Hub : Genes

METTL13

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.2280 0.0420 0.0e+00 0.234 0.244 0.245 0.274 0.270 4.5e-28 2.3e-29 1.6e-29 2.0e-33 8.0e-33
2 GTEx Brain Cerebellar Hemisphere 0.2050 0.0760 7.0e-03 0.180 NA 0.190 NA 0.157 2.2e-05 NA 1.3e-05 NA 7.7e-05
3 GTEx Brain Cerebellum 0.2230 0.0820 3.7e-03 -0.002 NA 0.048 NA 0.015 3.8e-01 NA 1.5e-02 NA 1.1e-01
4 GTEx Cells EBV-transformed lymphocytes 0.3490 0.1130 4.2e-03 0.000 NA 0.033 NA 0.023 3.3e-01 NA 3.0e-02 NA 5.9e-02
5 GTEx Esophagus Mucosa 0.0930 0.0420 4.5e-03 0.003 NA -0.004 NA -0.002 1.9e-01 NA 6.9e-01 NA 5.0e-01
6 GTEx Skin Sun Exposed Lower leg 0.1100 0.0330 2.2e-06 0.079 NA 0.122 NA 0.128 4.3e-07 NA 2.6e-10 NA 9.9e-11
7 GTEx Testis 0.2940 0.0880 6.8e-05 0.046 NA 0.030 NA 0.088 4.3e-03 NA 1.8e-02 NA 9.9e-05
8 METSIM Adipose 0.0620 0.0200 2.7e-06 0.047 0.042 0.037 0.042 0.039 1.2e-07 5.7e-07 2.4e-06 6.5e-07 1.4e-06
9 YFS Blood 0.1054 0.0212 0.0e+00 0.101 0.095 0.104 0.105 0.103 2.1e-31 1.7e-29 4.2e-32 1.5e-32 6.1e-32
10 TCGA Kidney Renal Papillary Cell Carcinoma 0.1390 0.0770 6.4e-03 0.003 0.030 0.023 NA 0.003 2.0e-01 8.0e-03 1.7e-02 NA 2.0e-01
11 TCGA Prostate Adenocarcinoma 0.0215 0.0130 3.2e-03 0.019 0.019 0.019 NA 0.020 3.8e-03 3.5e-03 4.2e-03 NA 3.2e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bipolar Disorder (2018) 0.6 1.0 4.0 -1.3 0.7 0.9 2.0 -0.5 0.1 -1.2 0.9 0.8 0.7 -0.4
Bipolar Disorder or Schizophrenia 0.8 2.0 6.0 -1.7 1.6 0.6 2.5 -1.8 -1.1 -0.7 0.4 1.6 0.5 1.3
Depressed Affect (Nagel 2018) 3.9 8.2 21.4 -2.2 3.0 4.6 2.2 -3.0 -3.5 0.4 -2.0 3.0 2.0 3.5
Depression (Nagel 2018) 2.0 3.0 8.7 -1.9 1.8 2.9 2.4 -1.7 -1.5 0.3 -0.9 1.5 1.1 1.4
Intelligence (Savage-Jansen 2018) 5.4 16.5 28.6 5.3 -4.9 -5.3 -3.7 4.2 3.7 3.0 2.3 -4.8 -3.0 -2.9
Neuroticism (Nagel 2018) 5.5 12.9 33.2 -3.5 3.9 5.8 3.6 -3.6 -3.7 -0.5 -0.9 4.1 3.2 3.7
Schizophrenia (2018) 0.8 1.6 4.0 -1.1 1.5 -0.1 1.5 -1.9 -1.5 0.1 -0.3 1.4 0.1 2.0
Schizophrenia vs Biploar Disorder 0.9 1.2 3.8 -0.8 1.2 0.6 1.7 -1.4 -0.9 -0.1 0.4 1.9 0.0 0.7
Worry (Nagel 2018) 5.0 10.5 18.0 -3.3 3.7 4.2 3.0 -3.6 -3.8 0.6 -0.8 3.6 3.1 3.7
Alzheimer’s Disease (in mother) 1.0 1.1 3.8 1.0 -1.1 0.8 0.3 1.9 1.3 0.0 0.8 -0.6 -1.0 -1.5
Alzheimer’s Disease (in father) 0.2 0.2 0.8 0.4 -0.4 -0.9 0.1 0.2 0.4 0.4 0.8 -0.3 0.2 -0.4
Alzheimer’s Disease (including proxy) 1.0 1.5 3.7 1.3 -1.4 -0.4 0.4 1.9 1.7 0.2 1.0 -0.9 -1.0 -1.8
Crohns Disease (2017) 0.1 0.2 0.5 0.6 -0.5 0.7 -0.6 0.4 0.2 0.0 0.0 -0.4 -0.2 -0.3
Irritable Bowel Disease (IBD) 0.1 0.3 0.8 0.8 0.0 0.9 -0.5 -0.2 -0.6 0.3 -0.3 0.2 0.0 0.7
Ulcerative Colitis (UC) 0.3 0.5 1.8 0.7 0.4 0.6 -0.1 -0.5 -1.2 0.4 -0.5 0.6 0.2 1.3
Major Depression (MDD) 0.7 0.9 3.3 0.2 0.2 1.6 0.6 -0.1 -1.0 1.8 -1.2 0.2 -0.1 0.9
Reaction Time 0.3 0.6 2.9 -0.2 0.1 1.7 1.1 0.1 0.4 -0.6 0.0 0.5 1.1 -0.6
Verbal and Numeric Reasoning (VNR) 7.0 16.8 27.5 5.2 -5.0 -5.2 -3.8 3.7 3.5 4.1 1.6 -5.2 -3.4 -2.7
Breast Cancer 0.4 0.9 2.9 1.4 -0.2 0.9 -1.7 -0.4 -1.0 1.0 -0.7 -0.1 0.2 1.3
Ovarian Cancer 3.2 4.2 7.2 -2.3 2.4 1.9 -0.0 -2.7 -2.1 -1.3 -1.9 2.3 2.4 1.9
