TWAS hub - PIGC

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1110	0.0470	9.4e-03	0.006	NA	0.001	NA	-0.001	9.9e-02	NA	2.8e-01	NA	4.4e-01
2	GTEx	Artery Tibial	0.1069	0.0483	6.9e-03	-0.001	NA	0.007	NA	-0.004	4.0e-01	NA	8.4e-02	NA	9.8e-01
3	GTEx	Cells Transformed fibroblasts	0.1240	0.0450	1.3e-03	-0.003	NA	0.045	NA	-0.001	6.9e-01	NA	2.7e-04	NA	4.0e-01
4	GTEx	Esophagus Gastroesophageal Junction	0.1840	0.0640	1.7e-03	0.075	NA	0.132	NA	0.117	1.1e-03	NA	1.7e-05	NA	5.2e-05
5	GTEx	Nerve Tibial	0.1003	0.0434	9.4e-03	0.020	NA	0.020	NA	0.017	1.4e-02	NA	1.3e-02	NA	2.2e-02
6	GTEx	Skin Sun Exposed Lower leg	0.0780	0.0320	2.1e-03	0.019	NA	0.005	NA	0.019	1.0e-02	NA	1.3e-01	NA	8.7e-03
7	GTEx	Small Intestine Terminal Ileum	0.2870	0.1090	9.9e-03	-0.007	NA	0.154	NA	0.021	5.0e-01	NA	2.7e-04	NA	1.1e-01
8	GTEx	Spleen	0.2860	0.1020	8.2e-03	0.035	NA	0.065	NA	0.072	4.4e-02	NA	9.6e-03	NA	6.6e-03
9	GTEx	Testis	0.2470	0.0750	2.5e-04	0.167	NA	0.064	NA	0.148	6.8e-08	NA	8.3e-04	NA	4.2e-07
10	GTEx	Whole Blood	0.1920	0.0400	6.6e-10	0.102	NA	0.121	NA	0.120	1.2e-09	NA	3.2e-11	NA	3.5e-11
11	YFS	Blood	0.0758	0.0183	1.0e-12	0.045	0.049	0.058	0.06	0.053	2.1e-14	1.2e-15	2.9e-18	6e-19	9.3e-17
12	TCGA	Breast Invasive Carcinoma	0.0470	0.0255	2.0e-03	0.000	0.013	0.016	NA	0.011	2.6e-01	7.8e-04	2.3e-04	NA	2.3e-03
13	TCGA	Head and Neck Squamous Cell Carcinoma	0.0223	0.0133	9.6e-03	0.032	0.009	0.022	NA	0.022	1.4e-04	2.9e-02	1.3e-03	NA	1.5e-03
14	TCGA	Kidney Renal Clear Cell Carcinoma	0.1005	0.0420	2.1e-05	0.006	0.054	0.042	NA	0.026	5.9e-02	1.0e-06	1.6e-05	NA	5.9e-04
15	TCGA	Brain Lower Grade Glioma	0.0942	0.0439	5.6e-05	0.004	0.039	0.038	NA	0.012	1.1e-01	2.9e-05	3.7e-05	NA	1.3e-02
16	TCGA	Lung Adenocarcinoma	0.0385	0.0202	5.1e-03	0.005	0.008	0.003	NA	0.007	8.2e-02	3.2e-02	1.1e-01	NA	4.6e-02
17	TCGA	Pheochromocytoma and Paraganglioma	0.1640	0.0840	6.4e-04	0.056	0.074	0.011	NA	0.021	2.8e-03	6.9e-04	1.1e-01	NA	4.9e-02
18	TCGA	Testicular Germ Cell Tumors	0.1810	0.0710	1.8e-04	0.046	0.062	0.011	NA	0.048	1.0e-02	3.2e-03	1.3e-01	NA	8.7e-03
19	TCGA	Thyroid Carcinoma	0.0940	0.0420	1.0e-04	0.020	0.054	0.033	NA	0.039	3.9e-03	5.2e-06	3.4e-04	NA	1.1e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19
Sitting height	4.6	32.6	110.2	5.2	10.5	-6.6	2.9	8.2	7.2	0.5	7.5	0.2	6.4	1.3	3.5	0.2	7.2	6.8	-2.0	-5.7	-3.5	7.2
Standing height	4.4	44.0	156.2	6.5	12.5	-8.1	3.8	9.2	8.2	1.0	8.8	0.7	7.6	0.8	4.7	-0.2	7.9	7.5	-3.3	-5.8	-3.6	8.3
Height	4.3	82.1	295.8	8.8	17.2	-11.3	5.5	12.3	11.3	3.2	13.3	2.3	10.9	0.4	5.8	-0.5	9.7	9.8	-5.3	-7.3	-5.0	10.4
Waist Hip Ratio (WHR)	4.3	19.5	85.9	-0.1	-4.5	-0.4	5.6	-4.8	9.3	-0.5	0.4	-2.9	4.5	1.3	-3.5	6.3	-3.9	-1.9	2.9	-9.1	-4.2	0.2
Heel T-Score	3.9	30.9	61.3	-4.3	-0.6	-7.7	-3.1	-3.7	-7.0	5.1	5.9	6.2	-2.0	-2.7	-4.7	-7.4	-7.6	-7.7	-5.9	7.8	0.3	-6.1
Comparative height size at age 10	3.5	19.4	69.6	2.4	8.3	-6.2	3.1	6.0	6.4	1.5	4.3	-1.4	5.1	2.2	2.8	1.7	5.3	4.3	-0.9	-6.0	-1.1	4.3
Trunk predicted mass	3.2	18.1	65.9	4.3	8.1	-4.0	3.0	6.1	6.4	-1.0	5.3	-0.1	4.9	1.4	3.2	0.5	4.9	4.4	-1.1	-4.3	-2.1	4.8
Trunk fat-free mass	3.1	18.1	65.3	4.2	8.1	-4.0	3.0	6.0	6.4	-1.0	5.3	-0.1	4.9	1.4	3.2	0.5	4.9	4.4	-1.1	-4.4	-2.1	4.8
Ever highly irritable/argumentative for 2 days	3.1	3.7	13.1	-0.4	2.2	-0.7	0.4	2.2	-0.5	2.8	1.4	3.3	1.9	-2.5	0.1	-3.0	-0.9	0.4	-3.6	1.3	-1.4	-1.3
Age started oral contraceptive pill	3.1	3.9	11.3	-1.6	-3.4	0.2	-1.6	-3.0	-2.3	-0.3	-0.7	-1.3	-3.0	2.3	-0.9	0.5	-1.0	-2.6	1.8	1.4	2.6	-2.4
Breast cancer (self-reported)	3.0	3.6	9.4	1.5	3.0	-1.1	2.6	2.5	1.8	0.5	0.4	-1.2	0.4	0.5	2.8	1.8	3.1	2.5	0.2	-2.2	1.2	1.8
Medication: Seretide 50 evohaler	2.9	3.3	10.2	0.1	0.3	-2.1	0.4	-0.2	-2.4	1.0	-0.0	2.7	0.8	-2.6	-2.0	-3.2	-1.5	-1.4	-2.5	3.0	-1.4	-0.5
Fasting Glucose	2.7	3.2	9.4	-1.6	-3.1	0.1	-1.6	-2.7	-0.3	0.4	-0.3	-2.2	-2.1	2.4	-0.6	1.9	-1.3	-2.2	2.1	-0.5	2.3	-1.5
Medication: Paracetamol	2.6	4.1	9.9	-2.4	-2.7	-0.2	-0.9	-2.8	-2.2	-1.8	-1.9	-0.1	-2.5	0.8	-2.4	0.1	-2.9	-3.1	0.8	1.5	1.3	-2.9
Alcohol usually taken with meals	2.5	4.0	11.6	-2.6	-2.4	-1.4	-3.0	-1.8	-3.4	0.7	-1.0	-0.6	-3.4	-0.6	0.1	-0.4	-1.9	-1.5	-0.2	1.3	2.9	-2.8
Whole body fat-free mass	2.4	13.7	51.7	3.6	7.2	-3.9	2.3	5.2	5.4	-0.5	5.1	-0.2	3.9	1.2	3.0	0.3	4.3	3.6	-0.9	-3.8	-1.6	4.1
Whole body water mass	2.4	13.7	50.6	3.6	7.1	-4.0	2.3	5.2	5.5	-0.5	5.2	-0.3	3.9	1.4	3.0	0.4	4.3	3.5	-0.8	-3.8	-1.5	4.0
Ovarian Cancer	2.3	3.0	9.3	-0.4	-0.0	1.9	0.5	0.3	-0.2	-0.8	-3.0	-2.7	-2.0	2.4	2.1	1.6	2.5	0.5	2.5	-0.8	2.3	0.6
HbA1C	2.3	2.6	6.7	-0.8	-2.1	0.1	0.8	-2.1	2.5	-1.5	-2.3	-2.6	-0.7	1.2	-0.3	1.8	-1.2	-0.9	2.0	-2.3	0.8	-0.2
Number of children fathered	2.3	2.6	8.3	-2.3	-0.9	-0.8	-1.8	-1.5	-2.5	1.8	-1.1	-0.4	-2.3	-0.3	-0.1	0.1	-1.6	-1.8	-0.1	1.0	2.5	-2.9
Ever had bowel cancer screening	2.3	2.6	6.4	-2.4	-1.6	-0.8	-1.4	-2.1	-2.3	0.8	-1.3	-1.1	-1.5	1.6	-2.0	0.8	-0.8	-2.5	0.8	0.6	1.8	-2.2
Cholesterol lowering medication	2.3	3.3	13.1	0.6	0.3	0.0	1.7	0.9	1.7	0.9	3.0	2.8	3.6	-1.3	-2.5	-0.8	-0.5	-0.0	-2.5	-0.6	-3.1	0.4
Mouth/teeth dental problems: Bleeding gums	2.2	2.9	9.1	-1.5	-2.5	-0.4	-3.0	-2.3	-2.2	-0.5	-2.0	-0.9	-2.6	0.6	-1.2	0.7	-1.9	-1.2	1.6	1.1	1.3	-1.5
Osteoarthritis (self-reported)	2.2	2.9	8.0	1.7	2.1	0.2	-0.5	2.7	-0.9	-0.3	1.2	2.6	0.6	-1.9	1.2	-2.7	0.8	1.0	-2.8	2.7	-0.4	0.9
Arm fat-free mass (left)	2.2	11.3	42.9	3.3	6.5	-3.6	2.6	4.7	5.2	-0.0	4.8	0.3	4.0	1.0	2.1	-0.0	3.3	2.9	-1.1	-3.2	-1.9	3.4
Heel bone mineral density (BMD) T-score, automated (left)	2.1	4.8	9.7	-2.2	-0.8	-2.7	-2.0	-2.6	-2.7	0.9	2.9	0.6	-2.5	-0.6	-0.2	-2.0	-2.8	-3.1	-1.0	2.3	2.6	-2.9
Chronic bronchitis/emphysema (mother)	2.1	2.4	6.7	2.6	0.2	0.5	2.0	-0.1	2.4	1.9	1.1	-2.0	0.0	1.2	2.0	1.7	1.5	0.9	2.0	-1.2	0.6	1.8
Supplements: Vitamin C	2.1	2.5	9.8	0.4	1.1	-0.5	0.7	1.1	-0.0	-0.2	1.0	2.6	2.4	-2.7	-1.6	-2.1	-0.5	-0.0	-3.1	1.3	-1.9	1.0
