Hub : Genes

METTL13

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2280	0.0420	0.0e+00	0.234	0.244	0.245	0.274	0.270	4.5e-28	2.3e-29	1.6e-29	2.0e-33	8.0e-33
2	GTEx	Brain Cerebellar Hemisphere	0.2050	0.0760	7.0e-03	0.180	NA	0.190	NA	0.157	2.2e-05	NA	1.3e-05	NA	7.7e-05
3	GTEx	Brain Cerebellum	0.2230	0.0820	3.7e-03	-0.002	NA	0.048	NA	0.015	3.8e-01	NA	1.5e-02	NA	1.1e-01
4	GTEx	Cells EBV-transformed lymphocytes	0.3490	0.1130	4.2e-03	0.000	NA	0.033	NA	0.023	3.3e-01	NA	3.0e-02	NA	5.9e-02
5	GTEx	Esophagus Mucosa	0.0930	0.0420	4.5e-03	0.003	NA	-0.004	NA	-0.002	1.9e-01	NA	6.9e-01	NA	5.0e-01
6	GTEx	Skin Sun Exposed Lower leg	0.1100	0.0330	2.2e-06	0.079	NA	0.122	NA	0.128	4.3e-07	NA	2.6e-10	NA	9.9e-11
7	GTEx	Testis	0.2940	0.0880	6.8e-05	0.046	NA	0.030	NA	0.088	4.3e-03	NA	1.8e-02	NA	9.9e-05
8	METSIM	Adipose	0.0620	0.0200	2.7e-06	0.047	0.042	0.037	0.042	0.039	1.2e-07	5.7e-07	2.4e-06	6.5e-07	1.4e-06
9	YFS	Blood	0.1054	0.0212	0.0e+00	0.101	0.095	0.104	0.105	0.103	2.1e-31	1.7e-29	4.2e-32	1.5e-32	6.1e-32
10	TCGA	Kidney Renal Papillary Cell Carcinoma	0.1390	0.0770	6.4e-03	0.003	0.030	0.023	NA	0.003	2.0e-01	8.0e-03	1.7e-02	NA	2.0e-01
11	TCGA	Prostate Adenocarcinoma	0.0215	0.0130	3.2e-03	0.019	0.019	0.019	NA	0.020	3.8e-03	3.5e-03	4.2e-03	NA	3.2e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.6	1.0	4.0	-1.3	0.7	0.9	2.0	-0.5	0.1	-1.2	0.9	0.8	0.7	-0.4
Bipolar Disorder or Schizophrenia	0.8	2.0	6.0	-1.7	1.6	0.6	2.5	-1.8	-1.1	-0.7	0.4	1.6	0.5	1.3
Depressed Affect (Nagel 2018)	3.9	8.2	21.4	-2.2	3.0	4.6	2.2	-3.0	-3.5	0.4	-2.0	3.0	2.0	3.5
Depression (Nagel 2018)	2.0	3.0	8.7	-1.9	1.8	2.9	2.4	-1.7	-1.5	0.3	-0.9	1.5	1.1	1.4
Intelligence (Savage-Jansen 2018)	5.4	16.5	28.6	5.3	-4.9	-5.3	-3.7	4.2	3.7	3.0	2.3	-4.8	-3.0	-2.9
Neuroticism (Nagel 2018)	5.5	12.9	33.2	-3.5	3.9	5.8	3.6	-3.6	-3.7	-0.5	-0.9	4.1	3.2	3.7
Schizophrenia (2018)	0.8	1.6	4.0	-1.1	1.5	-0.1	1.5	-1.9	-1.5	0.1	-0.3	1.4	0.1	2.0
Schizophrenia vs Biploar Disorder	0.9	1.2	3.8	-0.8	1.2	0.6	1.7	-1.4	-0.9	-0.1	0.4	1.9	0.0	0.7
Worry (Nagel 2018)	5.0	10.5	18.0	-3.3	3.7	4.2	3.0	-3.6	-3.8	0.6	-0.8	3.6	3.1	3.7
Alzheimer’s Disease (in mother)	1.0	1.1	3.8	1.0	-1.1	0.8	0.3	1.9	1.3	0.0	0.8	-0.6	-1.0	-1.5
Alzheimer’s Disease (in father)	0.2	0.2	0.8	0.4	-0.4	-0.9	0.1	0.2	0.4	0.4	0.8	-0.3	0.2	-0.4
Alzheimer’s Disease (including proxy)	1.0	1.5	3.7	1.3	-1.4	-0.4	0.4	1.9	1.7	0.2	1.0	-0.9	-1.0	-1.8
Crohns Disease (2017)	0.1	0.2	0.5	0.6	-0.5	0.7	-0.6	0.4	0.2	0.0	0.0	-0.4	-0.2	-0.3
Irritable Bowel Disease (IBD)	0.1	0.3	0.8	0.8	0.0	0.9	-0.5	-0.2	-0.6	0.3	-0.3	0.2	0.0	0.7
Ulcerative Colitis (UC)	0.3	0.5	1.8	0.7	0.4	0.6	-0.1	-0.5	-1.2	0.4	-0.5	0.6	0.2	1.3
Major Depression (MDD)	0.7	0.9	3.3	0.2	0.2	1.6	0.6	-0.1	-1.0	1.8	-1.2	0.2	-0.1	0.9
Reaction Time	0.3	0.6	2.9	-0.2	0.1	1.7	1.1	0.1	0.4	-0.6	0.0	0.5	1.1	-0.6
Verbal and Numeric Reasoning (VNR)	7.0	16.8	27.5	5.2	-5.0	-5.2	-3.8	3.7	3.5	4.1	1.6	-5.2	-3.4	-2.7
Breast Cancer	0.4	0.9	2.9	1.4	-0.2	0.9	-1.7	-0.4	-1.0	1.0	-0.7	-0.1	0.2	1.3
Ovarian Cancer	3.2	4.2	7.2	-2.3	2.4	1.9	-0.0	-2.7	-2.1	-1.3	-1.9	2.3	2.4	1.9
Prostate Cancer	1.1	1.5	3.3	1.8	-1.5	-0.1	-1.7	1.8	1.0	1.3	0.4	-1.1	-0.7	-0.7
Age at First Birth	0.5	0.7	1.8	-0.9	0.8	0.3	0.2	-0.5	-0.3	-0.7	1.4	1.1	1.3	0.1
Bipolar Disorder (2011)	0.2	0.2	0.9	-0.7	0.3	0.0	0.9	-0.0	0.1	-0.6	0.1	0.3	0.1	0.0
Body Mass Index (BMI) (2010)	1.0	1.3	2.4	1.1	-1.5	-0.4	0.3	1.4	1.4	0.9	0.4	-1.4	-1.6	-1.2
Coronary Artery Disease (CAD)	0.6	0.7	5.7	0.2	0.2	2.4	-0.6	0.1	-0.6	-0.1	-1.0	0.2	0.3	0.6
Crohns Disease (2012)	0.2	0.2	0.6	-0.4	0.5	0.3	-0.5	-0.6	-0.8	0.1	-0.6	0.4	0.5	0.5
Mean Putamen Volume	1.4	1.6	2.8	-1.5	1.6	1.3	0.3	-1.6	-1.2	-1.5	-0.4	1.7	0.7	0.8
Fasting Glucose	0.2	0.2	0.5	-0.6	0.5	0.2	0.4	-0.4	-0.6	-0.0	-0.3	0.3	-0.7	0.2
HbA1C	0.2	0.2	0.6	-0.0	0.1	0.6	-0.3	-0.5	-0.6	-0.0	-0.3	0.3	0.7	0.8
HDL Cholesterol	1.1	1.9	3.6	1.1	-1.3	-1.9	-1.4	1.7	1.5	0.4	0.7	-1.6	-0.6	-1.8
LDL Cholesterol	0.6	0.9	2.6	1.3	-1.2	-0.4	-1.6	1.4	0.8	0.3	-0.2	-0.9	-0.9	-0.5
Lupus	0.4	0.6	1.2	-0.6	0.8	-0.7	0.8	-0.9	-0.9	0.5	-1.1	0.4	-0.5	0.9
Neuroticism (2016)	2.4	3.5	7.0	-1.3	1.8	2.4	0.5	-1.8	-2.5	1.1	-2.6	1.5	1.8	2.3
