Hub : Genes

PWP1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.0698	0.0295	0.00650	0.095	NA	0.078	NA	0.093	7.4e-08	NA	1.0e-06	NA	8.9e-08
2	GTEx	Cells Transformed fibroblasts	0.1610	0.0630	0.00490	0.028	NA	0.044	NA	0.027	3.3e-03	NA	3.2e-04	NA	4.0e-03
3	NTR	Blood	0.0196	0.0074	0.00049	0.019	0.007	0.016	0.01	0.017	7.9e-07	2.0e-03	3.4e-06	2.1e-04	2.8e-06
4	YFS	Blood	0.1276	0.0233	0.00000	0.121	0.117	0.147	0.14	0.147	2.1e-37	2.5e-36	8.7e-46	1.6e-43	1.3e-45
5	TCGA	Brain Lower Grade Glioma	0.0728	0.0416	0.00130	0.029	0.012	0.014	NA	0.015	2.7e-04	1.4e-02	8.6e-03	NA	7.0e-03
6	TCGA	Prostate Adenocarcinoma	0.0639	0.0307	0.00071	0.016	0.024	0.035	NA	0.026	8.1e-03	1.4e-03	1.4e-04	NA	8.9e-04
7	TCGA	Thyroid Carcinoma	0.0490	0.0260	0.00064	0.034	0.023	0.032	NA	0.036	2.9e-04	2.3e-03	4.3e-04	NA	1.9e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.4	0.6	1.1	0.6	0.6	0.8	0.9	0.8	0.0	1.0
Bipolar Disorder or Schizophrenia	0.1	0.2	0.9	-0.0	1.0	0.1	-0.3	0.2	0.1	0.1
Depressed Affect (Nagel 2018)	0.2	0.5	1.3	0.0	0.8	-0.9	-0.4	-1.1	0.3	-0.6
Depression (Nagel 2018)	0.2	0.3	1.5	0.4	-0.4	0.1	0.2	-0.4	-1.2	0.2
Intelligence (Savage-Jansen 2018)	0.5	1.6	3.2	0.9	-0.7	1.8	0.7	1.3	-1.5	1.6
Neuroticism (Nagel 2018)	0.9	2.1	3.1	-1.2	1.1	-1.7	-1.6	-1.8	0.8	-1.7
Schizophrenia (2018)	0.2	0.4	1.3	-0.5	0.7	-0.4	-1.1	-0.4	0.0	-0.8
Schizophrenia vs Biploar Disorder	0.9	1.2	2.9	1.0	-1.7	1.4	0.5	1.3	-0.1	0.9
Worry (Nagel 2018)	1.5	3.2	5.2	-1.7	1.5	-2.0	-2.0	-2.3	1.1	-1.8
Alzheimer’s Disease (in mother)	1.5	1.8	6.0	0.7	2.2	0.7	0.1	0.4	-2.4	0.4
Alzheimer’s Disease (in father)	2.2	2.4	4.6	-1.9	0.7	-1.6	-2.1	-1.3	-0.5	-1.8
Alzheimer’s Disease (including proxy)	1.2	1.7	7.0	-0.1	1.9	-0.1	-0.8	-0.1	-2.7	-0.5
Crohns Disease (2017)	0.7	1.6	4.5	1.2	-0.1	0.8	1.4	1.0	2.1	1.2
Irritable Bowel Disease (IBD)	0.6	1.4	9.1	-0.3	-0.1	-0.8	0.4	-0.4	3.0	-0.0
Ulcerative Colitis (UC)	1.5	2.8	5.7	-1.8	-0.3	-2.1	-0.9	-1.8	2.4	-1.4
Major Depression (MDD)	0.5	0.6	1.8	-0.4	0.3	-1.1	-0.7	-0.6	-0.1	-1.4
Reaction Time	0.5	0.9	1.7	1.2	1.0	1.0	0.3	1.3	-0.7	0.7
Verbal and Numeric Reasoning (VNR)	0.9	2.1	4.4	1.3	-0.5	2.1	1.1	1.7	-0.8	1.8
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	1.3	1.8	2.5	1.0	-1.5	1.6	0.7	1.5	-1.6	1.3
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.6	0.9	3.2	1.0	0.5	0.7	0.8	0.9	-1.8	0.5
Bipolar Disorder (2011)	0.2	0.2	0.5	0.1	-0.7	0.5	-0.0	0.2	-0.6	0.5
Body Mass Index (BMI) (2010)	0.5	0.7	1.3	0.8	-1.0	0.6	1.2	0.4	-0.9	0.8
Coronary Artery Disease (CAD)	0.4	0.5	1.3	0.2	-1.0	0.2	1.2	0.1	0.7	0.6
Crohns Disease (2012)	0.2	0.3	1.6	0.3	0.5	-0.2	0.4	0.4	1.3	0.0
Mean Putamen Volume	0.6	0.7	1.2	0.8	-0.8	0.8	1.0	0.7	0.5	1.1
Fasting Glucose	1.1	1.3	2.5	1.4	-0.3	1.4	0.9	1.6	1.1	0.6
HbA1C	0.4	0.4	1.6	-0.8	-0.3	-0.2	-0.3	-0.7	-1.2	0.3
HDL Cholesterol	0.9	1.5	4.5	-0.8	-0.8	-1.1	-1.2	-0.7	2.1	-1.1
LDL Cholesterol	0.5	0.8	2.6	0.1	1.6	-0.8	0.0	-0.8	-0.8	-0.8
Lupus	1.0	1.5	2.8	-1.7	1.1	-1.4	-1.0	-1.2	0.7	-1.1
Neuroticism (2016)	0.1	0.1	0.4	-0.2	-0.1	-0.5	-0.3	-0.3	0.1	-0.6
Primary Biliary Cirrhosis	0.5	0.7	2.0	0.7	1.4	0.5	1.2	0.4	-0.2	0.7
Rheumatoid Arthritis	0.8	1.1	3.2	0.7	-0.2	0.9	1.8	0.9	0.8	1.3
Schizophrenia (2014)	0.3	0.6	1.1	-0.9	0.3	-0.5	-1.1	-0.6	-1.1	-0.7
Triglycerides	0.1	0.1	0.7	0.4	0.1	0.2	0.2	0.2	-0.8	0.2