Average weekly red wine intake	2.1	3.2	13.7	-2.2	-1.8	-0.1	-3.7	-1.4	-3.4	0.5	-0.7	0.0	-2.8	-0.9	-0.5	-1.2	-1.2	-1.2	-0.2	2.1	1.7	-2.0
Osteoporosis (self-reported)	2.1	2.5	6.2	1.8	1.7	0.7	1.2	2.3	1.7	0.1	0.3	0.3	1.9	-0.9	-0.3	1.2	2.4	2.5	-0.7	-1.9	-2.3	2.2
Arm predicted mass (left)	2.1	10.6	40.2	3.0	6.3	-3.8	2.6	4.4	5.2	0.3	4.7	0.2	3.9	1.0	2.0	0.1	3.1	2.6	-1.1	-3.4	-1.8	3.2
Chronotype (morning person)	2.0	4.6	15.1	1.9	3.9	1.3	2.5	2.5	1.7	-1.5	-0.8	-1.1	1.7	-0.3	1.3	2.0	2.8	3.6	0.8	-2.6	-1.6	3.0
Medication for hormone replacement therapy	2.0	2.3	6.9	2.5	0.2	-0.2	1.0	0.1	0.9	2.1	1.7	-1.9	-0.6	1.2	2.6	1.3	2.0	1.6	1.9	-0.9	0.5	1.5
Arm fat-free mass (right)	2.0	10.4	37.3	3.3	6.1	-3.6	2.0	4.5	4.9	0.4	4.8	0.3	3.9	1.1	1.9	-0.2	3.4	2.7	-0.9	-3.1	-2.0	3.5
Medication for pain relief, constipation, heartburn	2.0	3.4	11.6	1.7	3.3	-0.7	0.7	3.4	0.2	0.0	0.3	0.6	1.7	-0.7	2.1	-0.9	3.3	3.3	-1.2	0.1	-0.5	2.6
Arm predicted mass (right)	2.0	10.4	36.4	3.3	6.0	-3.5	1.9	4.5	4.9	0.3	4.7	0.3	3.9	1.2	2.1	-0.1	3.4	2.8	-1.0	-3.2	-1.9	3.4
Medication: Aspirin	2.0	2.7	9.2	-1.6	-1.6	-0.3	-1.4	-3.0	-0.3	1.7	0.9	-0.5	-1.7	0.2	-1.4	0.7	-2.9	-3.0	0.4	-0.6	0.8	-2.5
Financial situation satisfaction	2.0	2.5	13.2	0.8	0.4	-0.1	1.8	2.1	2.4	-0.9	-0.3	1.3	3.6	-0.5	-1.4	0.0	0.1	1.2	-1.2	-1.6	-3.0	0.8
Basal metabolic rate	2.0	11.2	43.8	3.2	6.6	-3.8	1.9	4.7	4.9	-0.2	4.9	-0.1	3.6	1.2	2.4	0.1	3.8	3.1	-0.9	-3.3	-1.4	3.6
Loud music exposure frequency	1.9	2.1	5.7	-0.5	-0.9	-0.1	-0.5	0.2	-0.8	2.1	-0.5	2.2	1.5	-1.9	-2.3	-1.4	-2.4	-0.3	-1.6	1.4	-2.2	-0.7
Forced vital capacity (FVC), Best measure	1.9	6.9	29.4	1.8	4.4	-2.7	0.2	4.5	2.2	0.9	5.4	0.7	1.7	0.1	4.0	-1.8	3.2	2.4	-1.9	-0.5	0.4	2.0
Blood Platelet Count	1.8	21.0	116.6	-1.3	-1.1	2.7	-2.0	-0.2	-3.2	-8.7	-4.1	-5.2	-10.8	1.3	6.0	4.0	3.0	3.0	4.0	0.5	7.1	-0.7
Forced expiratory volume in 1-second (FEV1)	1.8	6.1	18.8	2.0	4.2	-2.4	1.2	4.2	3.0	0.2	4.3	1.1	2.9	-0.3	2.4	-1.5	2.6	2.1	-2.2	-1.6	-1.0	2.2
Forced expiratory volume in 1-second (FEV1), Best measure	1.8	5.8	21.6	1.7	3.9	-2.0	0.5	4.1	3.2	0.6	4.6	0.4	2.3	0.4	3.4	-1.0	2.8	1.8	-1.6	-1.6	0.1	1.9
Seen a psychiatrist for nerves, anxiety, tension or depression	1.8	2.4	6.1	2.5	0.0	-0.5	2.2	0.1	2.5	1.0	1.1	-1.6	0.7	2.3	1.4	1.7	1.3	1.0	2.0	-1.8	-0.6	1.7
Mean time to correctly identify matches	1.8	3.4	14.1	-0.6	-1.7	-1.8	-0.5	-1.6	-1.4	0.1	0.8	2.1	-1.0	-2.1	-1.4	-3.2	-2.7	-2.2	-1.8	3.8	-0.3	-0.9
Leg pain on walking	1.8	2.2	7.5	1.7	1.1	-1.0	0.7	1.9	0.2	0.8	1.8	2.7	2.1	-1.2	-0.5	-1.9	0.3	0.8	-2.1	1.5	-1.8	0.8
Forced expiratory volume in 1-second (FEV1), predicted	1.8	3.8	18.1	1.5	4.3	-2.6	1.1	2.5	2.2	0.7	3.1	0.3	2.4	0.1	1.4	-0.7	1.8	1.7	-1.4	-1.3	-0.9	1.9
Medication: Aspirin	1.8	2.3	9.3	-1.6	-1.5	0.2	-1.2	-2.8	-0.3	1.1	0.5	-0.5	-1.4	-0.1	-1.5	0.5	-3.1	-2.9	0.4	-0.5	0.5	-2.5
Number of self-reported non-cancer illnesses	1.8	3.1	7.9	0.6	1.3	-2.1	0.1	0.4	-1.2	2.4	2.2	2.8	1.8	-2.4	-1.8	-2.0	-1.0	0.1	-2.2	1.6	-2.6	-0.0
Supplements: Fish oil (including cod liver oil)	1.8	2.3	6.9	2.0	2.6	0.4	1.2	1.7	-0.5	0.6	1.9	2.0	1.1	-1.2	-0.1	-1.9	1.2	1.4	-1.4	1.4	-1.9	1.8
Forced vital capacity (FVC)	1.7	6.5	22.9	1.8	4.6	-3.4	1.0	4.2	2.2	0.8	4.8	0.8	2.1	-0.1	2.8	-1.7	3.0	2.2	-2.1	-1.1	-0.4	2.2
Mouth/teeth dental problems: Dentures	1.7	2.9	9.8	1.1	-0.2	-0.2	-0.8	0.7	-0.8	1.1	2.8	3.1	1.3	-1.9	-1.2	-3.1	-1.0	-0.7	-2.5	2.5	-1.7	-0.2
Diabetes (mother)	1.6	2.0	12.3	-0.4	-1.6	1.5	0.7	-0.2	2.6	0.3	-1.1	-2.1	0.3	0.7	0.3	2.5	0.3	-0.1	1.0	-3.5	0.2	0.1
Number of incorrect matches in round	1.6	2.6	9.4	-1.8	-1.0	-3.1	0.6	-1.7	-1.0	0.9	0.9	-2.2	-2.0	1.5	-0.6	1.6	-0.8	-1.8	1.8	-0.7	2.3	-2.0
Had other major operations	1.6	1.9	7.4	-0.3	2.7	-2.7	0.8	0.2	-1.6	1.8	2.6	1.5	0.4	-1.0	-1.1	-0.7	-0.1	-0.2	-1.6	0.4	-0.3	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	1.6	3.8	10.2	-1.0	-0.3	-2.6	-2.0	-1.6	-2.6	1.2	3.2	1.2	-2.1	-1.2	0.4	-2.6	-2.1	-2.2	-1.5	2.5	1.8	-2.0
Birth weight of first child	1.6	2.8	9.0	0.9	0.8	-0.7	0.3	0.6	1.0	1.1	-0.7	-2.5	-1.4	3.0	2.9	1.4	2.5	0.9	2.3	-0.7	2.7	1.2
Medication: Paracetamol	1.6	2.7	6.8	-2.0	-2.5	-0.0	-0.6	-2.2	-1.2	-1.5	-1.5	-0.0	-1.8	0.8	-1.9	0.1	-2.6	-2.5	0.8	1.1	1.0	-2.5
Medication for cholesterol	1.6	2.4	11.4	-1.6	-1.1	1.3	-1.0	-1.0	-2.4	-2.0	-3.4	-0.7	-2.4	0.1	0.3	-0.2	-0.6	-1.1	0.6	1.9	1.8	-1.2
Leg predicted mass (right)	1.6	8.3	32.3	2.9	5.7	-3.2	1.5	3.8	4.0	-0.2	4.0	-0.8	2.5	1.2	2.6	0.5	3.7	2.8	-0.2	-3.1	-0.7	3.3
Leg fat-free mass (left)	1.5	8.0	31.7	2.7	5.6	-3.6	1.1	4.0	3.9	-0.2	4.3	-0.4	2.5	1.1	2.4	0.1	3.5	2.5	-0.6	-2.8	-0.7	3.0
Average weekly fortified wine intake	1.5	1.7	4.8	2.1	0.5	0.7	-1.0	1.0	0.8	-0.9	-0.9	-0.8	-1.0	2.2	2.2	0.6	2.1	0.7	1.5	0.5	1.5	1.4
Taking other prescription medications	1.5	2.3	7.8	1.0	0.6	-2.3	0.6	-0.2	-0.3	1.6	2.2	2.1	1.8	-1.3	-2.6	-0.7	-1.6	-0.5	-1.1	0.9	-2.8	0.2
Leg predicted mass (left)	1.5	8.2	32.4	2.6	5.7	-3.7	1.1	4.1	3.9	-0.1	4.4	-0.3	2.5	1.1	2.4	0.0	3.6	2.6	-0.7	-2.8	-0.8	3.0
Hayfever/allergic rhinitis (self-reported)	1.5	2.0	10.1	0.6	3.2	-2.1	0.7	0.7	-1.2	1.8	2.4	1.3	0.2	-1.9	0.2	-1.4	-0.2	0.6	-1.7	0.8	-0.5	0.5
Leg fat-free mass (right)	1.5	8.2	32.4	2.9	5.7	-3.2	1.4	3.8	4.0	-0.1	4.1	-0.7	2.4	1.2	2.6	0.4	3.7	2.8	-0.3	-3.0	-0.7	3.2
Basal cell carcinoma (self-reported)	1.5	1.8	5.7	1.4	1.9	-0.0	1.5	1.8	1.1	0.5	-0.9	0.8	2.4	-1.3	0.1	0.0	0.5	2.1	-0.8	-1.5	-2.0	1.3
Bipolar Disorder (2018)	1.4	2.2	4.9	-1.1	-0.4	1.5	-1.6	-0.4	-1.4	-2.2	-0.7	-2.2	-2.0	1.7	1.3	1.1	1.7	0.8	2.1	-0.3	2.1	0.2
Lupus	1.4	2.1	10.9	0.8	2.0	-3.3	2.3	0.6	1.1	2.2	2.3	0.6	1.1	-0.8	0.5	-0.8	0.1	0.8	-1.3	-0.7	-0.9	1.0
Supplements: Glucosamine	1.4	1.8	5.7	1.4	2.1	-0.0	0.8	2.4	-0.9	0.4	0.7	1.9	1.0	-1.2	0.3	-2.0	1.1	1.6	-1.5	1.1	-1.2	1.0
Number of live births	1.4	2.0	5.7	-2.0	-1.5	-2.4	-0.0	-0.6	-0.8	-0.1	1.4	1.1	0.5	-1.0	-2.0	-1.2	-1.7	-2.0	-1.9	0.0	-0.3	-2.0
