Hub : Genes

ACO2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Aorta 0.0800 0.0510 3.3e-03 0.078 NA 0.027 NA 0.061 4.5e-05 NA 1.2e-02 NA 2.8e-04
2 GTEx Artery Tibial 0.0629 0.0271 1.0e-05 0.023 NA 0.063 NA 0.049 6.3e-03 NA 1.2e-05 NA 1.0e-04
3 GTEx Muscle Skeletal 0.0690 0.0335 2.6e-03 0.020 NA 0.008 NA 0.017 4.1e-03 NA 5.0e-02 NA 6.9e-03
4 GTEx Nerve Tibial 0.0582 0.0277 1.6e-04 0.049 NA 0.018 NA 0.039 2.3e-04 NA 1.8e-02 NA 8.5e-04
5 GTEx Ovary 0.1430 0.0710 1.2e-03 0.118 NA 0.077 NA 0.130 7.9e-04 NA 6.1e-03 NA 4.5e-04
6 GTEx Thyroid 0.0770 0.0300 2.3e-07 0.086 NA 0.059 NA 0.095 3.9e-07 NA 2.8e-05 NA 9.6e-08
7 GTEx Uterus 0.1320 0.0630 1.4e-03 0.058 NA 0.083 NA 0.059 2.6e-02 NA 9.5e-03 NA 2.5e-02
8 TCGA Kidney Renal Papillary Cell Carcinoma 0.0340 0.0260 9.6e-03 0.014 0.036 0.023 NA 0.006 4.8e-02 0.0039 1.7e-02 NA 1.3e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bipolar Disorder (2018) 0.1 0.2 0.8 0.1 0.9 0.1 0.7 -0.2 0.1 0.1 0.0
Bipolar Disorder or Schizophrenia 0.7 1.8 3.3 1.1 0.3 -1.7 1.8 1.7 1.2 0.6 1.5
Depressed Affect (Nagel 2018) 8.7 18.2 22.9 4.5 4.5 -2.8 4.8 4.2 4.3 4.3 4.5
Depression (Nagel 2018) 0.8 1.2 2.7 1.1 0.3 -1.2 1.3 1.6 0.9 0.2 1.2
Intelligence (Savage-Jansen 2018) 2.2 6.8 12.7 -2.2 -1.6 2.8 -3.6 -2.6 -2.3 -1.8 -3.3
Neuroticism (Nagel 2018) 11.6 27.3 40.2 5.7 4.5 -2.6 6.3 5.5 5.4 5.6 5.3
Schizophrenia (2018) 1.3 2.7 5.4 1.4 -0.1 -2.3 1.7 2.3 1.4 0.7 1.9
Schizophrenia vs Biploar Disorder 0.4 0.5 1.7 0.4 -1.3 -0.7 0.2 1.0 0.4 0.4 0.7
Worry (Nagel 2018) 6.1 12.8 24.0 3.7 2.6 -0.8 4.9 4.0 3.8 4.0 3.2
Alzheimer’s Disease (in mother) 2.3 2.6 6.9 1.9 0.1 -0.2 1.6 2.6 1.7 1.5 1.8
Alzheimer’s Disease (in father) 0.8 0.9 2.8 0.3 -1.1 -1.4 0.5 1.7 0.3 -0.7 0.7
Alzheimer’s Disease (including proxy) 3.4 4.9 11.5 2.2 0.3 -2.4 2.0 3.4 2.1 1.1 2.6
Crohns Disease (2017) 5.9 13.0 16.1 3.8 3.1 -4.0 3.2 3.7 3.6 3.4 4.0
Irritable Bowel Disease (IBD) 3.5 8.4 14.1 3.0 1.6 -2.8 2.6 3.8 3.3 2.4 3.2
Ulcerative Colitis (UC) 1.2 2.3 5.8 1.5 -0.1 -1.1 1.4 2.4 1.9 0.9 1.6
Major Depression (MDD) 0.1 0.2 0.7 0.1 0.2 0.6 0.9 -0.0 0.2 0.2 -0.1
Reaction Time 2.8 5.3 9.1 -2.3 -3.0 0.5 -2.4 -2.1 -2.6 -2.4 -2.2
Verbal and Numeric Reasoning (VNR) 2.2 5.3 12.6 -2.0 -1.9 1.4 -3.6 -2.3 -2.2 -1.7 -2.8
Breast Cancer 0.6 1.5 4.2 0.8 2.1 -1.8 1.2 0.2 0.7 0.7 1.2
Ovarian Cancer 0.2 0.3 0.7 -0.5 -0.3 0.8 -0.5 -0.2 -0.6 -0.2 -0.8
Prostate Cancer 3.0 4.2 6.6 2.5 1.3 -1.3 1.8 2.5 2.6 1.8 2.2
Age at First Birth 4.8 6.9 11.4 3.0 2.5 -1.6 1.9 3.4 2.9 2.7 2.7
Bipolar Disorder (2011) 0.1 0.1 0.7 -0.2 0.1 -0.8 0.1 -0.1 0.1 -0.3 0.0
Body Mass Index (BMI) (2010) 2.5 3.4 6.2 1.5 2.5 -1.8 2.0 1.7 1.7 1.6 1.8
Coronary Artery Disease (CAD) 0.2 0.2 0.5 -0.2 -0.7 0.7 -0.4 0.2 -0.0 -0.4 -0.4
Crohns Disease (2012) 4.4 7.2 14.6 2.7 2.0 -3.8 2.0 2.9 2.5 2.0 3.0
Mean Putamen Volume 0.3 0.4 0.9 0.4 0.3 -0.3 0.0 0.8 0.9 0.8 0.9
Fasting Glucose 2.5 3.0 4.4 1.8 1.7 -2.1 1.4 1.6 1.7 1.0 2.1
HbA1C 0.3 0.3 1.0 0.1 0.8 -1.0 0.7 0.2 0.3 0.2 0.7
HDL Cholesterol 0.2 0.4 2.0 -0.4 -0.3 1.4 -0.4 -0.7 -0.1 -0.4 -0.5
LDL Cholesterol 0.0 0.1 0.2 -0.2 -0.1 -0.1 -0.2 0.4 0.1 -0.4 0.0
Lupus 0.9 1.4 3.6 1.1 0.7 0.3 1.6 1.9 1.2 0.3 1.2
Neuroticism (2016) 5.9 8.5 13.4 3.2 2.5 -1.5 3.7 2.4 3.2 3.4 2.8
Primary Biliary Cirrhosis 4.2 6.0 8.6 2.8 1.4 -2.4 2.1 2.9 2.4 2.4 2.9
Rheumatoid Arthritis 1.5 2.0 3.9 -1.5 -1.7 0.9 -1.4 -1.1 -1.3 -2.0 -1.3
Schizophrenia (2014) 0.8 1.8 6.3 0.8 -0.6 -2.5 1.2 1.8 0.7 0.2 1.4