Type 2 Diabetes (T2D) (2012)	1.0	1.2	2.2	-1.2	-1.3	-1.2	-0.7	-1.5	-0.0	-1.1
Ulcerative Colitis	2.5	3.6	6.1	-2.3	0.2	-2.5	-1.1	-2.1	2.2	-1.8
Blood Eosinophil Count	0.1	0.9	3.3	0.3	1.2	0.6	0.4	0.7	1.8	0.6
Blood Platelet Count	0.0	0.2	0.9	-0.4	-0.0	-0.2	-0.1	0.1	-1.0	-0.2
Blood Red Count	0.0	0.4	1.7	0.1	-0.0	0.4	0.6	0.1	-1.3	0.7
Blood White Count	0.8	5.8	8.3	2.1	-2.0	2.9	2.7	2.8	-0.7	2.8
Heel T-Score	0.3	2.5	4.7	-2.2	0.5	-1.6	-2.1	-1.5	0.7	-1.6
BMI	0.8	4.6	13.3	-1.9	0.2	-2.5	-1.0	-2.0	3.6	-2.0
Height	0.9	17.8	29.3	-3.5	3.2	-5.4	-2.6	-4.6	4.6	-4.9
Waist Hip Ratio (WHR)	0.0	0.0	0.0	-0.2	0.1	-0.0	-0.2	0.0	-0.1	-0.1
Systolic Blood Pressure	0.1	0.5	2.6	-0.4	-0.5	-0.4	0.2	-0.4	1.6	-0.2
Smoking Status	0.3	0.7	1.3	-0.7	0.0	-0.9	-0.8	-0.9	1.1	-0.9
Allergy or Eczema	0.1	0.3	0.8	0.7	0.2	0.4	0.5	0.5	0.9	0.5
Cardiovascular Disease	1.7	5.7	10.4	-2.3	0.3	-2.8	-3.2	-2.6	-0.2	-3.1
Hypothyroidism (self reported)	0.3	0.8	2.6	0.7	0.2	0.7	1.6	-0.3	0.3	1.3
Respiratory disease	0.6	1.3	2.8	1.4	-0.1	0.7	1.3	1.2	1.7	0.7
Type 2 Diabetes (T2D) (2018)	0.5	0.9	5.2	0.8	-0.1	0.5	0.2	0.2	2.3	0.5
Lung FEV1/FVC ratio	0.3	1.3	5.5	1.0	-1.5	0.7	0.2	0.5	-2.3	0.4
Lung FVC	0.3	1.6	4.0	-0.9	1.8	-0.9	-2.0	-0.8	0.0	-1.2
Neuroticism	1.4	3.4	5.9	-1.6	1.2	-2.3	-1.8	-2.4	1.1	-2.0
Chronotype (morning person)	0.2	0.5	1.5	-0.4	-0.9	-0.8	0.4	-1.2	0.3	-0.3
Hair Pigment	0.1	3.3	6.4	-1.5	1.7	-2.5	-0.8	-1.8	1.4	-2.4
Tanning	0.1	1.4	2.0	-0.9	0.9	-1.4	-1.1	-1.4	1.1	-1.3
Hand grip strength (left)	0.3	0.7	1.2	-1.0	0.1	-1.0	-0.5	-0.8	1.1	-0.9
Number of treatments/medications taken	1.2	2.2	4.2	-1.2	0.3	-1.9	-1.6	-1.9	0.4	-2.1
Average weekly spirits intake	0.4	0.5	1.7	-0.4	1.3	-0.5	-0.4	-0.5	0.4	-0.7
Sensitivity / hurt feelings	0.1	0.1	0.3	-0.4	-0.1	-0.6	0.0	-0.2	-0.4	-0.5
Frequency of depressed mood in last 2 weeks	0.4	0.5	2.3	0.1	0.6	-0.1	-0.7	-0.4	-1.5	-0.3
Hearing difficulty/problems: Yes	0.1	0.2	0.9	0.3	-0.3	0.1	0.2	0.2	-0.9	-0.2
Relative age of first facial hair	0.1	0.2	0.7	0.6	0.3	0.1	0.8	0.3	-0.7	0.0
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	3.7	0.4	0.9	0.5	0.2	0.8	1.9	0.3
Ever used hormone-replacement therapy (HRT)	0.5	0.7	1.3	0.7	1.1	0.3	1.0	0.6	1.1	0.6
Ever had hysterectomy (womb removed)	1.1	1.2	1.9	-1.4	1.1	-0.9	-1.3	-0.8	1.1	-0.9
Systolic blood pressure, automated reading	0.4	1.2	4.3	0.2	-2.1	-0.1	0.7	-0.3	1.9	0.2
Eye problems/disorders: Diabetes related eye disease	1.8	2.0	3.8	-1.0	1.7	-1.1	-1.9	-1.6	-0.9	-1.3
Angina	0.0	0.0	0.2	-0.2	0.1	-0.2	0.0	-0.5	0.0	-0.1
Medication for hormone replacement therapy	0.3	0.3	0.7	0.7	0.9	0.5	0.3	0.7	0.1	0.5
Vitamin and mineral supplements	2.9	3.9	5.6	2.0	-1.0	2.4	1.6	2.0	-2.3	2.2
Supplements: Zinc	0.9	0.9	2.3	-0.4	1.0	-1.2	-1.0	-0.8	-0.3	-1.5
Medication: Co-codamol	0.6	0.7	1.1	1.0	0.9	0.9	0.5	1.0	0.5	0.8
Medication: Metformin	0.4	0.5	1.0	-0.7	0.1	-0.6	-0.9	-0.9	1.0	-0.5
Diabetes (father)	0.0	0.0	0.1	0.0	0.0	-0.2	0.1	-0.3	0.3	-0.1
Diabetes (mother)	0.8	1.0	1.7	-1.2	0.8	-1.3	-0.5	-1.2	0.3	-1.2
Severe depression (siblings)	0.1	0.1	0.4	0.6	-0.5	0.1	0.1	-0.1	-0.5	-0.1
Pack years adult smoking proportion	0.2	0.3	0.5	0.6	0.6	0.6	0.4	0.5	0.1	0.7
Impedance of leg (right)	0.1	0.6	1.3	1.2	0.2	0.7	1.1	0.8	-0.1	0.7
Leg fat-free mass (left)	1.1	5.9	12.9	-2.1	1.6	-2.9	-1.5	-2.2	3.6	-2.5