High blood pressure (siblings)	1.4	2.1	5.1	1.9	0.9	0.4	0.1	1.6	2.3	0.5	1.9	1.5	2.2	-1.3	0.9	-1.5	0.4	1.1	-1.6	0.3	-1.8	2.0
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	5.6	-0.4	-1.1	-1.2	0.2	-1.2	0.2	0.1	1.1	1.8	0.3	-1.1	-1.2	-1.7	-2.4	-1.9	-1.2	1.4	-1.1	-1.1
Ever smoked	1.4	2.4	7.5	-1.3	-2.7	0.6	-2.3	-0.5	-1.2	-0.3	-1.8	1.6	0.6	-1.1	-2.1	-1.5	-2.5	-1.4	-0.8	1.5	-0.8	-1.5
Alzheimer’s Disease (in father)	1.3	1.5	5.6	2.0	1.1	0.1	0.6	1.1	1.1	-1.1	1.4	-0.3	0.8	-0.2	2.2	0.3	1.1	2.4	0.3	-0.2	-0.7	1.8
Rheumatoid Arthritis	1.3	1.8	7.0	1.9	0.7	-0.6	0.5	0.6	0.6	0.6	1.0	-1.5	-0.4	1.0	1.6	1.6	2.6	1.7	1.4	-1.3	0.5	2.3
Number of treatments/medications taken	1.3	2.4	6.7	-0.5	-0.3	-1.2	-0.3	-1.2	-0.6	1.9	2.2	2.1	1.0	-1.7	-2.6	-1.3	-2.6	-1.6	-1.6	0.7	-1.8	-1.1
Hand grip strength (right)	1.3	3.4	9.2	1.7	1.2	-0.9	-0.4	1.5	2.5	1.0	1.3	-1.8	1.0	2.2	1.4	1.9	3.0	2.3	1.9	-2.9	-0.5	2.5
Multivitamins +/- minerals	1.3	1.6	6.8	-1.8	-1.0	-0.5	0.2	-1.9	-0.8	-0.4	-1.1	0.5	-0.8	0.0	-2.0	-0.7	-2.6	-2.0	-0.4	0.0	0.0	-2.1
Medication: Gliclazide	1.3	1.4	6.5	0.7	-0.6	0.1	0.1	0.7	1.3	0.4	0.6	1.7	2.4	-0.9	-2.3	-0.7	-0.7	-0.4	-1.3	-0.5	-2.5	-0.0
Fractured/broken bones in last 5 years	1.3	1.6	5.8	1.1	1.0	0.9	2.1	1.9	1.9	0.9	0.3	0.5	2.4	-0.3	-0.9	0.3	1.0	1.4	-0.4	-1.3	-1.6	1.0
Reaction Time	1.2	2.2	7.3	-0.4	-1.7	-2.1	-0.2	-1.7	-0.6	0.5	0.8	1.6	-0.8	-1.7	-1.1	-2.3	-2.3	-1.8	-1.5	2.7	-0.3	-0.3
Neuroticism (2016)	1.2	1.7	5.7	-0.4	0.7	-0.9	0.7	0.2	-0.5	-0.7	0.4	2.0	1.5	-2.1	-1.7	-1.6	-1.6	-0.6	-2.0	0.2	-2.4	-0.7
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	5.0	-0.5	-1.6	-0.6	-0.6	-0.6	0.2	2.2	1.5	0.8	0.6	-0.4	-2.1	0.0	-1.6	-1.6	-0.5	-0.1	-0.7	-1.5
Vitamin and mineral supplements	1.2	1.7	5.3	1.7	-0.1	0.5	0.1	0.5	1.4	0.6	0.2	-1.8	-0.1	1.3	2.3	1.5	2.1	1.3	1.9	-1.0	0.7	1.6
Alcohol intake versus 10 years previously	1.2	1.8	5.9	1.8	1.3	0.6	1.4	1.4	1.4	1.0	1.2	1.2	2.2	-1.1	-0.2	-0.1	0.6	1.8	-1.0	-0.5	-2.4	1.6
Medication: Lansoprazole	1.2	1.4	4.4	-2.1	-1.5	-0.5	-0.5	-1.3	-1.4	0.3	1.1	0.8	-0.3	0.5	-1.5	-0.5	-1.0	-2.0	-0.8	0.8	0.4	-2.0
Headache pain in last month	1.2	2.0	6.8	1.4	0.2	2.0	2.6	0.1	2.2	-1.7	-1.1	-1.2	1.3	1.3	-0.0	1.6	0.5	0.6	1.7	-1.7	-0.8	1.1
Medication: Amlodipine	1.2	1.7	6.4	-0.5	-0.5	-1.6	0.3	-0.4	0.9	1.1	1.0	0.7	1.6	-1.6	-2.4	0.9	-1.3	0.5	-0.8	-2.1	-2.5	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	4.8	-2.0	-1.9	0.3	-0.7	-2.1	-0.2	0.7	-0.5	-1.0	-1.1	1.1	-1.0	0.4	-0.9	-2.2	1.1	-0.3	0.7	-1.2
Age at last live birth	1.2	1.7	5.8	1.1	-0.5	1.1	-0.2	-0.3	-0.5	-2.0	-1.3	-1.6	-2.4	1.5	1.6	0.4	1.4	0.1	1.5	0.9	2.2	0.7
Handedness (chirality/laterality): Left-handed	1.2	1.5	4.8	-1.4	-1.8	0.8	-1.8	-1.2	-0.5	0.7	-0.0	-0.4	-1.7	-0.4	0.4	-0.1	-2.2	-1.2	0.4	0.4	1.5	-2.1
Long-standing illness, disability or infirmity	1.2	1.9	6.0	0.9	0.9	-1.7	0.4	0.8	-0.5	1.3	2.5	2.2	1.2	-1.9	-1.0	-1.6	-1.0	-0.0	-1.8	1.4	-1.8	-0.3
Medication: Blood pressure	1.2	2.2	14.6	0.7	1.4	-2.2	1.2	0.3	2.0	1.1	3.8	1.0	2.2	-0.6	-1.1	0.0	-0.6	0.1	-1.1	-1.5	-1.4	0.4
Pain type(s) experienced in last month: Hip pain	1.2	1.5	5.3	1.8	1.6	-0.3	1.5	1.2	-1.3	0.8	2.3	1.2	0.1	-1.4	0.2	-0.9	1.2	1.0	-1.4	1.2	-0.7	1.0
Major Depression (MDD)	1.1	1.3	5.9	0.1	1.0	-1.3	-0.1	-0.3	-1.3	0.5	1.5	1.7	0.8	-1.1	-2.4	-1.1	-0.6	-0.3	-1.4	0.9	-1.8	0.2
Prostate Cancer	1.1	1.5	6.6	-1.7	-0.0	0.8	-0.4	-1.5	-1.3	0.6	-0.9	-1.5	-2.6	0.1	0.5	0.3	-0.8	-1.3	1.2	0.3	2.2	-1.4
Lung FVC	1.1	5.6	18.1	-2.5	-1.6	0.4	-1.1	0.1	-3.5	0.9	1.7	3.0	-1.0	-2.3	-0.7	-4.1	-2.3	-2.4	-3.1	4.3	0.6	-2.8
Angina	1.1	1.4	4.8	0.6	0.7	0.6	-0.4	0.8	0.5	1.2	1.6	1.8	2.1	-1.7	-1.1	-1.0	-0.6	0.2	-1.5	-0.4	-2.2	-0.3
Fed-up feelings	1.1	2.0	9.3	1.6	1.1	0.1	1.9	1.0	2.5	-0.6	0.6	1.4	3.0	-0.5	0.3	-0.6	-0.8	0.9	-0.6	-0.5	-2.4	1.6
Financial difficulties in last 2 years	1.1	1.5	11.2	0.2	1.8	-1.4	1.1	1.4	1.6	0.6	3.4	0.4	1.4	0.3	1.4	-0.3	0.0	0.1	-0.8	-1.1	0.2	-0.2
Heart attack	1.1	1.3	8.3	-1.5	-0.7	-1.0	0.3	-1.4	0.1	2.9	0.5	-0.2	0.9	-0.4	-1.5	0.5	-1.5	-0.9	-0.1	-1.4	-0.6	-1.4
Diabetes (self-reported)	1.1	1.7	10.6	-0.2	-0.4	-1.7	0.3	0.2	1.5	3.2	2.7	-0.4	1.3	0.8	-0.8	0.6	-0.4	-1.2	-0.1	-1.8	-0.2	-0.9
Asthma	1.1	2.1	11.3	-0.0	-0.8	-2.4	-0.7	-0.5	-1.7	0.7	-1.1	1.8	0.9	-1.7	-3.4	0.0	-0.6	0.7	-0.9	0.5	-3.0	0.3
Loneliness, isolation	1.1	1.5	5.1	0.1	1.4	-1.0	1.1	-1.0	-0.8	2.0	2.2	1.6	0.9	-1.3	-1.1	-0.5	-1.3	-0.6	-1.4	0.7	-1.6	-0.1
Mineral and other dietary supplements	1.1	1.5	5.0	-0.7	-2.2	0.6	-0.9	-1.3	1.1	-1.4	-2.1	-1.7	-0.8	0.7	0.6	1.3	-0.9	-0.4	1.8	-1.0	0.9	-0.6
Average weekly champagne plus white wine intake	1.1	1.5	6.1	-0.8	-0.0	0.6	-1.6	-0.4	-1.0	-0.2	-0.0	-1.9	-2.5	1.3	0.9	1.5	0.9	0.9	1.7	-0.7	1.9	-0.3
Eye problems/disorders: Glaucoma	1.1	1.3	3.2	1.6	1.1	1.2	0.6	0.1	1.5	1.0	0.5	-0.4	1.6	1.0	-0.1	0.8	0.9	0.9	1.2	-1.5	-1.8	1.5
Ever depressed for a whole week	1.1	1.4	5.3	0.0	0.8	-0.8	0.4	1.1	-0.3	1.1	1.1	2.2	1.7	-1.4	-1.2	-1.2	-0.3	0.3	-2.3	0.6	-1.7	-0.3
Vascular/heart problems diagnosed by doctor	1.1	3.0	9.7	0.6	0.5	2.2	-0.5	1.5	-0.9	-2.0	-3.1	-1.7	-2.1	1.7	2.3	0.8	2.8	1.8	1.6	0.4	1.7	1.1
Age at First Birth	1.0	1.4	5.0	-2.2	-1.5	0.7	-0.7	-1.2	-1.4	-1.0	-1.8	0.7	-0.5	-0.2	-2.1	0.5	-1.5	-0.9	-0.3	-0.1	-0.2	-1.7
Bipolar Disorder (2011)	1.0	0.9	4.0	0.2	0.4	-0.0	-1.6	0.4	-1.8	-0.8	0.1	0.6	-1.0	-0.4	0.9	-1.7	0.7	-0.2	-0.5	2.0	1.1	0.2
Coronary Artery Disease (CAD)	1.0	1.2	6.3	1.4	-1.1	2.5	-0.6	0.4	1.2	-0.9	-0.8	-0.3	-0.1	1.2	2.0	-0.5	0.7	-0.6	1.2	0.3	0.8	0.6
Cardiovascular Disease	1.0	3.3	11.5	-0.6	-1.1	-3.4	0.9	-2.2	1.7	1.6	2.3	1.1	2.3	-0.7	-2.5	-0.2	-2.9	-2.1	-1.1	-1.3	-1.8	-0.8
Medication: Metformin	1.0	1.3	6.3	-0.3	-1.0	-0.4	0.3	-0.4	1.0	2.4	1.3	0.6	1.5	-0.1	-2.5	0.5	-0.8	-1.3	-0.5	-1.1	-1.6	-0.5
Maternal smoking around birth	1.0	1.5	4.2	1.9	0.3	0.6	1.1	1.4	0.8	1.5	0.4	1.3	1.7	-1.1	0.2	-0.7	0.8	1.3	-1.0	0.6	-1.8	2.0
