TWAS hub - ALKBH2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Breast Mammary Tissue	0.202	0.0710	0.0029	0.017	NA	0.096	NA	0.086	0.04400	NA	1.2e-05	NA	3.3e-05
2	GTEx	Breast Mammary Tissue (Female)	0.219	0.0952	0.0130	0.095	NA	0.016	NA	0.115	0.00091	NA	1.1e-01	NA	2.8e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Supplements: Zinc	9.5	10.3	10.9	3.1	3.3
Maternal smoking around birth	6.7	9.7	13.1	2.5	3.6
HDL Cholesterol	6.3	10.4	16.0	2.2	4.0
Trunk fat mass	5.8	25.0	28.2	4.7	5.3
Whole body fat mass	5.4	22.5	25.9	4.4	5.1
Trunk fat percentage	5.1	20.6	21.8	4.4	4.7
Arm fat mass (right)	5.0	20.6	23.5	4.2	4.8
Leg fat mass (right)	5.0	19.5	22.8	4.0	4.8
Weight	4.9	24.3	29.6	4.4	5.4
Body fat percentage	4.6	18.3	18.6	4.2	4.3
Arm fat mass (left)	4.5	18.6	20.1	4.1	4.5
Waist circumference	4.4	16.0	19.2	4.4	3.6
Hip circumference	4.4	19.0	22.4	3.9	4.7
Leg fat mass (left)	4.4	17.3	20.8	3.7	4.6
Arm fat percentage (right)	4.0	15.7	16.0	3.9	4.0
Falls in the last year	3.7	5.0	7.4	1.6	2.7
Leg fat percentage (right)	3.6	13.0	13.8	3.7	3.5
Arm fat percentage (left)	3.5	13.9	14.2	3.7	3.8
Number of treatments/medications taken	3.4	6.1	10.1	1.5	3.2
Medication: Co-codamol	3.4	3.9	4.3	1.9	2.1
BMI	3.2	18.3	20.8	4.0	4.6
Cardiovascular Disease	3.2	10.5	13.8	2.7	3.7
Medication: Metformin	3.2	4.5	7.1	2.7	1.4
Heart disease (mother)	3.2	3.9	5.3	1.6	2.3
Leg fat-free mass (left)	3.1	16.5	22.6	3.2	4.8
Leg predicted mass (left)	3.1	16.3	22.3	3.2	4.7
Medication: Aspirin	3.1	4.0	4.6	1.9	2.2
Medication: Aspirin	3.1	4.0	4.2	1.9	2.1
Basal metabolic rate	3.0	16.7	21.5	3.4	4.6
Leg fat percentage (left)	3.0	10.7	11.2	3.3	3.2
Angina	2.9	3.8	4.7	1.7	2.2
Noisy workplace	2.9	3.5	3.9	1.8	2.0
Had major operations	2.9	3.4	4.5	1.5	2.1
Long-standing illness, disability or infirmity	2.9	4.5	8.1	0.9	2.9
Body mass index (BMI)	2.8	11.9	12.5	3.4	3.5
Medication for cholesterol, blood pressure or diabetes	2.7	4.4	5.7	-1.8	-2.4
Number of children fathered	2.7	3.0	4.3	-1.3	-2.1
Taking other prescription medications	2.6	4.1	5.2	1.7	2.3
Illnesses of mother	2.6	3.2	4.4	-1.4	-2.1
Medication: Seretide 50 evohaler	2.6	3.0	4.5	1.3	2.1
Angina (self-reported)	2.5	3.2	4.3	1.5	2.1
Knee pain experienced in last month	2.5	3.9	5.7	1.4	2.4
Leg fat-free mass (right)	2.5	13.4	18.7	2.8	4.3
Pain type(s) experienced in last month: Hip pain	2.5	3.1	3.8	1.9	1.6
Systolic blood pressure, automated reading	2.4	6.8	7.3	2.7	2.5
Medication: Cholesterol lowering	2.4	3.7	4.8	1.6	2.2
Ever highly irritable/argumentative for 2 days	2.4	2.9	3.1	1.6	1.8
Qualifications: NVQ or HND or HNC or equivalent	2.4	2.8	2.8	1.7	1.7
Leg predicted mass (right)	2.4	12.6	17.7	2.8	4.2
Arm predicted mass (left)	2.4	12.5	15.0	3.2	3.9
Glaucoma (self-reported)	2.3	2.7	2.7	1.6	1.6
Whole body water mass	2.3	13.3	17.7	3.0	4.2
Arm fat-free mass (left)	2.3	11.9	14.9	3.0	3.9
Diastolic blood pressure, automated reading	2.3	7.3	8.4	2.9	2.5
Vitamin and mineral supplements	2.2	3.0	4.2	-1.3	-2.0
