[Hub]/) : Traits : Trunk fat-free mass :

chr12:116,650,803-118,234,710

Best TWAS P=2.67e-13 · Best GWAS P=1.63e-13 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex TESC 0.11 0.08 bslmm 556 0.09 1.3e-10 -6.0 5.9 4.7e-09 -0.86 0.37 0.63 FALSE
2 GTEx Adipose Subcutaneous TESC 0.09 0.04 lasso 2 0.01 2.1e-02 -5.6 -6.0 2.0e-09 0.87 0.11 0.77 FALSE
3 GTEx Adipose Subcutaneous FBXW8 0.12 0.04 lasso 6 0.02 1.2e-02 -6.0 -6.3 3.0e-10 0.81 0.09 0.70 FALSE
4 GTEx Cells Transformed fibroblasts FBXW8 0.25 0.24 lasso 4 0.25 5.0e-19 -6.7 6.5 6.3e-11 -0.88 0.39 0.61 FALSE
5 GTEx Cells Transformed fibroblasts RP11-231I16.1 0.16 0.18 lasso 2 0.16 2.5e-12 -6.7 6.9 4.1e-12 -0.94 0.11 0.89 FALSE
6 GTEx Lung FBXW8 0.15 0.05 lasso 5 0.03 2.5e-03 -5.9 -5.7 1.3e-08 0.84 0.40 0.57 FALSE
7 GTEx Nerve Tibial FBXW8 0.17 0.17 lasso 3 0.19 2.5e-13 -6.7 -5.9 3.4e-09 0.78 0.34 0.66 FALSE
8 GTEx Skin Sun Exposed Lower leg FBXW8 0.19 0.10 enet 23 0.13 4.2e-11 -6.7 -5.5 3.4e-08 0.87 0.22 0.78 FALSE
9 GTEx Spleen FBXW8 0.36 0.16 lasso 2 0.12 5.8e-04 -6.7 -6.6 4.2e-11 0.90 0.05 0.78 FALSE
10 GTEx Testis FBXW8 0.27 0.10 lasso 4 0.06 1.9e-03 -6.6 -6.4 1.9e-10 0.83 0.18 0.67 FALSE
11 GTEx Thyroid FBXW8 0.14 0.08 lasso 3 0.07 2.3e-06 -6.3 -6.5 6.0e-11 0.93 0.31 0.69 FALSE
12 The Cancer Genome Atlas Bladder Urothelial Carcinoma FBXW8 0.14 0.09 lasso 8 0.08 1.8e-07 -6.6 6.6 4.6e-11 -0.90 0.05 0.95 FALSE
13 The Cancer Genome Atlas Breast Invasive Carcinoma FBXW8 0.16 0.17 blup 83 0.17 3.9e-34 -6.7 7.0 3.4e-12 -0.88 0.32 0.68 FALSE
14 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma FBXW8 0.09 0.04 blup 81 0.04 3.0e-03 -5.9 6.6 4.1e-11 -0.91 0.02 0.88 FALSE
15 The Cancer Genome Atlas Colon Adenocarcinoma FBXW8 0.25 0.18 blup 83 0.20 4.9e-12 -6.7 5.6 1.9e-08 -0.66 0.21 0.79 FALSE
16 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma FBXW8 0.20 0.22 enet 18 0.24 4.5e-26 -6.7 6.2 4.7e-10 -0.81 0.18 0.82 FALSE
17 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma FBXW8 0.12 0.17 enet 12 0.20 1.2e-21 -6.7 6.9 4.5e-12 -0.90 0.47 0.53 FALSE
18 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma FBXW8 0.10 0.10 lasso 7 0.09 7.5e-06 -7.3 7.3 2.7e-13 -0.99 0.01 0.99 TRUE
19 The Cancer Genome Atlas Brain Lower Grade Glioma FBXW8 0.17 0.02 blup 83 0.03 7.0e-05 3.6 6.5 1.1e-10 -0.70 0.04 0.70 FALSE
20 The Cancer Genome Atlas Liver Hepatocellular Carcinoma FBXW8 0.11 0.15 blup 75 0.12 2.4e-06 -5.9 6.3 3.7e-10 -0.94 0.06 0.94 FALSE
21 The Cancer Genome Atlas Lung Adenocarcinoma FBXW8 0.10 0.08 enet 15 0.08 1.2e-09 -6.6 7.0 1.8e-12 -0.89 0.10 0.90 FALSE
22 The Cancer Genome Atlas Lung Squamous Cell Carcinoma FBXW8 0.11 0.12 lasso 6 0.12 3.1e-13 -5.9 6.5 6.0e-11 -0.91 0.13 0.87 FALSE
23 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma FBXW8 0.15 0.11 blup 79 0.13 7.7e-09 -5.9 6.4 2.0e-10 -0.89 0.26 0.74 FALSE
24 The Cancer Genome Atlas Pancreatic Adenocarcinoma FBXW8 0.14 0.16 lasso 3 0.17 1.3e-07 -6.0 6.4 2.0e-10 -0.79 0.34 0.52 FALSE
25 The Cancer Genome Atlas Prostate Adenocarcinoma FBXW8 0.20 0.29 lasso 9 0.29 1.2e-30 -6.6 6.5 7.2e-11 -0.91 0.39 0.61 FALSE
26 The Cancer Genome Atlas Rectum Adenocarcinoma FBXW8 0.13 0.17 lasso 7 0.10 2.0e-03 -6.7 6.7 2.4e-11 -0.91 0.03 0.67 FALSE
27 The Cancer Genome Atlas Soft Tissue Sarcoma FBXW8 0.13 0.11 enet 18 0.12 7.0e-08 -6.6 6.2 7.1e-10 -0.78 0.09 0.91 FALSE
28 The Cancer Genome Atlas Stomach Adenocarcinoma FBXW8 0.09 0.12 lasso 3 0.12 9.1e-09 -6.0 6.4 1.7e-10 -0.88 0.23 0.77 FALSE
29 The Cancer Genome Atlas Thyroid Carcinoma FBXW8 0.22 0.16 blup 83 0.17 2.1e-16 -6.6 6.4 1.4e-10 -0.82 0.40 0.60 FALSE