Triglycerides 0.2 0.3 0.8 0.4 0.0 -0.9 0.6 0.1 0.5 0.8 0.4
Type 2 Diabetes (T2D) (2012) 0.6 0.6 1.3 -0.8 -1.1 0.9 -0.6 -0.5 -0.5 -0.8 -0.9
Ulcerative Colitis 0.4 0.6 1.3 0.8 0.2 -0.6 0.9 0.9 1.1 0.5 0.9
Blood Eosinophil Count 9.6 74.1 112.4 9.7 5.9 -4.8 7.8 10.6 9.9 9.3 9.2
Blood Platelet Count 1.6 18.0 28.0 -5.1 -2.8 4.0 -3.5 -4.0 -4.4 -4.3 -5.3
Blood Red Count 0.2 1.8 3.8 -1.3 -1.3 0.7 -1.4 -0.7 -2.0 -1.5 -1.5
Blood White Count 0.2 1.5 4.5 -0.3 -2.1 1.9 0.3 1.6 -0.4 -0.5 -0.8
Heel T-Score 1.7 13.2 24.2 4.8 1.7 -1.2 2.6 3.5 4.7 4.9 3.6
BMI 1.3 7.8 22.3 2.1 4.7 -2.2 3.2 1.3 2.3 2.1 3.0
Height 1.0 19.2 85.0 3.3 5.2 -9.2 1.5 -0.2 2.1 2.3 4.3
Waist Hip Ratio (WHR) 0.2 0.8 2.7 0.8 -1.6 -1.5 -0.2 0.7 0.4 0.1 0.5
Systolic Blood Pressure 0.1 0.7 2.7 -0.2 -1.6 -0.3 0.2 1.6 -0.5 -0.3 -0.2
Smoking Status 9.3 22.2 31.0 -4.8 -4.9 5.6 -4.4 -4.0 -4.0 -4.4 -5.4
Allergy or Eczema 10.9 28.8 36.0 6.0 4.8 -4.3 5.2 5.2 5.8 5.6 5.7
Cardiovascular Disease 0.8 2.6 5.9 1.6 0.6 -0.7 2.4 2.1 1.5 1.5 1.7
Hypothyroidism (self reported) 8.0 18.3 27.5 -4.8 -3.7 1.0 -5.2 -4.3 -4.7 -4.8 -4.2
Respiratory disease 12.4 27.5 38.6 5.9 4.1 -4.6 4.8 5.1 5.5 5.4 6.2
Type 2 Diabetes (T2D) (2018) 2.4 4.4 5.9 2.0 2.0 -2.1 2.4 1.8 2.0 2.0 2.4
Lung FEV1/FVC ratio 2.1 10.6 25.4 2.9 3.6 -0.9 5.0 3.7 3.0 2.5 3.0
Lung FVC 1.4 7.2 11.3 -3.1 -2.0 2.9 -2.8 -1.7 -2.8 -2.4 -3.4
Neuroticism 7.7 18.7 32.1 4.6 3.4 -1.6 5.7 4.6 4.7 4.6 4.2
Chronotype (morning person) 3.7 8.5 19.5 2.9 2.9 -4.4 2.8 1.1 2.0 2.7 3.3
Hair Pigment 0.6 15.9 20.9 -4.3 -3.9 2.4 -4.6 -4.3 -4.1 -4.1 -4.0
Tanning 0.5 5.8 10.2 -2.4 -1.5 1.2 -2.8 -3.2 -2.8 -2.4 -2.4
Hand grip strength (left) 0.7 1.8 4.0 -1.8 -0.0 -0.4 -1.2 -1.6 -1.2 -2.0 -1.3
Number of treatments/medications taken 2.8 5.0 7.3 2.1 2.1 -2.2 2.5 2.7 2.2 1.7 2.3
Average weekly spirits intake 4.1 5.1 8.1 -2.6 -1.6 0.9 -2.4 -2.1 -2.3 -2.9 -2.5
Sensitivity / hurt feelings 2.4 4.0 6.0 2.5 1.4 -1.5 2.4 1.5 2.0 2.4 2.0
Frequency of depressed mood in last 2 weeks 1.8 2.6 4.2 1.7 1.3 -1.6 1.5 2.0 1.6 1.0 1.7
Hearing difficulty/problems: Yes 0.9 1.4 2.4 -0.9 -0.8 0.1 -1.4 -1.6 -1.4 -1.4 -1.1
Relative age of first facial hair 3.0 6.3 8.1 2.8 2.4 -0.5 2.6 2.8 2.9 2.7 2.5
Other serious medical condition/disability diagnosed by doctor 0.2 0.2 0.5 0.4 -0.1 -0.7 0.2 0.3 0.5 0.7 0.4
Ever used hormone-replacement therapy (HRT) 0.2 0.2 1.0 0.3 0.0 -1.0 -0.5 -0.3 -0.2 -0.2 0.3
Ever had hysterectomy (womb removed) 0.3 0.4 1.0 0.6 0.6 0.2 0.8 -0.1 0.7 1.0 0.4
Systolic blood pressure, automated reading 0.2 0.5 1.3 -0.5 -1.1 -0.1 0.3 1.1 -0.6 -0.9 -0.1
Eye problems/disorders: Diabetes related eye disease 1.0 1.1 3.3 0.7 1.8 -0.7 1.2 0.7 0.8 1.0 0.8
Angina 1.3 1.7 6.3 1.0 0.3 -2.5 0.6 1.3 1.1 0.9 1.6
Medication for hormone replacement therapy 0.4 0.5 1.3 -0.7 -0.2 0.3 -0.4 -1.1 -0.7 -1.1 -0.6
Vitamin and mineral supplements 3.2 4.3 9.3 -2.0 -2.1 3.0 -1.6 -1.5 -1.8 -1.8 -2.4
Supplements: Zinc 1.4 1.5 2.5 1.2 1.3 0.3 1.4 1.4 1.3 1.6 0.9
Medication: Co-codamol 1.3 1.5 2.5 -1.4 -0.8 0.8 -1.1 -1.3 -1.2 -1.4 -1.6
Medication: Metformin 0.0 0.0 0.1 -0.2 -0.0 0.1 0.1 -0.3 -0.4 -0.2 -0.1
Diabetes (father) 0.8 0.9 2.3 0.9 0.5 -1.5 1.0 0.8 0.6 0.7 1.2
Diabetes (mother) 4.4 5.6 8.5 -2.5 -2.9 1.7 -2.3 -1.6 -2.4 -2.9 -2.3
Severe depression (siblings) 0.1 0.1 0.2 0.2 0.0 -0.3 0.3 0.4 0.2 0.2 0.4
Pack years adult smoking proportion 2.9 4.4 6.2 -2.4 -2.2 0.8 -2.1 -1.5 -2.5 -2.4 -2.2
Impedance of leg (right) 1.4 6.8 12.7 3.3 -0.3 -1.5 1.7 3.6 2.9 2.9 2.9