Townsend deprivation index at recruitment	2.2	3.0	4.6	2.1	1.2
Medication: Ramipril	2.2	2.8	3.5	1.5	1.9
Medication: Blood pressure	2.2	4.0	5.3	1.6	2.3
Whole body fat-free mass	2.2	12.8	17.0	2.9	4.1
Blood Platelet Count	2.1	24.4	27.9	-4.6	-5.3
Age at first live birth	2.1	3.7	5.2	-2.3	-1.5
Smoking status: Current	2.1	3.3	6.6	-0.3	-2.6
Vascular/heart problems diagnosed by doctor	2.1	5.8	7.0	-2.1	-2.6
Type 2 Diabetes (T2D) (2018)	2.0	3.8	6.6	2.6	1.0
Diabetes (self-reported)	2.0	3.1	5.2	2.3	1.0
Eye problems/disorders: None of the above	2.0	2.3	3.0	-1.3	-1.7
Supplements: Fish oil (including cod liver oil)	2.0	2.7	4.8	2.2	0.8
Age at First Birth	1.9	2.8	5.0	-2.2	-0.8
Trunk fat-free mass	1.9	11.1	14.2	2.8	3.8
Trunk predicted mass	1.9	10.6	13.6	2.8	3.7
Tense / ‘highly strung’	1.9	3.2	4.6	-2.1	-1.3
Unable to work because of sickness or disability	1.9	2.5	4.4	0.8	2.1
Primary Biliary Cirrhosis	1.8	2.6	3.9	1.2	2.0
Father’s age at death	1.8	2.4	4.5	-0.5	-2.1
Diabetes (mother)	1.7	2.1	3.8	0.7	-2.0
Medication: Simvastatin	1.7	2.4	3.3	1.2	1.8
Arm predicted mass (right)	1.7	8.9	11.9	2.4	3.5
Hypertension (Self-reported)	1.7	4.7	4.7	2.2	2.2
Intelligence (Savage-Jansen 2018)	1.6	4.8	6.7	1.7	2.6
Lupus	1.6	2.5	3.3	-1.3	-1.8
Systolic Blood Pressure	1.6	8.2	9.7	3.1	2.6
Alcohol intake versus 10 years previously	1.6	2.4	2.9	1.4	1.7
Pulse wave Arterial Stiffness index	1.6	1.9	3.4	0.6	1.8
Chronic bronchitis/emphysema (mother)	1.6	1.8	3.5	1.9	0.5
Arm fat-free mass (right)	1.6	8.4	11.1	2.4	3.3
Osteoarthritis (self-reported)	1.6	2.0	2.6	1.2	1.6
Hearing aid user	1.6	1.8	3.2	-0.7	-1.8
Fasting Glucose	1.5	1.8	3.3	1.8	0.4
Other serious medical condition/disability diagnosed by doctor	1.5	2.0	2.4	1.2	1.6
Standing height	1.5	14.8	22.5	2.7	4.7
Loud music exposure frequency	1.5	1.6	3.1	1.8	0.3
Age at last live birth	1.5	2.1	3.3	-1.8	-1.0
Diabetes diagnosed by doctor	1.5	2.5	4.0	2.0	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.5	1.8	2.5	1.0	1.6
Schizophrenia (2018)	1.4	3.0	3.4	1.8	1.6
HbA1C	1.4	1.5	2.4	-0.8	-1.5
High blood pressure	1.4	4.0	4.3	1.9	2.1
Diverticular disease/diverticulitis (self-reported)	1.4	1.7	2.4	-1.6	-1.0
Depression (self-reported)	1.4	1.7	2.4	-1.6	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.6	1.9	-1.1	-1.4
Smoking status: Previous	1.4	2.1	4.1	0.3	2.0
Alcohol drinker status: Previous	1.4	1.6	1.8	1.4	1.1
Body Mass Index (BMI) (2010)	1.3	1.8	1.8	1.4	1.3
Blood White Count	1.3	9.9	13.1	3.6	2.6
Lung FVC	1.3	6.4	7.0	-2.4	-2.6
Current tobacco smoking	1.3	2.2	4.3	0.1	-2.1
Illnesses of siblings: Diabetes	1.3	1.6	3.2	-0.2	-1.8
Neuroticism (Nagel 2018)	1.2	2.7	5.4	-2.3	0.3
Coronary Artery Disease (CAD)	1.2	1.4	2.5	-1.6	-0.5
Rheumatoid Arthritis	1.2	1.6	3.3	0.1	1.8
Blood Eosinophil Count	1.2	9.6	16.1	4.0	1.8
Multivitamins +/- minerals	1.2	1.5	2.0	1.0	1.4
Medication: Atenolol	1.2	1.5	2.2	0.9	1.5
High blood pressure (mother)	1.2	1.7	2.8	0.7	1.7