Primary Biliary Cirrhosis	1.4	2.0	3.9	1.3	-1.6	-1.1	0.2	1.6	1.9	0.8	0.7	-1.6	-1.6	-2.0
Rheumatoid Arthritis	1.0	1.4	8.2	-1.4	0.9	0.1	-0.3	-0.6	0.2	-2.9	0.6	1.0	1.4	-0.6
Schizophrenia (2014)	1.2	2.6	6.5	-1.8	2.0	0.9	2.5	-2.2	-1.4	-0.5	0.4	2.0	0.4	1.5
Triglycerides	0.5	0.7	1.6	-0.5	0.7	1.1	-0.5	-0.7	-1.0	-0.3	-1.3	0.6	1.3	0.9
Type 2 Diabetes (T2D) (2012)	0.3	0.3	1.1	0.5	-0.3	0.3	-0.7	0.8	0.0	1.1	-0.6	-0.1	-0.6	-0.0
Ulcerative Colitis	0.1	0.1	0.5	0.4	0.1	0.5	0.4	-0.1	0.0	-0.5	0.7	0.4	0.3	0.2
Blood Eosinophil Count	0.4	3.3	8.9	3.0	-1.7	-1.7	-2.7	0.8	0.8	2.5	-0.1	-2.3	-0.9	-0.5
Blood Platelet Count	8.4	97.9	228.0	4.8	-9.7	-5.4	-1.2	12.0	14.0	-8.6	14.5	-7.5	-4.6	-15.1
Blood Red Count	1.3	12.8	23.8	-4.1	3.9	4.9	3.0	-3.3	-3.2	-3.9	-1.2	4.7	3.0	2.6
Blood White Count	0.1	0.5	1.5	-0.5	0.7	1.2	-0.1	-0.6	-0.8	-0.8	-1.2	0.7	-0.0	0.5
Heel T-Score	0.5	3.9	19.5	-1.4	1.6	-2.2	4.4	-1.4	-0.9	1.9	-0.3	0.7	-2.8	0.0
BMI	0.8	4.4	27.4	-0.2	0.6	2.5	-1.6	-0.8	-1.4	1.1	-5.2	-0.2	2.4	1.4
Height	2.5	48.0	240.2	7.1	-3.5	-9.8	-4.1	0.2	-0.9	15.5	-4.5	-6.4	-6.8	2.0
Waist Hip Ratio (WHR)	0.4	1.6	4.0	-0.9	1.1	1.9	0.5	-1.2	-1.1	-0.6	0.1	1.8	2.0	1.2
Systolic Blood Pressure	0.9	4.5	10.5	2.2	-2.1	-3.0	-1.3	1.8	1.2	2.3	-0.7	-2.6	-3.2	-1.3
Smoking Status	1.3	3.1	7.6	-0.2	1.2	1.4	-0.6	-1.1	-2.3	1.9	-2.8	1.1	2.4	2.4
Allergy or Eczema	1.1	2.9	6.2	1.8	-1.9	-0.5	0.1	2.5	2.0	2.1	1.8	-1.2	-1.7	-1.8
Cardiovascular Disease	0.8	2.8	9.6	1.4	-1.1	-2.0	-1.6	0.7	0.2	2.3	-3.1	-1.9	-1.2	0.2
Hypothyroidism (self reported)	0.6	1.4	3.4	-1.5	1.5	1.2	1.9	-1.4	-0.9	-0.3	-0.5	1.1	0.9	0.6
Respiratory disease	0.3	0.6	1.4	0.9	-0.5	-0.6	-1.2	0.3	-0.1	1.0	-1.2	-0.5	-1.1	-0.1
Type 2 Diabetes (T2D) (2018)	0.4	0.7	3.5	-0.1	-0.5	0.3	0.3	0.7	1.5	-0.3	-0.3	-0.9	-0.7	-1.9
Lung FEV1/FVC ratio	0.4	2.0	7.3	2.7	-1.9	0.3	-0.0	1.5	0.4	2.3	-0.9	-1.6	-0.2	0.3
Lung FVC	0.3	1.3	6.4	-0.5	-0.1	-0.4	2.5	0.6	1.0	-1.5	1.4	0.1	-0.1	-1.2
Neuroticism	8.0	19.4	42.4	-4.4	4.8	6.5	5.0	-4.3	-4.5	-0.2	-1.4	5.1	4.1	4.5
Chronotype (morning person)	1.0	2.2	4.3	-0.3	1.1	2.1	0.7	-1.1	-1.9	1.7	-2.1	1.2	1.4	1.8
Hair Pigment	0.1	3.7	11.9	-2.3	1.6	3.5	2.5	-0.8	-0.6	-2.4	0.6	2.0	1.7	0.5
Tanning	0.1	1.5	3.4	-0.5	1.2	1.6	-0.1	-1.2	-1.7	0.1	-1.4	1.5	0.8	1.8
Hand grip strength (left)	0.2	0.4	1.5	0.5	-0.6	-0.9	-0.5	0.2	0.7	0.3	-0.8	-1.2	-0.6	-0.3
Number of treatments/medications taken	0.1	0.3	1.2	-0.1	0.0	0.9	1.1	0.0	0.4	0.7	0.2	0.3	-0.1	-0.4
Average weekly spirits intake	1.2	1.5	5.1	-0.7	1.1	1.1	-0.2	-1.4	-1.4	0.8	-2.3	1.1	0.7	1.4
Sensitivity / hurt feelings	4.9	8.3	24.4	-2.8	3.2	4.9	2.0	-3.0	-2.9	-0.5	-1.1	3.5	2.3	2.9
Frequency of depressed mood in last 2 weeks	1.2	1.6	4.8	-0.8	1.0	2.2	1.6	-1.0	-1.2	1.0	-1.2	1.0	1.1	1.2
Hearing difficulty/problems: Yes	0.7	1.1	1.8	-1.3	1.3	1.0	1.3	-1.3	-0.6	-1.3	-0.2	1.0	0.3	0.5
Relative age of first facial hair	0.5	1.1	3.4	0.9	-1.0	-0.9	-0.5	0.9	1.1	-0.0	1.8	-0.8	-1.0	-1.3
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	3.5	0.4	-0.8	-1.9	-0.2	1.1	1.0	-0.6	-0.6	-0.9	-0.8	-1.0
Ever used hormone-replacement therapy (HRT)	0.2	0.3	1.0	-0.5	0.4	-0.6	1.0	-0.8	-0.4	0.4	0.0	-0.3	-0.4	0.5
Ever had hysterectomy (womb removed)	0.6	0.6	3.9	-0.5	0.6	0.0	2.0	-0.9	-0.6	0.5	-0.6	0.3	-0.5	0.5
Systolic blood pressure, automated reading	0.2	0.4	2.0	0.3	-0.3	-0.9	0.6	0.1	0.2	1.1	-0.1	-0.4	-1.4	-0.3
Eye problems/disorders: Diabetes related eye disease	1.3	1.5	5.6	-0.4	-0.5	0.5	0.7	1.1	1.7	-1.9	1.1	-0.2	-0.9	-2.4
Angina	0.1	0.1	0.6	-0.2	0.3	0.3	0.2	0.2	-0.3	0.2	-0.8	0.3	0.5	0.1
Medication for hormone replacement therapy	0.4	0.4	0.9	-0.9	0.8	-0.1	0.9	-0.3	-0.7	-0.2	-0.2	0.6	0.4	0.9
Vitamin and mineral supplements	0.6	0.8	1.9	0.6	-1.0	-1.4	-1.1	0.7	0.9	-0.5	0.4	-1.4	-0.2	-0.9
Supplements: Zinc	1.3	1.4	4.2	1.0	0.0	0.1	-1.3	-0.4	-1.2	2.0	-2.0	0.2	0.1	1.7
Medication: Co-codamol	1.7	1.9	3.5	-1.9	1.7	1.0	0.5	-1.9	-1.2	-1.9	-0.9	1.7	0.9	0.8
Medication: Metformin	0.7	1.0	3.2	0.8	-1.1	-0.4	-0.7	0.9	1.5	0.4	-0.1	-1.3	-0.3	-1.8
Diabetes (father)	0.6	0.7	2.0	-1.4	0.9	-0.2	-0.4	-1.3	-0.5	-1.4	-0.8	0.5	0.6	-0.1
Diabetes (mother)	1.0	1.3	6.3	-1.6	0.8	0.5	0.5	-0.6	0.1	-2.5	0.7	0.8	1.6	-0.3