Trunk fat percentage	2.9	11.5	27.0	-2.5	1.9	-4.1	-1.6	-3.5	5.2	-3.5
Hand grip strength (right)	0.4	1.2	1.9	-1.4	0.8	-1.3	-0.8	-1.3	0.8	-1.1
Townsend deprivation index at recruitment	3.2	4.5	7.1	2.4	-2.2	2.7	1.3	2.4	-0.4	2.5
Current tobacco smoking	0.1	0.1	0.3	0.1	0.5	-0.0	0.3	-0.1	0.5	0.1
Average weekly fortified wine intake	2.4	2.8	11.1	1.2	-0.2	1.6	0.8	1.5	-3.3	1.3
Maternal smoking around birth	0.8	1.1	1.8	-1.2	-0.5	-1.2	-1.3	-1.3	0.5	-1.2
Fed-up feelings	0.5	1.0	1.5	-0.4	1.2	-1.2	-0.9	-1.2	0.4	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	2.0	0.1	-1.4	-0.1	0.0	-0.4	-0.7	0.0
Relative age voice broke	0.3	0.4	1.0	-1.0	-0.0	-0.8	-0.7	-0.5	0.4	-0.8
Taking other prescription medications	0.2	0.3	0.9	0.3	-0.1	-0.4	0.0	-0.9	0.9	-0.3
Age when periods started (menarche)	1.4	3.3	9.3	1.6	-1.4	1.1	3.1	1.5	1.9	1.6
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	1.0	0.4	0.7	0.3	0.2	0.5	1.0	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	4.1	-0.3	0.2	-1.2	-0.9	-0.9	2.0	-1.3
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.7	0.2	0.7	-0.3	-0.3	-0.3	-1.3	-0.5
Qualifications: CSEs or equivalent	0.9	1.2	2.6	-1.2	1.6	-1.1	-0.8	-1.0	1.0	-0.8
Serious illness, injury or assault to yourself	3.5	4.2	9.4	-2.1	3.1	-2.0	-1.6	-1.9	1.5	-1.8
High blood pressure	1.3	3.7	6.4	-1.8	0.0	-2.5	-2.1	-2.2	0.5	-2.5
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.7	0.2	0.8	-0.1	-0.1	0.3	0.8	-0.1
Multivitamins +/- minerals	1.6	2.0	3.5	-1.4	0.7	-1.9	-1.0	-1.4	1.5	-1.7
Stomach or abdominal pain in last month	1.5	1.9	2.8	1.7	1.2	1.5	1.4	1.5	-0.3	1.5
Supplements: Glucosamine	0.2	0.3	1.0	-1.0	0.4	0.0	0.3	-0.1	0.8	0.4
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.2	-1.1	-0.0	-1.1	-0.7	-0.9	0.4	-0.9
Medication: Atenolol	1.5	1.8	3.3	-1.4	-0.3	-1.6	-1.6	-1.4	0.3	-1.8
Medication: Levothyroxine sodium	0.1	0.2	0.4	0.6	-0.6	0.3	0.4	-0.3	-0.5	0.4
Sitting height	0.3	2.4	3.5	-1.7	0.3	-1.8	-1.3	-1.4	1.9	-1.7
Chronic bronchitis/emphysema (father)	0.5	0.6	1.2	-0.8	0.4	-0.8	-1.1	-0.7	0.8	-0.8
High blood pressure (mother)	0.9	1.2	5.0	-0.6	2.2	-1.0	-0.6	-0.8	0.5	-1.0
Body mass index (BMI)	0.9	3.8	8.8	-1.4	0.4	-2.4	-1.1	-2.2	3.0	-2.0
Impedance of leg (left)	0.1	0.3	0.9	0.6	0.9	0.1	0.8	0.3	0.4	0.2
Leg predicted mass (left)	1.1	5.7	12.1	-2.0	1.6	-2.8	-1.5	-2.2	3.5	-2.5
Trunk fat mass	3.0	13.0	27.2	-2.8	1.9	-4.4	-1.9	-3.8	5.2	-3.8
Waist circumference	0.9	3.3	10.9	-1.1	0.7	-2.1	-0.6	-1.8	3.3	-1.6
Number of incorrect matches in round	1.0	1.7	3.6	-1.3	0.1	-1.7	-1.1	-1.9	-0.1	-1.6
Past tobacco smoking	0.6	1.0	1.8	0.8	-0.2	0.9	1.3	1.1	-1.3	1.1
Alcohol usually taken with meals	2.3	3.8	6.3	-2.5	1.8	-2.0	-2.2	-2.1	0.8	-1.8
Nervous feelings	0.1	0.2	0.6	0.1	0.3	-0.3	-0.8	-0.5	0.2	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.3	-0.1	1.1	-0.3	-0.9	-0.2	0.0	-0.5
Hearing difficulty/problems with background noise	1.0	1.6	2.8	-1.1	0.7	-1.5	-1.3	-1.4	0.6	-1.7
Hair/balding pattern: Pattern 2	0.8	1.0	1.5	0.6	-0.9	1.1	0.6	1.1	1.2	1.2
Had menopause	0.8	1.0	4.6	0.8	-2.1	0.8	0.7	0.3	-0.2	0.8
Had other major operations	2.9	3.6	4.5	-2.1	1.7	-2.1	-1.7	-1.8	1.8	-2.0
Forced vital capacity (FVC)	0.6	2.3	6.3	-1.2	2.5	-1.4	-1.6	-0.9	0.6	-1.6
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	3.4	-1.0	-0.3	-1.2	-1.8	-1.3	0.3	-1.5