Hearing difficulty/problems with background noise	1.2	1.9	2.7	1.6	1.1
Pulse wave reflection index	1.2	1.5	2.6	0.6	1.6
Alcohol intake frequency.	1.2	2.7	3.0	1.7	1.6
Average weekly champagne plus white wine intake	1.2	1.7	2.2	1.1	-1.5
Major Depression (MDD)	1.1	1.3	2.5	0.3	1.6
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	2.1	1.4	0.7
Health satisfaction	1.1	1.5	1.5	1.2	1.2
Overall health rating	1.1	2.4	4.1	0.9	2.0
Eye problems/disorders: Cataract	1.1	1.3	1.4	1.1	1.2
Illnesses of father: None of the above (group 1)	1.1	1.4	1.9	-1.4	-0.9
Tinnitus: Yes, now most or all of the time	1.1	1.3	2.6	-0.0	-1.6
Myopia	1.1	1.5	3.0	1.7	-0.2
Hearing difficulty/problems: Yes	1.0	1.5	1.7	1.2	1.3
Diabetes (father)	1.0	1.2	1.4	1.2	1.0
Chronic bronchitis/emphysema (father)	1.0	1.1	2.1	0.4	1.4
Peak expiratory flow (PEF)	1.0	2.3	3.4	-1.8	-1.1
Number of full sisters	1.0	1.2	2.2	-0.4	-1.5
Supplements: Vitamin C	1.0	1.2	1.6	0.9	1.3
Mood swings	1.0	1.9	2.9	-0.9	1.7
Friendships satisfaction	1.0	1.2	2.2	0.5	1.5
Medication: Gliclazide	1.0	1.2	1.4	0.9	1.2
Number of self-reported non-cancer illnesses	1.0	1.7	2.2	1.5	1.1
Bipolar Disorder (2018)	0.9	1.4	2.0	0.9	-1.4
Bipolar Disorder or Schizophrenia	0.9	2.1	4.0	2.0	0.4
Depressed Affect (Nagel 2018)	0.9	1.9	3.7	-1.9	0.1
Alzheimer’s Disease (in father)	0.9	0.9	1.0	0.9	1.0
Number of live births	0.9	1.3	1.6	1.2	1.1
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.1	1.7	-0.7	-1.3
Illnesses of father: Heart disease	0.9	1.2	2.0	1.4	0.6
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	1.5	1.2	1.2
Medication for cholesterol	0.9	1.4	2.0	-0.9	-1.4
Pack years adult smoking proportion	0.8	1.1	2.1	-1.5	0.4
Hair/balding pattern: Pattern 4	0.8	1.9	3.8	0.2	1.9
Gout (self-reported)	0.8	1.2	1.7	1.3	-0.8
Exposure to tobacco smoke outside home	0.8	1.0	1.8	0.5	1.4
Pulse wave peak to peak time	0.8	0.9	1.8	-0.3	-1.3
Mouth/teeth dental problems: Loose teeth	0.8	1.0	1.7	1.3	0.5
Mineral and other dietary supplements	0.8	1.1	2.0	-1.4	0.4
Wears glasses or contact lenses	0.8	1.0	1.9	1.4	0.2
Number of operations (self-reported)	0.8	1.2	1.7	1.3	0.9
Irritability	0.8	1.4	2.4	-1.5	0.6
Pack years of smoking	0.8	1.2	1.9	-1.4	0.8
Height	0.7	12.9	24.5	1.1	4.9
Sensitivity / hurt feelings	0.7	1.2	2.4	-0.3	1.5
Supplements: Glucosamine	0.7	0.9	1.3	0.7	-1.2
Pain all over the body in last month	0.7	0.8	1.5	-0.2	1.2
Medication: Lansoprazole	0.7	0.8	1.6	-0.0	1.3
Blood clot in the leg (DVT)	0.7	0.9	0.9	0.9	1.0
Migraine (self-reported)	0.7	0.8	1.1	0.7	-1.1
Family relationship satisfaction	0.7	0.9	1.7	1.3	-0.2
Depression (Nagel 2018)	0.6	0.9	1.7	0.0	1.3
Verbal and Numeric Reasoning (VNR)	0.6	1.5	1.6	1.2	1.3
Bipolar Disorder (2011)	0.6	0.6	1.0	0.5	-1.0
Waist Hip Ratio (WHR)	0.6	2.5	4.4	2.1	-0.8
Ever had hysterectomy (womb removed)	0.6	0.7	1.1	1.0	0.6
Medication for hormone replacement therapy	0.6	0.6	1.0	0.5	1.0
Average weekly fortified wine intake	0.6	0.7	1.3	0.2	-1.1
