Best TWAS P=6.16e-16 · Best GWAS P=6.94e-17 conditioned to 0.29
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | COL14A1 | 0.07 | 0.02 | enet | 21 | 0.04 | 2.1e-05 | -1.8 | 5.2 | 2.2e-07 | -0.01 | 0.01 | 0.99 | TRUE |
2 | CommonMind | Brain Pre-frontal Cortex | NOV | 0.06 | 0.02 | enet | 8 | 0.05 | 1.5e-06 | -4.3 | -5.9 | 2.8e-09 | 0.71 | 0.18 | 0.82 | FALSE |
3 | GTEx | Adrenal Gland | DEPTOR | 0.16 | -0.01 | enet | 24 | 0.00 | 3.7e-01 | -3.6 | 5.8 | 8.3e-09 | -0.08 | 0.10 | 0.06 | TRUE |
4 | GTEx | Artery Aorta | NOV | 0.12 | 0.05 | enet | 18 | 0.04 | 3.7e-03 | -6.2 | -7.5 | 4.7e-14 | 0.79 | 0.03 | 0.84 | FALSE |
5 | GTEx | Cells Transformed fibroblasts | NOV | 0.10 | 0.04 | enet | 30 | 0.03 | 3.7e-03 | -7.8 | -5.5 | 3.0e-08 | 0.56 | 0.10 | 0.82 | FALSE |
6 | GTEx | Colon Sigmoid | NOV | 0.15 | 0.16 | lasso | 4 | 0.15 | 6.6e-06 | -7.9 | -7.9 | 3.6e-15 | 0.91 | 0.03 | 0.96 | FALSE |
7 | GTEx | Esophagus Muscularis | NOV | 0.11 | 0.03 | enet | 19 | 0.05 | 3.9e-04 | -7.9 | -5.2 | 2.3e-07 | 0.71 | 0.04 | 0.92 | FALSE |
8 | GTEx | Lung | NOV | 0.06 | 0.02 | enet | 23 | 0.03 | 2.5e-03 | -4.2 | -7.0 | 2.1e-12 | 0.66 | 0.20 | 0.46 | FALSE |
9 | GTEx | Nerve Tibial | TAF2 | 0.14 | 0.04 | enet | 10 | 0.07 | 1.5e-05 | 4.8 | -6.2 | 6.7e-10 | 0.19 | 0.89 | 0.04 | FALSE |
10 | GTEx | Skin Sun Exposed Lower leg | NOV | 0.11 | 0.03 | lasso | 7 | 0.04 | 1.4e-04 | -7.7 | -6.9 | 4.6e-12 | 0.95 | 0.01 | 0.99 | FALSE |
11 | NTR | Blood | NOV | 0.02 | 0.01 | bslmm | 481 | 0.01 | 1.7e-04 | -7.9 | -7.0 | 2.5e-12 | 0.78 | 0.02 | 0.98 | FALSE |
12 | YFS | Blood | ENPP2 | 0.03 | 0.02 | enet | 8 | 0.03 | 7.6e-09 | -4.5 | -5.7 | 1.2e-08 | 0.10 | 1.00 | 0.00 | TRUE |
13 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | NOV | 0.03 | 0.00 | blup | 42 | 0.01 | 5.3e-02 | -7.7 | -7.9 | 3.7e-15 | 0.97 | 0.02 | 0.78 | FALSE |
14 | The Cancer Genome Atlas | Colon Adenocarcinoma | NOV | 0.31 | 0.10 | blup | 42 | 0.10 | 1.2e-06 | -8.3 | -6.8 | 8.3e-12 | 0.83 | 0.01 | 0.99 | FALSE |
15 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | NOV | 0.11 | 0.02 | enet | 15 | 0.05 | 2.9e-03 | -8.3 | -8.1 | 6.2e-16 | 0.84 | 0.01 | 0.65 | TRUE |
16 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NOV | 0.04 | 0.05 | blup | 42 | 0.05 | 8.7e-06 | -7.9 | -6.9 | 6.7e-12 | 0.82 | 0.05 | 0.95 | FALSE |