Leg fat-free mass (left) 1.3 6.9 24.0 1.7 4.9 -3.3 2.5 -0.1 1.7 1.6 2.4
Trunk fat percentage 7.7 30.9 38.6 5.9 5.8 -2.7 6.2 5.2 6.1 5.9 5.9
Hand grip strength (right) 0.6 1.5 3.0 -1.4 -0.1 -1.1 -1.3 -1.6 -1.1 -1.7 -0.8
Townsend deprivation index at recruitment 0.1 0.2 1.0 0.1 -0.1 0.2 -0.2 -1.0 0.0 -0.3 -0.1
Current tobacco smoking 16.3 26.7 34.1 -5.3 -5.0 5.4 -5.0 -4.9 -4.6 -5.1 -5.8
Average weekly fortified wine intake 0.3 0.4 0.8 0.8 0.3 -0.3 -0.4 0.9 0.5 0.8 0.5
Maternal smoking around birth 10.4 15.0 20.9 -4.1 -3.3 2.1 -3.9 -3.8 -4.5 -4.6 -4.1
Fed-up feelings 8.0 14.5 18.4 4.1 4.3 -2.9 3.9 3.3 3.9 4.0 3.9
Frequency of unenthusiasm / disinterest in last 2 weeks 3.0 4.0 6.6 2.3 1.5 -1.5 2.6 2.1 2.0 1.4 2.3
Relative age voice broke 1.3 2.0 4.3 1.6 0.6 -1.1 1.3 2.1 1.5 0.9 1.7
Taking other prescription medications 4.1 6.4 9.6 2.6 2.3 -1.4 2.9 3.1 2.6 2.5 2.6
Age when periods started (menarche) 1.1 2.6 6.9 -1.5 -2.6 1.8 -1.8 -0.3 -0.6 -1.2 -1.7
Bilateral oophorectomy (both ovaries removed) 0.1 0.1 0.4 0.1 -0.0 -0.5 0.1 -0.5 -0.6 -0.0 0.1
Heel bone mineral density (BMD) T-score, automated (left) 2.2 4.9 8.5 2.8 1.0 -0.1 2.4 2.2 2.9 2.7 2.0
Tinnitus: Yes, but not now, but have in the past 0.5 0.5 0.9 -0.9 -0.5 0.6 -0.4 -0.7 -0.9 -0.8 -0.7
Qualifications: CSEs or equivalent 0.8 1.1 1.9 1.2 0.9 -0.4 1.1 0.8 1.2 0.9 1.4
Serious illness, injury or assault to yourself 2.9 3.5 8.9 2.1 1.3 -3.0 1.3 1.5 1.6 1.5 2.2
High blood pressure 0.1 0.3 0.9 0.4 -0.2 0.1 1.0 0.8 0.6 0.0 0.4
Hayfever, allergic rhinitis or eczema 8.8 19.2 25.3 5.0 4.0 -4.0 4.1 3.9 4.5 4.6 4.7
Multivitamins +/- minerals 3.1 3.9 7.1 1.8 1.8 -2.7 1.8 1.8 2.0 1.4 2.2
Stomach or abdominal pain in last month 0.4 0.5 1.3 -0.9 -0.9 -0.2 -0.3 0.1 -0.8 -1.1 -0.6
Supplements: Glucosamine 0.7 0.9 1.6 -0.9 -0.3 0.8 -1.3 -1.0 -1.0 -0.9 -1.2
Diverticular disease/diverticulitis (self-reported) 2.0 2.3 3.5 -1.9 -1.4 0.8 -1.6 -1.5 -1.7 -1.2 -1.8
Medication: Atenolol 2.3 2.8 5.6 -1.6 -1.6 -0.6 -1.5 -2.1 -2.4 -1.6 -1.4
Medication: Levothyroxine sodium 7.1 12.0 16.2 -3.7 -3.9 0.6 -4.0 -2.8 -3.9 -4.0 -3.3
Sitting height 0.6 4.2 18.6 0.6 3.2 -4.3 0.0 -1.5 -0.0 0.4 1.3
Chronic bronchitis/emphysema (father) 0.4 0.5 1.3 -0.9 -0.6 -0.7 -0.4 -1.2 -0.3 -0.9 -0.3
High blood pressure (mother) 0.2 0.3 0.8 -0.5 -0.8 -0.3 -0.1 0.2 -0.5 -0.9 -0.1
Body mass index (BMI) 1.0 4.3 13.0 1.5 3.6 -1.0 2.7 1.3 1.8 1.6 2.0
Impedance of leg (left) 1.3 6.5 10.9 3.3 -0.2 -1.7 1.7 3.3 2.9 2.8 2.9
Leg predicted mass (left) 1.3 7.1 24.4 1.7 4.9 -3.4 2.5 -0.1 1.8 1.7 2.5
Trunk fat mass 5.4 23.4 35.2 4.8 5.9 -3.2 5.4 3.8 5.0 4.8 5.1
Waist circumference 1.9 7.1 11.7 2.6 3.4 -2.1 3.1 2.0 2.6 2.3 2.9
Number of incorrect matches in round 1.7 2.8 5.8 1.4 2.2 -0.5 2.4 1.3 1.6 1.8 1.6
Past tobacco smoking 0.2 0.4 0.6 -0.6 0.6 -0.6 -0.6 -0.8 -0.6 -0.8 -0.2
Alcohol usually taken with meals 0.7 1.2 3.1 0.8 1.5 -1.7 0.7 0.6 0.8 1.1 1.1
Nervous feelings 2.3 4.3 7.6 2.4 0.5 -0.4 2.8 2.7 2.2 2.3 1.6
Frequency of tenseness / restlessness in last 2 weeks 3.1 4.9 7.9 2.5 1.4 -1.4 2.6 2.8 2.5 1.8 2.3
Hearing difficulty/problems with background noise 0.2 0.4 0.7 -0.4 -0.7 0.2 -0.1 -0.6 -0.7 -0.9 -0.7
Hair/balding pattern: Pattern 2 0.2 0.3 1.0 -0.1 -0.2 -1.0 0.1 0.9 -0.1 -0.7 0.1
Had menopause 0.3 0.4 0.7 -0.4 -0.4 0.8 -0.8 -0.3 -0.4 -0.7 -0.6
Had other major operations 0.4 0.5 1.4 0.6 0.7 0.7 0.8 -0.1 0.9 1.2 0.0