Prostate Cancer 1.1 1.5 3.3 1.8 -1.5 -0.1 -1.7 1.8 1.0 1.3 0.4 -1.1 -0.7 -0.7
Age at First Birth 0.5 0.7 1.8 -0.9 0.8 0.3 0.2 -0.5 -0.3 -0.7 1.4 1.1 1.3 0.1
Bipolar Disorder (2011) 0.2 0.2 0.9 -0.7 0.3 0.0 0.9 -0.0 0.1 -0.6 0.1 0.3 0.1 0.0
Body Mass Index (BMI) (2010) 1.0 1.3 2.4 1.1 -1.5 -0.4 0.3 1.4 1.4 0.9 0.4 -1.4 -1.6 -1.2
Coronary Artery Disease (CAD) 0.6 0.7 5.7 0.2 0.2 2.4 -0.6 0.1 -0.6 -0.1 -1.0 0.2 0.3 0.6
Crohns Disease (2012) 0.2 0.2 0.6 -0.4 0.5 0.3 -0.5 -0.6 -0.8 0.1 -0.6 0.4 0.5 0.5
Mean Putamen Volume 1.4 1.6 2.8 -1.5 1.6 1.3 0.3 -1.6 -1.2 -1.5 -0.4 1.7 0.7 0.8
Fasting Glucose 0.2 0.2 0.5 -0.6 0.5 0.2 0.4 -0.4 -0.6 -0.0 -0.3 0.3 -0.7 0.2
HbA1C 0.2 0.2 0.6 -0.0 0.1 0.6 -0.3 -0.5 -0.6 -0.0 -0.3 0.3 0.7 0.8
HDL Cholesterol 1.1 1.9 3.6 1.1 -1.3 -1.9 -1.4 1.7 1.5 0.4 0.7 -1.6 -0.6 -1.8
LDL Cholesterol 0.6 0.9 2.6 1.3 -1.2 -0.4 -1.6 1.4 0.8 0.3 -0.2 -0.9 -0.9 -0.5
Lupus 0.4 0.6 1.2 -0.6 0.8 -0.7 0.8 -0.9 -0.9 0.5 -1.1 0.4 -0.5 0.9
Neuroticism (2016) 2.4 3.5 7.0 -1.3 1.8 2.4 0.5 -1.8 -2.5 1.1 -2.6 1.5 1.8 2.3
Primary Biliary Cirrhosis 1.4 2.0 3.9 1.3 -1.6 -1.1 0.2 1.6 1.9 0.8 0.7 -1.6 -1.6 -2.0
Rheumatoid Arthritis 1.0 1.4 8.2 -1.4 0.9 0.1 -0.3 -0.6 0.2 -2.9 0.6 1.0 1.4 -0.6
Schizophrenia (2014) 1.2 2.6 6.5 -1.8 2.0 0.9 2.5 -2.2 -1.4 -0.5 0.4 2.0 0.4 1.5
Triglycerides 0.5 0.7 1.6 -0.5 0.7 1.1 -0.5 -0.7 -1.0 -0.3 -1.3 0.6 1.3 0.9
Type 2 Diabetes (T2D) (2012) 0.3 0.3 1.1 0.5 -0.3 0.3 -0.7 0.8 0.0 1.1 -0.6 -0.1 -0.6 -0.0
Ulcerative Colitis 0.1 0.1 0.5 0.4 0.1 0.5 0.4 -0.1 0.0 -0.5 0.7 0.4 0.3 0.2
Blood Eosinophil Count 0.4 3.3 8.9 3.0 -1.7 -1.7 -2.7 0.8 0.8 2.5 -0.1 -2.3 -0.9 -0.5
Blood Platelet Count 8.4 97.9 228.0 4.8 -9.7 -5.4 -1.2 12.0 14.0 -8.6 14.5 -7.5 -4.6 -15.1
Blood Red Count 1.3 12.8 23.8 -4.1 3.9 4.9 3.0 -3.3 -3.2 -3.9 -1.2 4.7 3.0 2.6
Blood White Count 0.1 0.5 1.5 -0.5 0.7 1.2 -0.1 -0.6 -0.8 -0.8 -1.2 0.7 -0.0 0.5
Heel T-Score 0.5 3.9 19.5 -1.4 1.6 -2.2 4.4 -1.4 -0.9 1.9 -0.3 0.7 -2.8 0.0
BMI 0.8 4.4 27.4 -0.2 0.6 2.5 -1.6 -0.8 -1.4 1.1 -5.2 -0.2 2.4 1.4
Height 2.5 48.0 240.2 7.1 -3.5 -9.8 -4.1 0.2 -0.9 15.5 -4.5 -6.4 -6.8 2.0
Waist Hip Ratio (WHR) 0.4 1.6 4.0 -0.9 1.1 1.9 0.5 -1.2 -1.1 -0.6 0.1 1.8 2.0 1.2
Systolic Blood Pressure 0.9 4.5 10.5 2.2 -2.1 -3.0 -1.3 1.8 1.2 2.3 -0.7 -2.6 -3.2 -1.3
Smoking Status 1.3 3.1 7.6 -0.2 1.2 1.4 -0.6 -1.1 -2.3 1.9 -2.8 1.1 2.4 2.4
Allergy or Eczema 1.1 2.9 6.2 1.8 -1.9 -0.5 0.1 2.5 2.0 2.1 1.8 -1.2 -1.7 -1.8
Cardiovascular Disease 0.8 2.8 9.6 1.4 -1.1 -2.0 -1.6 0.7 0.2 2.3 -3.1 -1.9 -1.2 0.2
Hypothyroidism (self reported) 0.6 1.4 3.4 -1.5 1.5 1.2 1.9 -1.4 -0.9 -0.3 -0.5 1.1 0.9 0.6
Respiratory disease 0.3 0.6 1.4 0.9 -0.5 -0.6 -1.2 0.3 -0.1 1.0 -1.2 -0.5 -1.1 -0.1
Type 2 Diabetes (T2D) (2018) 0.4 0.7 3.5 -0.1 -0.5 0.3 0.3 0.7 1.5 -0.3 -0.3 -0.9 -0.7 -1.9
Lung FEV1/FVC ratio 0.4 2.0 7.3 2.7 -1.9 0.3 -0.0 1.5 0.4 2.3 -0.9 -1.6 -0.2 0.3
Lung FVC 0.3 1.3 6.4 -0.5 -0.1 -0.4 2.5 0.6 1.0 -1.5 1.4 0.1 -0.1 -1.2
Neuroticism 8.0 19.4 42.4 -4.4 4.8 6.5 5.0 -4.3 -4.5 -0.2 -1.4 5.1 4.1 4.5
Chronotype (morning person) 1.0 2.2 4.3 -0.3 1.1 2.1 0.7 -1.1 -1.9 1.7 -2.1 1.2 1.4 1.8
Hair Pigment 0.1 3.7 11.9 -2.3 1.6 3.5 2.5 -0.8 -0.6 -2.4 0.6 2.0 1.7 0.5
