Best TWAS P=6.23e-16 · Best GWAS P=8.24e-20 conditioned to 2.55e-08
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | PIGC | 0.11 | 0.00 | enet | 21 | 0.01 | 8.4e-02 | -0.85 | 8.1 | 6.2e-16 | 0.37 | 0.05 | 0.30 | TRUE |
| 2 | GTEx | Muscle Skeletal | SUCO | 0.09 | 0.07 | lasso | 7 | 0.07 | 1.0e-07 | -5.35 | -5.2 | 2.1e-07 | 0.00 | 0.99 | 0.00 | TRUE |
| 3 | GTEx | Nerve Tibial | PIGC | 0.10 | 0.02 | enet | 10 | 0.02 | 1.3e-02 | -3.53 | 6.0 | 1.7e-09 | 0.09 | 0.16 | 0.04 | FALSE |
| 4 | GTEx | Skin Sun Exposed Lower leg | PIGC | 0.08 | 0.02 | lasso | 5 | 0.02 | 8.8e-03 | 6.26 | 6.4 | 1.3e-10 | -0.13 | 0.52 | 0.02 | FALSE |
| 5 | GTEx | Spleen | PIGC | 0.29 | 0.04 | lasso | 6 | 0.07 | 6.6e-03 | 2.72 | 5.3 | 9.2e-08 | 0.38 | 0.07 | 0.06 | FALSE |
| 6 | GTEx | Testis | METTL13 | 0.29 | 0.05 | lasso | 10 | 0.09 | 9.9e-05 | -3.98 | 6.7 | 1.6e-11 | 0.39 | 0.22 | 0.21 | TRUE |