Forced vital capacity (FVC) 0.4 1.5 4.2 1.0 2.1 -1.7 0.5 0.4 0.9 1.1 1.2
Heel bone mineral density (BMD) T-score, automated (right) 1.7 3.8 6.1 2.4 0.8 -0.1 2.4 1.8 2.5 2.4 1.8
Ever unenthusiastic/disinterested for a whole week 2.1 2.5 4.4 1.4 1.7 -2.1 2.1 1.6 0.9 0.6 1.6
Qualifications: None of the above 0.7 1.6 4.6 -1.4 -2.1 1.3 -0.5 -0.4 -0.9 -1.5 -0.9
Financial difficulties in last 2 years 0.1 0.1 0.5 0.2 -0.7 -0.1 -0.5 -0.5 0.0 -0.0 0.0
Mouth/teeth dental problems 0.4 0.6 1.2 0.9 0.3 -0.9 0.6 0.6 0.7 0.9 1.1
Heart attack 0.2 0.3 1.3 0.2 0.3 -1.2 0.0 0.4 0.2 0.5 0.6
Allergy 13.0 30.0 37.8 -6.2 -5.0 5.2 -4.8 -5.0 -5.7 -5.7 -6.1
Pain all over the body in last month 0.2 0.2 1.2 -0.5 -0.2 -0.1 0.1 -1.1 -0.2 -0.1 -0.3
Diabetes (self-reported) 0.9 1.3 2.0 1.1 1.2 -1.4 1.3 1.0 1.0 0.7 1.3
Hayfever/allergic rhinitis (self-reported) 4.1 5.5 7.1 2.7 2.2 -2.2 2.2 2.6 2.0 2.3 2.6
Medication: Ramipril 0.4 0.5 1.4 0.7 0.1 -0.8 0.9 1.2 0.5 0.5 0.5
Medication: Simvastatin 1.5 2.2 3.8 -1.8 -1.1 0.8 -0.8 -2.0 -1.8 -1.4 -1.6
Fluid intelligence score 1.2 2.5 5.2 -1.5 -1.6 0.7 -2.3 -1.0 -1.8 -1.3 -1.9
Illnesses of siblings 0.2 0.3 0.8 -0.2 -0.0 0.9 -0.6 -0.5 -0.1 0.5 -0.6
Neuroticism score 8.6 17.9 29.6 4.6 3.9 -2.2 5.4 4.0 4.3 4.6 4.1
Weight 2.5 12.1 29.8 3.0 5.5 -3.4 3.7 1.6 3.0 2.8 3.6
Impedance of arm (right) 6.1 28.3 42.8 6.5 2.4 -2.2 5.0 6.2 6.2 6.3 5.6
Arm fat percentage (right) 5.1 19.9 27.5 4.4 5.1 -2.0 5.2 4.1 4.8 4.6 4.7
Trunk fat-free mass 0.8 4.3 13.9 -1.1 2.8 -3.7 -0.4 -2.9 -1.2 -1.2 0.1
Hip circumference 2.6 11.3 25.0 3.0 5.0 -1.9 4.0 2.1 3.2 3.2 3.4
Time employed in main current job 0.1 0.2 0.5 -0.0 0.3 0.4 0.6 0.7 0.3 -0.1 0.0
Alcohol intake versus 10 years previously 0.4 0.6 2.1 0.7 0.4 -1.4 0.9 0.0 0.4 0.3 1.1
Father’s age at death 0.5 0.6 1.4 -0.4 -1.2 1.0 -0.8 -0.9 -0.3 -0.6 -0.9
Worrier / anxious feelings 6.7 12.6 19.2 3.8 2.7 -2.4 4.4 3.5 3.7 3.7 3.7
Frequency of tiredness / lethargy in last 2 weeks 8.9 14.4 20.3 4.0 4.1 -3.0 4.5 3.2 3.6 3.8 3.9
Falls in the last year 0.1 0.1 0.3 0.4 -0.1 -0.5 0.5 0.3 0.1 0.1 0.2
Hair/balding pattern: Pattern 3 0.1 0.1 0.4 -0.2 0.2 0.6 0.6 -0.2 -0.1 0.1 -0.3
Number of live births 0.1 0.2 0.6 0.5 -0.6 0.7 0.5 0.2 0.4 0.2 0.2
Forced expiratory volume in 1-second (FEV1) 1.4 4.8 10.0 2.0 3.2 -2.2 1.9 1.8 1.9 2.0 2.3
Pulse rate 0.3 0.6 2.3 0.2 0.9 1.5 0.6 0.8 0.2 0.3 -0.3
Happiness 2.6 3.1 13.2 1.4 1.4 -3.6 1.3 1.2 1.0 0.9 1.8
Noisy workplace 0.2 0.3 1.3 -0.6 -0.2 0.1 -0.4 -0.4 -0.3 -1.2 -0.1
Qualifications: A levels/AS levels or equivalent 0.3 0.7 2.9 -0.2 -1.0 1.7 -0.8 0.4 -0.2 -0.1 -0.8
Serious illness, injury or assault of a close relative in last 2 years 7.3 8.4 13.1 -3.0 -3.1 0.6 -3.3 -2.8 -3.0 -3.6 -2.7
Mouth/teeth dental problems: Dentures 3.1 5.2 8.5 -2.5 -2.5 0.3 -2.9 -2.0 -2.3 -2.7 -2.1
Asthma 10.7 21.1 28.5 5.2 3.5 -3.7 4.3 4.5 5.0 4.8 5.3
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.3 0.6 0.7 0.5 -0.8 0.2 0.4 0.4 0.7 0.4
Medication: Cholesterol lowering 0.4 0.6 1.3 -0.8 0.1 -0.7 -0.3 -1.2 -1.2 -0.7 -0.5
Depression (self-reported) 2.9 3.5 4.8 1.8 1.9 -1.4 2.0 2.2 2.1 1.7 1.7
Medication: Lansoprazole 0.8 1.0 2.1 0.9 0.1 -1.5 1.0 1.3 0.6 0.6 1.1
Prospective memory result 1.3 1.6 2.8 1.3 1.4 -0.6 1.5 0.9 1.7 1.1 1.4
Lung cancer (father) 1.8 2.1 4.0 -1.5 -0.9 1.0 -2.0 -1.1 -1.7 -1.5 -1.5
Illnesses of mother 1.7 2.1 4.0 -1.6 -1.5 1.0 -2.0 -1.5 -1.1 -1.1 -1.7
Forced expiratory volume in 1-second (FEV1), Best measure 1.4 4.6 9.8 1.8 3.1 -2.3 2.0 1.6 1.9 1.8 2.2