Tanning 0.1 1.5 3.4 -0.5 1.2 1.6 -0.1 -1.2 -1.7 0.1 -1.4 1.5 0.8 1.8
Hand grip strength (left) 0.2 0.4 1.5 0.5 -0.6 -0.9 -0.5 0.2 0.7 0.3 -0.8 -1.2 -0.6 -0.3
Number of treatments/medications taken 0.1 0.3 1.2 -0.1 0.0 0.9 1.1 0.0 0.4 0.7 0.2 0.3 -0.1 -0.4
Average weekly spirits intake 1.2 1.5 5.1 -0.7 1.1 1.1 -0.2 -1.4 -1.4 0.8 -2.3 1.1 0.7 1.4
Sensitivity / hurt feelings 4.9 8.3 24.4 -2.8 3.2 4.9 2.0 -3.0 -2.9 -0.5 -1.1 3.5 2.3 2.9
Frequency of depressed mood in last 2 weeks 1.2 1.6 4.8 -0.8 1.0 2.2 1.6 -1.0 -1.2 1.0 -1.2 1.0 1.1 1.2
Hearing difficulty/problems: Yes 0.7 1.1 1.8 -1.3 1.3 1.0 1.3 -1.3 -0.6 -1.3 -0.2 1.0 0.3 0.5
Relative age of first facial hair 0.5 1.1 3.4 0.9 -1.0 -0.9 -0.5 0.9 1.1 -0.0 1.8 -0.8 -1.0 -1.3
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 3.5 0.4 -0.8 -1.9 -0.2 1.1 1.0 -0.6 -0.6 -0.9 -0.8 -1.0
Ever used hormone-replacement therapy (HRT) 0.2 0.3 1.0 -0.5 0.4 -0.6 1.0 -0.8 -0.4 0.4 0.0 -0.3 -0.4 0.5
Ever had hysterectomy (womb removed) 0.6 0.6 3.9 -0.5 0.6 0.0 2.0 -0.9 -0.6 0.5 -0.6 0.3 -0.5 0.5
Systolic blood pressure, automated reading 0.2 0.4 2.0 0.3 -0.3 -0.9 0.6 0.1 0.2 1.1 -0.1 -0.4 -1.4 -0.3
Eye problems/disorders: Diabetes related eye disease 1.3 1.5 5.6 -0.4 -0.5 0.5 0.7 1.1 1.7 -1.9 1.1 -0.2 -0.9 -2.4
Angina 0.1 0.1 0.6 -0.2 0.3 0.3 0.2 0.2 -0.3 0.2 -0.8 0.3 0.5 0.1
Medication for hormone replacement therapy 0.4 0.4 0.9 -0.9 0.8 -0.1 0.9 -0.3 -0.7 -0.2 -0.2 0.6 0.4 0.9
Vitamin and mineral supplements 0.6 0.8 1.9 0.6 -1.0 -1.4 -1.1 0.7 0.9 -0.5 0.4 -1.4 -0.2 -0.9
Supplements: Zinc 1.3 1.4 4.2 1.0 0.0 0.1 -1.3 -0.4 -1.2 2.0 -2.0 0.2 0.1 1.7
Medication: Co-codamol 1.7 1.9 3.5 -1.9 1.7 1.0 0.5 -1.9 -1.2 -1.9 -0.9 1.7 0.9 0.8
Medication: Metformin 0.7 1.0 3.2 0.8 -1.1 -0.4 -0.7 0.9 1.5 0.4 -0.1 -1.3 -0.3 -1.8
Diabetes (father) 0.6 0.7 2.0 -1.4 0.9 -0.2 -0.4 -1.3 -0.5 -1.4 -0.8 0.5 0.6 -0.1
Diabetes (mother) 1.0 1.3 6.3 -1.6 0.8 0.5 0.5 -0.6 0.1 -2.5 0.7 0.8 1.6 -0.3
Severe depression (siblings) 0.6 0.7 1.7 -0.4 0.7 1.3 -0.0 -1.1 -0.9 0.6 -0.9 0.8 0.2 1.2
Pack years adult smoking proportion 0.4 0.6 1.5 -0.3 0.6 -0.0 -0.1 -0.8 -1.1 1.0 -1.2 0.3 0.6 1.1
Impedance of leg (right) 0.3 1.2 3.2 -1.1 1.2 -0.2 1.8 -1.4 -1.0 -0.5 1.2 1.1 -0.8 0.9
Leg fat-free mass (left) 1.3 6.9 34.0 2.5 -1.2 -2.4 -3.1 0.1 -0.6 5.8 -3.5 -2.3 -0.3 1.1
Trunk fat percentage 0.7 2.8 10.9 -0.8 1.2 0.5 -1.0 -1.8 -2.0 1.7 -3.3 0.4 1.6 1.9
Hand grip strength (right) 0.6 1.5 3.6 1.5 -1.4 -0.9 -1.5 1.0 1.0 1.2 -0.7 -1.9 -1.3 -0.7
Townsend deprivation index at recruitment 0.7 1.0 3.6 -0.4 0.6 1.2 1.3 -0.0 -0.7 0.5 -1.1 1.1 1.9 0.9
Current tobacco smoking 0.4 0.6 1.6 0.6 -0.0 0.5 -0.6 -0.0 -0.7 1.3 -1.0 -0.0 1.2 0.9
Average weekly fortified wine intake 0.4 0.5 3.0 -0.5 0.4 -0.1 0.8 -0.5 0.3 -1.7 0.5 0.2 -0.7 -0.2
Maternal smoking around birth 2.9 4.2 8.9 -2.7 2.3 1.2 0.9 -2.1 -1.5 -2.7 -1.6 2.0 3.0 1.4
Fed-up feelings 3.5 6.3 14.4 -1.0 2.1 3.8 1.0 -2.5 -3.1 2.0 -3.0 2.0 2.3 3.3
Frequency of unenthusiasm / disinterest in last 2 weeks 3.1 4.1 11.2 -1.7 2.1 3.3 1.8 -2.0 -2.1 0.8 -0.9 2.0 1.9 2.3