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	4.1	0.8	1.6	-0.4	0.1	1.9	0.1	0.1	0.4	2.0	1.1	-1.2	0.2	-1.8	0.2	0.7	-2.0	0.8	-1.2	0.1
Mouth/teeth dental problems	1.0	1.5	4.7	0.3	1.2	0.5	2.1	0.6	2.1	-0.3	-0.2	-1.0	1.2	1.0	0.7	1.7	1.5	0.9	0.4	-2.2	-0.3	1.4
Father’s age at death	1.0	1.4	10.1	-0.8	-0.1	-0.6	-1.6	-0.0	-1.8	0.0	0.1	-0.7	-3.2	0.1	0.5	0.1	0.8	-0.6	0.3	1.0	2.4	-0.8
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	6.8	-1.0	-1.2	-1.2	-1.8	-1.5	-0.0	-0.8	-1.1	-0.4	-0.4	0.8	-2.6	1.0	-1.4	-2.1	0.7	-0.7	-0.5	-1.5
Angina (self-reported)	1.0	1.3	3.4	0.7	0.9	0.7	-0.4	1.0	0.5	0.9	1.4	1.8	1.7	-1.8	-0.7	-1.1	-0.5	0.4	-1.5	-0.2	-1.8	-0.2
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	5.6	-0.4	-0.2	2.0	-1.3	-0.1	-2.1	-0.7	-2.4	0.4	-1.0	-1.7	-0.3	-0.3	-0.4	0.5	-0.5	1.1	0.5	-0.3
Asthma (self-reported)	1.0	1.9	10.5	0.0	-0.8	-2.0	-0.5	-0.6	-1.5	0.6	-1.5	1.5	0.9	-1.5	-3.2	0.3	-0.5	0.8	-0.5	0.2	-3.0	0.3
Risk taking	1.0	1.5	6.9	-0.7	-2.0	0.7	-1.2	-0.8	-2.6	0.8	-0.2	0.3	-2.4	-0.7	0.5	-1.2	-0.8	-0.1	-0.0	1.6	0.9	-1.4
Heart attack/myocardial infarction (self-reported)	1.0	1.3	7.0	-1.6	-0.6	-1.0	0.6	-1.3	0.2	2.6	0.5	-0.5	0.8	-0.2	-1.4	0.7	-1.4	-1.0	0.1	-1.6	-0.4	-1.4
Bipolar Disorder or Schizophrenia	0.9	2.1	8.6	-0.6	0.8	1.3	-2.9	0.6	-2.0	-2.0	-0.8	-0.6	-2.0	0.0	1.6	-1.0	1.7	0.3	0.2	1.4	2.5	0.5
Depression (Nagel 2018)	0.9	1.3	5.4	0.3	-0.2	-2.3	1.4	-1.4	0.5	1.1	1.6	1.0	0.7	-0.3	-1.2	-0.5	-2.0	-1.4	-0.5	0.6	-1.0	-0.5
Breast Cancer	0.9	2.1	10.3	-0.9	-0.2	-0.7	2.0	1.3	3.2	-0.4	-0.2	-0.1	2.4	1.2	-0.6	1.7	0.7	0.1	-0.3	-3.2	-0.5	0.2
Mean Putamen Volume	0.9	1.0	6.2	-1.0	-1.1	-1.4	0.0	-2.5	-0.5	0.8	-0.3	0.3	-0.7	-0.8	-0.8	-0.6	-1.8	-1.4	-0.1	0.3	0.2	-0.9
Primary Biliary Cirrhosis	0.9	1.2	7.1	-1.3	0.5	-1.8	1.2	-0.9	-1.1	2.7	-0.0	0.0	-0.8	0.9	-1.0	0.2	-0.3	-1.2	-0.2	0.2	1.0	-1.5
Blood Red Count	0.9	8.8	28.3	-0.1	-5.3	3.0	3.3	-2.1	4.5	-1.7	-1.1	0.3	4.7	0.1	-3.6	2.6	-2.2	-1.2	0.9	-4.5	-4.6	0.2
Lung FEV1/FVC ratio	0.9	4.5	23.8	2.5	0.1	2.5	1.1	1.0	4.9	-2.8	-1.0	-0.6	3.4	0.9	1.5	1.4	1.2	1.4	0.9	-2.5	-2.0	2.5
Hand grip strength (left)	0.9	2.5	8.0	1.3	1.4	-0.6	-0.9	1.6	1.9	1.1	0.5	-1.5	0.5	1.9	1.6	1.4	2.8	2.1	1.6	-2.1	0.1	2.2
Current tobacco smoking	0.9	1.5	5.2	0.9	-0.5	1.6	-1.2	0.1	0.2	0.2	0.0	2.3	1.6	-1.2	-0.9	-1.9	-0.7	-0.4	-1.4	1.9	-1.7	0.9
High blood pressure	0.9	2.4	8.9	-0.3	-0.1	-2.4	0.4	-1.0	0.7	1.7	3.0	1.7	1.9	-1.6	-2.0	-1.1	-2.2	-1.4	-1.7	-0.1	-1.6	-0.7
Hair/balding pattern: Pattern 2	0.9	1.1	5.5	1.0	0.5	2.2	1.1	0.5	0.0	0.1	0.6	0.2	1.0	-0.6	0.4	0.0	0.7	2.3	0.4	-0.1	-1.5	1.8
Peak expiratory flow (PEF)	0.9	2.2	9.1	1.2	0.9	-0.3	1.5	1.7	3.0	-0.4	0.9	0.8	2.9	-0.5	-0.4	-0.3	0.2	0.6	-0.7	-2.5	-2.6	1.0
Eye problems/disorders: None of the above	0.9	1.0	7.3	-0.9	-1.8	1.4	-0.6	-0.5	-0.2	-2.7	-1.6	-0.8	-0.7	-0.0	0.5	0.1	0.2	-0.3	0.5	0.7	1.0	-0.1
Heart disease (mother)	0.9	1.1	5.3	0.3	-0.2	1.2	-0.3	-0.4	-1.5	-0.5	0.4	1.4	-0.8	-0.8	-1.3	-1.3	-1.6	-0.5	-0.3	2.3	-1.0	-0.8
Illnesses of father: High blood pressure	0.9	1.1	6.3	1.2	0.9	0.3	0.9	0.1	1.0	0.7	2.5	0.5	1.6	-0.4	-1.2	0.2	0.0	0.6	-0.2	-0.5	-1.8	1.1
Diastolic blood pressure, automated reading	0.9	2.9	7.4	-1.7	-2.1	-2.0	-0.2	-2.5	2.4	-0.4	-0.1	-1.5	0.5	1.7	-1.5	2.0	-1.9	-2.7	1.2	-2.5	0.4	-0.9
Schizophrenia (2018)	0.8	1.6	6.2	0.2	1.3	0.4	-2.5	1.1	-1.4	-0.6	-0.4	1.0	-0.9	-1.4	1.1	-2.1	0.8	-0.3	-1.4	2.0	1.4	0.5
Crohns Disease (2017)	0.8	1.9	23.1	0.3	-1.8	2.4	-4.8	-0.6	0.5	-0.6	-0.3	-0.2	0.6	-0.4	-0.0	-0.1	-0.4	0.7	0.5	0.1	-0.4	0.7
Respiratory disease	0.8	1.9	11.6	1.1	-0.8	-1.7	-0.2	0.4	-0.8	0.7	-1.0	1.8	1.7	-0.8	-2.9	0.4	0.2	1.2	-0.1	0.2	-3.4	0.6
Serious illness, injury or assault to yourself	0.8	1.0	5.9	0.6	0.4	-2.4	-0.6	1.3	1.1	1.2	1.9	0.7	1.3	-0.3	-0.3	-0.4	0.2	0.3	-0.6	-0.6	-0.8	0.1
Chronic bronchitis/emphysema (father)	0.8	0.9	3.1	-1.1	0.1	0.2	-1.8	0.0	-1.4	-0.5	-1.4	0.9	-0.7	-1.0	-0.6	-0.7	-0.9	-0.3	-1.2	1.1	0.2	-1.4
Nervous feelings	0.8	1.5	11.2	1.3	-0.2	0.5	0.5	0.0	0.6	-0.8	0.8	1.2	2.4	-0.9	-1.8	0.1	-0.4	1.0	-0.2	-0.6	-3.3	1.1
Had menopause	0.8	1.0	2.5	-0.1	0.8	-1.5	1.0	-0.0	-0.3	0.0	0.1	1.5	0.3	-1.5	-1.0	-1.2	-1.2	-1.1	-1.6	1.3	-0.3	-0.6
Hip circumference	0.8	3.3	10.4	0.6	3.2	-1.7	-2.2	2.5	-2.3	0.8	2.1	1.7	-0.5	-0.4	0.8	-3.1	1.1	0.2	-1.7	3.0	0.9	-0.0
Prospective memory result	0.8	0.9	3.8	0.1	0.5	-0.1	1.9	0.3	-0.4	-0.2	1.0	-1.3	-1.4	0.8	1.3	0.8	1.1	-0.2	0.9	-0.2	1.8	-0.5
Exposure to tobacco smoke at home	0.8	0.9	2.9	-0.0	-1.1	0.6	-0.3	-0.5	0.0	-0.7	-1.2	1.3	0.9	-1.7	-1.1	-0.8	-1.5	-0.1	-0.8	0.0	-1.7	-0.1
Breastfed as a baby	0.8	1.0	3.8	-1.0	-1.1	-0.7	-0.7	-0.7	0.1	0.0	-0.2	-1.4	-0.7	2.0	-0.4	0.9	0.2	-1.4	0.8	-1.1	1.5	-1.3
Leg fat percentage (right)	0.8	3.0	9.1	-1.4	-1.7	0.6	-1.8	-1.6	-2.0	1.6	0.3	1.4	-1.2	-1.4	-1.9	-1.9	-3.0	-2.6	-1.0	2.2	-0.1	-2.3
Mouth/teeth dental problems: Loose teeth	0.8	1.0	3.4	1.7	0.6	0.3	1.1	0.2	1.0	0.8	-0.8	-0.6	0.4	-0.1	0.8	0.7	0.9	1.5	1.0	-1.0	-1.1	1.8
Hypertension (Self-reported)	0.8	2.2	8.2	-0.1	-0.4	-2.4	0.2	-0.9	0.8	1.5	2.9	1.6	1.8	-1.5	-1.9	-0.9	-2.1	-1.3	-1.7	-0.2	-1.5	-0.7
Diabetes diagnosed by doctor	0.8	1.3	7.3	0.3	-0.3	-1.2	-0.0	0.1	1.2	2.7	2.5	0.0	1.1	0.2	-1.2	0.1	-0.7	-1.2	-0.2	-1.1	-0.8	-0.8
Back pain experienced in last month	0.8	1.1	4.0	0.9	0.9	0.1	0.5	1.6	0.9	0.7	1.6	1.5	2.0	-0.5	-0.2	-1.3	0.4	0.0	-1.3	0.0	-1.6	0.6
Illnesses of father: None of the above (group 1)	0.8	1.0	5.0	-0.7	0.9	0.2	1.1	-0.0	-1.0	0.4	-1.6	-0.8	-1.6	-0.1	2.1	0.2	0.6	-0.2	-0.0	0.2	2.2	-0.4
Hearing aid user	0.8	0.9	3.7	-0.4	0.4	-0.7	-0.7	1.3	-0.5	0.8	0.5	1.5	-0.2	-0.5	0.3	-1.9	-0.4	-0.7	-1.5	1.9	0.6	-0.8
Leg fat percentage (left)	0.8	3.0	9.4	-1.2	-1.9	1.1	-1.5	-2.0	-2.0	1.8	-0.1	1.2	-1.2	-1.4	-2.0	-1.7	-3.1	-2.5	-0.5	2.2	-0.2	-2.0
Number of operations (self-reported)	0.8	1.2	3.5	-0.0	1.8	-1.7	1.9	-0.2	0.8	0.8	1.7	-1.1	0.2	1.1	0.0	1.2	0.7	-0.1	1.1	-1.7	0.3	0.1
