Best TWAS P=7.92e-10 · Best GWAS P=1.57e-11 conditioned to 0.000219
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | DHX36 | 0.05 | 0.06 | blup | 357 | 0.05 | 1.3e-06 | -5.1 | -6.0 | 1.6e-09 | 0.58 | 0.94 | 0.06 | FALSE |
2 | GTEx | Adipose Subcutaneous | ARHGEF26 | 0.10 | 0.06 | enet | 8 | 0.07 | 2.2e-06 | -5.1 | 5.5 | 3.7e-08 | -0.56 | 0.88 | 0.10 | FALSE |
3 | GTEx | Ovary | ARHGEF26 | 0.14 | 0.03 | enet | 15 | 0.06 | 1.4e-02 | 4.8 | 6.0 | 1.6e-09 | -0.53 | 0.10 | 0.30 | FALSE |
4 | GTEx | Pancreas | ARHGEF26 | 0.26 | 0.26 | lasso | 5 | 0.28 | 3.2e-12 | -4.8 | 5.8 | 8.2e-09 | -0.62 | 0.98 | 0.02 | FALSE |
5 | GTEx | Skin Not Sun Exposed Suprapubic | ARHGEF26 | 0.13 | 0.11 | lasso | 4 | 0.07 | 6.8e-05 | -4.8 | 5.5 | 4.7e-08 | -0.60 | 0.87 | 0.08 | FALSE |
6 | GTEx | Spleen | DHX36 | 0.39 | 0.09 | enet | 21 | 0.34 | 2.1e-09 | -3.7 | -5.8 | 6.1e-09 | 0.58 | 0.83 | 0.07 | FALSE |
7 | GTEx | Thyroid | ARHGEF26 | 0.09 | 0.07 | enet | 17 | 0.08 | 1.9e-06 | -5.0 | 5.8 | 5.8e-09 | -0.62 | 0.20 | 0.78 | FALSE |
8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SGEF | 0.04 | 0.04 | enet | 12 | 0.04 | 1.1e-05 | -5.1 | 6.2 | 7.9e-10 | -0.63 | 0.06 | 0.92 | TRUE |
9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | DHX36 | 0.11 | 0.09 | enet | 11 | 0.10 | 6.4e-12 | -4.7 | -5.2 | 2.6e-07 | 0.38 | 0.08 | 0.90 | FALSE |