Relative age voice broke 0.9 1.4 2.6 0.6 -1.2 -0.8 -0.1 1.3 1.5 -0.8 1.6 -0.8 -1.5 -1.6
Taking other prescription medications 0.3 0.5 1.4 -0.6 0.2 0.8 1.2 -0.1 0.6 0.1 0.7 0.2 1.2 -0.8
Age when periods started (menarche) 1.4 3.3 7.1 1.9 -2.3 -2.7 -1.4 1.9 2.0 -0.2 0.5 -2.3 -1.4 -1.8
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.8 0.4 0.2 -0.4 0.9 0.1 -0.3 0.9 0.1 0.3 -0.6 -0.0
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.7 3.5 -1.3 1.6 0.3 1.9 -1.6 -1.6 0.8 -1.5 0.9 -0.1 1.2
Tinnitus: Yes, but not now, but have in the past 0.6 0.7 2.1 -1.1 1.0 0.8 0.0 -0.3 -0.6 -1.5 0.8 1.0 1.0 0.1
Qualifications: CSEs or equivalent 0.6 0.8 2.7 -0.7 0.6 1.6 -1.1 -0.3 -0.6 -1.0 -0.9 0.7 1.1 0.3
Serious illness, injury or assault to yourself 0.5 0.6 1.8 -0.6 0.6 0.3 0.5 -0.5 -0.9 1.4 -0.7 0.1 0.9 0.9
High blood pressure 0.3 0.8 2.5 0.1 -0.2 -1.6 -0.1 0.0 -0.1 1.6 -1.5 -0.9 -0.5 0.4
Hayfever, allergic rhinitis or eczema 0.8 1.7 5.2 1.5 -1.4 -1.1 -0.2 1.6 1.2 2.3 0.9 -1.2 -1.1 -0.9
Multivitamins +/- minerals 1.5 2.0 3.3 -1.2 1.6 1.6 1.0 -1.5 -1.7 0.0 -1.5 1.7 0.1 1.8
Stomach or abdominal pain in last month 0.0 0.1 0.2 -0.4 0.2 0.1 0.1 -0.2 -0.1 0.1 -0.4 0.3 0.1 0.4
Supplements: Glucosamine 0.2 0.3 0.8 -0.7 0.5 -0.9 -0.1 -0.7 -0.4 -0.7 -0.1 0.2 0.2 0.4
Diverticular disease/diverticulitis (self-reported) 0.6 0.8 4.2 0.7 -0.7 -2.1 -0.7 0.5 0.6 0.3 -0.6 -1.1 -0.1 -0.5
Medication: Atenolol 0.7 0.9 2.2 0.9 -0.7 -1.3 -1.1 0.5 -0.1 1.5 -1.2 -1.1 -1.0 0.3
Medication: Levothyroxine sodium 0.5 0.8 2.2 -1.5 0.9 0.2 0.8 -0.8 0.2 -1.5 0.2 0.5 1.2 -0.7
Sitting height 2.1 14.6 92.7 3.9 -1.3 -4.0 -3.2 -0.2 -1.2 9.6 -3.1 -2.8 -1.6 1.8
Chronic bronchitis/emphysema (father) 0.2 0.3 1.8 -0.0 -0.1 -0.4 -0.4 0.6 0.4 -0.4 0.5 -0.1 1.3 -0.2
High blood pressure (mother) 0.2 0.3 0.9 -0.3 -0.1 -0.2 1.0 0.1 0.7 -0.3 0.8 -0.1 -0.4 -0.5
Body mass index (BMI) 0.8 3.4 13.8 -1.1 1.3 2.4 -0.7 -1.5 -1.8 0.4 -3.7 0.9 2.4 1.8
Impedance of leg (left) 0.3 1.7 3.3 -1.5 1.6 0.3 1.8 -1.5 -1.2 -1.1 1.2 1.7 -0.5 1.1
Leg predicted mass (left) 1.3 7.0 34.7 2.5 -1.2 -2.4 -3.1 0.1 -0.6 5.9 -3.6 -2.3 -0.3 1.1
Trunk fat mass 0.9 4.0 15.8 0.0 0.9 -0.1 -1.7 -1.7 -2.1 3.3 -4.0 -0.1 1.3 2.1
Waist circumference 0.9 3.1 10.9 -0.5 1.1 1.0 -0.8 -1.9 -2.1 2.0 -3.3 0.5 1.9 2.2
Number of incorrect matches in round 1.0 1.6 9.1 -1.8 0.9 1.1 3.0 -0.6 -0.0 -0.3 1.1 0.7 0.9 -0.0
Past tobacco smoking 1.0 1.7 3.8 1.3 -1.5 -1.8 -0.8 1.0 1.2 0.9 0.9 -1.6 -1.9 -1.1
Alcohol usually taken with meals 1.4 2.3 9.2 0.5 -1.2 -3.0 -0.9 1.1 1.6 -1.1 1.3 -1.6 -1.0 -1.6
Nervous feelings 2.8 5.2 11.0 -2.5 2.5 3.3 2.5 -2.2 -2.0 -0.8 1.1 2.9 2.1 2.0
Frequency of tenseness / restlessness in last 2 weeks 6.0 9.3 13.1 -3.0 3.6 3.3 3.4 -3.4 -3.5 0.3 -1.8 3.4 2.5 3.5
Hearing difficulty/problems with background noise 1.1 1.7 3.7 -1.3 1.4 1.7 1.4 -1.9 -1.3 -0.4 -0.8 1.3 0.6 1.4
Hair/balding pattern: Pattern 2 1.3 1.7 5.5 -1.4 0.6 1.9 1.2 -0.0 0.6 -2.3 0.9 1.2 1.7 -0.6
Had menopause 0.3 0.4 2.9 -0.2 0.2 -0.2 1.7 -0.6 -0.1 0.8 -0.1 0.2 -0.7 0.4
Had other major operations 0.5 0.7 2.1 -0.1 0.5 -1.0 -1.3 -0.8 -0.8 1.4 -0.5 -0.1 0.7 0.6