Severe depression (siblings)	0.6	0.7	1.7	-0.4	0.7	1.3	-0.0	-1.1	-0.9	0.6	-0.9	0.8	0.2	1.2
Pack years adult smoking proportion	0.4	0.6	1.5	-0.3	0.6	-0.0	-0.1	-0.8	-1.1	1.0	-1.2	0.3	0.6	1.1
Impedance of leg (right)	0.3	1.2	3.2	-1.1	1.2	-0.2	1.8	-1.4	-1.0	-0.5	1.2	1.1	-0.8	0.9
Leg fat-free mass (left)	1.3	6.9	34.0	2.5	-1.2	-2.4	-3.1	0.1	-0.6	5.8	-3.5	-2.3	-0.3	1.1
Trunk fat percentage	0.7	2.8	10.9	-0.8	1.2	0.5	-1.0	-1.8	-2.0	1.7	-3.3	0.4	1.6	1.9
Hand grip strength (right)	0.6	1.5	3.6	1.5	-1.4	-0.9	-1.5	1.0	1.0	1.2	-0.7	-1.9	-1.3	-0.7
Townsend deprivation index at recruitment	0.7	1.0	3.6	-0.4	0.6	1.2	1.3	-0.0	-0.7	0.5	-1.1	1.1	1.9	0.9
Current tobacco smoking	0.4	0.6	1.6	0.6	-0.0	0.5	-0.6	-0.0	-0.7	1.3	-1.0	-0.0	1.2	0.9
Average weekly fortified wine intake	0.4	0.5	3.0	-0.5	0.4	-0.1	0.8	-0.5	0.3	-1.7	0.5	0.2	-0.7	-0.2
Maternal smoking around birth	2.9	4.2	8.9	-2.7	2.3	1.2	0.9	-2.1	-1.5	-2.7	-1.6	2.0	3.0	1.4
Fed-up feelings	3.5	6.3	14.4	-1.0	2.1	3.8	1.0	-2.5	-3.1	2.0	-3.0	2.0	2.3	3.3
Frequency of unenthusiasm / disinterest in last 2 weeks	3.1	4.1	11.2	-1.7	2.1	3.3	1.8	-2.0	-2.1	0.8	-0.9	2.0	1.9	2.3
Relative age voice broke	0.9	1.4	2.6	0.6	-1.2	-0.8	-0.1	1.3	1.5	-0.8	1.6	-0.8	-1.5	-1.6
Taking other prescription medications	0.3	0.5	1.4	-0.6	0.2	0.8	1.2	-0.1	0.6	0.1	0.7	0.2	1.2	-0.8
Age when periods started (menarche)	1.4	3.3	7.1	1.9	-2.3	-2.7	-1.4	1.9	2.0	-0.2	0.5	-2.3	-1.4	-1.8
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.8	0.4	0.2	-0.4	0.9	0.1	-0.3	0.9	0.1	0.3	-0.6	-0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.7	3.5	-1.3	1.6	0.3	1.9	-1.6	-1.6	0.8	-1.5	0.9	-0.1	1.2
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	2.1	-1.1	1.0	0.8	0.0	-0.3	-0.6	-1.5	0.8	1.0	1.0	0.1
Qualifications: CSEs or equivalent	0.6	0.8	2.7	-0.7	0.6	1.6	-1.1	-0.3	-0.6	-1.0	-0.9	0.7	1.1	0.3
Serious illness, injury or assault to yourself	0.5	0.6	1.8	-0.6	0.6	0.3	0.5	-0.5	-0.9	1.4	-0.7	0.1	0.9	0.9
High blood pressure	0.3	0.8	2.5	0.1	-0.2	-1.6	-0.1	0.0	-0.1	1.6	-1.5	-0.9	-0.5	0.4
Hayfever, allergic rhinitis or eczema	0.8	1.7	5.2	1.5	-1.4	-1.1	-0.2	1.6	1.2	2.3	0.9	-1.2	-1.1	-0.9
Multivitamins +/- minerals	1.5	2.0	3.3	-1.2	1.6	1.6	1.0	-1.5	-1.7	0.0	-1.5	1.7	0.1	1.8
Stomach or abdominal pain in last month	0.0	0.1	0.2	-0.4	0.2	0.1	0.1	-0.2	-0.1	0.1	-0.4	0.3	0.1	0.4
Supplements: Glucosamine	0.2	0.3	0.8	-0.7	0.5	-0.9	-0.1	-0.7	-0.4	-0.7	-0.1	0.2	0.2	0.4
Diverticular disease/diverticulitis (self-reported)	0.6	0.8	4.2	0.7	-0.7	-2.1	-0.7	0.5	0.6	0.3	-0.6	-1.1	-0.1	-0.5
Medication: Atenolol	0.7	0.9	2.2	0.9	-0.7	-1.3	-1.1	0.5	-0.1	1.5	-1.2	-1.1	-1.0	0.3
Medication: Levothyroxine sodium	0.5	0.8	2.2	-1.5	0.9	0.2	0.8	-0.8	0.2	-1.5	0.2	0.5	1.2	-0.7
Sitting height	2.1	14.6	92.7	3.9	-1.3	-4.0	-3.2	-0.2	-1.2	9.6	-3.1	-2.8	-1.6	1.8
Chronic bronchitis/emphysema (father)	0.2	0.3	1.8	-0.0	-0.1	-0.4	-0.4	0.6	0.4	-0.4	0.5	-0.1	1.3	-0.2
High blood pressure (mother)	0.2	0.3	0.9	-0.3	-0.1	-0.2	1.0	0.1	0.7	-0.3	0.8	-0.1	-0.4	-0.5
Body mass index (BMI)	0.8	3.4	13.8	-1.1	1.3	2.4	-0.7	-1.5	-1.8	0.4	-3.7	0.9	2.4	1.8
Impedance of leg (left)	0.3	1.7	3.3	-1.5	1.6	0.3	1.8	-1.5	-1.2	-1.1	1.2	1.7	-0.5	1.1
Leg predicted mass (left)	1.3	7.0	34.7	2.5	-1.2	-2.4	-3.1	0.1	-0.6	5.9	-3.6	-2.3	-0.3	1.1
Trunk fat mass	0.9	4.0	15.8	0.0	0.9	-0.1	-1.7	-1.7	-2.1	3.3	-4.0	-0.1	1.3	2.1
Waist circumference	0.9	3.1	10.9	-0.5	1.1	1.0	-0.8	-1.9	-2.1	2.0	-3.3	0.5	1.9	2.2
Number of incorrect matches in round	1.0	1.6	9.1	-1.8	0.9	1.1	3.0	-0.6	-0.0	-0.3	1.1	0.7	0.9	-0.0
Past tobacco smoking	1.0	1.7	3.8	1.3	-1.5	-1.8	-0.8	1.0	1.2	0.9	0.9	-1.6	-1.9	-1.1
Alcohol usually taken with meals	1.4	2.3	9.2	0.5	-1.2	-3.0	-0.9	1.1	1.6	-1.1	1.3	-1.6	-1.0	-1.6
Nervous feelings	2.8	5.2	11.0	-2.5	2.5	3.3	2.5	-2.2	-2.0	-0.8	1.1	2.9	2.1	2.0
Frequency of tenseness / restlessness in last 2 weeks	6.0	9.3	13.1	-3.0	3.6	3.3	3.4	-3.4	-3.5	0.3	-1.8	3.4	2.5	3.5
Hearing difficulty/problems with background noise	1.1	1.7	3.7	-1.3	1.4	1.7	1.4	-1.9	-1.3	-0.4	-0.8	1.3	0.6	1.4
Hair/balding pattern: Pattern 2	1.3	1.7	5.5	-1.4	0.6	1.9	1.2	-0.0	0.6	-2.3	0.9	1.2	1.7	-0.6
