.3	0.5	-0.0
Age at last live birth	0.1	0.1	0.2	0.2	0.5
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.2	0.0	0.5
Back pain experienced in last month	0.1	0.2	0.3	-0.6	0.2
Osteoarthritis (self-reported)	0.1	0.2	0.4	-0.1	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.4	0.1	-0.7
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.1	-0.3	-0.2
Irritability	0.1	0.1	0.2	-0.4	0.3
Cholesterol lowering medication	0.1	0.1	0.1	0.4	0.4
Bipolar Disorder (2018)	0.0	0.0	0.0	0.2	-0.1
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.0	0.0	0.0	0.0	-0.1
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0
Mean Putamen Volume	0.0	0.0	0.0	-0.2	0.0
Allergy or Eczema	0.0	0.0	0.0	0.2	-0.2
Neuroticism	0.0	0.0	0.1	-0.2	-0.1
Relative age voice broke	0.0	0.0	0.1	-0.2	-0.2
Forced vital capacity (FVC)	0.0	0.2	0.2	0.5	0.3
Mouth/teeth dental problems	0.0	0.0	0.0	-0.0	-0.2
Neuroticism score	0.0	0.0	0.0	-0.2	0.1
Mouth/teeth dental problems: Dentures	0.0	0.0	0.1	0.2	0.2
Birth weight of first child	0.0	0.1	0.1	0.1	0.4
Medication: Ibuprofen	0.0	0.1	0.1	-0.3	0.0
Comparative height size at age 10	0.0	0.2	0.2	-0.3	0.5
Chest pain or discomfort	0.0	0.0	0.0	-0.1	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.0	0.0	0.0	0.1	-0.0
Eye problems/disorders: Cataract	0.0	0.0	0.0	0.0	-0.2
Breast cancer (self-reported)	0.0	0.1	0.1	-0.3	-0.2

Hub : Genes

PSMG3

Models

Trait associations