Forced vital capacity (FVC) 1.2 4.5 14.8 2.4 -1.4 -3.7 -1.3 0.9 0.2 3.9 -1.1 -2.2 -2.0 -0.0
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.5 3.2 -1.5 1.6 0.5 1.8 -1.5 -1.4 0.4 -1.4 1.1 -0.5 0.7
Ever unenthusiastic/disinterested for a whole week 0.1 0.1 1.0 0.2 0.2 1.0 0.1 -0.3 -0.1 0.2 -0.1 0.3 -0.1 0.3
Qualifications: None of the above 1.2 2.5 7.5 -1.3 1.2 2.7 1.5 -1.0 -1.2 0.1 -2.2 1.6 1.8 1.4
Financial difficulties in last 2 years 1.5 2.0 5.7 -0.0 0.8 0.3 -0.3 -1.0 -1.6 2.4 -2.0 0.4 1.9 2.1
Mouth/teeth dental problems 0.3 0.5 1.8 0.1 0.3 0.2 -1.4 -0.8 -1.0 0.2 -0.7 0.3 0.4 1.0
Heart attack 1.1 1.4 5.2 1.3 -0.7 -0.2 -0.2 0.1 -0.2 2.3 -2.3 -1.0 -1.1 0.3
Allergy 0.4 1.0 5.4 -1.2 1.0 0.5 0.1 -1.2 -0.5 -2.3 -0.2 0.8 0.5 0.6
Pain all over the body in last month 1.4 1.5 4.2 1.3 -1.0 -1.3 -1.0 0.3 -0.3 2.0 -2.0 -1.3 -0.7 1.0
Diabetes (self-reported) 0.6 1.0 3.8 -0.1 -0.5 -0.2 1.2 0.8 1.7 -0.4 0.4 -0.4 -1.0 -1.9
Hayfever/allergic rhinitis (self-reported) 4.1 5.5 8.0 2.5 -2.8 -2.6 -1.8 2.7 2.5 2.1 1.0 -2.7 -2.0 -2.5
Medication: Ramipril 2.2 2.8 6.1 1.7 -2.0 -2.0 -1.2 1.8 1.9 0.9 0.6 -2.5 -0.8 -1.8
Medication: Simvastatin 0.2 0.3 0.7 0.4 -0.4 -0.0 -0.6 0.9 0.7 0.4 0.2 -0.4 0.0 -0.8
Fluid intelligence score 6.4 13.2 23.1 4.8 -4.4 -4.3 -3.4 3.7 3.0 3.8 1.4 -4.2 -3.3 -2.4
Illnesses of siblings 0.3 0.5 2.7 -0.3 0.0 -0.5 0.1 0.3 0.3 -1.2 1.6 0.2 0.4 -0.6
Neuroticism score 8.3 17.3 39.7 -3.8 4.5 6.3 4.2 -4.4 -4.6 0.3 -1.5 4.7 3.6 4.7
Weight 1.1 5.6 26.4 1.4 -0.2 -1.0 -2.3 -0.9 -1.6 5.1 -4.3 -1.3 0.5 1.9
Impedance of arm (right) 0.5 2.1 7.1 0.5 -0.9 -2.4 0.8 0.8 1.3 -0.5 2.7 -0.9 -1.8 -1.4
Arm fat percentage (right) 0.7 2.6 10.8 -0.9 1.2 1.8 -0.8 -1.5 -1.7 0.4 -3.3 0.6 1.9 1.6
Trunk fat-free mass 1.3 7.7 45.4 2.9 -1.2 -2.4 -2.5 0.1 -0.8 6.7 -3.1 -2.2 -0.9 1.3
Hip circumference 0.8 3.4 13.8 1.0 -0.2 -1.5 -1.8 -0.6 -1.2 3.7 -3.5 -1.4 0.1 1.4
Time employed in main current job 0.6 0.7 2.3 1.1 -0.9 0.3 -1.5 1.1 0.7 0.2 0.9 -0.3 0.2 -0.6
Alcohol intake versus 10 years previously 0.9 1.4 2.8 -0.9 1.3 1.1 0.6 -1.0 -1.7 1.3 -1.2 1.2 1.0 1.4
Father’s age at death 0.8 1.1 2.3 0.2 -0.8 -1.5 1.1 1.0 1.4 -1.0 1.1 -0.6 -0.7 -1.4
Worrier / anxious feelings 6.6 12.6 18.7 -3.5 4.2 4.2 2.3 -4.2 -4.3 0.1 -1.6 4.2 3.4 4.2
Frequency of tiredness / lethargy in last 2 weeks 1.3 2.1 3.9 -1.6 1.4 2.0 2.0 -1.1 -1.3 0.2 -1.7 1.3 1.1 1.2
Falls in the last year 2.4 3.2 8.5 2.2 -1.4 -1.6 -2.8 0.3 -0.4 2.9 -2.0 -2.0 -0.4 1.0
Hair/balding pattern: Pattern 3 0.6 0.8 2.8 0.6 0.4 -0.7 -1.1 -0.3 -1.1 1.7 -1.2 0.6 -0.1 1.1
Number of live births 0.3 0.5 1.5 -0.8 0.3 0.1 1.2 -0.2 0.5 -0.8 0.8 0.3 0.3 -1.0
Forced expiratory volume in 1-second (FEV1) 1.2 4.0 14.4 2.7 -1.6 -2.7 -1.2 1.0 0.2 3.8 -1.4 -2.2 -1.9 0.0
Pulse rate 1.5 2.5 5.6 0.7 -1.5 -0.8 -0.3 2.2 2.0 -1.6 2.2 -1.1 -0.6 -2.4
Happiness 1.9 2.3 6.1 -0.8 1.5 2.5 0.8 -1.6 -2.1 0.3 -1.2 1.6 0.9 2.0
Noisy workplace 4.6 5.7 10.6 -3.0 2.7 3.1 0.3 -2.1 -1.6 -2.5 -2.0 2.7 3.3 1.5
Qualifications: A levels/AS levels or equivalent 1.9 4.2 16.5 2.3 -1.9 -4.1 -1.9 1.0 1.1 1.6 1.0 -2.3 -2.4 -0.7