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.2	0.5	-1.1	0.3	0.8	0.1	0.3	0.4
Qualifications: None of the above	1.7	3.6	6.7	2.2	-2.6	1.8	2.2	1.7	0.1	1.8
Financial difficulties in last 2 years	0.1	0.2	0.8	-0.3	-0.4	0.1	-0.2	0.3	-0.9	0.1
Mouth/teeth dental problems	0.4	0.7	1.3	-0.7	0.7	-0.9	-1.1	-0.5	0.2	-1.1
Heart attack	0.1	0.1	0.2	-0.4	-0.3	-0.2	-0.2	-0.3	-0.1	-0.2
Allergy	0.1	0.3	1.4	-0.2	-0.7	0.4	-0.2	0.0	-1.2	0.2
Pain all over the body in last month	0.1	0.1	0.4	-0.0	0.6	0.2	-0.3	0.1	-0.5	0.1
Diabetes (self-reported)	0.3	0.5	2.7	0.2	-0.6	0.1	-0.2	-0.4	1.6	0.2
Hayfever/allergic rhinitis (self-reported)	0.0	0.1	0.1	-0.0	0.2	0.2	-0.1	0.4	0.4	0.3
Medication: Ramipril	0.3	0.4	1.0	1.0	-0.4	0.7	-0.0	0.9	-0.0	0.4
Medication: Simvastatin	0.1	0.1	0.3	-0.3	-0.4	-0.0	-0.4	-0.5	0.3	-0.1
Fluid intelligence score	0.6	1.2	2.2	0.7	0.7	1.5	0.9	1.3	0.8	1.4
Illnesses of siblings	0.2	0.3	1.1	-0.2	0.1	0.5	-0.6	0.7	-1.1	0.2
Neuroticism score	1.2	2.4	4.1	-1.1	1.1	-2.0	-1.6	-1.9	0.8	-2.0
Weight	1.9	9.2	18.1	-2.4	1.5	-3.8	-1.7	-3.3	4.3	-3.3
Impedance of arm (right)	0.3	1.6	2.6	-0.8	1.0	-1.6	-1.0	-1.5	1.2	-1.6
Arm fat percentage (right)	2.2	8.7	16.6	-2.2	0.9	-3.7	-1.7	-3.4	4.1	-3.2
Trunk fat-free mass	0.2	1.1	2.5	-1.0	0.8	-1.2	-0.5	-1.0	1.6	-1.0
Hip circumference	1.3	5.4	13.1	-1.7	1.2	-2.8	-1.0	-2.5	3.6	-2.4
Time employed in main current job	3.1	3.5	6.0	1.6	-2.2	1.9	2.4	1.7	0.1	2.2
Alcohol intake versus 10 years previously	0.8	1.2	2.3	-0.7	0.6	-1.1	-1.5	-0.9	0.9	-1.5
Father’s age at death	1.2	1.7	3.3	1.8	0.7	1.3	1.4	1.6	0.4	1.1
Worrier / anxious feelings	0.3	0.6	0.9	-0.9	0.6	-0.9	-0.8	-0.7	0.4	-0.8
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	2.2	0.4	1.5	-0.0	-0.5	-0.2	-0.6	-0.2
Falls in the last year	1.1	1.4	5.4	0.1	2.3	-1.1	-0.2	-0.7	1.4	-1.1
Hair/balding pattern: Pattern 3	0.8	1.1	2.0	-1.2	1.3	-0.6	-1.4	-0.9	-1.1	-0.7
Number of live births	0.7	1.0	1.5	-1.2	0.6	-1.0	-1.0	-1.2	-0.7	-0.9
Forced expiratory volume in 1-second (FEV1)	0.8	2.5	4.5	-1.5	2.1	-1.6	-1.9	-1.1	0.7	-1.8
Pulse rate	2.6	4.3	7.8	-2.1	0.7	-2.5	-2.8	-1.8	1.1	-2.6
Happiness	0.1	0.2	0.4	0.2	0.2	-0.3	-0.6	-0.2	-0.4	-0.7
Noisy workplace	1.3	1.6	4.5	2.1	-0.5	1.1	1.6	1.0	0.5	1.0
Qualifications: A levels/AS levels or equivalent	0.3	0.6	2.1	-1.4	1.3	0.1	-0.4	0.0	-0.1	0.2
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	6.5	0.3	-0.5	0.9	1.3	0.5	-2.5	0.9
Mouth/teeth dental problems: Dentures	0.7	1.2	2.1	0.8	-1.3	0.8	1.2	0.8	1.4	1.0
Asthma	0.3	0.6	3.0	0.7	0.2	0.1	0.5	0.3	1.7	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.4	-0.3	-0.0	-0.3	-0.6	-0.4	0.5	-0.3
Medication: Cholesterol lowering	0.7	1.1	1.8	-0.8	-1.3	-0.8	-0.9	-1.3	-1.2	-0.9
Depression (self-reported)	0.4	0.5	1.0	-0.2	0.4	-0.7	-0.5	-1.0	-0.9	-0.7
Medication: Lansoprazole	0.8	0.9	2.0	-0.6	-0.2	-1.4	-0.3	-1.3	-0.6	-1.4
Prospective memory result	0.2	0.2	0.9	0.5	0.2	-0.3	0.1	0.2	-1.0	-0.5
Lung cancer (father)	1.8	2.1	3.6	0.9	-1.6	1.7	1.1	1.0	-1.5	1.9
Illnesses of mother	2.1	2.7	4.3	1.6	-1.5	2.1	1.3	2.0	-0.3	2.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.2	5.7	-0.7	2.4	-1.4	-1.4	-0.8	1.6	-1.6
Pulse wave Arterial Stiffness index	2.5	2.9	4.2	-1.9	-0.1	-1.8	-2.0	-2.1	-1.4	-1.9