Had menopause	0.3	0.4	2.9	-0.2	0.2	-0.2	1.7	-0.6	-0.1	0.8	-0.1	0.2	-0.7	0.4
Had other major operations	0.5	0.7	2.1	-0.1	0.5	-1.0	-1.3	-0.8	-0.8	1.4	-0.5	-0.1	0.7	0.6
Forced vital capacity (FVC)	1.2	4.5	14.8	2.4	-1.4	-3.7	-1.3	0.9	0.2	3.9	-1.1	-2.2	-2.0	-0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.5	3.2	-1.5	1.6	0.5	1.8	-1.5	-1.4	0.4	-1.4	1.1	-0.5	0.7
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	1.0	0.2	0.2	1.0	0.1	-0.3	-0.1	0.2	-0.1	0.3	-0.1	0.3
Qualifications: None of the above	1.2	2.5	7.5	-1.3	1.2	2.7	1.5	-1.0	-1.2	0.1	-2.2	1.6	1.8	1.4
Financial difficulties in last 2 years	1.5	2.0	5.7	-0.0	0.8	0.3	-0.3	-1.0	-1.6	2.4	-2.0	0.4	1.9	2.1
Mouth/teeth dental problems	0.3	0.5	1.8	0.1	0.3	0.2	-1.4	-0.8	-1.0	0.2	-0.7	0.3	0.4	1.0
Heart attack	1.1	1.4	5.2	1.3	-0.7	-0.2	-0.2	0.1	-0.2	2.3	-2.3	-1.0	-1.1	0.3
Allergy	0.4	1.0	5.4	-1.2	1.0	0.5	0.1	-1.2	-0.5	-2.3	-0.2	0.8	0.5	0.6
Pain all over the body in last month	1.4	1.5	4.2	1.3	-1.0	-1.3	-1.0	0.3	-0.3	2.0	-2.0	-1.3	-0.7	1.0
Diabetes (self-reported)	0.6	1.0	3.8	-0.1	-0.5	-0.2	1.2	0.8	1.7	-0.4	0.4	-0.4	-1.0	-1.9
Hayfever/allergic rhinitis (self-reported)	4.1	5.5	8.0	2.5	-2.8	-2.6	-1.8	2.7	2.5	2.1	1.0	-2.7	-2.0	-2.5
Medication: Ramipril	2.2	2.8	6.1	1.7	-2.0	-2.0	-1.2	1.8	1.9	0.9	0.6	-2.5	-0.8	-1.8
Medication: Simvastatin	0.2	0.3	0.7	0.4	-0.4	-0.0	-0.6	0.9	0.7	0.4	0.2	-0.4	0.0	-0.8
Fluid intelligence score	6.4	13.2	23.1	4.8	-4.4	-4.3	-3.4	3.7	3.0	3.8	1.4	-4.2	-3.3	-2.4
Illnesses of siblings	0.3	0.5	2.7	-0.3	0.0	-0.5	0.1	0.3	0.3	-1.2	1.6	0.2	0.4	-0.6
Neuroticism score	8.3	17.3	39.7	-3.8	4.5	6.3	4.2	-4.4	-4.6	0.3	-1.5	4.7	3.6	4.7
Weight	1.1	5.6	26.4	1.4	-0.2	-1.0	-2.3	-0.9	-1.6	5.1	-4.3	-1.3	0.5	1.9
Impedance of arm (right)	0.5	2.1	7.1	0.5	-0.9	-2.4	0.8	0.8	1.3	-0.5	2.7	-0.9	-1.8	-1.4
Arm fat percentage (right)	0.7	2.6	10.8	-0.9	1.2	1.8	-0.8	-1.5	-1.7	0.4	-3.3	0.6	1.9	1.6
Trunk fat-free mass	1.3	7.7	45.4	2.9	-1.2	-2.4	-2.5	0.1	-0.8	6.7	-3.1	-2.2	-0.9	1.3
Hip circumference	0.8	3.4	13.8	1.0	-0.2	-1.5	-1.8	-0.6	-1.2	3.7	-3.5	-1.4	0.1	1.4
Time employed in main current job	0.6	0.7	2.3	1.1	-0.9	0.3	-1.5	1.1	0.7	0.2	0.9	-0.3	0.2	-0.6
Alcohol intake versus 10 years previously	0.9	1.4	2.8	-0.9	1.3	1.1	0.6	-1.0	-1.7	1.3	-1.2	1.2	1.0	1.4
Father’s age at death	0.8	1.1	2.3	0.2	-0.8	-1.5	1.1	1.0	1.4	-1.0	1.1	-0.6	-0.7	-1.4
Worrier / anxious feelings	6.6	12.6	18.7	-3.5	4.2	4.2	2.3	-4.2	-4.3	0.1	-1.6	4.2	3.4	4.2
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.1	3.9	-1.6	1.4	2.0	2.0	-1.1	-1.3	0.2	-1.7	1.3	1.1	1.2
Falls in the last year	2.4	3.2	8.5	2.2	-1.4	-1.6	-2.8	0.3	-0.4	2.9	-2.0	-2.0	-0.4	1.0
Hair/balding pattern: Pattern 3	0.6	0.8	2.8	0.6	0.4	-0.7	-1.1	-0.3	-1.1	1.7	-1.2	0.6	-0.1	1.1
Number of live births	0.3	0.5	1.5	-0.8	0.3	0.1	1.2	-0.2	0.5	-0.8	0.8	0.3	0.3	-1.0
Forced expiratory volume in 1-second (FEV1)	1.2	4.0	14.4	2.7	-1.6	-2.7	-1.2	1.0	0.2	3.8	-1.4	-2.2	-1.9	0.0
Pulse rate	1.5	2.5	5.6	0.7	-1.5	-0.8	-0.3	2.2	2.0	-1.6	2.2	-1.1	-0.6	-2.4
Happiness	1.9	2.3	6.1	-0.8	1.5	2.5	0.8	-1.6	-2.1	0.3	-1.2	1.6	0.9	2.0
Noisy workplace	4.6	5.7	10.6	-3.0	2.7	3.1	0.3	-2.1	-1.6	-2.5	-2.0	2.7	3.3	1.5
Qualifications: A levels/AS levels or equivalent	1.9	4.2	16.5	2.3	-1.9	-4.1	-1.9	1.0	1.1	1.6	1.0	-2.3	-2.4	-0.7
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	2.9	-0.1	-0.1	-0.4	1.3	0.2	0.8	-0.9	1.7	0.2	-0.7	-1.0
Mouth/teeth dental problems: Dentures	0.7	1.1	5.3	-0.9	0.1	-0.0	2.3	0.4	1.2	-0.9	1.1	0.3	-0.4	-1.5
Asthma	0.7	1.3	2.8	1.4	-1.1	-1.1	-1.7	0.8	0.2	1.6	-1.3	-1.1	-1.1	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	2.0	-0.4	0.0	0.4	1.4	0.1	0.3	-0.1	1.2	0.4	-0.1	-0.2
Medication: Cholesterol lowering	0.4	0.6	2.1	-0.5	0.6	0.3	-0.8	-0.4	-0.6	0.2	-1.4	0.3	1.4	0.6
Depression (self-reported)	2.0	2.4	6.9	-0.5	1.3	1.6	-0.2	-1.8	-2.2	1.1	-2.1	1.0	0.8	2.6
Medication: Lansoprazole	1.2	1.3	3.2	0.5	-1.1	-0.3	0.7	1.7	1.7	-0.5	1.7	-0.8	0.2	-1.8
Prospective memory result	3.7	4.5	11.3	-3.1	2.6	1.4	0.8	-2.8	-2.0	-1.5	-0.7	1.7	3.4	1.6
Lung cancer (father)	0.2	0.2	0.5	-0.6	0.7	0.3	0.7	-0.3	-0.4	-0.4	-0.1	0.5	-0.1	0.0