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 2.9 -0.1 -0.1 -0.4 1.3 0.2 0.8 -0.9 1.7 0.2 -0.7 -1.0
Mouth/teeth dental problems: Dentures 0.7 1.1 5.3 -0.9 0.1 -0.0 2.3 0.4 1.2 -0.9 1.1 0.3 -0.4 -1.5
Asthma 0.7 1.3 2.8 1.4 -1.1 -1.1 -1.7 0.8 0.2 1.6 -1.3 -1.1 -1.1 -0.3
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 2.0 -0.4 0.0 0.4 1.4 0.1 0.3 -0.1 1.2 0.4 -0.1 -0.2
Medication: Cholesterol lowering 0.4 0.6 2.1 -0.5 0.6 0.3 -0.8 -0.4 -0.6 0.2 -1.4 0.3 1.4 0.6
Depression (self-reported) 2.0 2.4 6.9 -0.5 1.3 1.6 -0.2 -1.8 -2.2 1.1 -2.1 1.0 0.8 2.6
Medication: Lansoprazole 1.2 1.3 3.2 0.5 -1.1 -0.3 0.7 1.7 1.7 -0.5 1.7 -0.8 0.2 -1.8
Prospective memory result 3.7 4.5 11.3 -3.1 2.6 1.4 0.8 -2.8 -2.0 -1.5 -0.7 1.7 3.4 1.6
Lung cancer (father) 0.2 0.2 0.5 -0.6 0.7 0.3 0.7 -0.3 -0.4 -0.4 -0.1 0.5 -0.1 0.0
Illnesses of mother 0.8 0.9 3.3 0.7 0.1 0.5 -1.0 -0.2 -1.3 1.8 -1.4 -0.2 -0.1 1.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.9 2.9 9.8 2.1 -1.3 -2.7 -0.4 0.7 0.3 3.1 -0.9 -2.0 -1.9 -0.2
Pulse wave Arterial Stiffness index 0.4 0.5 1.0 1.0 -0.8 -0.2 -0.9 0.6 0.6 0.5 0.9 -0.7 -0.3 -0.4
Impedance of arm (left) 0.7 3.0 9.3 1.2 -1.4 -3.0 -0.2 1.2 1.6 0.0 2.6 -1.5 -2.1 -1.7
Arm fat mass (right) 0.7 3.0 15.1 -0.1 0.8 0.8 -1.2 -1.2 -1.8 2.4 -3.9 0.0 1.3 1.8
Trunk predicted mass 1.3 7.7 44.5 2.9 -1.2 -2.5 -2.5 0.1 -0.8 6.7 -3.1 -2.3 -0.9 1.3
Standing height 2.3 22.7 110.2 5.3 -2.9 -7.1 -3.7 0.9 0.1 10.5 -1.8 -4.5 -3.6 0.7
Length of working week for main job 1.4 1.5 5.1 -0.9 1.1 0.7 -0.9 -1.2 -1.4 0.7 -1.5 0.7 2.3 1.3
Exposure to tobacco smoke at home 0.3 0.4 1.3 -0.7 0.4 1.1 0.6 -0.2 -0.3 -0.7 -0.9 0.5 0.3 0.2
Breastfed as a baby 1.0 1.3 2.8 1.2 -0.9 -1.4 -1.2 0.5 -0.0 1.6 -0.3 -1.7 -1.6 0.1
Tense / ‘highly strung’ 6.1 10.2 14.8 -3.2 3.5 3.9 3.5 -3.6 -3.5 0.4 -0.5 3.6 3.1 3.7
Seen doctor (GP) for nerves, anxiety, tension or depression 2.2 3.4 8.4 -0.9 1.6 1.8 -1.2 -1.9 -2.5 1.2 -1.5 0.8 2.6 2.9
Hair/balding pattern: Pattern 4 0.2 0.5 3.2 -0.3 -0.2 0.1 0.5 0.5 0.3 -0.6 1.8 0.1 1.0 -0.4
Birth weight of first child 1.1 2.1 6.8 0.8 0.3 -0.4 -1.4 -0.9 -1.6 2.6 -2.0 -0.4 -0.4 2.3
Peak expiratory flow (PEF) 0.8 2.0 5.7 1.7 -0.6 -0.4 -2.4 -0.2 -0.9 2.2 -2.1 -0.8 -0.3 1.4
Pulse wave reflection index 0.3 0.4 1.1 -0.1 0.2 1.0 -0.4 -1.0 -0.5 -0.3 -0.5 -0.0 0.8 0.8
Ever highly irritable/argumentative for 2 days 1.5 1.8 6.4 -0.5 1.0 -0.6 -1.1 -1.5 -1.4 1.2 -2.5 0.1 1.4 1.6
Loud music exposure frequency 0.3 0.3 2.2 -0.2 -0.1 0.1 1.5 -0.1 0.2 -0.7 -0.7 -0.1 -0.3 -0.1
Qualifications: O levels/GCSEs or equivalent 2.5 3.9 9.9 3.0 -1.9 -2.5 -2.1 1.0 0.2 3.1 -0.1 -1.9 -2.3 0.3
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 1.2 -0.8 1.0 0.8 0.4 -1.0 -1.0 -0.3 0.2 0.8 0.6 1.1
Blood clot in the leg (DVT) 2.5 3.3 5.7 -1.6 2.1 1.5 0.2 -1.9 -2.3 0.4 -1.9 1.8 2.4 2.1
Medication: Paracetamol 0.7 1.1 5.2 -0.6 0.7 2.3 0.5 -0.7 -0.5 -0.2 0.8 1.0 1.6 0.9
Headache pain in last month 0.4 0.7 3.9 -0.4 0.0 2.0 0.5 0.5 0.1 -0.3 1.3 0.8 1.0 -0.2
Medication for cholesterol, blood pressure or diabetes 1.0 1.6 8.1 0.5 -0.7 -0.1 1.3 0.8 1.2 -1.1 2.9 -0.2 -1.5 -1.1
