Best TWAS P=1.86e-58 · Best GWAS P=3.76e-59 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CENPW | 0.04 | 0.06 | lasso | 10 | 0.06 | 2.4e-07 | 16.05 | -16.1 | 1.9e-58 | -0.99 | 0.02 | 0.98 | TRUE |
| 2 | CommonMind | Brain Pre-frontal Cortex | HEY2 | 0.15 | 0.20 | lasso | 10 | 0.21 | 6.7e-25 | -8.65 | -8.6 | 7.2e-18 | -0.07 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Artery Coronary | TPD52L1 | 0.31 | -0.01 | enet | 19 | 0.05 | 7.0e-03 | -0.08 | -6.2 | 5.0e-10 | -0.15 | 0.03 | 0.54 | FALSE |
| 4 | GTEx | Breast Mammary Tissue (Female) | HINT3 | 0.39 | -0.01 | enet | 16 | 0.08 | 2.2e-03 | -3.44 | -6.0 | 2.2e-09 | -0.13 | 0.13 | 0.06 | FALSE |
| 5 | GTEx | Esophagus Muscularis | HINT3 | 0.08 | 0.00 | enet | 14 | 0.00 | 2.9e-01 | 8.41 | -7.3 | 3.0e-13 | -0.11 | 0.07 | 0.04 | FALSE |
| 6 | GTEx | Heart Atrial Appendage | CENPW | 0.17 | 0.01 | enet | 15 | 0.06 | 1.8e-03 | 16.05 | -8.7 | 3.4e-18 | -0.70 | 0.03 | 0.48 | FALSE |
| 7 | GTEx | Pancreas | HEY2 | 0.28 | 0.11 | lasso | 3 | 0.10 | 3.5e-05 | -6.32 | -7.0 | 2.1e-12 | -0.05 | 0.10 | 0.90 | FALSE |
| 8 | GTEx | Skin Sun Exposed Lower leg | HINT3 | 0.08 | 0.01 | lasso | 4 | 0.03 | 2.0e-03 | -6.01 | -7.3 | 3.2e-13 | -0.19 | 0.22 | 0.14 | FALSE |
| 9 | GTEx | Testis | HEY2 | 0.31 | 0.17 | lasso | 5 | 0.19 | 7.4e-09 | -8.55 | -8.6 | 8.4e-18 | -0.07 | 0.01 | 0.99 | FALSE |
| 10 | GTEx | Thyroid | HEY2 | 0.22 | 0.24 | lasso | 6 | 0.23 | 1.0e-17 | -8.55 | -8.8 | 1.1e-18 | -0.08 | 0.01 | 0.99 | TRUE |
| 11 | GTEx | Vagina | CENPW | 0.24 | -0.01 | lasso | 8 | -0.01 | 7.9e-01 | 6.18 | 7.8 | 4.6e-15 | 0.40 | 0.04 | 0.06 | FALSE |
| 12 | METSIM | Adipose | CENPW | 0.02 | 0.02 | blup | 189 | 0.01 | 8.3e-03 | 16.05 | -10.6 | 2.2e-26 | -0.74 | 0.02 | 0.74 | FALSE |
| 13 | METSIM | Adipose | HEY2 | 0.02 | 0.04 | lasso | 1 | 0.02 | 1.6e-04 | -6.30 | -6.3 | 2.9e-10 | -0.06 | 0.02 | 0.97 | FALSE |
| 14 | METSIM | Adipose | NCOA7 | 0.05 | 0.05 | enet | 5 | 0.05 | 1.9e-07 | 6.62 | 9.3 | 9.3e-21 | 0.23 | 0.95 | 0.02 | FALSE |
| 15 | ROSMAP | Brain Pre-frontal Cortex | HEY2 | 0.10 | 0.12 | enet | 15 | 0.13 | 9.8e-17 | 8.16 | -7.9 | 2.0e-15 | -0.06 | 0.02 | 0.98 | FALSE |
| 16 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TRMT11 | 0.03 | 0.03 | lasso | 1 | 0.03 | 3.3e-07 | -6.03 | 6.0 | 1.7e-09 | 0.23 | 0.01 | 0.99 | FALSE |
| 17 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CENPW | 0.04 | 0.05 | lasso | 5 | 0.05 | 2.6e-06 | 16.06 | -15.4 | 1.4e-53 | -0.98 | 0.02 | 0.98 | FALSE |
| 18 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | HEY2 | 0.05 | 0.05 | blup | 36 | 0.05 | 4.9e-06 | -6.32 | -5.3 | 1.1e-07 | -0.04 | 0.15 | 0.84 | FALSE |
| 19 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CENPW | 0.04 | 0.06 | blup | 35 | 0.05 | 9.2e-07 | 15.89 | -15.7 | 2.8e-55 | -0.98 | 0.03 | 0.97 | FALSE |
| 20 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | HEY2 | 0.09 | 0.06 | lasso | 8 | 0.06 | 2.3e-03 | -6.32 | -6.1 | 8.3e-10 | -0.04 | 0.03 | 0.76 | FALSE |
| 21 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TRMT11 | 0.03 | 0.00 | blup | 33 | 0.01 | 1.3e-02 | -5.98 | 5.2 | 1.7e-07 | 0.21 | 0.01 | 0.85 | TRUE |
| 22 | The Cancer Genome Atlas | Thyroid Carcinoma | HEY2 | 0.03 | 0.04 | lasso | 3 | 0.02 | 3.8e-03 | 7.47 | -7.7 | 1.1e-14 | -0.07 | 0.01 | 0.98 | FALSE |