Illnesses of mother	0.8	0.9	3.3	0.7	0.1	0.5	-1.0	-0.2	-1.3	1.8	-1.4	-0.2	-0.1	1.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.9	9.8	2.1	-1.3	-2.7	-0.4	0.7	0.3	3.1	-0.9	-2.0	-1.9	-0.2
Pulse wave Arterial Stiffness index	0.4	0.5	1.0	1.0	-0.8	-0.2	-0.9	0.6	0.6	0.5	0.9	-0.7	-0.3	-0.4
Impedance of arm (left)	0.7	3.0	9.3	1.2	-1.4	-3.0	-0.2	1.2	1.6	0.0	2.6	-1.5	-2.1	-1.7
Arm fat mass (right)	0.7	3.0	15.1	-0.1	0.8	0.8	-1.2	-1.2	-1.8	2.4	-3.9	0.0	1.3	1.8
Trunk predicted mass	1.3	7.7	44.5	2.9	-1.2	-2.5	-2.5	0.1	-0.8	6.7	-3.1	-2.3	-0.9	1.3
Standing height	2.3	22.7	110.2	5.3	-2.9	-7.1	-3.7	0.9	0.1	10.5	-1.8	-4.5	-3.6	0.7
Length of working week for main job	1.4	1.5	5.1	-0.9	1.1	0.7	-0.9	-1.2	-1.4	0.7	-1.5	0.7	2.3	1.3
Exposure to tobacco smoke at home	0.3	0.4	1.3	-0.7	0.4	1.1	0.6	-0.2	-0.3	-0.7	-0.9	0.5	0.3	0.2
Breastfed as a baby	1.0	1.3	2.8	1.2	-0.9	-1.4	-1.2	0.5	-0.0	1.6	-0.3	-1.7	-1.6	0.1
Tense / ‘highly strung’	6.1	10.2	14.8	-3.2	3.5	3.9	3.5	-3.6	-3.5	0.4	-0.5	3.6	3.1	3.7
Seen doctor (GP) for nerves, anxiety, tension or depression	2.2	3.4	8.4	-0.9	1.6	1.8	-1.2	-1.9	-2.5	1.2	-1.5	0.8	2.6	2.9
Hair/balding pattern: Pattern 4	0.2	0.5	3.2	-0.3	-0.2	0.1	0.5	0.5	0.3	-0.6	1.8	0.1	1.0	-0.4
Birth weight of first child	1.1	2.1	6.8	0.8	0.3	-0.4	-1.4	-0.9	-1.6	2.6	-2.0	-0.4	-0.4	2.3
Peak expiratory flow (PEF)	0.8	2.0	5.7	1.7	-0.6	-0.4	-2.4	-0.2	-0.9	2.2	-2.1	-0.8	-0.3	1.4
Pulse wave reflection index	0.3	0.4	1.1	-0.1	0.2	1.0	-0.4	-1.0	-0.5	-0.3	-0.5	-0.0	0.8	0.8
Ever highly irritable/argumentative for 2 days	1.5	1.8	6.4	-0.5	1.0	-0.6	-1.1	-1.5	-1.4	1.2	-2.5	0.1	1.4	1.6
Loud music exposure frequency	0.3	0.3	2.2	-0.2	-0.1	0.1	1.5	-0.1	0.2	-0.7	-0.7	-0.1	-0.3	-0.1
Qualifications: O levels/GCSEs or equivalent	2.5	3.9	9.9	3.0	-1.9	-2.5	-2.1	1.0	0.2	3.1	-0.1	-1.9	-2.3	0.3
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.2	-0.8	1.0	0.8	0.4	-1.0	-1.0	-0.3	0.2	0.8	0.6	1.1
Blood clot in the leg (DVT)	2.5	3.3	5.7	-1.6	2.1	1.5	0.2	-1.9	-2.3	0.4	-1.9	1.8	2.4	2.1
Medication: Paracetamol	0.7	1.1	5.2	-0.6	0.7	2.3	0.5	-0.7	-0.5	-0.2	0.8	1.0	1.6	0.9
Headache pain in last month	0.4	0.7	3.9	-0.4	0.0	2.0	0.5	0.5	0.1	-0.3	1.3	0.8	1.0	-0.2
Medication for cholesterol, blood pressure or diabetes	1.0	1.6	8.1	0.5	-0.7	-0.1	1.3	0.8	1.2	-1.1	2.9	-0.2	-1.5	-1.1
Glaucoma (self-reported)	0.8	1.0	2.2	1.0	-1.1	-1.5	-0.3	1.2	0.9	1.3	0.2	-0.7	-0.8	-1.0
Gout (self-reported)	1.9	2.6	5.2	2.1	-1.7	-1.8	-1.7	1.2	0.7	2.0	-0.4	-1.9	-2.3	-0.7
Hypothyroidism/myxoedema (self-reported)	0.3	0.7	2.1	-1.2	1.1	0.4	1.4	-0.9	-0.5	-0.2	-0.5	0.6	0.8	0.1
Medication: Amlodipine	0.1	0.2	0.5	-0.3	-0.1	0.5	0.1	0.4	0.6	-0.6	0.3	0.0	0.7	-0.6
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.2	-0.4	0.2	-0.3	0.5	-0.3	-0.2	0.0	0.2	0.3	-0.2	-0.4
Birth weight	0.2	0.4	1.1	0.3	0.3	-0.4	0.1	-1.0	-0.5	0.8	0.9	-0.0	0.5	1.1
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.5	-0.7	0.2	0.4	0.0	-0.4	0.1	-0.7	-0.4	0.3	0.0	-0.2
High blood pressure (siblings)	0.3	0.5	1.3	0.4	-0.7	-0.0	-0.0	0.6	0.7	0.5	-0.9	-1.1	-1.1	-0.6
Forced vital capacity (FVC), Best measure	0.8	2.9	9.7	1.9	-1.1	-3.1	-0.4	0.8	0.5	3.0	-0.4	-2.0	-1.9	-0.7
Body fat percentage	0.9	3.4	11.2	-1.3	1.6	1.4	-0.6	-2.1	-2.2	0.8	-3.4	0.9	2.0	2.1
Leg fat percentage (right)	1.2	4.2	10.7	-1.8	2.0	2.6	0.1	-2.3	-2.3	0.1	-3.3	1.5	2.0	2.2
Arm fat-free mass (right)	1.1	5.8	32.5	1.5	-0.0	-1.5	-2.2	-0.9	-1.6	5.7	-3.8	-1.1	0.1	1.9
Exposure to tobacco smoke outside home	0.7	0.9	4.5	-0.6	0.5	2.1	-0.3	0.0	-0.5	0.0	-0.7	0.9	1.6	0.5
Comparative body size at age 10	1.8	4.9	9.4	-2.3	2.3	2.8	1.4	-2.6	-1.8	-2.2	-0.3	2.2	3.1	1.8
Number of full brothers	1.5	1.9	4.8	-1.3	1.4	2.2	-0.0	-1.4	-1.1	-1.4	-1.5	1.6	1.3	0.9
Worry too long after embarrassment	1.4	2.3	7.6	-1.3	1.3	2.7	2.2	-1.0	-1.1	-0.9	0.4	1.8	1.1	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	2.6	-1.0	1.1	1.4	-0.2	-1.1	-1.3	0.2	-1.1	1.0	1.1	1.6
Wheeze or whistling in the chest in last year	2.4	4.2	12.5	-1.0	1.8	0.8	0.0	-2.1	-2.9	1.5	-3.5	1.5	1.7	3.0
Number of children fathered	0.4	0.5	1.7	0.6	-0.7	-1.3	-0.3	0.4	0.3	0.9	-0.5	-0.8	-0.8	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	2.9	-0.7	0.7	1.7	0.9	-1.2	-0.9	0.6	-0.1	0.7	0.2	1.1
