[Hub]/) : Traits : Trunk fat-free mass :

chr1:154,282,146-155,910,830

Best TWAS P=3.43e-38 · Best GWAS P=1.38e-34 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Brain Cerebellar Hemisphere DCST2 0.45 0.10 lasso 6 0.16 6.6e-05 -3.60 9.0 2.5e-19 0.75 0.01 0.96 FALSE
2 GTEx Brain Nucleus accumbens basal ganglia DCST2 0.28 0.04 lasso 5 0.13 2.0e-04 12.27 7.9 3.6e-15 0.69 0.02 0.90 TRUE
3 GTEx Breast Mammary Tissue (Female) FAM189B 0.05 -0.01 lasso 2 0.00 4.8e-01 -6.49 6.5 9.4e-11 0.09 0.04 0.07 TRUE
4 GTEx Esophagus Mucosa ADAM15 0.11 0.02 enet 16 0.04 1.5e-03 -5.31 -6.0 1.8e-09 -0.43 0.13 0.78 FALSE
5 GTEx Esophagus Mucosa MUC1 0.17 0.20 lasso 4 0.18 5.6e-12 -7.54 -7.1 1.6e-12 -0.12 1.00 0.00 TRUE
6 GTEx Pancreas THBS3 0.36 0.14 lasso 6 0.12 1.0e-05 2.19 -5.2 2.2e-07 -0.34 0.18 0.54 TRUE
7 GTEx Pancreas RP11-263K19.4 0.22 0.06 enet 23 0.05 3.1e-03 2.19 -7.6 2.3e-14 -0.43 0.06 0.49 FALSE
8 GTEx Skin Not Sun Exposed Suprapubic GBAP1 0.15 0.06 lasso 4 0.06 3.6e-04 -7.62 5.9 3.1e-09 0.11 0.54 0.04 FALSE
9 GTEx Skin Sun Exposed Lower leg ADAM15 0.14 0.09 lasso 4 0.08 6.1e-07 12.27 -12.9 3.4e-38 -0.96 0.00 1.00 TRUE
10 GTEx Testis MUC1 0.20 0.02 lasso 7 0.07 7.5e-04 -7.62 -6.5 7.1e-11 -0.11 0.27 0.05 FALSE
11 GTEx Thyroid DCST2 0.16 0.12 lasso 2 0.11 6.4e-09 -3.60 5.6 2.2e-08 0.53 0.38 0.62 TRUE
12 NTR Blood ZBTB7B 0.02 0.02 lasso 1 0.01 5.4e-05 6.57 6.6 5.0e-11 0.67 0.87 0.03 FALSE
13 ROSMAP Brain Pre-frontal Cortex SLC50A1 0.06 0.02 bslmm 331 0.03 4.3e-05 -7.54 -6.9 6.0e-12 -0.27 0.65 0.04 FALSE
14 The Cancer Genome Atlas Bladder Urothelial Carcinoma TRIM46 0.03 0.00 blup 33 0.02 3.6e-03 -7.54 -6.0 2.3e-09 -0.11 0.03 0.17 FALSE
15 The Cancer Genome Atlas Breast Invasive Carcinoma TRIM46 0.03 0.01 blup 32 0.01 4.9e-03 -7.48 -5.2 1.8e-07 -0.11 0.01 0.14 FALSE
16 The Cancer Genome Atlas Colon Adenocarcinoma ADAM15 0.15 0.02 blup 49 0.08 1.4e-05 7.48 -6.5 5.7e-11 -0.34 0.03 0.04 FALSE
17 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma MUC1 0.04 0.01 enet 4 0.02 1.3e-03 -7.54 -6.2 4.8e-10 -0.15 0.02 0.40 FALSE
18 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma RAG1AP1 0.07 0.00 blup 76 0.00 2.9e-01 -3.52 -6.5 8.7e-11 -0.17 0.02 0.09 TRUE
19 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma ADAM15 0.09 0.00 blup 49 0.02 3.6e-02 -0.64 -5.8 4.9e-09 -0.43 0.01 0.09 TRUE
20 The Cancer Genome Atlas Lung Squamous Cell Carcinoma ZBTB7B 0.05 0.06 lasso 2 0.05 1.8e-06 12.27 -12.3 1.4e-34 -1.00 0.00 1.00 FALSE
21 The Cancer Genome Atlas Prostate Adenocarcinoma GBA 0.05 0.01 lasso 2 0.01 2.3e-02 8.00 -6.8 7.4e-12 -0.07 0.00 0.85 FALSE