Pulse wave Arterial Stiffness index 0.6 0.7 2.8 0.4 1.4 -1.7 0.5 0.4 0.0 0.2 0.7
Impedance of arm (left) 7.3 33.6 49.3 7.0 3.0 -2.7 5.5 6.5 6.6 6.9 6.2
Arm fat mass (right) 3.9 15.9 29.3 3.7 5.4 -2.8 4.6 2.8 3.9 3.7 4.3
Trunk predicted mass 0.8 4.3 13.9 -1.1 2.9 -3.7 -0.3 -2.9 -1.2 -1.2 0.2
Standing height 1.4 13.6 36.8 3.5 4.5 -6.1 2.5 0.8 2.9 2.9 4.0
Length of working week for main job 0.6 0.7 2.9 0.2 1.2 -1.7 -0.0 -0.7 0.1 -0.3 0.3
Exposure to tobacco smoke at home 0.4 0.5 1.3 -0.6 -1.1 0.8 -0.7 -0.0 -0.5 -0.6 -0.8
Breastfed as a baby 3.5 4.4 6.4 2.5 1.5 -2.0 1.4 2.5 2.3 1.8 2.3
Tense / ‘highly strung’ 10.4 17.2 26.5 4.3 4.1 -2.3 5.1 4.1 4.1 4.5 4.0
Seen doctor (GP) for nerves, anxiety, tension or depression 1.1 1.7 3.0 1.3 1.5 -1.3 1.7 1.1 1.2 0.8 1.2
Hair/balding pattern: Pattern 4 1.6 3.8 6.8 -1.4 -2.0 2.6 -1.7 -2.3 -1.7 -1.5 -2.0
Birth weight of first child 0.5 0.9 5.8 0.1 2.4 -0.2 0.7 -0.3 0.2 0.5 0.3
Peak expiratory flow (PEF) 1.4 3.2 4.2 1.7 2.1 -1.8 1.8 1.8 1.6 1.4 2.0
Pulse wave reflection index 0.5 0.6 2.5 -0.1 1.3 -1.6 -0.1 -0.4 -0.3 0.2 0.3
Ever highly irritable/argumentative for 2 days 0.7 0.8 2.8 0.7 1.0 -1.7 0.8 0.7 0.3 -0.1 1.0
Loud music exposure frequency 0.2 0.2 1.1 0.0 -1.0 0.1 -0.7 -0.0 0.1 -0.1 -0.1
Qualifications: O levels/GCSEs or equivalent 0.1 0.1 0.7 -0.0 0.2 -0.5 -0.9 -0.0 -0.2 -0.2 0.0
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 1.5 0.3 1.2 0.5 1.2 0.8 0.3 0.5 0.3
Blood clot in the leg (DVT) 0.1 0.1 0.8 -0.3 0.9 -0.1 0.3 -0.0 -0.2 -0.1 -0.2
Medication: Paracetamol 1.0 1.7 3.7 0.7 1.8 -1.9 1.3 1.2 1.0 0.4 1.3
Headache pain in last month 1.3 2.2 7.6 0.9 2.3 -2.8 0.9 0.9 0.4 0.1 1.4
Medication for cholesterol, blood pressure or diabetes 0.1 0.1 0.5 0.1 -0.6 -0.0 -0.7 -0.2 0.3 -0.2 0.1
Glaucoma (self-reported) 3.7 4.3 9.0 2.4 1.2 -0.1 2.1 3.0 2.6 1.8 2.0
Gout (self-reported) 1.1 1.5 2.3 1.5 0.7 -1.0 0.9 1.2 1.4 1.4 1.4
Hypothyroidism/myxoedema (self-reported) 6.5 12.7 18.6 -4.0 -3.0 0.1 -4.3 -3.8 -4.1 -4.0 -3.4
Medication: Amlodipine 1.3 1.8 2.8 -1.5 -0.8 1.6 -1.1 -0.8 -1.6 -1.5 -1.7
Medication: Ventolin 100micrograms inhaler 10.3 13.2 16.8 4.1 2.8 -3.0 3.2 4.0 4.1 3.6 4.0
Birth weight 0.4 0.9 1.7 -1.3 1.1 0.1 -0.5 -1.3 -0.5 -1.3 -0.9
Chronic bronchitis/emphysema (mother) 0.5 0.6 2.5 0.3 1.6 -0.9 0.6 -0.3 0.5 0.3 0.5
High blood pressure (siblings) 0.1 0.1 0.5 -0.3 -0.4 -0.0 0.3 -0.4 -0.2 -0.7 -0.1
Forced vital capacity (FVC), Best measure 0.2 0.8 2.7 0.6 1.6 -1.5 0.2 0.1 0.6 0.7 0.7
Body fat percentage 6.1 23.9 32.0 5.0 5.2 -1.9 5.7 4.7 5.3 5.1 5.1
Leg fat percentage (right) 2.5 9.0 13.6 2.9 3.5 -0.6 3.7 3.0 3.2 3.0 3.0
Arm fat-free mass (right) 0.7 3.7 11.1 -0.7 3.3 -3.3 -0.0 -2.4 -0.8 -0.9 0.4
Exposure to tobacco smoke outside home 1.4 1.9 3.7 -1.3 -1.7 1.0 -1.9 -0.8 -1.0 -1.4 -1.5
Comparative body size at age 10 3.1 8.4 13.8 -3.5 -0.8 3.7 -2.1 -3.0 -3.0 -2.9 -3.2
Number of full brothers 0.4 0.5 1.2 -0.1 -1.0 0.9 -0.6 -1.1 -0.5 -0.1 -0.6
Worry too long after embarrassment 1.2 1.9 3.8 1.8 -0.0 -1.2 1.9 1.1 1.1 1.6 1.5
Seen a psychiatrist for nerves, anxiety, tension or depression 5.6 7.3 11.2 2.8 2.3 -1.7 3.3 3.0 3.1 2.4 2.7
Wheeze or whistling in the chest in last year 2.7 4.9 6.9 2.6 1.8 -1.9 1.9 1.7 2.5 2.6 2.4
Number of children fathered 3.0 3.4 5.8 -2.3 -1.2 0.7 -1.2 -2.0 -2.3 -2.4 -1.8
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.3 0.8 -0.4 -0.9 0.1 -0.4 -0.6 -0.6 -0.5 -0.4