Average weekly beer plus cider intake	0.8	1.1	4.4	1.9	0.6	1.8	0.9	0.4	0.6	0.5	-0.2	0.9	1.5	-0.6	0.7	-0.7	1.0	0.4	-0.4	0.7	-1.3	2.1
Schizophrenia vs Biploar Disorder	0.7	0.9	4.0	0.4	-1.3	-0.1	0.2	-0.6	2.0	0.7	0.6	-1.3	-0.3	1.1	0.9	1.3	-0.1	-1.1	0.8	-1.2	1.1	-0.3
Crohns Disease (2012)	0.7	1.1	13.0	0.5	-0.9	1.2	-3.6	-0.1	0.4	-0.3	-0.2	-1.0	-0.5	-0.2	0.9	0.2	0.0	0.9	1.0	0.2	0.6	0.7
Triglycerides	0.7	1.2	5.4	0.8	-1.2	-0.4	0.7	-0.2	2.2	-0.3	-0.8	0.3	2.3	-0.1	-0.7	-0.5	-0.4	-0.3	-0.2	-1.1	-2.2	1.1
Allergy or Eczema	0.7	1.7	7.1	0.9	1.7	-2.7	2.1	0.5	0.1	2.1	1.7	1.1	1.5	-1.1	-1.1	-0.8	-0.2	0.2	-0.6	-0.4	-1.8	0.3
Relative age of first facial hair	0.7	1.5	4.2	0.4	-0.4	-1.4	-0.6	-1.1	1.8	-1.1	-0.9	-2.0	-0.7	1.4	0.9	1.9	-0.1	0.6	2.1	-1.5	0.8	0.7
Supplements: Zinc	0.7	0.7	5.8	-0.1	0.6	1.7	0.8	-0.1	0.6	-0.8	-2.4	0.5	1.0	-0.2	-0.6	-0.2	-0.1	-0.5	-0.9	0.4	-0.3	0.1
Severe depression (siblings)	0.7	0.8	3.0	-0.8	-0.6	-0.8	0.0	-1.5	-0.9	1.1	-1.1	-0.4	-1.7	-0.3	-0.8	0.9	-0.9	-0.8	0.3	0.0	1.0	-0.8
Pack years adult smoking proportion	0.7	1.1	2.4	0.5	-0.5	-0.1	-1.5	-1.0	-0.8	1.4	1.4	1.4	-0.1	-1.0	-0.7	-1.4	-1.6	-0.7	-0.8	1.2	-1.4	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	4.7	-0.1	-0.9	-1.4	1.2	-1.6	0.6	0.9	0.9	0.6	0.5	-0.1	-1.1	0.1	-2.2	-1.3	-0.2	-0.1	-0.8	-0.6
Age when periods started (menarche)	0.7	1.6	5.8	0.4	-0.5	0.3	0.0	1.2	-0.1	-0.5	-0.9	1.9	2.2	-2.4	-0.8	-1.7	-0.1	0.5	-2.2	0.3	-2.1	0.6
Medication: Atenolol	0.7	0.8	3.7	-0.8	-0.5	-1.0	0.1	-1.4	0.8	1.9	0.4	-0.3	0.4	0.2	-0.8	0.9	-0.8	-1.5	-0.1	-1.5	0.2	-0.7
Medication: Ramipril	0.7	0.9	3.2	1.2	1.4	-1.2	-0.3	1.2	-0.4	1.8	1.8	0.5	-0.2	-0.2	0.5	-0.8	0.4	0.4	-0.3	1.3	0.3	0.2
Illnesses of siblings	0.7	0.9	2.4	-0.6	-1.4	-0.1	-0.2	-0.7	-1.1	-0.5	-1.1	-1.0	-1.3	1.6	-0.2	1.3	0.4	-0.7	1.2	-0.2	1.5	-1.2
Weight	0.7	3.5	15.3	1.4	3.9	-3.0	0.4	2.5	2.3	0.7	3.6	0.4	2.0	0.5	0.3	-0.7	1.4	0.8	-0.9	-1.4	-1.1	1.4
Qualifications: A levels/AS levels or equivalent	0.7	1.5	11.3	-1.2	-1.2	-1.8	-3.4	-0.0	-0.7	-1.5	-1.0	-0.4	-1.3	1.0	-0.9	0.7	0.1	-0.5	-0.0	-0.2	1.3	-1.1
Illnesses of mother	0.7	0.9	3.6	1.3	0.7	0.3	0.5	0.6	-0.1	-1.2	0.5	1.1	1.2	-0.9	0.8	-1.9	0.4	0.5	-0.6	0.9	-1.0	1.1
Length of working week for main job	0.7	0.8	3.3	-0.2	1.1	1.8	0.9	1.6	0.8	-0.3	0.2	0.1	0.6	1.4	0.5	0.1	1.8	0.5	0.2	-0.8	0.1	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	7.2	0.5	0.8	-0.3	2.7	0.3	-0.2	2.4	0.4	-0.0	1.3	0.5	-1.3	0.7	0.2	0.4	0.3	-0.5	-1.2	0.1
Hair/balding pattern: Pattern 4	0.7	1.6	5.2	-0.8	-2.3	0.2	0.4	0.2	2.1	-2.3	-0.2	0.1	1.5	1.7	-1.5	0.9	-0.2	-1.2	0.7	-1.6	-1.3	-0.5
Comparative body size at age 10	0.7	2.0	7.0	-2.6	-2.2	1.3	-0.3	-1.2	-1.9	-0.6	-2.1	-0.1	-1.4	0.2	-1.6	-0.1	-1.3	-1.2	0.8	0.5	0.7	-2.3
Health satisfaction	0.7	0.9	3.8	-1.1	-0.8	-0.0	-0.4	-1.1	-1.2	0.0	-2.0	0.5	-0.1	0.0	-1.6	-0.3	-1.5	-1.6	-0.2	0.3	-0.3	-1.3
Number of full sisters	0.7	0.9	3.0	-0.6	0.8	-0.7	-0.1	0.9	-0.6	-1.7	0.7	1.6	0.8	-1.3	-1.0	-0.9	0.3	0.1	-1.7	0.2	-1.2	0.1
Chest pain or discomfort	0.7	1.0	3.9	0.2	-1.4	-0.5	1.6	-0.8	-0.0	0.9	0.6	1.0	0.6	-0.0	-2.0	-0.4	-1.3	-1.8	-0.2	0.7	-0.8	-1.1
Had major operations	0.7	0.8	3.3	0.6	0.1	0.2	-0.3	0.3	0.7	0.1	0.4	-1.3	-0.2	1.5	0.6	1.4	0.8	1.0	1.8	-1.2	0.1	0.5
Knee pain experienced in last month	0.7	1.0	2.8	1.2	1.3	-0.1	-0.0	1.4	0.2	1.0	1.7	0.9	0.3	-1.0	1.2	-1.2	1.0	1.1	-0.9	0.8	-0.2	1.3
Illnesses of father: Heart disease	0.7	1.0	3.5	1.1	-1.3	0.2	-1.2	0.6	1.9	0.6	1.2	0.5	1.7	0.9	-0.9	-0.5	0.6	-0.4	-0.1	-0.1	-1.4	1.1
Arm fat percentage (left)	0.7	2.9	8.4	-1.7	-2.0	0.6	-2.2	-2.1	-2.1	0.9	0.0	-0.2	-2.3	-0.1	-1.6	-0.8	-2.4	-2.9	0.6	1.6	1.1	-2.6
Smoking status: Current	0.7	1.2	3.7	0.9	-0.7	1.7	-1.0	-0.1	0.5	0.0	-0.1	1.9	1.5	-0.9	-0.8	-1.5	-0.7	-0.6	-1.2	1.5	-1.6	0.8
Wears glasses or contact lenses	0.7	0.8	3.1	0.1	0.2	-0.3	1.4	-0.9	0.8	0.9	-0.0	-1.1	-0.9	1.2	1.2	0.6	0.2	-0.9	0.9	-0.4	1.8	-0.1
Alcohol drinker status: Never	0.7	0.8	2.9	-0.4	1.5	-0.3	1.4	0.3	-0.6	1.7	0.4	-1.1	-0.7	0.4	0.6	1.1	0.3	0.1	0.6	-0.6	1.5	-1.1
Irritability	0.7	1.1	4.3	-0.2	-1.5	1.1	-0.7	0.2	1.5	-2.0	-0.3	0.9	1.8	-0.3	-0.7	-0.7	-1.3	0.1	-0.1	-0.4	-2.1	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	3.6	0.2	-0.5	-0.4	1.9	-0.7	1.1	0.9	1.4	0.4	1.4	-0.2	-0.9	0.1	-0.8	-1.5	-0.2	-0.7	-0.9	-0.4
Supplements: Calcium	0.7	0.7	2.8	0.4	1.7	0.7	0.9	0.9	0.8	-0.7	-0.9	-0.1	1.0	-0.7	-0.2	0.6	0.9	1.1	-0.4	-0.6	-1.0	1.1
Heart disease (siblings)	0.7	0.8	4.0	-2.0	-0.1	-1.5	-0.1	-0.7	0.7	-0.8	0.3	-0.6	-0.1	0.6	-0.2	0.8	-0.8	-1.1	-0.1	-1.3	0.7	-1.5
Irritable Bowel Disease (IBD)	0.6	1.4	9.6	0.3	-2.2	2.5	-3.1	-1.1	0.2	-0.5	-1.4	-0.3	0.3	0.0	-1.1	0.7	-0.5	0.2	0.9	0.2	-0.4	0.5
Ulcerative Colitis (UC)	0.6	1.1	4.4	0.1	-2.1	1.6	-0.3	-1.5	-0.0	-0.2	-1.8	-0.6	-0.4	0.8	-1.5	1.2	-0.7	-0.7	1.3	0.3	-0.1	-0.0
Type 2 Diabetes (T2D) (2012)	0.6	0.7	2.9	-0.2	-0.9	-0.3	0.5	-1.7	-0.3	0.4	0.3	0.9	0.4	-0.8	-1.7	-0.3	-1.4	-1.3	-0.6	0.1	-1.1	-0.2
BMI	0.6	3.3	10.5	-1.7	-1.9	0.5	-2.1	-2.4	-2.1	0.5	-0.4	-0.9	-2.6	0.5	-1.2	-0.7	-2.3	-3.2	1.4	1.5	1.8	-2.7
Hypothyroidism (self reported)	0.6	1.4	5.5	-1.4	0.1	-2.3	1.9	-1.2	-0.6	-0.0	1.1	0.2	0.3	0.8	-2.1	0.0	-1.0	-1.9	0.3	0.1	-0.3	-1.5
Type 2 Diabetes (T2D) (2018)	0.6	1.1	7.9	0.2	-0.1	-1.6	0.4	0.1	0.5	2.8	2.5	-0.1	0.5	0.5	-0.9	-0.2	-0.4	-1.1	-0.2	-0.5	-0.3	-0.7
Neuroticism	0.6	1.5	6.4	-1.2	-1.6	-0.9	-0.1	-2.5	-1.1	-0.2	0.1	0.9	0.7	-0.8	-1.7	-0.5	-2.4	-1.1	-0.1	0.5	-1.7	-0.9
Sensitivity / hurt feelings	0.6	1.1	4.5	0.1	-1.3	-0.6	2.1	-1.3	1.0	-0.8	-0.0	-0.1	1.8	0.2	-0.5	1.0	-0.7	-0.2	0.4	-1.6	-1.5	0.6
Hearing difficulty/problems: Yes	0.6	0.9	2.1	-0.9	-0.7	-1.3	0.3	-0.6	-1.0	1.5	0.2	1.2	-0.1	-0.2	-1.0	-0.7	-1.3	-1.3	-0.9	0.9	0.3	-1.2
Ever had hysterectomy (womb removed)	0.6	0.6	1.5	0.8	1.1	-0.5	0.6	0.5	0.3	1.2	1.1	1.0	1.2	-1.0	-0.7	-0.2	-0.3	0.4	-1.0	-0.2	-1.1	-0.3
Diabetes (father)	0.6	0.8	3.5	-0.4	-1.9	-0.6	0.4	-1.2	-0.0	1.0	1.1	-0.5	0.1	0.1	-0.9	0.7	-1.1	-0.3	1.2	-0.9	-1.0	-0.8
