Best TWAS P=6.29e-15 · Best GWAS P=9.63e-20 conditioned to 4.96e-07
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | LIN7C | 0.08 | 0.06 | lasso | 1 | 0.04 | 4.1e-04 | 7.5 | 7.5 | 7.1e-14 | 0.63 | 0.75 | 0.13 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | LIN7C | 0.26 | 0.22 | lasso | 6 | 0.25 | 1.4e-18 | 7.5 | 6.6 | 4.5e-11 | 0.62 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Esophagus Muscularis | LIN7C | 0.14 | 0.08 | enet | 11 | 0.07 | 5.4e-05 | 3.7 | 5.8 | 6.8e-09 | 0.60 | 0.66 | 0.19 | FALSE |
| 4 | GTEx | Liver | METTL15 | 0.18 | 0.05 | lasso | 3 | 0.09 | 1.9e-03 | 0.2 | -5.9 | 2.8e-09 | -0.68 | 0.02 | 0.80 | FALSE |
| 5 | GTEx | Thyroid | LIN7C | 0.08 | 0.04 | lasso | 4 | 0.04 | 6.0e-04 | 7.5 | 7.5 | 6.9e-14 | 0.69 | 0.51 | 0.37 | FALSE |
| 6 | NTR | Blood | LIN7C | 0.01 | 0.00 | lasso | 3 | 0.01 | 2.2e-03 | 8.0 | -7.8 | 6.3e-15 | -0.72 | 0.07 | 0.87 | TRUE |
| 7 | The Cancer Genome Atlas | Colon Adenocarcinoma | LIN7C | 0.10 | 0.03 | blup | 32 | 0.08 | 2.8e-05 | 7.7 | 5.8 | 8.9e-09 | 0.57 | 0.01 | 0.94 | FALSE |
| 8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LIN7C | 0.05 | 0.02 | lasso | 3 | 0.03 | 2.9e-04 | 7.8 | 7.3 | 2.0e-13 | 0.63 | 0.00 | 0.98 | FALSE |