Impedance of arm (left)	0.5	2.5	3.8	-1.2	1.3	-2.0	-1.4	-1.6	1.5	-1.9
Arm fat mass (right)	2.1	8.5	18.1	-2.2	1.2	-3.6	-1.7	-3.1	4.3	-3.1
Trunk predicted mass	0.2	1.0	2.5	-0.9	0.8	-1.2	-0.4	-0.9	1.6	-1.0
Standing height	0.7	6.7	10.6	-2.2	2.2	-3.2	-1.3	-2.5	3.3	-2.9
Length of working week for main job	0.6	0.7	3.5	0.3	-0.9	-0.4	0.4	-0.2	1.9	-0.1
Exposure to tobacco smoke at home	0.5	0.6	1.3	0.1	1.1	-0.2	-1.0	0.2	1.1	-0.6
Breastfed as a baby	1.8	2.2	3.7	-1.5	1.9	-1.7	-1.3	-1.6	-0.5	-1.6
Tense / ‘highly strung’	1.4	2.3	4.1	-1.3	0.8	-1.6	-2.0	-1.7	0.9	-1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.3	2.3	-1.3	1.0	-1.2	-1.2	-1.5	-0.2	-1.1
Hair/balding pattern: Pattern 4	0.7	1.7	6.5	0.0	-1.9	0.4	-1.2	0.5	-2.6	-0.2
Birth weight of first child	0.1	0.1	0.4	-0.0	0.6	0.2	0.4	0.3	-0.3	0.2
Peak expiratory flow (PEF)	1.5	3.6	5.6	-2.4	2.2	-2.1	-1.6	-1.9	1.0	-1.7
Pulse wave reflection index	0.8	1.0	4.9	-0.8	0.2	-0.5	-0.2	-1.1	-2.2	-0.3
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.3	-0.7	0.4	-0.7	-0.6	-1.2	-0.2	-0.6
Loud music exposure frequency	1.4	1.6	3.8	-1.3	0.9	-1.0	-1.0	-1.0	-1.9	-1.2
Qualifications: O levels/GCSEs or equivalent	4.1	6.5	12.5	-2.5	3.5	-2.5	-2.8	-2.3	0.3	-2.6
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.8	-0.5	0.9	-0.4	-0.9	-0.9	0.1	-0.3
Blood clot in the leg (DVT)	0.2	0.2	0.6	0.2	0.6	-0.3	0.5	-0.5	0.8	-0.1
Medication: Paracetamol	0.4	0.6	1.1	-0.7	1.0	-1.1	-0.8	-0.7	0.3	-0.8
Headache pain in last month	0.3	0.6	3.1	0.5	1.8	-0.3	0.3	-0.3	0.4	-0.2
Medication for cholesterol, blood pressure or diabetes	2.1	3.5	6.2	1.9	1.1	2.1	1.7	2.5	0.9	2.2
Glaucoma (self-reported)	1.6	1.9	3.4	-1.8	0.3	-1.5	-1.8	-1.5	0.3	-1.5
Gout (self-reported)	1.2	1.7	2.9	1.4	-1.7	1.2	1.6	1.0	-0.1	1.4
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.1	0.9	-0.5	0.8	1.1	-0.3	-0.2	1.1
Medication: Amlodipine	1.9	2.7	4.7	-1.8	0.6	-1.9	-2.2	-2.1	0.1	-1.6
Medication: Ventolin 100micrograms inhaler	1.2	1.5	2.4	-0.5	1.6	-1.3	-1.2	-1.1	1.4	-1.3
Birth weight	0.2	0.4	0.8	-0.4	0.5	-0.7	-0.4	-0.9	-0.6	-0.5
Chronic bronchitis/emphysema (mother)	0.4	0.5	2.0	-0.2	-1.0	-0.1	0.0	-0.7	-1.4	0.2
High blood pressure (siblings)	0.4	0.6	1.7	-0.8	0.5	-1.1	-0.2	-1.3	0.2	-0.7
Forced vital capacity (FVC), Best measure	1.0	3.7	8.8	-1.2	3.0	-1.9	-1.6	-1.2	1.9	-2.1
Body fat percentage	2.6	10.3	22.6	-2.4	1.5	-3.9	-1.6	-3.5	4.8	-3.3
Leg fat percentage (right)	1.2	4.2	11.8	-1.3	0.5	-2.5	-0.8	-2.3	3.4	-1.9
Arm fat-free mass (right)	0.5	2.6	8.3	-1.4	1.1	-1.7	-0.7	-1.1	2.9	-1.4
Exposure to tobacco smoke outside home	0.3	0.4	0.8	0.5	0.9	0.5	0.3	0.6	0.7	0.7
Comparative body size at age 10	0.3	0.9	1.8	-0.5	-0.5	-1.0	-1.0	-0.5	-1.3	-1.3
Number of full brothers	0.2	0.3	0.9	0.5	0.3	0.4	-0.5	0.6	1.0	0.3
Worry too long after embarrassment	0.6	1.0	2.0	-1.4	-0.3	-1.1	-1.2	-1.0	-0.4	-1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.1	2.9	-0.6	1.7	-0.9	-1.1	-0.9	-0.9	-1.1
Wheeze or whistling in the chest in last year	0.8	1.4	4.8	-1.0	0.6	-1.3	-0.5	-1.0	2.2	-0.9
Number of children fathered	0.5	0.6	1.2	-1.1	-0.3	-1.1	-0.3	-0.9	-0.0	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.9	-0.4	0.3	-0.6	-0.2	-0.8	1.0	-0.3
Age at first live birth	0.2	0.3	1.0	-1.0	-0.2	-0.4	-0.6	-0.2	0.2	-0.5
Pulse wave peak to peak time	2.2	2.5	3.5	1.8	0.1	1.6	1.9	1.9	1.4	1.7