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.2	-1.1	-0.4
Stomach or abdominal pain in last month	0.6	0.7	0.7	-0.8	-0.8
Mouth/teeth dental problems	0.6	1.0	1.9	-0.3	-1.4
Heart attack	0.6	0.8	0.9	0.8	1.0
Medication: Ventolin 100micrograms inhaler	0.6	0.8	1.4	1.2	0.5
Wheeze or whistling in the chest in last year	0.6	1.2	2.2	1.5	0.3
Shortness of breath walking on level ground	0.6	0.7	1.5	0.1	1.2
Comparative height size at age 10	0.6	3.2	3.2	1.8	1.8
Chest pain or discomfort	0.6	0.9	1.3	0.6	1.2
Qualifications: nursing, teaching	0.6	1.0	1.0	1.0	0.9
Medication: Lisinopril	0.6	0.8	1.1	0.7	1.0
Alzheimer’s Disease (in mother)	0.5	0.5	1.0	-0.2	-1.0
Reaction Time	0.5	0.9	1.0	1.0	0.9
Crohns Disease (2012)	0.5	0.7	1.2	1.1	0.5
Schizophrenia (2014)	0.5	1.1	1.8	1.3	0.7
Hypothyroidism (self reported)	0.5	1.1	2.0	1.4	0.4
Hand grip strength (right)	0.5	1.3	2.6	0.2	1.6
Age when periods started (menarche)	0.5	1.1	1.3	-1.0	1.1
Had other major operations	0.5	0.6	1.1	1.0	-0.3
Fluid intelligence score	0.5	0.9	1.2	1.1	0.8
Illnesses of siblings	0.5	0.7	0.9	-0.9	-0.7
Prospective memory result	0.5	0.6	1.2	-1.1	-0.2
Lung cancer (father)	0.5	0.6	1.0	1.0	0.5
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	1.3	0.2	1.1
Comparative body size at age 10	0.5	1.4	2.8	0.1	1.7
Commuting to job workplace: Walk	0.5	0.5	1.1	0.1	1.0
Medication: Paracetamol	0.5	0.8	1.0	-0.8	-1.0
Ever depressed for a whole week	0.5	0.6	1.1	0.1	1.1
Commuting to job workplace: Cycle	0.5	0.6	0.7	-0.7	-0.9
Basal cell carcinoma (self-reported)	0.5	0.6	1.3	1.1	0.1
Heart attack/myocardial infarction (self-reported)	0.5	0.6	0.7	0.7	0.8
Worry (Nagel 2018)	0.4	0.8	1.4	-1.2	-0.4
Neuroticism	0.4	0.9	1.5	-1.2	0.5
Ever used hormone-replacement therapy (HRT)	0.4	0.5	0.9	0.9	0.5
Serious illness, injury or assault to yourself	0.4	0.5	0.9	0.2	1.0
Medication: Levothyroxine sodium	0.4	0.6	1.0	1.0	-0.4
Impedance of leg (left)	0.4	2.1	3.5	-0.8	-1.9
Number of incorrect matches in round	0.4	0.7	1.2	0.5	1.1
Hair/balding pattern: Pattern 2	0.4	0.5	0.9	1.0	-0.1
Time employed in main current job	0.4	0.5	0.5	-0.7	-0.6
Worrier / anxious feelings	0.4	0.7	0.9	0.9	0.8
Length of working week for main job	0.4	0.4	0.9	0.1	0.9
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.1	1.1	-0.3
Medication: Allopurinol	0.4	0.5	1.1	1.0	-0.1
Suffer from ‘nerves’	0.4	0.6	1.2	1.1	-0.2
Loneliness, isolation	0.4	0.6	0.8	-0.9	-0.7
Back pain experienced in last month	0.4	0.6	1.3	-1.1	-0.1
Alcohol drinker status: Never	0.4	0.5	0.8	-0.4	-0.9
Average weekly beer plus cider intake	0.4	0.5	0.9	-0.5	-0.9
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	0.6	0.8	0.7
Ovarian Cancer	0.3	0.4	0.6	-0.4	0.8
Mean Putamen Volume	0.3	0.4	0.7	-0.2	0.8
Ulcerative Colitis	0.3	0.4	0.7	0.9	-0.3
Respiratory disease	0.3	0.8	0.9	0.8	1.0
Severe depression (siblings)	0.3	0.3	0.3	-0.6	-0.5
Impedance of leg (right)	0.3	1.6	2.7	-0.6	-1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.8	0.9	0.3