Age at first live birth 1.4 2.5 4.2 1.5 2.1 0.6 1.7 1.8 1.8 1.8 1.0
Pulse wave peak to peak time 0.4 0.4 1.9 -0.1 -1.1 1.4 -0.2 -0.3 0.2 0.1 -0.4
Health satisfaction 1.0 1.3 8.4 0.3 0.4 -2.9 0.6 0.1 0.4 -0.1 0.9
Shortness of breath walking on level ground 0.7 0.8 1.4 0.9 0.4 -1.1 0.9 1.0 0.9 0.0 1.2
Qualifications: College or University degree 0.1 0.4 1.2 0.4 0.2 1.1 -0.2 0.9 0.5 0.6 -0.4
Eye problems/disorders: None of the above 2.1 2.4 6.3 -1.1 -2.5 -0.0 -2.0 -1.9 -1.3 -1.2 -0.9
Mouth/teeth dental problems: Loose teeth 7.1 8.4 14.3 -2.9 -3.8 1.9 -2.7 -2.4 -3.2 -3.0 -3.0
Emphysema/chronic bronchitis 0.1 0.1 0.2 -0.5 0.2 0.2 -0.3 -0.4 -0.1 -0.1 -0.4
Medication for pain relief, constipation, heartburn 1.6 2.8 4.8 -1.3 -1.7 2.2 -1.7 -1.7 -1.6 -1.1 -1.8
Neck or shoulder pain in last month 0.5 0.8 3.2 0.4 1.2 -1.8 0.8 0.1 0.6 0.1 0.7
Medication: Blood pressure 0.1 0.3 1.0 0.2 0.4 0.3 0.8 1.0 0.2 0.3 0.1
Angina (self-reported) 0.9 1.2 5.1 0.7 -0.1 -2.2 0.3 1.1 0.7 0.6 1.3
Migraine (self-reported) 1.4 1.7 3.1 1.4 1.7 -1.0 1.8 1.2 1.1 0.9 1.2
Medication: Ibuprofen 0.5 0.5 0.8 0.9 0.8 -0.9 0.2 0.7 0.8 0.7 0.7
Medication: Allopurinol 2.9 3.8 6.3 2.3 1.5 -2.5 1.5 1.6 1.8 2.0 2.2
Medication: Omeprazole 0.3 0.3 0.8 0.6 -0.2 -0.8 0.2 0.9 0.5 0.5 0.6
Medication: Seretide 50 evohaler 2.3 2.6 3.9 1.8 0.8 -1.3 1.7 1.3 1.9 1.7 2.0
Mean time to correctly identify matches 5.3 10.1 14.5 -3.2 -3.8 1.6 -3.3 -3.0 -3.5 -3.2 -3.4
Heart disease (mother) 0.7 0.9 1.3 1.0 1.2 -0.9 1.1 0.5 0.5 1.0 1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.3 1.3 0.5 -1.1 0.3 0.1 0.4 0.8 -0.1 0.4
Whole body fat mass 4.4 18.4 29.4 4.2 5.4 -2.8 4.9 3.4 4.4 4.1 4.6
Leg fat mass (right) 2.3 9.0 18.6 2.7 4.3 -1.7 3.5 2.1 2.9 2.7 3.1
Arm predicted mass (right) 0.7 3.7 9.7 -1.1 3.0 -3.1 -0.2 -2.7 -1.1 -1.2 0.1
Pulse rate, automated reading 0.3 0.9 3.3 -0.0 1.3 1.8 0.6 1.1 0.6 -0.1 -0.4
Alcohol intake frequency. 4.7 11.0 16.7 3.3 3.1 -2.7 4.1 3.1 3.2 2.9 3.9
Comparative height size at age 10 0.4 2.1 7.1 0.4 2.3 -2.7 0.2 -1.8 -0.1 0.2 0.7
Number of full sisters 6.4 7.7 15.8 -2.7 -4.0 2.0 -3.0 -1.8 -2.2 -3.4 -2.6
Suffer from ‘nerves’ 1.2 1.8 5.4 1.4 0.8 0.5 2.3 1.4 1.4 1.4 1.0
Overall health rating 1.3 2.7 4.2 1.5 1.0 -2.0 2.1 1.5 1.5 1.3 1.9
Chest pain or discomfort 1.7 2.5 7.6 1.5 1.5 -2.8 1.2 1.1 1.0 1.3 1.6
Had major operations 0.7 0.9 1.8 -0.8 -0.9 -0.1 -1.0 -0.7 -1.3 -1.2 -0.9
Age at last live birth 2.7 4.0 6.3 2.0 2.2 0.7 2.5 1.7 2.5 2.3 1.3
Family relationship satisfaction 2.3 2.8 10.3 1.4 1.4 -3.2 1.4 0.9 1.1 1.2 1.7
Leg pain on walking 0.1 0.2 0.4 -0.6 -0.5 0.5 -0.2 -0.6 0.0 -0.4 -0.3
Qualifications: NVQ or HND or HNC or equivalent 3.1 3.8 6.1 -2.5 -1.0 0.6 -2.3 -1.8 -2.1 -2.3 -2.1
Commuting to job workplace: Car/motor vehicle 1.1 1.3 2.1 -1.0 -0.6 -1.4 -1.1 -1.4 -1.4 -1.2 -0.7
Illness, injury, bereavement, stress in last 2 years 1.2 1.4 4.9 0.5 0.4 2.2 1.2 1.5 1.1 1.1 0.1
Medication: Aspirin 0.4 0.5 1.1 -1.0 -0.9 0.3 -0.6 -0.2 -0.6 -1.1 -0.7
Supplements: Vitamin C 0.2 0.2 0.5 -0.0 0.7 -0.6 -0.5 -0.5 -0.2 0.2 0.1
Knee pain experienced in last month 0.1 0.1 0.4 -0.3 0.6 0.1 0.4 -0.1 -0.3 -0.1 -0.2
Hypertension (Self-reported) 0.2 0.7 1.7 0.7 -0.1 -0.1 1.2 1.3 0.9 0.4 0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.2 0.7 -0.3 -0.8 -0.4 -0.2 0.5 -0.3 -0.3 -0.1
Illnesses of father: Heart disease 0.3 0.4 2.7 -0.0 0.3 -1.6 0.3 -0.2 -0.3 0.1 0.4