Health satisfaction	0.1	0.1	0.2	0.3	0.5	-0.2	0.4	0.0	0.1	-0.2
Shortness of breath walking on level ground	0.2	0.2	0.6	0.3	0.8	0.1	-0.5	0.6	0.5	-0.3
Qualifications: College or University degree	0.0	0.1	0.3	0.1	-0.3	0.5	0.1	0.5	0.2	0.5
Eye problems/disorders: None of the above	3.6	4.2	6.7	2.5	-0.9	2.2	2.6	2.3	0.3	2.2
Mouth/teeth dental problems: Loose teeth	0.2	0.3	1.9	-0.2	-0.0	0.0	-0.2	-0.1	1.4	0.1
Emphysema/chronic bronchitis	0.7	0.8	2.4	-0.1	-1.5	-0.2	-0.3	-0.6	-1.5	-0.3
Medication for pain relief, constipation, heartburn	2.4	4.1	6.5	2.2	-0.4	2.5	2.3	2.2	-0.5	2.5
Neck or shoulder pain in last month	0.7	1.0	1.7	-0.9	0.9	-1.3	-0.8	-1.2	-0.5	-1.2
Medication: Blood pressure	4.0	7.0	11.5	-2.8	-0.3	-3.2	-3.0	-3.1	-1.2	-3.4
Angina (self-reported)	0.0	0.0	0.1	-0.0	-0.0	-0.1	0.2	-0.3	-0.0	0.0
Migraine (self-reported)	0.5	0.6	2.6	-0.0	1.6	-0.8	-0.3	-0.7	-0.3	-0.7
Medication: Ibuprofen	0.2	0.2	0.6	-0.4	0.3	-0.4	-0.4	-0.3	0.8	-0.4
Medication: Allopurinol	0.5	0.7	2.7	0.7	-1.7	0.4	0.8	0.4	-0.6	0.4
Medication: Omeprazole	0.6	0.7	1.6	-1.2	0.2	-0.8	-0.3	-1.3	1.0	-0.3
Medication: Seretide 50 evohaler	0.8	0.9	1.9	1.1	-1.4	0.8	1.2	0.4	0.6	1.0
Mean time to correctly identify matches	1.1	2.0	3.7	1.9	-0.0	1.7	1.0	1.8	-1.5	1.2
Heart disease (mother)	0.1	0.1	0.6	-0.4	-0.8	-0.1	-0.1	-0.2	0.1	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.0	0.4	-1.0	0.4	0.8	0.1	-0.7	0.5
Whole body fat mass	2.8	11.6	24.3	-2.7	1.5	-4.2	-1.8	-3.6	4.9	-3.6
Leg fat mass (right)	1.8	6.8	16.9	-1.9	1.1	-3.2	-1.2	-2.7	4.1	-2.7
Arm predicted mass (right)	0.4	2.3	7.9	-1.3	1.0	-1.6	-0.5	-1.0	2.8	-1.2
Pulse rate, automated reading	0.4	1.3	2.6	-0.7	0.7	-1.2	-1.6	-0.5	1.1	-1.5
Alcohol intake frequency.	0.3	0.8	1.5	-0.6	0.6	-1.2	-0.6	-1.2	-0.1	-1.1
Comparative height size at age 10	0.5	2.5	7.3	-1.2	0.9	-1.9	-0.1	-1.6	2.7	-1.5
Number of full sisters	1.0	1.2	5.3	-0.6	2.3	-0.6	-0.5	-0.3	-1.1	-0.7
Suffer from ‘nerves’	2.4	3.7	9.3	-1.6	3.0	-1.8	-2.0	-1.9	0.9	-1.7
Overall health rating	0.4	0.8	4.5	0.1	0.6	-0.4	-0.2	-0.7	2.1	-0.3
Chest pain or discomfort	0.3	0.5	3.2	-0.1	1.8	-0.1	-0.2	-0.3	-0.3	0.0
Had major operations	2.1	2.5	4.8	-2.0	0.7	-1.6	-2.2	-1.5	-0.4	-1.8
Age at last live birth	0.1	0.2	0.3	-0.3	-0.5	-0.2	-0.6	-0.1	-0.5	-0.6
Family relationship satisfaction	0.2	0.3	0.7	0.5	-0.3	0.4	0.8	0.3	-0.8	0.3
Leg pain on walking	0.7	0.9	2.4	-0.4	-1.1	-1.2	-0.8	-0.7	-0.4	-1.5
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	2.0	-0.4	1.4	-0.5	-0.7	-0.6	-0.2	-0.5
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.3	-0.6	0.2	-0.2	0.5	-0.0	0.0	-0.0
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	2.8	1.6	-1.1	1.2	1.1	0.9	1.7	1.2
Medication: Aspirin	2.1	2.8	6.0	-1.6	0.2	-1.8	-2.4	-1.8	-0.3	-2.1
Supplements: Vitamin C	0.1	0.2	0.9	0.3	0.1	-0.0	0.3	0.1	-1.0	-0.3
Knee pain experienced in last month	0.8	1.3	2.2	1.0	-0.0	1.4	1.5	1.3	0.3	1.5
Hypertension (Self-reported)	1.7	4.8	7.9	-2.2	-0.0	-2.8	-2.5	-2.6	0.2	-2.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.7	0.3	-0.8	0.4	0.8	0.5	0.1	0.4
Illnesses of father: Heart disease	0.3	0.5	0.8	-0.7	-0.6	-0.7	-0.6	-0.9	-0.4	-0.7
Illnesses of siblings: Diabetes	0.5	0.6	1.2	-0.3	-0.1	-1.0	-0.9	-1.0	0.0	-1.1