Townsend deprivation index at recruitment	0.6	0.8	4.5	0.2	0.6	0.8	1.1	0.7	1.1	0.2	0.8	0.9	1.4	-0.8	-0.8	-0.1	-0.5	0.6	-0.4	-0.8	-2.1	0.3
Relative age voice broke	0.6	1.0	2.9	1.6	-0.4	1.1	-1.2	-0.1	0.0	-0.6	-1.5	-1.1	-1.1	0.8	1.1	0.6	0.6	1.1	1.7	0.6	0.7	0.9
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	4.3	-0.6	0.6	-2.1	-0.2	-0.3	-0.6	1.0	1.7	-0.1	-0.1	-0.1	-0.5	0.4	-0.7	-0.8	-0.2	-0.4	0.4	-1.3
Hayfever, allergic rhinitis or eczema	0.6	1.4	7.1	0.3	2.0	-2.7	2.1	0.3	0.1	1.9	1.6	0.1	0.9	-0.8	-0.1	-0.1	-0.3	0.7	-0.2	-1.2	-0.6	0.2
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	4.7	0.6	0.8	-1.1	0.5	0.1	0.6	2.2	0.8	0.1	1.0	-0.8	-0.4	0.4	0.3	0.0	-1.1	-1.4	-0.2	0.7
High blood pressure (mother)	0.6	0.8	3.9	-0.6	0.6	-1.6	-0.8	0.8	1.4	2.0	0.5	-0.2	0.3	0.0	-0.1	0.8	0.5	0.2	-0.8	-1.7	0.5	-0.0
Medication: Simvastatin	0.6	0.9	4.8	0.7	0.1	-0.4	0.3	-0.2	1.1	0.3	2.2	1.4	1.3	-0.7	-1.0	-0.7	-1.3	-0.8	-1.0	0.1	-1.3	0.2
Arm fat percentage (right)	0.6	2.3	7.1	-1.8	-1.6	0.4	-1.5	-1.9	-1.8	0.8	0.0	-0.3	-2.0	-0.1	-1.6	-0.6	-2.2	-2.7	0.4	1.3	1.0	-2.5
Worrier / anxious feelings	0.6	1.2	6.2	-0.3	-0.2	-0.4	0.3	-1.7	0.2	0.0	0.4	0.7	2.1	-1.1	-1.1	0.4	-1.1	1.1	-0.3	-1.5	-2.5	1.0
Falls in the last year	0.6	0.8	4.4	-0.3	2.1	0.1	0.8	1.4	0.8	-0.4	-0.0	-0.4	1.0	0.3	1.0	0.6	1.2	1.0	-0.1	-1.6	0.2	0.5
Blood clot in the leg (DVT)	0.6	0.8	4.2	-1.3	-0.3	0.3	-0.5	-0.6	-1.9	-0.2	-0.8	-0.6	-2.0	-0.1	0.5	-0.2	-0.6	-0.2	0.6	0.4	1.0	-1.4
Gout (self-reported)	0.6	0.9	2.8	0.4	0.9	-0.9	-0.1	-0.8	-1.3	0.3	-1.1	-1.4	-1.7	0.6	1.0	0.9	1.0	0.7	1.0	-0.3	0.9	0.9
Body fat percentage	0.6	2.4	6.5	-1.6	-1.6	-0.3	-1.8	-1.6	-1.7	1.8	0.5	0.5	-1.5	-0.7	-1.7	-1.3	-2.5	-2.5	-0.3	1.5	0.3	-2.2
Wheeze or whistling in the chest in last year	0.6	1.0	4.7	1.0	-0.1	-1.0	0.3	-0.4	-0.1	0.3	-0.5	1.4	1.1	-1.3	-1.7	-0.7	-1.1	-0.4	-0.8	1.0	-2.2	0.5
Medication: Omeprazole	0.6	0.7	3.7	0.7	-0.2	-0.0	1.9	0.1	1.2	1.1	1.3	0.0	1.4	0.0	-0.5	0.5	-0.1	-0.7	0.3	-1.1	-1.1	0.0
Suffer from ‘nerves’	0.6	0.9	2.7	1.6	1.0	0.8	1.6	0.9	0.5	-0.9	0.4	-0.3	0.7	0.4	0.7	0.3	0.8	1.3	1.1	-0.5	-1.2	1.1
Family relationship satisfaction	0.6	0.7	5.2	-0.5	-0.4	-0.0	0.6	0.6	0.2	-0.4	-2.3	-0.1	0.3	0.9	-0.2	1.0	0.9	1.4	0.4	-1.0	-0.8	0.3
Commuting to job workplace: Car/motor vehicle	0.6	0.7	2.2	0.2	-0.6	-0.9	-0.9	-1.0	1.3	-0.6	1.5	-0.7	0.1	1.1	0.4	1.5	0.4	-0.2	0.4	-1.5	0.1	-0.2
Commuting to job workplace: Walk	0.6	0.6	2.2	-0.1	-0.2	0.1	-1.3	1.5	-1.1	-1.1	-1.4	0.0	-1.0	0.0	0.2	-0.4	0.3	0.1	-0.1	0.9	1.1	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	5.7	-1.3	-0.8	0.3	-0.5	0.4	-0.5	-0.4	2.4	1.0	0.2	-0.8	0.4	-1.9	-1.1	-1.3	-1.6	1.0	0.7	-1.8
Commuting to job workplace: Public transport	0.6	0.8	3.5	1.0	1.4	-0.2	0.6	1.5	0.0	-0.1	0.9	0.0	0.3	-0.2	1.1	0.2	1.1	1.9	-0.2	0.0	-0.1	1.4
Medication: Lisinopril	0.6	0.8	3.3	-0.5	-0.5	-1.8	0.9	-1.5	-0.1	1.0	0.8	-0.0	-0.1	0.1	-0.6	-0.0	-1.7	-1.3	0.1	-0.4	-0.0	-1.2
Medication: Atorvastatin	0.6	0.7	2.0	0.4	-0.3	1.4	-0.2	0.6	0.4	-0.5	-0.7	1.4	1.4	-0.8	-0.1	-0.7	-0.1	0.7	-1.4	0.3	-1.4	0.2
Unable to work because of sickness or disability	0.6	0.8	2.5	1.2	0.7	-0.0	1.2	0.8	1.3	-0.8	1.6	0.7	1.4	-0.4	0.8	-0.6	-0.6	0.3	-0.5	0.0	-1.0	0.6
Neuroticism (Nagel 2018)	0.5	1.1	4.5	-0.1	-1.4	0.2	0.8	-1.8	0.1	-0.7	-0.2	1.0	1.7	-0.8	-1.1	-0.2	-2.0	-0.3	-0.1	0.3	-2.1	0.1
Verbal and Numeric Reasoning (VNR)	0.5	1.2	5.8	-0.3	0.0	-0.9	-0.1	0.7	1.4	0.2	-0.3	-1.6	0.5	2.4	0.0	1.7	1.5	0.6	1.7	-1.8	0.2	-0.0
Body Mass Index (BMI) (2010)	0.5	0.7	2.6	0.9	0.3	0.4	0.6	-1.0	0.1	-0.2	1.1	-0.7	-1.2	0.2	1.6	-0.8	-0.1	-1.0	0.9	0.8	1.4	0.3
HDL Cholesterol	0.5	0.8	3.2	-0.4	1.0	-0.7	-1.0	0.6	-1.7	0.5	0.3	-0.3	-1.8	0.1	1.0	0.0	1.1	0.8	-0.3	0.7	1.7	0.2
LDL Cholesterol	0.5	0.7	2.0	-0.6	-0.7	0.2	1.3	-1.1	0.7	-0.7	0.1	-1.2	-0.2	1.2	-0.1	1.1	-0.3	-0.8	1.3	-1.4	0.5	-0.3
Schizophrenia (2014)	0.5	1.0	4.9	-0.8	0.8	-0.7	-2.2	0.5	-0.5	-1.3	-0.1	-0.8	-1.5	-0.6	1.4	-0.3	1.0	-0.1	-0.4	-0.3	2.0	0.3
Ulcerative Colitis	0.5	0.8	2.3	0.6	-0.6	1.1	-0.8	-0.6	-0.4	0.1	-1.0	-1.1	-1.5	0.9	-0.0	1.5	0.5	0.4	1.5	0.2	1.0	0.5
Frequency of depressed mood in last 2 weeks	0.5	0.7	4.1	0.4	0.1	-0.6	0.7	-0.8	0.4	0.0	0.6	1.4	0.6	-0.7	-0.6	-0.8	-2.0	-1.0	-0.8	1.1	-0.9	-0.3
Ever used hormone-replacement therapy (HRT)	0.5	0.7	3.0	0.5	-0.3	-1.1	-0.7	-0.5	-1.6	1.7	0.2	0.7	-0.1	-0.2	-1.5	-0.1	-0.1	0.4	-0.2	0.9	-1.1	-0.1
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	2.9	0.1	-0.6	1.5	-1.2	0.9	0.1	-0.7	-0.2	0.6	0.4	0.8	0.4	-0.8	0.2	-0.2	-0.1	1.7	0.4	-0.3
Body mass index (BMI)	0.5	2.0	7.3	-1.4	-1.7	0.8	-1.3	-1.8	-1.3	0.2	-0.3	-0.0	-1.5	0.3	-1.8	-0.4	-2.2	-2.7	0.7	1.1	0.6	-2.3
Allergy	0.5	1.2	5.7	0.0	-1.6	2.4	-1.5	-0.3	1.3	-1.1	-0.3	-0.4	-0.5	1.4	1.1	0.1	0.1	-1.4	0.2	0.8	1.4	-0.3
Neuroticism score	0.5	1.1	6.7	0.2	-0.8	0.2	0.5	-1.4	0.5	-0.7	0.2	1.0	1.8	-1.0	-0.9	-0.2	-1.8	0.3	-0.0	-0.3	-2.6	0.5
Noisy workplace	0.5	0.7	2.3	1.5	0.6	1.5	1.2	0.8	0.6	1.4	0.1	0.3	0.7	-0.6	0.4	-0.4	0.1	0.1	-0.0	0.9	-0.2	1.0
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	4.5	0.1	-1.0	-0.2	-2.1	-0.1	-0.1	-0.7	0.8	0.6	-0.1	0.2	-0.0	-0.9	-1.2	-0.3	0.2	0.7	-0.3	-0.9
Tense / ‘highly strung’	0.5	0.8	4.1	0.3	-0.1	0.4	1.3	-0.2	-0.2	-0.7	0.4	0.9	2.0	-1.1	-0.8	-0.2	-0.9	0.6	-0.2	-0.7	-2.0	0.4
Medication: Ventolin 100micrograms inhaler	0.5	0.6	3.8	-0.2	-0.6	-0.5	-0.6	-0.3	-2.0	-0.3	-1.6	0.1	-0.6	-1.0	-1.1	0.5	-0.4	0.7	0.2	0.4	-0.8	-0.7
Exposure to tobacco smoke outside home	0.5	0.7	2.4	0.6	-0.8	1.2	-0.9	0.0	0.9	-0.6	1.5	0.7	1.0	-1.2	-0.3	-0.1	-1.0	0.4	-0.4	-0.5	-1.4	0.3
Number of full brothers	0.5	0.6	1.9	1.3	0.5	0.9	0.5	1.0	0.6	-0.2	-0.7	-0.4	-0.1	0.5	1.0	0.3	1.2	1.4	0.7	0.3	-0.4	1.2
Shortness of breath walking on level ground	0.5	0.6	1.9	0.3	-0.2	-1.4	-0.2	0.2	-0.3	1.4	1.0	1.4	0.7	-0.5	-0.5	-0.8	-0.3	-0.6	-1.3	0.5	-0.8	-0.3