Illnesses of siblings: Diabetes 0.1 0.1 0.3 -0.6 0.1 -0.4 0.3 -0.0 -0.4 -0.5 -0.1
Smoking status: Previous 1.2 1.7 2.9 1.4 1.0 -0.4 1.7 1.4 1.4 1.6 1.3
Forced expiratory volume in 1-second (FEV1), predicted 2.5 5.1 10.8 2.0 3.1 -3.3 1.6 0.9 1.9 1.9 2.5
Whole body fat-free mass 0.7 4.3 14.8 -0.1 3.8 -3.7 0.7 -2.0 -0.2 -0.2 1.0
Leg fat-free mass (right) 1.2 6.2 22.8 1.4 4.8 -3.3 2.2 -0.5 1.5 1.3 2.1
Arm fat percentage (left) 5.4 21.7 29.4 4.6 5.4 -2.2 5.4 4.2 4.9 4.8 4.9
Average weekly red wine intake 2.4 3.5 6.7 -2.0 -0.7 0.9 -2.6 -1.9 -2.3 -1.6 -2.2
Handedness (chirality/laterality): Left-handed 0.1 0.2 0.4 -0.5 -0.1 0.6 -0.1 0.2 -0.1 -0.5 -0.6
Mood swings 11.9 21.6 30.5 4.9 4.4 -2.7 5.5 4.7 5.2 4.5 4.6
Loneliness, isolation 2.2 3.1 5.0 1.9 2.2 -1.3 1.9 1.0 1.5 2.1 1.7
Long-standing illness, disability or infirmity 0.7 1.1 3.4 0.9 0.9 -1.9 1.2 0.5 0.5 0.7 1.0
Ever had bowel cancer screening 0.3 0.3 1.2 -0.2 0.1 0.7 0.8 1.1 0.4 -0.2 0.1
Diabetes diagnosed by doctor 1.1 1.9 3.2 1.3 1.4 -1.3 1.8 1.0 1.4 1.2 1.5
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.8 1.3 0.8 1.1 0.9 1.0 -0.8 0.7 1.1 0.3
Friendships satisfaction 1.0 1.3 9.4 0.0 -0.0 -3.1 -0.3 -0.5 -0.3 -0.5 0.4
Qualifications: nursing, teaching 2.0 3.1 4.1 1.8 2.0 -0.8 1.8 2.0 1.7 1.9 1.6
Commuting to job workplace: Walk 0.1 0.1 0.2 0.1 0.4 0.5 -0.1 -0.3 0.3 -0.1 -0.2
Eye problems/disorders: Cataract 2.4 2.7 7.2 1.2 2.7 0.7 2.1 1.8 1.6 1.4 1.0
Mouth/teeth dental problems: Mouth ulcers 0.5 0.8 1.4 0.9 0.9 0.4 0.9 1.2 1.1 1.0 0.5
Medication for cholesterol 0.2 0.3 1.1 0.5 0.8 0.1 -0.1 0.4 0.5 1.0 0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.1 0.5 0.2 0.4 0.2 0.7 0.2 0.5 -0.1 0.1
Back pain experienced in last month 0.2 0.3 1.3 0.2 0.9 -1.1 -0.0 0.5 -0.0 -0.2 0.3
Mineral and other dietary supplements 0.2 0.3 0.8 0.5 0.4 0.9 0.5 -0.3 0.6 0.8 0.1
Breast cancer (self-reported) 0.2 0.3 1.1 0.4 0.4 1.0 0.4 0.0 0.5 0.5 -0.2
Asthma (self-reported) 11.1 22.1 29.9 5.4 3.8 -3.8 4.4 4.3 5.1 5.1 5.5
Osteoporosis (self-reported) 0.5 0.6 2.1 0.7 0.4 -0.7 0.6 1.4 0.5 0.5 0.8
Osteoarthritis (self-reported) 0.2 0.2 0.7 0.1 0.4 -0.5 0.2 0.9 0.7 0.3 0.5
Medication: Aspirin 0.6 0.7 1.6 -1.0 -1.2 0.3 -0.8 -0.3 -0.7 -1.3 -0.8
Medication: Gliclazide 0.5 0.6 1.0 -0.9 -0.7 0.8 -0.3 -0.8 -0.6 -1.0 -0.7
Illnesses of father: None of the above (group 1) 2.3 2.8 6.2 -1.5 -0.5 2.5 -1.7 -1.3 -1.8 -0.9 -2.2
Smoking status: Current 12.9 20.5 26.4 -4.6 -4.6 5.1 -4.4 -3.9 -3.9 -4.4 -5.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.9 1.8 0.6 1.3 0.8 1.0 0.9 0.8 1.3 0.4
Whole body water mass 0.7 4.0 13.8 -0.2 3.7 -3.6 0.6 -2.1 -0.3 -0.3 0.9
Leg predicted mass (right) 1.2 6.2 22.7 1.4 4.8 -3.3 2.2 -0.5 1.5 1.3 2.1
Arm fat mass (left) 3.9 16.2 29.5 3.7 5.4 -3.1 4.5 2.8 3.9 3.7 4.3
Number of self-reported non-cancer illnesses 7.5 13.0 20.1 3.4 3.1 -4.5 3.7 3.5 3.2 3.1 4.1
Average weekly champagne plus white wine intake 0.7 1.0 5.5 0.4 1.1 -2.4 0.3 0.4 -0.2 0.6 0.8
Miserableness 3.2 5.5 9.0 2.5 2.4 0.2 3.0 2.6 2.6 2.3 2.1
Guilty feelings 3.3 5.0 9.0 2.5 2.0 -1.5 3.0 2.1 2.1 2.2 2.1
Wears glasses or contact lenses 0.8 0.9 3.6 0.6 1.9 0.2 1.3 0.0 0.6 1.0 0.5
Ever taken oral contraceptive pill 2.0 2.2 3.2 -1.4 -1.5 1.3 -1.8 -1.7 -1.4 -1.0 -1.7
Hearing aid user 0.6 0.6 1.9 -0.8 0.5 0.9 -0.3 -1.4 -0.8 -0.3 -0.8
Mother’s age at death 0.6 0.7 1.3 -0.6 -0.7 1.0 -1.1 -0.9 -0.6 -0.6 -1.0
Financial situation satisfaction 1.0 1.3 4.7 1.1 1.0 -2.2 0.9 -0.1 0.6 0.9 1.1