Smoking status: Previous	0.6	0.8	1.3	-0.9	0.2	-1.0	-1.1	-1.1	0.7	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	1.7	3.6	8.9	-1.2	2.5	-2.0	-0.6	-1.1	3.0	-1.8
Whole body fat-free mass	0.5	3.0	7.5	-1.4	1.3	-2.0	-0.8	-1.5	2.7	-1.7
Leg fat-free mass (right)	1.3	7.1	13.0	-2.4	2.0	-3.1	-1.8	-2.5	3.6	-2.8
Arm fat percentage (left)	2.3	9.3	19.2	-2.3	1.1	-3.8	-1.9	-3.4	4.4	-3.3
Average weekly red wine intake	3.6	5.3	8.3	-2.9	1.4	-2.6	-2.3	-2.8	-1.2	-2.4
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	-0.1	0.3	-0.2	0.0	-0.5	0.2	-0.2
Mood swings	0.4	0.8	2.3	-0.2	1.5	-0.8	-0.9	-0.7	0.1	-0.9
Loneliness, isolation	0.3	0.4	0.6	0.3	0.1	-0.7	-0.7	-0.8	0.5	-0.8
Long-standing illness, disability or infirmity	0.5	0.7	2.6	-0.3	1.5	0.0	-0.4	-0.4	1.6	0.1
Ever had bowel cancer screening	0.2	0.3	0.9	0.7	0.0	0.1	0.8	0.2	0.9	0.3
Diabetes diagnosed by doctor	0.3	0.5	2.8	0.4	-0.6	0.2	-0.1	-0.2	1.7	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	1.0	-1.0	0.2	-1.0	-0.3	-1.0	-0.6	-0.8
Friendships satisfaction	0.2	0.2	0.7	-0.6	0.3	-0.3	-0.8	-0.1	-0.1	-0.7
Qualifications: nursing, teaching	1.0	1.6	2.6	1.2	-0.8	1.4	1.6	1.5	-0.5	1.5
Commuting to job workplace: Walk	0.6	0.6	2.8	0.2	-1.7	0.5	-0.2	-0.1	-1.0	0.3
Eye problems/disorders: Cataract	1.1	1.3	2.6	-1.6	0.5	-1.3	-0.9	-1.6	-0.2	-1.0
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	2.8	1.1	0.7	1.4	0.6	1.0	-1.7	1.1
Medication for cholesterol	1.4	2.2	4.6	1.0	-1.1	1.5	2.2	1.3	-0.7	1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.7	3.5	-1.7	0.8	-1.8	-0.5	-1.9	-0.1	-1.1
Back pain experienced in last month	1.4	2.1	4.0	-1.3	1.1	-2.0	-1.1	-1.4	0.8	-2.0
Mineral and other dietary supplements	1.2	1.6	3.9	2.0	-1.0	1.2	1.0	1.3	-1.3	0.7
Breast cancer (self-reported)	1.4	1.7	2.8	-1.2	1.1	-1.3	-1.3	-1.2	1.7	-1.3
Asthma (self-reported)	0.3	0.7	3.4	0.8	0.2	0.2	0.7	0.3	1.8	0.3
Osteoporosis (self-reported)	3.1	3.8	6.1	2.5	-0.5	2.1	2.4	2.4	0.2	2.0
Osteoarthritis (self-reported)	1.1	1.4	2.9	1.2	-0.4	1.7	0.9	1.4	-0.0	1.6
Medication: Aspirin	2.0	2.6	5.1	-1.6	0.4	-1.7	-2.3	-1.6	-0.3	-2.1
Medication: Gliclazide	1.1	1.2	2.0	1.4	-0.6	1.4	1.0	1.2	-0.3	1.3
Illnesses of father: None of the above (group 1)	1.9	2.4	4.2	1.3	-0.1	1.9	1.8	1.6	-1.0	2.1
Smoking status: Current	0.1	0.1	0.5	0.1	0.7	-0.1	0.1	-0.2	0.5	0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	2.2	0.0	1.5	0.5	-0.4	0.6	-1.3	0.1
Whole body water mass	0.5	2.9	6.9	-1.5	1.2	-2.0	-0.9	-1.5	2.6	-1.7
Leg predicted mass (right)	1.3	6.7	12.7	-2.3	2.0	-3.0	-1.7	-2.4	3.6	-2.7
Arm fat mass (left)	2.2	9.2	19.1	-2.3	1.5	-3.7	-1.7	-3.3	4.4	-3.2
Number of self-reported non-cancer illnesses	0.7	1.2	2.3	-0.7	0.7	-1.3	-1.2	-1.2	0.5	-1.5
Average weekly champagne plus white wine intake	0.1	0.1	0.3	0.1	-0.2	-0.0	0.5	0.2	0.4	0.1
Miserableness	1.0	1.7	3.3	1.7	-0.8	1.3	1.8	1.2	0.1	1.3
Guilty feelings	0.4	0.7	1.1	-0.9	0.2	-1.0	-0.7	-1.0	0.9	-0.7
Wears glasses or contact lenses	0.3	0.4	1.5	0.6	-0.4	0.5	0.4	0.1	-1.2	0.3
Ever taken oral contraceptive pill	0.7	0.8	4.2	-0.2	2.0	-0.2	-0.9	-0.1	0.5	-0.3
Hearing aid user	0.5	0.6	1.0	-0.8	0.0	-1.0	-0.7	-0.7	0.7	-1.0
Mother’s age at death	1.5	1.9	3.4	0.8	-0.4	1.9	1.3	1.6	-1.5	1.7
Financial situation satisfaction	0.3	0.4	0.7	-0.7	-0.8	-0.8	0.0	-0.7	0.3	-0.4
