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chr16:3,301,360-5,706,977

Best TWAS P=1.86e-20 · Best GWAS P=1.71e-26 conditioned to 6.11e-08

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Artery Aorta	UBN1	0.18	0.15	lasso	4	0.14	6.8e-08	6.9	-6.3	2.8e-10	-0.04	0.05	0.95	FALSE
2	GTEx	Artery Tibial	UBN1	0.20	0.06	lasso	7	0.07	4.8e-06	5.7	-5.5	3.1e-08	-0.02	0.14	0.86	FALSE
3	GTEx	Brain Cerebellar Hemisphere	ZNF500	0.27	0.13	enet	13	0.12	4.4e-04	3.5	6.1	1.4e-09	0.00	0.22	0.44	TRUE
4	GTEx	Brain Cortex	ZNF500	0.18	0.02	enet	8	0.04	2.5e-02	-4.8	6.0	2.1e-09	0.05	0.08	0.14	FALSE
5	GTEx	Brain Frontal Cortex BA9	ROGDI	0.19	0.03	enet	43	0.05	2.0e-02	6.3	-5.5	5.1e-08	-0.06	0.03	0.82	FALSE
6	GTEx	Brain Putamen basal ganglia	ROGDI	0.41	0.38	lasso	7	0.30	7.9e-08	4.9	-5.3	1.3e-07	-0.06	0.07	0.91	FALSE
7	GTEx	Cells Transformed fibroblasts	RP11-95P2.1	0.13	0.11	lasso	3	0.12	2.0e-09	5.2	-5.6	2.1e-08	0.05	1.00	0.00	FALSE
8	GTEx	Esophagus Mucosa	ZNF500	0.12	0.03	lasso	4	0.03	2.5e-03	3.1	5.2	1.8e-07	-0.05	0.35	0.19	FALSE
9	GTEx	Esophagus Mucosa	UBN1	0.12	0.06	lasso	3	0.08	5.1e-06	6.3	-6.5	7.4e-11	-0.05	0.10	0.90	FALSE
10	GTEx	Esophagus Muscularis	UBN1	0.18	0.19	lasso	4	0.19	9.1e-12	6.9	-6.7	2.6e-11	-0.04	0.06	0.94	FALSE
11	GTEx	Muscle Skeletal	ZNF500	0.06	0.00	enet	15	0.00	2.8e-01	3.5	6.0	1.8e-09	0.05	0.06	0.15	FALSE
12	GTEx	Nerve Tibial	UBN1	0.14	0.12	lasso	4	0.11	5.6e-08	6.7	-6.8	1.5e-11	-0.04	0.08	0.92	TRUE
13	GTEx	Skin Not Sun Exposed Suprapubic	UBN1	0.22	0.16	lasso	4	0.14	2.5e-08	6.2	-5.9	3.8e-09	-0.04	0.10	0.90	FALSE
14	GTEx	Skin Sun Exposed Lower leg	ZNF500	0.13	0.09	enet	13	0.11	4.7e-09	3.0	5.5	4.5e-08	-0.01	0.99	0.01	FALSE
15	GTEx	Skin Sun Exposed Lower leg	PPL	0.10	0.04	lasso	6	0.02	5.7e-03	6.3	6.1	8.7e-10	0.05	0.08	0.72	FALSE
16	GTEx	Skin Sun Exposed Lower leg	UBN1	0.16	0.15	lasso	5	0.17	9.5e-14	6.9	-6.3	2.4e-10	-0.05	0.07	0.93	FALSE
17	GTEx	Testis	ROGDI	0.17	0.09	enet	10	0.10	2.1e-05	5.5	-5.9	2.9e-09	0.01	0.19	0.57	FALSE
18	GTEx	Thyroid	RP11-95P2.1	0.15	0.10	lasso	5	0.10	3.9e-08	5.5	-5.9	4.7e-09	0.03	0.94	0.00	TRUE
19	ROSMAP	Brain Pre-frontal Cortex	ROGDI	0.26	0.30	enet	27	0.30	5.2e-39	-5.0	-5.6	2.8e-08	-0.03	1.00	0.00	FALSE
20	ROSMAP	Brain Pre-frontal Cortex	SEPT12	0.40	0.47	enet	29	0.48	7.1e-71	-4.8	5.5	3.7e-08	0.05	1.00	0.00	FALSE
21	ROSMAP	Brain Pre-frontal Cortex	RP11-462G12.1	0.11	0.07	enet	18	0.06	1.1e-08	-10.3	-9.3	1.9e-20	0.86	0.00	1.00	TRUE
22	YFS	Blood	ZNF500	0.05	0.05	enet	16	0.06	1.6e-17	3.5	5.6	1.8e-08	-0.01	1.00	0.00	FALSE
23	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ZNF500	0.06	0.00	enet	10	0.03	3.1e-03	-5.3	5.7	1.6e-08	-0.01	0.01	0.91	FALSE
24	The Cancer Genome Atlas	Colon Adenocarcinoma	UBN1	0.05	0.04	enet	7	0.05	4.2e-04	-6.2	5.5	4.0e-08	0.06	0.02	0.75	FALSE
25	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ROGDI	0.03	0.04	lasso	3	0.03	1.6e-04	5.7	-5.6	1.9e-08	0.01	0.03	0.92	FALSE
26	The Cancer Genome Atlas	Brain Lower Grade Glioma	ROGDI	0.05	0.02	lasso	2	0.03	6.0e-04	-4.8	-5.3	9.0e-08	-0.05	0.05	0.09	FALSE
27	The Cancer Genome Atlas	Brain Lower Grade Glioma	SEPT12	0.19	0.27	enet	17	0.25	5.4e-28	-4.8	5.2	2.1e-07	0.04	0.20	0.80	FALSE