[Hub]/) : Traits : Trunk fat-free mass :

chr8:56,094,665-57,683,880

Best TWAS P=2.61e-35 · Best GWAS P=2.45e-60 conditioned to 1.71e-27

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Artery Tibial RP11-446E9.1 0.07 0.00 lasso 6 0.00 6.6e-01 -7.5 8.9 7.0e-19 -0.76 0.02 0.75 FALSE
2 GTEx Brain Cerebellum RPS20 0.26 0.07 enet 17 0.10 5.4e-04 -10.7 -9.7 4.1e-22 0.60 0.30 0.23 FALSE
3 GTEx Brain Cerebellum RP11-446E9.1 0.15 0.05 lasso 3 0.03 3.7e-02 -7.6 7.4 1.6e-13 -0.53 0.05 0.55 FALSE
4 GTEx Brain Nucleus accumbens basal ganglia RPS20 0.41 0.05 lasso 8 0.13 3.1e-04 -8.0 -7.5 5.5e-14 0.53 0.05 0.23 FALSE
5 GTEx Cells EBV-transformed lymphocytes LYN 0.35 0.07 enet 37 0.17 4.5e-06 11.6 -5.7 1.3e-08 -0.07 0.15 0.04 FALSE
6 GTEx Esophagus Muscularis RPS20 0.12 0.04 lasso 6 0.05 7.2e-04 -10.8 -10.6 2.6e-26 0.76 0.22 0.65 FALSE
7 GTEx Muscle Skeletal RPS20 0.07 0.09 lasso 1 0.07 1.5e-07 -7.5 -7.5 7.2e-14 0.49 0.99 0.01 FALSE
8 GTEx Skin Not Sun Exposed Suprapubic RPS20 0.18 0.03 enet 12 0.07 1.5e-04 -10.3 -12.4 2.6e-35 0.81 0.11 0.60 TRUE
9 GTEx Stomach RP11-446E9.1 0.12 0.08 lasso 4 0.03 1.7e-02 -6.8 6.8 1.5e-11 -0.48 0.30 0.08 FALSE
10 ROSMAP Brain Pre-frontal Cortex RPS20 0.24 0.20 lasso 6 0.23 3.4e-29 -9.3 -8.3 7.6e-17 0.51 1.00 0.00 FALSE
11 ROSMAP Brain Pre-frontal Cortex RP11-446E9.1 0.23 0.32 lasso 7 0.34 2.0e-45 -7.5 8.6 1.2e-17 -0.53 1.00 0.00 FALSE
12 The Cancer Genome Atlas Bladder Urothelial Carcinoma PENK 0.03 0.01 blup 40 0.03 9.1e-04 -5.5 -6.0 1.5e-09 -0.01 0.02 0.77 TRUE
13 The Cancer Genome Atlas Breast Invasive Carcinoma PENK 0.03 0.04 enet 7 0.05 6.2e-10 4.9 -5.7 1.2e-08 -0.06 0.16 0.83 FALSE
14 The Cancer Genome Atlas Colon Adenocarcinoma PENK 0.11 0.13 lasso 2 0.14 2.6e-08 -5.8 -6.0 2.3e-09 0.06 0.01 0.99 FALSE
15 The Cancer Genome Atlas Esophageal Carcinoma PENK 0.35 0.21 enet 12 0.33 3.8e-11 5.1 -5.7 1.1e-08 -0.02 0.04 0.96 FALSE
16 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma PENK 0.07 0.06 enet 8 0.08 2.4e-09 -5.3 -6.0 1.6e-09 0.04 0.02 0.98 FALSE
17 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma RPS20 0.04 0.02 blup 29 0.03 4.8e-04 -9.1 -8.2 3.8e-16 0.49 0.03 0.03 FALSE
18 The Cancer Genome Atlas Brain Lower Grade Glioma RPS20 0.33 0.07 enet 8 0.07 1.7e-08 -9.3 -10.5 1.2e-25 0.49 0.96 0.03 FALSE
19 The Cancer Genome Atlas Pancreatic Adenocarcinoma PENK 0.23 0.15 lasso 5 0.22 8.2e-10 4.8 -5.7 1.6e-08 -0.02 0.04 0.96 FALSE
20 The Cancer Genome Atlas Prostate Adenocarcinoma RPS20 0.04 0.03 lasso 3 0.04 1.3e-04 -9.3 -9.2 2.4e-20 0.58 0.15 0.05 FALSE
21 The Cancer Genome Atlas Rectum Adenocarcinoma PENK 0.18 0.11 lasso 1 0.09 3.4e-03 -5.8 -5.8 8.9e-09 0.08 0.01 0.67 FALSE
22 The Cancer Genome Atlas Stomach Adenocarcinoma PENK 0.07 0.08 lasso 2 0.06 2.0e-05 -5.3 -5.3 1.2e-07 0.11 0.02 0.98 FALSE
23 The Cancer Genome Atlas Thyroid Carcinoma LYN 0.09 0.12 lasso 2 0.12 8.4e-12 -6.8 6.9 4.1e-12 -0.49 1.00 0.00 FALSE