Age at first live birth	0.8	1.4	3.6	1.5	-1.2	-1.9	-1.6	0.9	0.7	0.7	0.8	-1.4	-0.9	-0.5
Pulse wave peak to peak time	0.3	0.3	1.6	-0.6	0.6	-0.4	0.5	-0.5	-0.6	0.3	-1.2	0.4	0.0	0.5
Health satisfaction	0.3	0.4	1.5	0.4	-0.5	-0.6	-0.6	0.2	-0.2	1.2	-0.7	-0.8	0.3	0.2
Shortness of breath walking on level ground	0.1	0.2	0.9	-0.2	0.2	-0.1	0.7	-0.2	-0.2	-0.1	-0.9	-0.1	-0.4	0.0
Qualifications: College or University degree	1.2	3.9	11.4	0.5	-1.2	-3.4	0.5	1.3	2.3	-1.3	3.3	-1.1	-1.8	-2.2
Eye problems/disorders: None of the above	2.2	2.5	6.6	-1.0	1.5	2.6	-0.6	-1.8	-1.6	-1.5	-0.0	1.5	2.1	1.8
Mouth/teeth dental problems: Loose teeth	1.3	1.6	2.9	1.6	-1.4	-1.3	-0.9	1.7	0.7	1.5	-0.4	-1.4	-1.5	-0.8
Emphysema/chronic bronchitis	1.7	2.0	4.0	1.4	-1.8	-1.4	-0.4	1.2	1.8	0.2	0.9	-2.0	-1.3	-1.8
Medication for pain relief, constipation, heartburn	0.9	1.6	4.2	1.2	-1.1	-2.0	-1.8	1.0	0.9	-0.6	-0.3	-1.6	-1.3	-1.0
Neck or shoulder pain in last month	1.4	2.0	5.0	-2.1	1.7	1.0	0.6	-1.7	-1.6	-0.4	-0.7	1.0	2.2	1.0
Medication: Blood pressure	0.8	1.4	6.1	0.3	-0.0	-0.6	-1.8	-0.2	-0.7	1.8	-2.5	-0.6	0.8	0.8
Angina (self-reported)	0.1	0.1	0.5	-0.3	0.3	0.1	0.3	0.2	-0.1	-0.0	-0.7	0.2	0.4	-0.2
Migraine (self-reported)	0.7	0.9	2.1	1.5	-1.4	0.7	-0.6	1.2	0.7	0.7	0.6	-1.3	-0.5	-0.2
Medication: Ibuprofen	0.8	0.9	2.1	-1.2	0.8	1.3	1.4	-0.6	-0.1	-1.0	1.2	1.2	0.5	0.0
Medication: Allopurinol	2.7	3.5	6.3	2.4	-2.5	-1.4	-0.4	1.8	1.9	1.8	0.9	-2.5	-2.5	-1.3
Medication: Omeprazole	0.2	0.3	0.9	-0.3	0.4	0.9	-0.0	-0.4	-0.3	-0.4	-0.9	0.5	0.3	0.6
Medication: Seretide 50 evohaler	0.9	1.0	2.0	-1.2	1.3	0.2	0.8	-1.4	-1.0	-1.1	-0.7	1.3	0.5	0.6
Mean time to correctly identify matches	0.5	0.9	3.3	-0.6	0.2	1.8	1.6	0.4	0.7	-0.5	0.8	0.8	1.1	-0.9
Heart disease (mother)	0.3	0.3	1.1	0.2	-0.4	0.3	-0.4	0.6	0.9	-0.4	0.9	-0.2	0.0	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.1	2.9	-1.1	1.1	1.7	0.7	-1.1	-0.9	-0.4	-0.7	1.2	1.4	1.0
Whole body fat mass	1.0	4.1	17.2	-0.4	1.2	0.5	-1.5	-1.9	-2.2	2.6	-4.2	0.2	1.6	2.3
Leg fat mass (right)	1.3	4.9	18.2	-1.0	1.8	1.4	-0.9	-2.4	-2.6	2.1	-4.3	0.9	2.0	2.6
Arm predicted mass (right)	1.2	6.0	33.1	1.7	-0.2	-1.6	-2.2	-0.8	-1.4	5.8	-3.9	-1.4	-0.2	1.8
Pulse rate, automated reading	0.1	0.3	0.8	0.5	-0.4	-0.9	-0.3	0.1	0.3	0.0	0.9	-0.4	-0.7	-0.3
Alcohol intake frequency.	0.2	0.5	2.2	-0.8	0.5	0.9	0.6	0.1	-0.3	0.5	-1.5	0.5	0.7	-0.3
Comparative height size at age 10	3.7	20.3	94.9	4.6	-1.8	-4.7	-4.4	-0.7	-1.9	9.7	-5.6	-3.6	-2.5	2.8
Number of full sisters	0.7	0.9	3.1	-0.9	0.6	1.0	0.7	0.1	0.1	-1.3	1.1	0.9	1.8	-0.3
Suffer from ‘nerves’	2.5	4.0	8.5	-2.2	2.1	2.9	2.0	-1.8	-1.8	-0.4	0.9	2.2	2.5	1.8
Overall health rating	0.9	1.9	4.8	-0.8	1.0	2.2	1.5	-1.0	-1.5	1.4	-1.5	1.0	0.9	1.4
Chest pain or discomfort	0.1	0.2	0.8	-0.0	0.2	0.4	-0.2	0.0	-0.3	0.2	-0.9	0.3	0.6	0.6
Had major operations	0.2	0.2	0.5	-0.2	0.2	-0.3	-0.4	-0.4	-0.7	0.0	-0.2	-0.4	0.7	0.7
Age at last live birth	0.2	0.3	1.1	-0.1	0.2	-1.1	-1.0	-0.2	-0.4	-0.7	0.2	0.1	0.3	0.3
Family relationship satisfaction	1.8	2.2	6.4	-1.5	1.3	2.5	0.7	-1.6	-1.3	-1.1	-1.4	1.1	1.3	1.6
Leg pain on walking	0.4	0.5	1.5	-0.7	0.7	0.2	-0.5	-0.9	-0.6	0.4	-0.9	0.0	1.2	0.7
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.7	3.6	-1.0	1.3	1.9	-1.9	-0.9	-1.4	-0.8	-0.9	1.1	1.6	1.1
Commuting to job workplace: Car/motor vehicle	0.7	0.9	1.9	1.4	-1.0	-1.0	-0.8	0.6	0.4	1.0	0.1	-1.2	-1.3	-0.1
Illness, injury, bereavement, stress in last 2 years	2.7	3.4	6.9	1.7	-2.1	-1.0	-0.6	2.2	2.4	-0.8	1.6	-1.7	-2.2	-2.6
Medication: Aspirin	0.1	0.2	0.9	-0.4	0.2	-0.1	0.5	-0.1	0.2	1.0	0.0	0.3	0.1	-0.5
Supplements: Vitamin C	0.8	0.9	3.6	0.8	-0.5	-1.7	-0.5	0.3	-0.3	1.9	-1.1	-0.5	-0.8	0.4
Knee pain experienced in last month	0.3	0.5	1.5	-0.5	0.6	0.5	0.6	-0.8	-0.8	0.9	-1.2	0.3	-0.1	0.8
Hypertension (Self-reported)	0.2	0.6	2.5	0.2	-0.4	-1.6	-0.2	0.4	0.2	1.2	-1.1	-1.0	-0.7	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	2.1	-1.0	0.7	0.8	1.1	-0.9	-0.4	-0.4	0.2	0.8	1.5	0.6
Illnesses of father: Heart disease	0.5	0.7	2.2	0.6	-1.0	-0.2	-0.2	1.5	1.5	0.1	0.1	-1.0	-0.3	-1.2
