Best TWAS P=2.83e-15 · Best GWAS P=1.36e-15 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | PRDM4 | 0.07 | 0.08 | lasso | 2 | 0.07 | 5.0e-09 | 7.8 | 7.8 | 7.7e-15 | 0.97 | 0.01 | 0.99 | FALSE |
2 | GTEx | Breast Mammary Tissue (Female) | ALKBH2 | 0.22 | 0.09 | lasso | 3 | 0.12 | 2.8e-04 | 5.2 | 5.3 | 1.1e-07 | -0.04 | 0.02 | 0.75 | FALSE |
3 | GTEx | Cells EBV-transformed lymphocytes | KCTD10 | 0.36 | 0.18 | lasso | 7 | 0.19 | 1.0e-06 | 5.2 | -5.3 | 1.1e-07 | 0.06 | 0.00 | 0.99 | FALSE |
4 | GTEx | Cells EBV-transformed lymphocytes | ARPC3 | 0.13 | 0.09 | lasso | 4 | 0.04 | 2.0e-02 | 5.5 | -5.6 | 1.8e-08 | 0.05 | 0.02 | 0.88 | FALSE |
5 | GTEx | Muscle Skeletal | ARPC3 | 0.14 | 0.11 | enet | 23 | 0.10 | 2.2e-10 | 5.5 | -5.2 | 1.9e-07 | 0.04 | 0.02 | 0.98 | FALSE |
6 | GTEx | Muscle Skeletal | IFT81 | 0.08 | 0.08 | lasso | 5 | 0.07 | 1.7e-07 | 5.6 | 5.9 | 4.5e-09 | -0.05 | 0.01 | 0.99 | TRUE |
7 | GTEx | Skin Sun Exposed Lower leg | ARPC3 | 0.13 | 0.15 | lasso | 3 | 0.15 | 1.9e-12 | 5.5 | -5.4 | 5.0e-08 | 0.04 | 0.03 | 0.97 | FALSE |
8 | GTEx | Spleen | VPS29 | 0.24 | 0.01 | enet | 14 | 0.04 | 2.9e-02 | 3.7 | 5.2 | 2.2e-07 | -0.03 | 0.02 | 0.73 | FALSE |
9 | GTEx | Testis | ARPC3 | 0.16 | 0.16 | lasso | 3 | 0.14 | 7.5e-07 | 5.4 | -5.4 | 5.4e-08 | 0.04 | 0.02 | 0.98 | FALSE |
10 | GTEx | Whole Blood | PRDM4 | 0.10 | 0.08 | lasso | 5 | 0.05 | 1.8e-05 | 7.8 | -7.9 | 2.8e-15 | -0.99 | 0.01 | 0.99 | TRUE |
11 | NTR | Blood | UBE3B | 0.09 | 0.05 | lasso | 8 | 0.08 | 1.0e-25 | 4.6 | 5.7 | 1.2e-08 | -0.05 | 0.01 | 0.98 | TRUE |
12 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PRDM4 | 0.01 | 0.01 | lasso | 1 | 0.01 | 6.3e-03 | 6.7 | -6.7 | 2.0e-11 | -0.87 | 0.02 | 0.84 | FALSE |
13 | The Cancer Genome Atlas | Lung Adenocarcinoma | RAD9B | 0.04 | 0.03 | lasso | 5 | 0.01 | 7.0e-03 | 5.5 | 5.3 | 8.8e-08 | -0.04 | 0.01 | 0.99 | FALSE |
14 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ASCL4 | 0.03 | 0.03 | blup | 49 | 0.03 | 2.9e-04 | 7.8 | 7.6 | 3.4e-14 | 0.88 | 0.01 | 0.94 | FALSE |
15 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PWP1 | 0.06 | 0.02 | enet | 13 | 0.03 | 1.4e-04 | -1.7 | 5.2 | 1.9e-07 | 0.56 | 0.03 | 0.53 | FALSE |
16 | The Cancer Genome Atlas | Thyroid Carcinoma | RAD9B | 0.10 | 0.06 | enet | 5 | 0.06 | 1.2e-06 | 5.5 | 5.5 | 5.0e-08 | -0.05 | 0.01 | 0.99 | FALSE |