Best TWAS P=2.02e-09 · Best GWAS P=1.5e-08 conditioned to 0.392
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adrenal Gland | RABEP1 | 0.13 | 0.03 | lasso | 13 | 0.02 | 7.2e-02 | -4.8 | -5.6 | 2.2e-08 | 0.01 | 0.04 | 0.83 | FALSE |
2 | GTEx | Artery Coronary | RP11-810M2.2 | 0.30 | 0.02 | lasso | 4 | 0.02 | 8.5e-02 | 5.6 | 6.0 | 2.0e-09 | 0.89 | 0.02 | 0.81 | TRUE |
3 | GTEx | Brain Putamen basal ganglia | AC012146.7 | 0.30 | 0.03 | enet | 23 | 0.03 | 7.6e-02 | 3.7 | -5.5 | 2.9e-08 | 0.03 | 0.08 | 0.24 | FALSE |
4 | GTEx | Esophagus Gastroesophageal Junction | DHX33 | 0.12 | 0.08 | lasso | 5 | 0.07 | 1.8e-03 | 5.6 | -5.5 | 3.1e-08 | 0.01 | 0.02 | 0.96 | FALSE |
5 | GTEx | Esophagus Gastroesophageal Junction | GP1BA | 0.35 | 0.16 | lasso | 11 | 0.18 | 5.9e-07 | 3.9 | 5.7 | 1.5e-08 | 0.00 | 0.26 | 0.59 | FALSE |
6 | GTEx | Esophagus Muscularis | RABEP1 | 0.13 | 0.09 | lasso | 10 | 0.10 | 2.1e-06 | 5.6 | -5.3 | 1.5e-07 | 0.01 | 0.02 | 0.98 | FALSE |
7 | GTEx | Heart Atrial Appendage | RABEP1 | 0.13 | 0.10 | enet | 11 | 0.12 | 7.2e-06 | 4.6 | -5.1 | 2.7e-07 | 0.02 | 0.06 | 0.92 | FALSE |
8 | GTEx | Muscle Skeletal | ZZEF1 | 0.11 | 0.01 | lasso | 3 | 0.01 | 1.9e-02 | 5.5 | 5.5 | 2.9e-08 | 0.97 | 0.02 | 0.96 | FALSE |
9 | ROSMAP | Brain Pre-frontal Cortex | RABEP1 | 0.20 | 0.22 | bslmm | 546 | 0.20 | 7.4e-25 | 4.4 | -5.1 | 2.7e-07 | 0.02 | 0.62 | 0.37 | FALSE |
10 | ROSMAP | Brain Pre-frontal Cortex | RPAIN | 0.06 | 0.06 | lasso | 3 | 0.06 | 3.1e-08 | 5.6 | -5.9 | 3.3e-09 | 0.01 | 0.00 | 1.00 | TRUE |
11 | The Cancer Genome Atlas | Glioblastoma Multiforme | RABEP1 | 0.23 | 0.13 | blup | 79 | 0.15 | 3.4e-05 | 4.5 | -5.2 | 2.1e-07 | 0.04 | 0.06 | 0.83 | FALSE |
12 | The Cancer Genome Atlas | Thyroid Carcinoma | RABEP1 | 0.04 | 0.03 | enet | 5 | 0.03 | 1.5e-03 | -4.8 | -5.7 | 1.2e-08 | -0.03 | 0.08 | 0.83 | FALSE |