Illnesses of siblings: Diabetes	0.2	0.2	0.8	0.1	-0.1	-0.4	-0.9	0.1	0.3	-0.6	-0.7	0.1	-0.2	-0.5
Smoking status: Previous	1.0	1.5	3.0	-1.3	1.4	1.7	0.9	-1.0	-1.1	-1.0	-0.8	1.5	1.4	1.0
Forced expiratory volume in 1-second (FEV1), predicted	1.7	3.5	15.8	2.1	-1.1	-2.7	-1.9	0.8	-0.2	4.0	-1.1	-1.8	-0.9	0.6
Whole body fat-free mass	1.3	7.3	40.8	2.6	-1.1	-2.3	-2.7	-0.0	-0.8	6.4	-3.4	-2.2	-0.6	1.3
Leg fat-free mass (right)	1.2	6.4	30.4	2.6	-1.3	-2.4	-3.0	0.4	-0.4	5.5	-3.2	-2.3	-0.4	0.8
Arm fat percentage (left)	0.6	2.3	10.0	-0.8	1.1	1.6	-1.1	-1.4	-1.6	0.3	-3.2	0.5	1.9	1.3
Average weekly red wine intake	0.1	0.1	0.3	-0.4	0.1	-0.1	-0.3	-0.4	-0.0	-0.5	0.4	-0.1	-0.3	0.1
Handedness (chirality/laterality): Left-handed	1.9	2.3	6.4	-2.0	1.4	2.2	2.5	-0.9	-0.2	-1.9	0.6	1.7	1.0	0.3
Mood swings	4.7	8.5	25.6	-2.4	3.0	5.1	2.8	-2.8	-3.2	0.3	-1.1	3.1	2.2	3.4
Loneliness, isolation	1.4	1.9	6.9	-0.9	1.2	2.6	2.0	-1.1	-1.3	1.0	-0.8	1.1	-0.0	1.2
Long-standing illness, disability or infirmity	0.3	0.4	1.3	-0.9	0.2	-0.7	1.2	0.1	0.5	0.4	-0.8	-0.1	0.1	-0.8
Ever had bowel cancer screening	0.2	0.2	1.0	0.3	-0.1	-0.0	-1.0	-0.1	-0.2	0.7	0.1	-0.5	0.3	0.5
Diabetes diagnosed by doctor	0.9	1.6	5.8	-0.0	-0.8	0.6	1.5	1.2	2.0	-0.6	0.6	-0.6	-1.2	-2.4
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.2	0.5	-0.7	0.3	0.3	0.3	-0.0	0.1	-0.5	0.1	0.4	0.7	0.1
Friendships satisfaction	0.3	0.3	0.7	0.2	-0.2	0.8	0.7	-0.2	-0.5	0.7	-0.8	-0.4	-0.6	0.8
Qualifications: nursing, teaching	1.2	1.9	5.6	1.6	-1.2	-2.4	-0.7	1.0	0.9	1.4	1.3	-1.0	-1.8	-0.8
Commuting to job workplace: Walk	0.4	0.5	2.7	-0.6	0.2	-0.9	-0.9	-0.5	0.2	-1.7	-0.6	-0.2	-0.1	-0.3
Eye problems/disorders: Cataract	0.8	0.9	2.2	0.8	-0.9	-1.5	0.5	1.1	0.8	0.9	0.4	-0.8	-1.2	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.7	0.4	-0.1	0.8	0.5	-0.0	-0.2	0.5	0.2	0.1	-0.5	0.4
Medication for cholesterol	0.4	0.6	2.9	0.0	0.3	0.1	-1.7	-0.4	-0.7	-0.6	-0.2	0.5	1.5	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	3.5	-0.7	0.9	1.0	-0.5	-1.2	-1.5	0.3	-1.9	0.1	1.9	1.2
Back pain experienced in last month	1.2	1.8	6.6	0.1	0.4	-0.0	-0.8	-1.2	-1.2	2.3	-2.6	0.1	0.7	1.9
Mineral and other dietary supplements	0.3	0.4	1.4	-0.5	0.5	0.0	0.5	-1.1	-0.5	-1.2	-0.1	0.1	0.5	0.9
Breast cancer (self-reported)	0.9	1.0	4.5	1.4	-1.1	-0.7	-2.1	0.5	0.6	0.3	-0.1	-1.2	-0.9	-0.3
Asthma (self-reported)	0.6	1.1	2.9	1.1	-0.7	-0.9	-1.7	0.3	-0.2	1.6	-1.7	-0.8	-0.8	0.1
Osteoporosis (self-reported)	0.7	0.9	1.9	0.7	-1.0	0.4	0.6	1.1	1.4	-0.5	1.3	-0.2	-0.9	-1.3
Osteoarthritis (self-reported)	0.8	1.0	3.5	0.5	-0.1	-1.6	-0.8	-0.5	-0.7	1.5	-1.9	-0.7	0.1	1.0
Medication: Aspirin	0.2	0.2	0.9	0.1	-0.2	-0.1	0.1	0.4	0.4	1.0	0.2	0.1	-0.7	-0.8
Medication: Gliclazide	0.8	0.9	3.2	-0.6	0.9	1.8	1.2	-0.6	-0.8	0.7	-1.0	1.3	0.3	0.1
Illnesses of father: None of the above (group 1)	1.0	1.2	2.2	-0.8	1.1	1.2	-0.4	-1.3	-1.5	-0.5	-1.5	1.2	0.4	1.3
Smoking status: Current	0.5	0.9	2.2	0.5	0.2	0.8	-0.6	-0.2	-0.9	1.5	-1.3	0.1	1.4	1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	3.9	0.3	-0.9	-1.3	2.0	1.3	1.5	-1.2	1.2	-0.8	-0.5	-1.6
Whole body water mass	1.3	7.4	41.7	2.6	-1.1	-2.3	-2.7	0.0	-0.8	6.5	-3.4	-2.2	-0.6	1.3
Leg predicted mass (right)	1.2	6.4	30.0	2.6	-1.3	-2.4	-3.1	0.4	-0.4	5.5	-3.2	-2.2	-0.4	0.8
Arm fat mass (left)	0.7	2.9	13.9	-0.3	0.9	0.9	-1.3	-1.4	-1.7	2.2	-3.7	0.2	1.6	1.7
Number of self-reported non-cancer illnesses	1.2	2.1	11.5	0.7	-0.5	-1.1	0.0	0.1	-0.4	3.4	-2.8	-1.1	-0.5	0.6
Average weekly champagne plus white wine intake	0.4	0.6	1.4	-1.2	0.7	-0.2	1.0	-0.8	-0.1	-0.9	1.2	0.6	0.3	-0.1
Miserableness	4.3	7.4	23.6	-2.4	2.9	4.9	2.0	-2.6	-2.9	-0.7	-1.4	3.3	1.9	2.8
Guilty feelings	5.2	7.7	20.2	-2.9	3.0	4.5	3.5	-2.4	-2.5	-0.8	-0.4	3.6	2.2	2.3
Wears glasses or contact lenses	0.1	0.1	0.5	-0.7	0.1	0.2	0.4	-0.2	0.4	-0.6	0.2	-0.1	0.0	-0.3
Ever taken oral contraceptive pill	1.0	1.1	3.1	-1.8	1.2	-0.4	1.6	-0.6	-0.4	-1.3	0.4	1.2	1.2	-0.1
Hearing aid user	1.1	1.3	4.0	-0.8	0.0	-0.0	1.1	0.5	1.3	-2.0	1.9	0.6	-0.8	-1.4
Mother’s age at death	0.6	0.7	4.0	-1.0	0.3	-0.3	0.9	-0.4	0.4	-2.0	1.2	0.1	-0.3	-0.4
Financial situation satisfaction	0.8	1.1	3.5	-1.3	0.8	1.0	1.2	-0.7	-0.3	-1.9	0.3	1.1	0.9	0.7