Tinnitus: Yes, now most or all of the time 0.2 0.2 0.5 -0.3 -0.6 0.3 -0.6 -0.7 -0.1 -0.3 -0.4
Commuting to job workplace: Public transport 3.1 3.7 7.0 -1.6 -2.6 2.6 -2.1 -0.8 -1.4 -1.4 -2.0
Eye problems/disorders: Glaucoma 2.7 3.2 9.3 2.0 0.8 -0.0 1.6 3.0 2.1 1.4 1.6
Medication: Blood pressure 0.1 0.2 0.7 0.1 -0.9 -0.2 0.5 0.6 0.1 -0.4 0.2
Pain type(s) experienced in last month: Hip pain 1.1 1.4 2.4 -1.3 -1.1 -0.1 -1.6 -0.1 -1.4 -1.5 -1.1
Supplements: Fish oil (including cod liver oil) 0.4 0.5 2.0 0.3 0.3 -1.4 0.4 0.9 0.3 -0.1 0.9
High cholesterol (Self-reported) 1.1 2.0 3.6 -1.5 -1.8 0.4 -0.5 -1.9 -1.6 -1.4 -1.3
Medication: Bendroflumethiazide 0.8 1.1 3.8 0.7 -0.1 1.5 1.1 1.9 1.0 0.6 0.5
Medication: Paracetamol 0.7 1.0 2.3 0.6 1.3 -1.5 1.1 0.9 0.9 0.4 1.0
Medication: Lisinopril 0.2 0.3 0.4 0.6 0.6 -0.6 0.5 0.6 0.4 0.5 0.5
Medication: Atorvastatin 0.3 0.4 0.8 0.6 0.5 -0.3 0.9 0.7 0.6 0.5 0.6
Illnesses of father: High blood pressure 3.0 3.8 5.6 2.2 1.3 -2.0 2.1 1.4 2.4 1.6 2.3
Alcohol drinker status: Never 2.1 2.5 4.0 1.5 1.6 -0.3 2.0 1.9 1.8 1.5 1.4
Ever smoked 0.3 0.5 2.6 0.1 -1.1 1.6 0.0 0.2 0.1 0.4 -0.6
Basal metabolic rate 1.0 5.4 19.8 0.8 4.5 -3.8 1.6 -1.1 0.8 0.7 1.8
Leg fat percentage (left) 2.4 8.8 13.5 2.9 3.6 -0.7 3.7 2.9 3.2 2.9 3.0
Arm fat-free mass (left) 0.7 3.4 10.0 -0.7 3.2 -3.1 0.2 -2.3 -0.7 -0.8 0.4
Number of operations (self-reported) 0.3 0.5 1.1 -0.5 -1.0 1.0 -0.4 -0.4 -0.3 -0.3 -0.9
Average weekly beer plus cider intake 3.4 4.8 5.9 -2.2 -2.4 2.3 -2.4 -1.8 -1.7 -2.4 -2.3
Irritability 9.6 16.2 21.4 4.3 4.0 -2.2 4.6 4.1 4.3 4.1 4.1
Risk taking 0.1 0.2 1.0 0.2 -0.4 1.0 -0.2 -0.2 0.1 -0.1 -0.3
Ever had prostate specific antigen (PSA) test 0.3 0.3 0.6 -0.8 -0.2 -0.6 -0.4 -0.4 -0.6 -0.7 -0.4
Fractured/broken bones in last 5 years 0.7 0.9 1.2 1.0 0.8 -1.1 0.8 0.7 1.1 0.7 1.1
Age started oral contraceptive pill 0.9 1.2 2.3 1.2 0.8 0.2 1.3 1.0 1.2 1.5 0.9
Diastolic blood pressure, automated reading 0.6 1.8 3.7 1.0 1.7 -0.7 1.9 1.7 0.9 0.8 1.3
Ever depressed for a whole week 0.3 0.4 1.1 0.4 0.9 -0.7 1.1 0.1 0.3 0.3 0.5
Unable to work because of sickness or disability 1.1 1.4 2.5 -1.4 -1.3 0.5 -1.0 -0.9 -1.1 -1.6 -1.3
Commuting to job workplace: Cycle 0.6 0.7 1.6 0.7 1.3 0.7 1.0 0.1 1.0 1.0 0.5
Myopia 3.6 5.2 9.2 -2.0 -3.0 2.8 -2.3 -1.1 -1.9 -2.3 -2.4
Vascular/heart problems diagnosed by doctor 0.0 0.1 0.5 -0.1 0.3 0.3 -0.7 -0.3 -0.3 0.2 -0.2
Cholesterol lowering medication 0.2 0.3 0.7 -0.5 -0.6 -0.5 0.3 -0.8 -0.7 -0.4 -0.3
Medication: Omeprazole (e.g. Zanprol) 1.5 1.9 2.8 1.6 0.6 -1.3 1.1 1.7 1.4 1.6 1.4
Pain experienced in last month 1.0 1.7 4.5 1.3 -0.2 1.6 0.8 1.0 1.5 2.1 0.7
Supplements: Calcium 5.6 6.2 8.0 2.8 2.5 -2.1 2.0 2.6 2.4 2.6 2.7
Basal cell carcinoma (self-reported) 11.7 13.9 19.4 4.2 3.4 -0.7 4.3 4.0 4.4 3.9 3.6
Heart attack/myocardial infarction (self-reported) 0.3 0.4 2.2 0.3 0.3 -1.5 -0.1 0.4 0.3 0.4 0.7
Deep venous thrombosis (DVT) (self-reported) 0.2 0.2 0.4 -0.6 0.1 0.1 -0.2 -0.4 -0.6 -0.5 -0.6
Heart disease (siblings) 0.1 0.1 0.2 -0.0 -0.5 -0.4 0.1 0.2 -0.4 -0.3 0.0
Alcohol drinker status: Previous 0.2 0.2 0.6 -0.5 -0.3 0.5 -0.0 -0.0 -0.4 -0.8 -0.6
Pack years of smoking 3.7 5.4 7.8 -2.7 -2.3 1.1 -2.3 -1.8 -2.8 -2.6 -2.5
Impedance of whole body 4.9 24.8 38.4 6.2 1.9 -2.4 4.4 5.9 5.8 5.8 5.4
Leg fat mass (left) 2.2 8.7 18.6 2.7 4.3 -1.7 3.5 2.0 2.9 2.6 3.1
Arm predicted mass (left) 0.6 3.2 10.1 -0.6 3.0 -3.2 0.2 -2.1 -0.7 -0.9 0.5