Medication: Blood pressure	0.5	0.9	3.8	-0.7	-0.1	-1.0	-0.8	-2.0	-0.9	0.8	0.9	-0.1	-1.2	-1.2	-0.3	-0.4	-1.5	-1.5	-0.4	0.5	0.5	-0.9
Medication: Allopurinol	0.5	0.6	1.6	0.3	0.1	-1.3	0.9	-0.5	0.0	0.3	-0.5	-1.1	-0.7	1.1	1.2	0.9	1.0	0.5	1.0	-0.5	0.8	0.9
Pulse rate, automated reading	0.5	1.5	4.4	-1.2	-1.4	-1.4	-1.6	-1.1	-0.1	-0.1	0.7	1.4	0.3	-0.7	-1.4	-1.3	-2.1	-1.8	-1.4	0.6	-0.6	-1.4
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.5	1.9	-0.2	-0.9	0.1	-0.5	0.0	-0.9	0.3	-0.8	1.4	0.3	-0.6	-1.4	-0.7	-0.3	-0.6	-0.6	1.0	-1.1	-0.4
Illnesses of siblings: Diabetes	0.5	0.6	3.9	0.6	0.2	0.9	1.1	-1.1	-0.7	2.0	0.1	0.4	0.2	-0.1	-0.7	0.1	-0.2	0.3	0.3	0.7	-0.7	0.9
Friendships satisfaction	0.5	0.7	5.9	-0.4	-0.2	1.3	0.1	-0.3	-0.5	-0.7	-2.4	0.7	0.4	-0.7	-0.7	-0.3	-1.0	0.1	-0.3	-0.1	-1.2	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.5	0.7	2.5	-1.6	0.2	-0.1	0.7	-0.5	-0.8	-0.0	-1.3	-0.8	-1.5	0.0	-0.2	0.5	-0.9	-0.6	0.6	-0.4	1.1	-1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	2.8	-1.5	0.0	-0.4	1.7	-0.7	-0.8	0.7	-0.2	-0.3	-0.7	-0.1	-1.1	0.7	-0.5	-0.5	0.2	-1.0	0.1	-1.1
Miserableness	0.5	0.9	3.6	0.4	-0.7	0.6	0.4	-0.6	1.7	-1.0	0.2	1.0	1.8	-0.9	0.6	-0.7	-1.9	0.2	-0.5	0.1	-1.5	0.4
Ever taken oral contraceptive pill	0.5	0.5	2.6	-1.0	-0.6	-0.1	-0.4	0.1	-1.4	0.8	0.2	-0.1	-1.1	0.6	0.7	-0.2	0.1	-0.2	-0.0	1.0	1.6	-0.8
Medication: Bendroflumethiazide	0.5	0.7	5.3	0.1	0.6	-0.4	1.0	-0.3	1.6	-0.3	2.3	-0.7	0.4	0.5	0.4	0.9	0.1	-0.3	0.4	-1.3	0.6	0.5
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	2.9	-1.2	-0.0	-0.1	-0.6	-0.4	-1.7	-0.4	-0.8	-0.3	-1.7	-0.3	0.4	-0.4	-0.7	-0.1	0.2	0.5	0.8	-1.4
Pack years of smoking	0.5	0.7	1.6	0.4	-0.4	-0.4	-1.2	-1.0	-0.7	1.3	1.1	0.9	-0.2	-0.7	-0.5	-0.9	-1.3	-0.6	-0.4	0.7	-1.0	-0.5
Depressed Affect (Nagel 2018)	0.4	0.7	4.1	0.1	-0.5	0.1	0.5	-1.2	0.0	0.0	0.3	1.2	1.1	-1.1	-0.3	-0.8	-2.0	-0.0	-0.6	0.8	-1.5	-0.1
Intelligence (Savage-Jansen 2018)	0.4	1.2	7.2	-0.1	-1.1	-1.0	-0.4	-0.5	1.8	-0.6	-0.5	-1.2	0.5	2.7	-0.7	1.2	1.1	-0.2	1.5	-1.1	0.0	0.3
Worry (Nagel 2018)	0.4	0.8	5.0	0.1	-0.6	-0.0	1.1	-1.7	-0.3	-0.2	0.2	0.3	1.4	-0.5	-1.1	0.6	-1.1	0.3	0.4	-0.8	-2.2	0.3
Systolic Blood Pressure	0.4	1.8	6.2	1.0	1.5	-2.0	0.1	-0.8	2.1	0.8	1.8	-0.2	1.5	-1.0	-0.6	1.3	-0.7	0.8	-0.3	-2.5	-1.8	1.4
Average weekly spirits intake	0.4	0.5	2.4	-0.4	0.2	0.6	0.1	0.6	0.8	1.5	1.6	0.8	0.5	-0.2	0.1	-0.7	0.2	0.2	-0.7	-0.5	-0.4	-0.4
Impedance of leg (right)	0.4	2.2	7.4	-0.2	-0.2	-1.4	-0.2	0.5	-0.3	1.8	1.0	2.6	1.8	-2.1	-1.1	-2.0	-1.3	0.3	-2.7	1.1	-2.1	0.2
Trunk fat percentage	0.4	1.4	4.3	-1.0	-0.5	-1.1	-1.6	-0.8	-1.2	2.1	1.1	0.4	-1.1	-0.6	-1.0	-1.3	-1.7	-1.9	-0.5	1.1	0.4	-1.6
Past tobacco smoking	0.4	0.8	3.9	0.7	2.0	-0.2	0.9	0.1	0.4	-0.2	0.6	-0.8	-0.6	0.6	1.7	0.4	1.4	1.0	0.3	-0.5	0.6	0.9
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	3.3	-0.2	-0.4	-1.0	0.9	-0.8	0.9	-0.3	0.7	0.9	1.1	0.1	-0.2	-0.3	-1.8	-0.8	-0.4	-0.5	-1.0	-0.7
Qualifications: None of the above	0.4	0.8	5.9	1.4	0.8	0.1	2.4	-0.1	1.2	-0.5	0.3	0.5	0.6	-0.9	0.9	-0.4	-0.2	0.4	-0.1	0.6	-0.8	1.2
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	2.0	1.4	-0.0	-0.3	0.7	-0.2	1.2	1.4	0.8	-0.2	1.2	0.4	-0.0	0.5	-0.6	-0.1	0.8	-0.7	-1.1	0.6
Hair/balding pattern: Pattern 3	0.4	0.5	3.6	0.6	0.3	-1.9	0.2	-0.9	0.2	0.9	0.7	-1.1	-0.5	0.3	0.2	0.7	0.2	-0.3	0.6	-0.6	0.7	0.5
Depression (self-reported)	0.4	0.5	2.9	0.8	0.6	-0.8	1.7	0.4	0.7	0.0	-1.2	-0.2	0.4	0.6	1.3	0.1	0.5	0.0	0.1	0.4	0.4	0.6
Lung cancer (father)	0.4	0.5	1.7	0.8	0.7	-1.0	-0.1	-0.3	-0.7	-0.0	0.5	1.1	0.5	0.1	-0.4	-0.6	-0.2	0.6	-0.3	1.0	-1.3	0.8
Pulse wave Arterial Stiffness index	0.4	0.5	3.3	-0.9	0.3	-1.8	1.1	-0.2	-0.0	-0.1	-0.1	0.1	0.3	-0.6	-0.8	-0.2	-0.7	-0.7	-0.8	-0.7	-0.4	-0.7
Pulse wave reflection index	0.4	0.5	2.7	-0.1	-0.6	0.1	0.7	0.5	1.4	-0.1	-0.2	-0.6	0.6	-0.3	0.5	0.8	0.5	0.6	0.1	-1.6	-0.2	0.4
Glaucoma (self-reported)	0.4	0.5	1.5	0.4	0.7	0.9	0.4	-0.7	-0.1	0.7	0.4	-0.6	0.4	1.1	-1.0	1.1	0.3	0.1	1.2	-0.8	-0.9	0.3
Birth weight	0.4	0.9	5.0	-1.7	-0.3	-1.9	0.3	-0.0	1.0	-2.2	0.1	-0.5	0.1	0.8	-0.6	0.6	-0.3	-0.9	0.1	-1.2	0.5	-0.9
Worry too long after embarrassment	0.4	0.6	2.9	0.5	-1.4	0.5	-1.0	-1.7	-0.2	-0.3	-1.1	0.1	0.2	-0.1	-0.3	0.0	-1.2	-0.4	0.7	0.3	-1.0	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	3.0	-1.1	0.1	-0.8	-0.4	0.8	-1.1	1.7	0.2	0.1	-0.2	-0.2	-0.1	0.2	0.4	0.5	-0.3	0.4	0.9	-0.8
Pulse wave peak to peak time	0.4	0.5	1.5	1.1	0.5	1.2	-1.0	0.6	0.3	0.3	0.6	0.2	0.1	0.5	0.8	-0.0	1.0	1.0	0.5	0.6	0.2	1.0
Qualifications: College or University degree	0.4	1.4	4.6	0.7	-0.1	1.5	-1.1	1.2	-0.1	-0.6	-0.5	-0.9	-1.7	1.1	2.1	-0.1	1.9	1.4	0.6	0.3	2.0	0.9
Migraine (self-reported)	0.4	0.5	2.1	0.3	-0.3	0.6	1.0	0.1	0.5	-0.8	-0.6	-1.1	-0.3	0.3	-0.4	1.4	0.4	0.6	1.1	-0.6	-0.2	0.4
Overall health rating	0.4	0.9	3.7	-0.3	-0.6	-1.5	-1.2	-1.1	0.5	-0.0	0.2	0.5	1.4	-0.3	-1.9	0.1	-1.6	-0.8	0.1	-0.2	-1.4	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	3.3	-0.6	-0.9	-0.3	1.8	-0.0	0.5	1.1	0.8	0.1	0.3	0.5	-0.1	0.2	-0.3	-0.8	0.1	-0.3	0.0	-1.0
Qualifications: nursing, teaching	0.4	0.7	2.1	-1.2	0.9	-1.0	-1.3	0.3	-1.4	-0.4	-1.1	0.1	-1.3	-0.1	0.5	-0.1	0.0	0.8	-0.6	-0.3	0.8	-1.0
Guilty feelings	0.4	0.7	2.0	0.4	-0.9	0.3	-0.8	-1.1	-0.5	-0.5	-0.2	1.2	0.5	-0.9	-0.6	-0.9	-0.9	0.3	-0.6	1.4	-1.4	0.6
High cholesterol (Self-reported)	0.4	0.8	2.7	0.6	-0.4	0.0	-0.3	0.5	1.2	-0.5	1.4	1.5	1.6	-0.5	-0.5	-0.6	-0.3	0.3	-1.0	-0.2	-1.6	0.6
Ever had prostate specific antigen (PSA) test	0.4	0.4	1.9	-0.1	0.8	-0.3	-0.9	0.2	-0.0	0.5	-0.1	-0.0	-0.1	-1.3	1.4	-0.2	0.1	1.3	-0.6	-0.1	0.2	0.8
Commuting to job workplace: Cycle	0.4	0.5	1.3	0.3	-0.1	0.7	-1.1	1.1	-0.4	0.8	0.2	1.0	0.4	-1.1	0.5	-0.8	0.3	0.8	-1.0	0.5	-0.5	0.1
Myopia	0.4	0.6	2.6	-0.9	1.6	-1.5	1.4	-0.2	0.3	-0.3	0.1	-1.0	-0.3	0.1	0.7	0.6	-0.1	0.0	-0.0	-0.8	0.8	0.0
Alcohol drinker status: Previous	0.4	0.5	2.5	1.5	0.6	1.6	-0.4	0.1	0.6	-1.2	0.7	-0.5	-0.1	0.0	0.4	0.2	0.3	0.5	0.5	0.1	-0.3	0.7