Tinnitus: Yes, now most or all of the time	0.1	0.2	1.1	0.2	0.1	-0.2	-0.2	0.1	-0.3	1.1	-0.5	0.2	0.0	0.2
Commuting to job workplace: Public transport	0.7	0.8	4.5	-0.8	0.2	-0.5	1.1	0.0	0.5	-0.8	2.1	0.2	0.2	-1.0
Eye problems/disorders: Glaucoma	0.2	0.2	1.5	0.4	-0.3	-0.5	-0.5	0.3	-0.1	1.2	-0.5	-0.0	0.1	0.1
Medication: Blood pressure	0.8	1.6	3.8	0.8	-1.0	-1.1	1.4	1.1	1.2	1.6	0.8	-1.3	-2.0	-1.1
Pain type(s) experienced in last month: Hip pain	0.4	0.6	1.8	-0.5	-0.2	-1.3	0.6	0.6	0.9	-0.7	1.0	-0.3	-0.2	-0.9
Supplements: Fish oil (including cod liver oil)	1.1	1.4	3.0	1.2	-1.2	-0.7	-0.4	1.7	1.2	1.7	0.1	-0.8	-1.5	-1.4
High cholesterol (Self-reported)	0.1	0.1	0.3	0.2	-0.3	0.6	0.1	0.3	0.5	0.2	-0.4	-0.3	-0.4	-0.3
Medication: Bendroflumethiazide	0.7	1.0	6.2	-1.3	0.9	0.3	2.5	-0.7	-0.3	0.4	0.7	0.8	0.3	0.5
Medication: Paracetamol	1.0	1.5	6.0	-0.9	1.0	2.4	0.9	-1.1	-0.7	-0.5	0.4	1.3	1.6	1.2
Medication: Lisinopril	0.5	0.7	3.3	-0.4	0.2	-1.8	-0.0	-0.6	-0.3	0.6	-1.5	-0.7	0.4	0.3
Medication: Atorvastatin	0.1	0.2	1.3	0.1	-0.0	-0.4	-0.0	-0.4	-0.2	0.1	-1.2	-0.1	-0.4	0.1
Illnesses of father: High blood pressure	0.9	1.1	2.0	0.8	-0.9	-1.1	0.4	1.2	1.1	1.0	1.1	-0.5	-1.4	-1.3
Alcohol drinker status: Never	0.2	0.2	0.6	-0.2	-0.3	-0.7	0.3	0.0	0.4	0.3	-0.3	-0.7	-0.8	-0.4
Ever smoked	0.4	0.7	1.6	-0.1	0.7	1.1	0.4	-0.3	-1.1	0.3	-0.4	1.0	1.1	1.3
Basal metabolic rate	1.3	7.4	40.8	2.5	-0.9	-2.0	-2.8	-0.3	-1.1	6.4	-3.8	-2.0	-0.4	1.6
Leg fat percentage (left)	1.3	4.6	11.7	-1.9	2.1	2.7	-0.0	-2.3	-2.4	-0.2	-3.4	1.7	2.2	2.2
Arm fat-free mass (left)	1.1	5.8	32.8	1.5	-0.1	-1.3	-1.9	-0.9	-1.6	5.7	-3.8	-1.2	-0.0	2.0
Number of operations (self-reported)	0.3	0.4	1.7	0.3	-0.0	-0.2	-0.9	-0.2	-0.5	1.3	-0.4	-0.6	0.9	0.7
Average weekly beer plus cider intake	0.5	0.8	3.4	-0.3	0.7	1.9	-0.2	-0.4	-0.7	-0.2	-1.3	1.0	1.1	0.3
Irritability	2.0	3.4	9.2	-1.4	1.6	3.0	2.7	-1.5	-1.4	-0.8	0.5	2.0	1.9	1.8
Risk taking	1.0	1.5	9.0	-1.7	1.0	0.6	1.1	-1.0	-0.2	-3.0	-0.4	0.5	0.3	-0.1
Ever had prostate specific antigen (PSA) test	0.9	1.1	2.8	-0.6	1.0	1.0	-1.7	-1.1	-1.0	-0.6	-0.5	0.8	1.5	1.0
Fractured/broken bones in last 5 years	0.4	0.5	1.5	-0.5	0.5	-0.8	-0.6	-1.2	-0.5	-0.9	0.6	0.2	0.6	0.6
Age started oral contraceptive pill	1.4	1.8	5.6	-1.7	1.5	0.1	2.4	-1.6	-1.1	-0.9	0.7	1.5	-0.2	1.2
Diastolic blood pressure, automated reading	0.5	1.5	5.8	1.1	-0.5	-1.1	-1.0	-0.2	-0.7	2.4	-1.9	-0.8	-0.7	1.1
Ever depressed for a whole week	0.1	0.2	0.9	-0.2	0.4	0.9	-0.0	-0.4	-0.4	0.2	-0.1	0.4	0.2	0.5
Unable to work because of sickness or disability	0.2	0.3	1.6	0.2	-0.0	0.3	-0.1	0.3	-0.5	1.2	-0.8	-0.2	0.1	0.5
Commuting to job workplace: Cycle	0.3	0.4	1.5	-0.6	0.2	-0.6	0.6	0.1	0.5	-1.2	0.5	0.4	0.4	-0.7
Myopia	0.7	1.0	4.4	1.3	-1.1	1.0	-0.5	1.2	0.7	2.1	0.0	-0.7	-0.5	-0.3
Vascular/heart problems diagnosed by doctor	0.4	1.1	4.6	-0.2	0.1	1.2	-0.2	0.0	0.4	-2.1	2.0	0.8	0.5	-0.7
Cholesterol lowering medication	1.1	1.6	3.7	1.1	-1.3	-1.1	0.4	1.3	1.6	0.2	0.6	-1.3	-1.9	-1.7
Medication: Omeprazole (e.g. Zanprol)	0.6	0.8	1.7	-0.6	0.8	0.9	-0.3	-0.9	-1.0	0.1	-1.3	0.8	1.0	1.2
Pain experienced in last month	0.5	0.9	4.2	-1.0	1.0	0.2	0.5	-0.5	-0.3	-2.1	1.0	1.2	-0.3	-0.7
Supplements: Calcium	0.7	0.8	2.7	1.6	-1.2	0.1	-0.7	0.7	0.5	1.4	0.5	-0.9	-0.5	-0.1
Basal cell carcinoma (self-reported)	0.4	0.5	2.5	0.8	-0.2	-0.0	0.0	-0.2	-0.4	1.6	-0.5	-0.1	-1.0	0.7
Heart attack/myocardial infarction (self-reported)	0.9	1.2	4.6	1.2	-0.7	-0.2	-0.1	0.1	-0.1	2.1	-2.1	-1.0	-1.0	0.3
Deep venous thrombosis (DVT) (self-reported)	2.5	3.2	5.4	-1.6	2.1	1.4	0.5	-2.1	-2.3	0.6	-1.8	2.0	2.1	2.2
Heart disease (siblings)	0.2	0.3	1.0	0.6	-0.4	-0.0	0.2	0.2	0.2	1.0	-0.8	-0.6	-0.6	-0.3
Alcohol drinker status: Previous	0.4	0.4	1.5	0.5	-0.7	0.3	0.3	1.2	0.9	0.4	0.3	-0.1	-0.0	-1.1
Pack years of smoking	0.3	0.5	1.1	-0.5	0.7	0.0	0.1	-0.9	-1.0	0.5	-1.1	0.4	0.4	0.9
Impedance of whole body	0.2	1.1	4.9	-0.3	0.2	-1.8	1.1	-0.2	0.2	-0.7	2.2	0.1	-1.4	-0.3
Leg fat mass (left)	1.3	5.0	18.9	-1.0	1.8	1.5	-1.1	-2.3	-2.7	1.9	-4.3	1.0	2.1	2.7
Arm predicted mass (left)	1.1	5.8	33.9	1.7	-0.3	-1.3	-1.9	-0.7	-1.4	5.8	-3.7	-1.3	-0.0	1.9