Hayfever, allergic rhinitis or eczema	0.3	0.7	0.9	-0.6	-1.0
Sitting height	0.3	1.8	3.2	0.6	1.8
Past tobacco smoking	0.3	0.6	1.0	-0.4	-1.0
Forced vital capacity (FVC)	0.3	1.0	1.9	-1.4	0.2
Mouth/teeth dental problems: Dentures	0.3	0.5	0.5	-0.7	0.7
Birth weight of first child	0.3	0.6	0.6	0.7	0.8
High blood pressure (siblings)	0.3	0.4	0.8	-0.9	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	0.4	0.6	0.7
Medication for pain relief, constipation, heartburn	0.3	0.5	0.8	-0.9	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.4	0.5	-0.6
Medication: Bendroflumethiazide	0.3	0.4	0.5	0.6	0.7
Age started oral contraceptive pill	0.3	0.3	0.6	0.2	0.8
Pain experienced in last month	0.3	0.6	1.2	-0.1	-1.1
Heart disease (siblings)	0.3	0.3	0.6	-0.2	0.8
Irritable Bowel Disease (IBD)	0.2	0.5	0.8	0.9	0.3
LDL Cholesterol	0.2	0.3	0.4	0.4	0.7
Neuroticism (2016)	0.2	0.2	0.4	-0.6	-0.3
Triglycerides	0.2	0.3	0.3	-0.5	0.6
Heel T-Score	0.2	1.3	2.5	-0.4	1.6
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.4	-0.6	0.4
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.4	0.2	0.7
Had menopause	0.2	0.2	0.4	0.3	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.6	0.8	-0.9	0.5
Qualifications: None of the above	0.2	0.5	0.9	-1.0	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	0.7	0.3	0.8
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	1.6	-1.2	-0.1
Exposure to tobacco smoke at home	0.2	0.2	0.4	0.1	-0.7
Medication: Paracetamol	0.2	0.4	0.7	0.1	-0.9
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.8	0.9	0.1
Birth weight	0.2	0.4	0.8	0.9	-0.0
Qualifications: College or University degree	0.2	0.5	0.9	0.4	-1.0
Mean time to correctly identify matches	0.2	0.5	0.7	0.8	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.3	-0.5	0.5
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.5	-0.7	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.3	0.6	0.3	0.8
Asthma (self-reported)	0.2	0.5	0.7	0.9	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.8	-0.9	-0.1
Guilty feelings	0.2	0.2	0.5	-0.0	0.7
Medication: Blood pressure	0.2	0.4	0.6	0.8	0.5
Cholesterol lowering medication	0.2	0.3	0.3	0.6	0.6
Schizophrenia vs Biploar Disorder	0.1	0.1	0.1	-0.2	0.4
Crohns Disease (2017)	0.1	0.2	0.4	0.6	0.1
Type 2 Diabetes (T2D) (2012)	0.1	0.2	0.3	0.5	-0.2
Smoking Status	0.1	0.3	0.6	0.8	0.2
Lung FEV1/FVC ratio	0.1	0.7	1.1	1.1	0.5
Chronotype (morning person)	0.1	0.2	0.3	-0.6	-0.3
Hair Pigment	0.1	2.1	4.1	0.3	-2.0
Hand grip strength (left)	0.1	0.4	0.4	-0.6	0.6
Relative age of first facial hair	0.1	0.2	0.2	0.4	0.4
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	0.0	0.4
Relative age voice broke	0.1	0.1	0.1	0.3	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.2	-0.4	0.4
Alcohol usually taken with meals	0.1	0.2	0.4	-0.6	-0.0
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.3	0.5	0.2
Allergy	0.1	0.3	0.5	0.1	0.7
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.3	-0.0	-0.6