Alzheimer’s Disease (in mother)	0.3	0.4	2.0	0.3	-0.4	-0.0	-0.2	-0.5	0.6	-0.1	0.3	0.2	0.7	0.2	-1.4	1.0	0.0	0.2	0.2	-0.4	-1.4	1.0
Blood Eosinophil Count	0.3	2.2	10.8	0.8	2.7	-2.9	3.3	1.9	-0.4	1.7	1.4	1.2	1.3	0.1	-0.5	-1.3	0.4	-0.3	-0.9	0.4	-0.7	-0.3
Smoking Status	0.3	0.6	1.9	0.4	-1.0	0.6	-0.5	-0.3	0.5	0.5	0.7	1.3	1.4	-0.2	-1.2	-0.6	-0.9	-0.9	-0.4	0.7	-1.1	0.0
Medication: Co-codamol	0.3	0.4	1.4	-0.4	-0.5	-1.2	0.3	-0.1	-0.7	0.0	0.3	1.0	-0.1	-0.4	-0.6	-0.5	-0.4	-0.7	-0.8	1.1	-0.0	-0.8
Medication: Levothyroxine sodium	0.3	0.5	2.0	-0.7	0.7	-0.9	0.0	0.9	-0.9	0.6	0.6	0.8	0.5	0.5	-0.9	-0.3	-0.1	-0.4	-0.4	0.4	-0.3	-1.4
Impedance of leg (left)	0.3	1.6	4.8	0.1	-0.5	-0.5	0.3	-0.1	-0.3	2.2	0.3	2.0	1.6	-1.9	-1.0	-1.4	-1.4	0.4	-1.9	1.0	-2.0	0.5
Waist circumference	0.3	1.0	4.2	-0.0	-0.2	-0.9	0.5	-0.5	2.0	0.7	1.3	-0.4	1.0	0.4	-1.3	0.7	-1.3	-1.4	0.4	-1.6	-0.7	-0.5
Time employed in main current job	0.3	0.3	2.1	0.4	-0.8	0.9	-0.7	-0.1	1.4	0.0	-0.3	-0.1	0.8	0.5	0.0	0.2	-0.1	-0.3	0.4	-0.3	-0.3	0.4
Pulse rate	0.3	0.5	1.5	-0.4	-1.0	0.4	0.2	-0.2	0.2	-0.5	0.6	1.0	0.4	-0.6	-0.3	-0.9	-1.2	-1.2	-1.2	0.3	-0.6	-0.9
Happiness	0.3	0.4	3.6	0.4	0.6	-0.1	-0.4	0.3	-0.5	-0.8	-1.9	0.7	-0.2	-0.3	-0.0	-0.2	-0.2	0.6	-0.3	0.5	-0.7	0.6
Medication: Cholesterol lowering	0.3	0.4	1.4	0.7	-0.4	-0.3	-0.8	-0.4	0.1	0.2	0.7	0.8	0.4	-1.0	-0.2	-1.1	-1.0	-0.4	-0.6	0.6	-1.2	0.3
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.7	-0.0	0.3	1.3	0.6	1.3	0.4	-1.1	-1.1	-0.1	0.4	0.7	0.3	0.3	0.9	1.1	0.2	-0.2	0.3	0.5
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	2.5	-0.5	0.5	-1.6	1.2	-0.1	-0.2	-0.4	-0.2	0.4	1.0	0.4	-1.4	0.1	-0.5	-0.6	-0.0	-0.2	-0.7	-0.8
Age at first live birth	0.3	0.6	2.2	0.5	-0.5	0.4	-1.5	-0.1	-0.9	-0.7	-1.3	-0.6	-1.4	0.3	0.7	0.3	0.8	0.4	0.5	0.3	1.2	0.3
Neck or shoulder pain in last month	0.3	0.4	2.1	0.7	0.5	0.4	0.1	1.0	-0.6	-1.4	0.3	-0.2	-0.4	-0.1	0.7	-0.5	0.4	0.3	0.6	0.8	0.6	-0.0
Alcohol intake frequency.	0.3	0.8	4.0	1.4	1.1	1.1	0.9	0.1	0.5	1.0	2.0	0.4	0.9	-0.3	-0.5	0.2	-0.1	0.6	0.2	-0.0	-1.6	0.5
Mood swings	0.3	0.5	2.6	0.3	-0.8	0.7	0.1	-0.9	1.1	-0.4	0.7	0.3	1.0	0.0	0.1	-0.3	-1.6	-0.1	0.6	0.1	-1.1	0.3
Mother’s age at death	0.3	0.3	1.3	-0.3	-0.0	0.1	0.3	0.4	-0.2	-0.1	-1.1	-0.9	-0.3	1.2	-0.1	0.8	0.6	0.3	0.7	-0.7	0.2	0.2
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.8	-0.5	0.7	-1.3	0.6	-0.1	0.0	1.1	0.4	-0.4	-0.3	0.0	-0.3	0.1	-0.6	-0.6	-0.2	-0.8	0.1	-0.9
Pain experienced in last month	0.3	0.5	2.4	-1.1	-1.2	-0.4	-0.8	-1.5	0.1	0.7	-0.0	-0.3	-0.2	-0.5	-0.0	0.7	-1.1	-0.1	-0.4	-0.9	0.1	-0.7
Alzheimer’s Disease (including proxy)	0.2	0.3	1.3	0.2	-0.2	-0.3	-0.4	-0.7	0.1	-0.3	0.9	0.5	0.4	-0.4	-0.7	0.2	-0.6	0.4	-0.3	0.3	-1.2	0.4
Blood White Count	0.2	1.6	4.5	-0.3	-2.0	0.8	-0.5	-2.1	-1.2	2.0	-0.8	0.1	-1.8	0.4	-1.0	-0.1	-1.8	-1.6	0.4	1.5	0.9	-1.2
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.7	0.8	0.2	-0.2	0.4	0.5	-0.2	0.7	-0.2	-0.1	-0.7	0.3	0.4	-0.4	0.2	0.2	0.7	0.9	0.2	-0.2
Systolic blood pressure, automated reading	0.2	0.5	1.7	0.3	0.3	-1.3	-0.9	-0.4	0.5	-0.1	0.8	0.7	0.4	-1.0	-0.9	-0.4	-1.1	-0.3	-0.8	0.2	-0.9	0.3
Qualifications: CSEs or equivalent	0.2	0.3	1.5	0.4	0.1	1.0	-1.2	0.3	0.7	0.7	0.0	-0.5	0.4	-0.2	-0.0	0.0	0.4	-0.1	0.4	-0.5	-0.2	0.9
Trunk fat mass	0.2	1.0	5.9	0.3	1.7	-1.9	-0.7	0.8	0.4	1.6	2.4	0.4	0.3	-0.3	-0.1	-1.2	-0.2	-0.6	-0.8	0.0	-0.3	-0.1
Hearing difficulty/problems with background noise	0.2	0.4	1.9	0.5	-0.6	-0.7	0.5	0.1	1.4	0.3	-0.3	0.8	1.0	0.5	-0.2	-0.1	-0.2	0.2	-0.4	-0.1	-1.1	0.5
Pain all over the body in last month	0.2	0.2	1.3	-0.3	-0.3	-1.1	-0.6	-0.5	0.3	-0.1	-0.1	0.1	0.3	-0.6	-0.1	-0.0	-0.6	-0.5	-0.1	-0.0	0.4	-0.0
Fluid intelligence score	0.2	0.4	1.3	-0.4	-0.1	-0.3	-1.1	-0.2	0.1	-0.4	-1.1	-0.9	-0.1	1.1	0.1	0.9	0.9	0.6	1.0	-0.5	0.1	0.4
Impedance of arm (right)	0.2	1.1	3.6	-0.6	0.3	-1.6	-0.1	0.3	-1.7	1.1	0.1	1.0	-0.5	-1.7	0.0	-1.4	-0.3	0.3	-1.9	1.6	0.4	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	1.9	0.1	-0.6	0.3	-0.5	-0.6	-0.1	0.2	0.2	-0.0	0.3	0.3	-1.4	0.1	-0.8	-0.5	0.4	0.0	-0.6	0.1
Impedance of arm (left)	0.2	1.0	3.1	-0.2	-0.2	-1.4	-1.1	0.2	-1.8	1.4	0.3	0.8	-0.4	-1.4	0.2	-1.6	-0.1	0.2	-1.5	1.7	0.3	0.1
Emphysema/chronic bronchitis	0.2	0.3	1.0	-0.3	0.0	-0.7	0.1	0.3	-0.6	-0.1	0.0	0.4	0.9	-1.0	-0.8	-0.6	-0.1	0.7	-0.4	0.1	-0.7	0.4
Medication: Ibuprofen	0.2	0.2	0.8	0.4	-0.3	0.9	-0.8	-0.5	-0.1	-0.5	0.2	0.2	0.0	-0.1	-0.9	-0.3	-0.7	-0.1	0.3	0.3	-0.6	0.4
Leg fat mass (right)	0.2	0.6	2.6	-0.0	0.5	-0.8	-0.9	-0.1	0.0	1.1	1.6	0.5	-0.1	-0.2	-0.9	-1.0	-1.0	-1.2	-0.5	0.5	-0.4	-0.6
Smoking status: Previous	0.2	0.2	1.3	-0.1	-1.1	-0.6	-0.0	0.4	-0.1	0.1	0.0	0.4	0.4	-0.3	-1.1	-0.2	-0.6	-0.3	-0.1	0.4	-0.5	-0.5
Eye problems/disorders: Cataract	0.2	0.2	0.6	-0.3	0.4	-0.7	0.2	-0.5	-0.3	0.7	0.5	0.3	0.0	-0.4	-0.0	-0.2	-0.7	-0.3	-0.8	-0.4	0.3	-0.4
Impedance of whole body	0.2	1.2	3.7	-0.3	-0.3	-1.1	-0.6	-0.1	-1.5	1.9	0.2	1.5	0.3	-1.8	-0.6	-1.6	-0.8	0.3	-1.9	1.6	-0.8	0.2
Hair Pigment	0.1	2.3	7.9	0.7	-1.1	1.4	1.8	-0.3	2.0	-2.8	-0.3	0.9	1.5	1.9	-0.8	2.5	0.4	1.1	1.5	-2.0	-1.6	1.0
Stomach or abdominal pain in last month	0.1	0.1	0.7	0.9	-0.0	0.7	-0.3	0.2	-0.2	-0.2	-0.4	-0.0	0.1	0.2	0.3	-0.4	-0.1	-0.0	0.7	0.4	0.1	-0.1
Arm fat mass (right)	0.1	0.6	3.2	-0.3	1.0	-1.0	-0.4	0.1	0.1	0.8	1.8	0.3	0.0	-0.1	-0.8	-0.9	-0.9	-1.3	-0.4	0.2	-0.2	-0.9
Whole body fat mass	0.1	0.6	3.2	-0.1	1.0	-1.4	-0.8	0.2	0.1	1.3	1.8	0.2	-0.2	-0.0	-0.5	-0.9	-0.6	-1.1	-0.4	0.2	-0.0	-0.6
Arm fat mass (left)	0.1	0.5	3.5	-0.0	0.6	-0.8	-0.5	-0.2	0.2	0.9	1.9	0.1	-0.3	0.3	-0.7	-0.7	-0.8	-1.5	-0.0	0.3	0.0	-0.8
Leg fat mass (left)	0.1	0.5	1.8	0.0	0.4	-0.4	-0.7	-0.3	0.0	1.1	1.4	0.5	-0.0	-0.3	-1.0	-0.9	-1.1	-1.1	-0.3	0.4	-0.6	-0.5
Tanning	0.0	0.3	1.5	0.1	-0.7	-0.1	-1.2	-1.2	0.2	0.7	-0.3	-0.5	-0.7	-0.1	0.0	0.1	-0.6	-0.8	0.7	0.3	0.2	0.2

Hub : Genes

PIGC

Models

Trait associations