Best TWAS P=3.01e-09 · Best GWAS P=2.22e-08 conditioned to 0.0113
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CCDC134 | 0.06 | 0.07 | enet | 5 | 0.06 | 1.2e-07 | -4.1 | -5.1 | 2.8e-07 | 0.90 | 0.01 | 0.98 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | MEI1 | 0.09 | 0.10 | blup | 343 | 0.10 | 3.1e-12 | 4.0 | 5.4 | 8.2e-08 | -0.60 | 0.56 | 0.40 | FALSE |
| 3 | GTEx | Artery Tibial | ACO2 | 0.06 | 0.02 | enet | 15 | 0.06 | 1.2e-05 | 4.7 | 5.9 | 3.0e-09 | -0.60 | 0.12 | 0.86 | TRUE |
| 4 | GTEx | Nerve Tibial | ACO2 | 0.06 | 0.05 | lasso | 5 | 0.04 | 8.5e-04 | 4.8 | 5.4 | 7.3e-08 | -0.48 | 0.10 | 0.88 | FALSE |
| 5 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | ACO2 | 0.03 | 0.01 | blup | 41 | 0.04 | 3.9e-03 | -3.2 | 5.1 | 2.6e-07 | -0.58 | 0.02 | 0.42 | FALSE |
| 6 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | TOB2 | 0.03 | 0.00 | blup | 28 | 0.02 | 3.4e-03 | 4.9 | 5.5 | 4.5e-08 | -0.55 | 0.02 | 0.35 | FALSE |