Neuroticism score	0.1	0.2	0.2	-0.4	0.4
Asthma	0.1	0.3	0.3	0.5	-0.5
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.2	-0.0	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.6	0.0	0.8
Medication: Amlodipine	0.1	0.2	0.3	-0.2	-0.5
Forced vital capacity (FVC), Best measure	0.1	0.3	0.5	-0.2	0.7
Number of full brothers	0.1	0.1	0.3	0.5	0.1
Worry too long after embarrassment	0.1	0.2	0.2	-0.4	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.2	-0.0	0.4
Emphysema/chronic bronchitis	0.1	0.1	0.2	-0.2	0.4
Neck or shoulder pain in last month	0.1	0.1	0.2	-0.4	-0.3
Medication: Ibuprofen	0.1	0.1	0.2	0.5	0.2
Medication: Omeprazole	0.1	0.1	0.2	-0.4	0.3
Pulse rate, automated reading	0.1	0.3	0.4	0.3	0.7
Leg pain on walking	0.1	0.1	0.1	-0.3	0.2
Average weekly red wine intake	0.1	0.1	0.1	-0.4	0.1
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	-0.5	-0.2
Ever had bowel cancer screening	0.1	0.2	0.2	-0.4	-0.3
Breast cancer (self-reported)	0.1	0.2	0.3	0.5	0.3
Osteoporosis (self-reported)	0.1	0.1	0.2	-0.2	-0.4
Ever taken oral contraceptive pill	0.1	0.1	0.3	0.5	-0.2
Financial situation satisfaction	0.1	0.2	0.2	0.5	-0.3
Commuting to job workplace: Public transport	0.1	0.1	0.2	-0.1	0.5
Eye problems/disorders: Glaucoma	0.1	0.2	0.3	0.0	0.6
Illnesses of father: High blood pressure	0.1	0.1	0.1	-0.1	-0.4
Ever smoked	0.1	0.2	0.2	0.5	-0.4
Ever had prostate specific antigen (PSA) test	0.1	0.2	0.2	-0.4	-0.4
Fractured/broken bones in last 5 years	0.1	0.1	0.2	0.4	0.3
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.2	-0.2	0.4
Supplements: Calcium	0.1	0.1	0.2	0.3	-0.4
Impedance of whole body	0.1	0.3	0.6	-0.1	-0.8
Alzheimer’s Disease (including proxy)	0.0	0.0	0.1	0.3	0.1
Ulcerative Colitis (UC)	0.0	0.1	0.1	0.2	-0.3
Breast Cancer	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0
Blood Red Count	0.0	0.1	0.2	0.2	0.4
Allergy or Eczema	0.0	0.1	0.1	-0.1	-0.4
Tanning	0.0	0.3	0.5	-0.7	0.4
Average weekly spirits intake	0.0	0.0	0.0	0.2	0.2
Fed-up feelings	0.0	0.1	0.1	-0.3	-0.1
Qualifications: CSEs or equivalent	0.0	0.0	0.1	-0.3	-0.1
Nervous feelings	0.0	0.0	0.0	-0.1	0.1
Financial difficulties in last 2 years	0.0	0.1	0.1	0.2	0.3
Impedance of arm (right)	0.0	0.0	0.1	0.2	-0.1
Hair/balding pattern: Pattern 3	0.0	0.1	0.1	-0.2	0.3
Pulse rate	0.0	0.0	0.1	0.3	-0.0
Happiness	0.0	0.0	0.1	0.2	-0.1
Qualifications: A levels/AS levels or equivalent	0.0	0.0	0.0	0.2	0.0
Impedance of arm (left)	0.0	0.0	0.0	0.2	-0.0
Breastfed as a baby	0.0	0.0	0.1	0.1	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.1	0.1	-0.3	-0.1
Headache pain in last month	0.0	0.1	0.1	-0.0	0.3
Commuting to job workplace: Car/motor vehicle	0.0	0.0	0.0	0.0	0.0
Miserableness	0.0	0.1	0.1	-0.3	0.2
Mother’s age at death	0.0	0.1	0.1	0.1	-0.3
High cholesterol (Self-reported)	0.0	0.0	0.0	-0.2	0.2
Medication: Atorvastatin	0.0	0.0	0.0	-0.1	-0.0
Risk taking	0.0	0.0	0.1	0.2	-0.2

Hub : Genes

ALKBH2

Models

Trait associations