Glaucoma (self-reported) 0.8 1.0 2.2 1.0 -1.1 -1.5 -0.3 1.2 0.9 1.3 0.2 -0.7 -0.8 -1.0
Gout (self-reported) 1.9 2.6 5.2 2.1 -1.7 -1.8 -1.7 1.2 0.7 2.0 -0.4 -1.9 -2.3 -0.7
Hypothyroidism/myxoedema (self-reported) 0.3 0.7 2.1 -1.2 1.1 0.4 1.4 -0.9 -0.5 -0.2 -0.5 0.6 0.8 0.1
Medication: Amlodipine 0.1 0.2 0.5 -0.3 -0.1 0.5 0.1 0.4 0.6 -0.6 0.3 0.0 0.7 -0.6
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.2 -0.4 0.2 -0.3 0.5 -0.3 -0.2 0.0 0.2 0.3 -0.2 -0.4
Birth weight 0.2 0.4 1.1 0.3 0.3 -0.4 0.1 -1.0 -0.5 0.8 0.9 -0.0 0.5 1.1
Chronic bronchitis/emphysema (mother) 0.1 0.1 0.5 -0.7 0.2 0.4 0.0 -0.4 0.1 -0.7 -0.4 0.3 0.0 -0.2
High blood pressure (siblings) 0.3 0.5 1.3 0.4 -0.7 -0.0 -0.0 0.6 0.7 0.5 -0.9 -1.1 -1.1 -0.6
Forced vital capacity (FVC), Best measure 0.8 2.9 9.7 1.9 -1.1 -3.1 -0.4 0.8 0.5 3.0 -0.4 -2.0 -1.9 -0.7
Body fat percentage 0.9 3.4 11.2 -1.3 1.6 1.4 -0.6 -2.1 -2.2 0.8 -3.4 0.9 2.0 2.1
Leg fat percentage (right) 1.2 4.2 10.7 -1.8 2.0 2.6 0.1 -2.3 -2.3 0.1 -3.3 1.5 2.0 2.2
Arm fat-free mass (right) 1.1 5.8 32.5 1.5 -0.0 -1.5 -2.2 -0.9 -1.6 5.7 -3.8 -1.1 0.1 1.9
Exposure to tobacco smoke outside home 0.7 0.9 4.5 -0.6 0.5 2.1 -0.3 0.0 -0.5 0.0 -0.7 0.9 1.6 0.5
Comparative body size at age 10 1.8 4.9 9.4 -2.3 2.3 2.8 1.4 -2.6 -1.8 -2.2 -0.3 2.2 3.1 1.8
Number of full brothers 1.5 1.9 4.8 -1.3 1.4 2.2 -0.0 -1.4 -1.1 -1.4 -1.5 1.6 1.3 0.9
Worry too long after embarrassment 1.4 2.3 7.6 -1.3 1.3 2.7 2.2 -1.0 -1.1 -0.9 0.4 1.8 1.1 1.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.9 1.2 2.6 -1.0 1.1 1.4 -0.2 -1.1 -1.3 0.2 -1.1 1.0 1.1 1.6
Wheeze or whistling in the chest in last year 2.4 4.2 12.5 -1.0 1.8 0.8 0.0 -2.1 -2.9 1.5 -3.5 1.5 1.7 3.0
Number of children fathered 0.4 0.5 1.7 0.6 -0.7 -1.3 -0.3 0.4 0.3 0.9 -0.5 -0.8 -0.8 -0.4
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 2.9 -0.7 0.7 1.7 0.9 -1.2 -0.9 0.6 -0.1 0.7 0.2 1.1
Age at first live birth 0.8 1.4 3.6 1.5 -1.2 -1.9 -1.6 0.9 0.7 0.7 0.8 -1.4 -0.9 -0.5
Pulse wave peak to peak time 0.3 0.3 1.6 -0.6 0.6 -0.4 0.5 -0.5 -0.6 0.3 -1.2 0.4 0.0 0.5
Health satisfaction 0.3 0.4 1.5 0.4 -0.5 -0.6 -0.6 0.2 -0.2 1.2 -0.7 -0.8 0.3 0.2
Shortness of breath walking on level ground 0.1 0.2 0.9 -0.2 0.2 -0.1 0.7 -0.2 -0.2 -0.1 -0.9 -0.1 -0.4 0.0
Qualifications: College or University degree 1.2 3.9 11.4 0.5 -1.2 -3.4 0.5 1.3 2.3 -1.3 3.3 -1.1 -1.8 -2.2
Eye problems/disorders: None of the above 2.2 2.5 6.6 -1.0 1.5 2.6 -0.6 -1.8 -1.6 -1.5 -0.0 1.5 2.1 1.8
Mouth/teeth dental problems: Loose teeth 1.3 1.6 2.9 1.6 -1.4 -1.3 -0.9 1.7 0.7 1.5 -0.4 -1.4 -1.5 -0.8
Emphysema/chronic bronchitis 1.7 2.0 4.0 1.4 -1.8 -1.4 -0.4 1.2 1.8 0.2 0.9 -2.0 -1.3 -1.8
Medication for pain relief, constipation, heartburn 0.9 1.6 4.2 1.2 -1.1 -2.0 -1.8 1.0 0.9 -0.6 -0.3 -1.6 -1.3 -1.0
Neck or shoulder pain in last month 1.4 2.0 5.0 -2.1 1.7 1.0 0.6 -1.7 -1.6 -0.4 -0.7 1.0 2.2 1.0
Medication: Blood pressure 0.8 1.4 6.1 0.3 -0.0 -0.6 -1.8 -0.2 -0.7 1.8 -2.5 -0.6 0.8 0.8
Angina (self-reported) 0.1 0.1 0.5 -0.3 0.3 0.1 0.3 0.2 -0.1 -0.0 -0.7 0.2 0.4 -0.2
Migraine (self-reported) 0.7 0.9 2.1 1.5 -1.4 0.7 -0.6 1.2 0.7 0.7 0.6 -1.3 -0.5 -0.2