Tinnitus: Yes, now most or all of the time	2.8	3.3	4.8	1.8	-2.2	2.2	1.3	2.1	-1.1	1.6
Commuting to job workplace: Public transport	0.4	0.4	1.0	-0.6	-0.3	-0.7	-1.0	-0.8	0.3	-0.7
Eye problems/disorders: Glaucoma	2.5	3.0	5.7	-2.4	0.2	-1.9	-2.0	-2.1	0.2	-1.8
Medication: Blood pressure	0.4	0.8	1.5	-0.5	0.6	-1.0	-1.2	-0.7	0.9	-1.1
Pain type(s) experienced in last month: Hip pain	0.6	0.7	1.2	-0.9	0.5	-0.8	-1.1	-0.9	-0.5	-1.0
Supplements: Fish oil (including cod liver oil)	0.6	0.8	2.0	-1.4	0.9	-0.7	-0.4	-1.0	1.1	-0.3
High cholesterol (Self-reported)	1.0	1.8	3.8	-1.2	-0.7	-0.9	-1.9	-1.0	-1.7	-1.4
Medication: Bendroflumethiazide	0.5	0.7	1.9	1.0	-1.4	0.6	0.9	0.5	-0.4	0.6
Medication: Paracetamol	0.4	0.6	1.1	-0.5	1.0	-1.1	-0.6	-0.6	0.4	-0.9
Medication: Lisinopril	1.3	1.7	3.3	-1.2	0.1	-1.8	-1.2	-1.5	0.7	-1.8
Medication: Atorvastatin	1.6	1.9	5.2	-1.3	-0.4	-1.0	-1.7	-1.2	-2.3	-1.1
Illnesses of father: High blood pressure	2.3	2.8	5.5	-0.9	1.4	-2.1	-1.6	-1.5	1.5	-2.3
Alcohol drinker status: Never	2.0	2.4	4.8	1.7	-1.2	1.5	2.2	0.8	-1.1	1.8
Ever smoked	0.8	1.5	2.5	-0.7	1.3	-1.0	-1.6	-1.0	1.3	-1.4
Basal metabolic rate	0.8	4.5	10.6	-1.7	1.6	-2.5	-1.1	-1.9	3.2	-2.1
Leg fat percentage (left)	1.5	5.3	13.4	-1.6	1.0	-2.8	-0.9	-2.5	3.7	-2.2
Arm fat-free mass (left)	0.4	2.1	6.3	-1.1	1.1	-1.6	-0.4	-1.2	2.5	-1.3
Number of operations (self-reported)	0.5	0.7	2.0	-0.9	1.4	-0.6	-0.8	-0.7	0.1	-0.6
Average weekly beer plus cider intake	0.2	0.2	0.5	0.7	0.4	0.5	0.6	0.5	0.2	0.4
Irritability	0.6	1.1	2.4	-0.6	0.8	-1.2	-1.3	-0.9	-0.1	-1.6
Risk taking	0.1	0.2	0.8	0.6	-0.2	-0.2	0.9	-0.1	-0.3	0.2
Ever had prostate specific antigen (PSA) test	0.3	0.4	1.2	1.1	-0.4	0.5	0.9	0.2	-0.1	0.4
Fractured/broken bones in last 5 years	1.9	2.5	3.9	-2.0	0.9	-1.8	-1.5	-1.0	1.8	-1.8
Age started oral contraceptive pill	2.9	3.6	6.4	1.9	-2.5	2.1	1.9	1.9	-0.2	2.0
Diastolic blood pressure, automated reading	0.6	1.7	9.9	-0.3	0.0	-1.0	0.8	-0.6	3.1	-0.5
Ever depressed for a whole week	0.0	0.0	0.3	-0.0	0.6	0.0	0.1	0.0	-0.0	0.1
Unable to work because of sickness or disability	0.5	0.7	1.9	0.8	1.4	0.7	1.1	0.5	-0.5	0.6
Commuting to job workplace: Cycle	1.8	2.2	3.5	1.1	-1.7	1.6	1.8	1.2	0.5	1.9
Myopia	0.6	0.8	1.3	1.0	-1.0	1.0	0.8	1.2	-0.4	0.8
Vascular/heart problems diagnosed by doctor	1.6	4.3	7.7	2.0	0.1	2.8	2.2	2.5	-0.2	2.8
Cholesterol lowering medication	0.6	0.9	1.8	-0.9	0.8	-0.7	-1.2	-0.6	1.4	-0.8
Medication: Omeprazole (e.g. Zanprol)	2.5	3.0	5.4	-2.3	1.3	-2.0	-1.4	-2.3	0.8	-1.5
Pain experienced in last month	0.4	0.7	1.4	0.4	-0.4	1.2	0.6	1.1	0.1	1.2
Supplements: Calcium	0.3	0.4	1.0	0.1	0.6	-0.7	-0.2	-0.7	1.0	-0.6
Basal cell carcinoma (self-reported)	0.2	0.2	0.6	-0.1	0.8	0.4	-0.2	0.4	0.7	0.4
Heart attack/myocardial infarction (self-reported)	0.0	0.0	0.1	-0.2	-0.3	-0.1	-0.1	-0.1	-0.3	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.4	0.2	0.4	-0.3	0.4	-0.5	0.7	-0.1
Heart disease (siblings)	0.2	0.2	0.7	0.4	-0.5	0.2	0.3	0.1	-0.8	0.0
Alcohol drinker status: Previous	0.4	0.5	1.3	-0.2	-0.7	-0.9	-0.7	-0.6	-0.1	-1.2
Pack years of smoking	0.3	0.4	0.6	0.8	0.6	0.8	0.6	0.6	0.2	0.8
Impedance of whole body	0.2	1.0	1.8	-0.5	1.3	-1.1	-0.5	-0.9	1.1	-1.1
Leg fat mass (left)	1.8	7.1	17.6	-2.0	1.2	-3.3	-1.2	-2.8	4.2	-2.7
Arm predicted mass (left)	0.3	1.7	7.1	-0.9	0.8	-1.3	0.1	-0.9	2.7	-0.9