Medication: Ibuprofen 0.8 0.9 2.1 -1.2 0.8 1.3 1.4 -0.6 -0.1 -1.0 1.2 1.2 0.5 0.0
Medication: Allopurinol 2.7 3.5 6.3 2.4 -2.5 -1.4 -0.4 1.8 1.9 1.8 0.9 -2.5 -2.5 -1.3
Medication: Omeprazole 0.2 0.3 0.9 -0.3 0.4 0.9 -0.0 -0.4 -0.3 -0.4 -0.9 0.5 0.3 0.6
Medication: Seretide 50 evohaler 0.9 1.0 2.0 -1.2 1.3 0.2 0.8 -1.4 -1.0 -1.1 -0.7 1.3 0.5 0.6
Mean time to correctly identify matches 0.5 0.9 3.3 -0.6 0.2 1.8 1.6 0.4 0.7 -0.5 0.8 0.8 1.1 -0.9
Heart disease (mother) 0.3 0.3 1.1 0.2 -0.4 0.3 -0.4 0.6 0.9 -0.4 0.9 -0.2 0.0 -1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.0 1.1 2.9 -1.1 1.1 1.7 0.7 -1.1 -0.9 -0.4 -0.7 1.2 1.4 1.0
Whole body fat mass 1.0 4.1 17.2 -0.4 1.2 0.5 -1.5 -1.9 -2.2 2.6 -4.2 0.2 1.6 2.3
Leg fat mass (right) 1.3 4.9 18.2 -1.0 1.8 1.4 -0.9 -2.4 -2.6 2.1 -4.3 0.9 2.0 2.6
Arm predicted mass (right) 1.2 6.0 33.1 1.7 -0.2 -1.6 -2.2 -0.8 -1.4 5.8 -3.9 -1.4 -0.2 1.8
Pulse rate, automated reading 0.1 0.3 0.8 0.5 -0.4 -0.9 -0.3 0.1 0.3 0.0 0.9 -0.4 -0.7 -0.3
Alcohol intake frequency. 0.2 0.5 2.2 -0.8 0.5 0.9 0.6 0.1 -0.3 0.5 -1.5 0.5 0.7 -0.3
Comparative height size at age 10 3.7 20.3 94.9 4.6 -1.8 -4.7 -4.4 -0.7 -1.9 9.7 -5.6 -3.6 -2.5 2.8
Number of full sisters 0.7 0.9 3.1 -0.9 0.6 1.0 0.7 0.1 0.1 -1.3 1.1 0.9 1.8 -0.3
Suffer from ‘nerves’ 2.5 4.0 8.5 -2.2 2.1 2.9 2.0 -1.8 -1.8 -0.4 0.9 2.2 2.5 1.8
Overall health rating 0.9 1.9 4.8 -0.8 1.0 2.2 1.5 -1.0 -1.5 1.4 -1.5 1.0 0.9 1.4
Chest pain or discomfort 0.1 0.2 0.8 -0.0 0.2 0.4 -0.2 0.0 -0.3 0.2 -0.9 0.3 0.6 0.6
Had major operations 0.2 0.2 0.5 -0.2 0.2 -0.3 -0.4 -0.4 -0.7 0.0 -0.2 -0.4 0.7 0.7
Age at last live birth 0.2 0.3 1.1 -0.1 0.2 -1.1 -1.0 -0.2 -0.4 -0.7 0.2 0.1 0.3 0.3
Family relationship satisfaction 1.8 2.2 6.4 -1.5 1.3 2.5 0.7 -1.6 -1.3 -1.1 -1.4 1.1 1.3 1.6
Leg pain on walking 0.4 0.5 1.5 -0.7 0.7 0.2 -0.5 -0.9 -0.6 0.4 -0.9 0.0 1.2 0.7
Qualifications: NVQ or HND or HNC or equivalent 1.4 1.7 3.6 -1.0 1.3 1.9 -1.9 -0.9 -1.4 -0.8 -0.9 1.1 1.6 1.1
Commuting to job workplace: Car/motor vehicle 0.7 0.9 1.9 1.4 -1.0 -1.0 -0.8 0.6 0.4 1.0 0.1 -1.2 -1.3 -0.1
Illness, injury, bereavement, stress in last 2 years 2.7 3.4 6.9 1.7 -2.1 -1.0 -0.6 2.2 2.4 -0.8 1.6 -1.7 -2.2 -2.6
Medication: Aspirin 0.1 0.2 0.9 -0.4 0.2 -0.1 0.5 -0.1 0.2 1.0 0.0 0.3 0.1 -0.5
Supplements: Vitamin C 0.8 0.9 3.6 0.8 -0.5 -1.7 -0.5 0.3 -0.3 1.9 -1.1 -0.5 -0.8 0.4
Knee pain experienced in last month 0.3 0.5 1.5 -0.5 0.6 0.5 0.6 -0.8 -0.8 0.9 -1.2 0.3 -0.1 0.8
Hypertension (Self-reported) 0.2 0.6 2.5 0.2 -0.4 -1.6 -0.2 0.4 0.2 1.2 -1.1 -1.0 -0.7 -0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 2.1 -1.0 0.7 0.8 1.1 -0.9 -0.4 -0.4 0.2 0.8 1.5 0.6
Illnesses of father: Heart disease 0.5 0.7 2.2 0.6 -1.0 -0.2 -0.2 1.5 1.5 0.1 0.1 -1.0 -0.3 -1.2
Illnesses of siblings: Diabetes 0.2 0.2 0.8 0.1 -0.1 -0.4 -0.9 0.1 0.3 -0.6 -0.7 0.1 -0.2 -0.5
Smoking status: Previous 1.0 1.5 3.0 -1.3 1.4 1.7 0.9 -1.0 -1.1 -1.0 -0.8 1.5 1.4 1.0
Forced expiratory volume in 1-second (FEV1), predicted 1.7 3.5 15.8 2.1 -1.1 -2.7 -1.9 0.8 -0.2 4.0 -1.1 -1.8 -0.9 0.6
Whole body fat-free mass 1.3 7.3 40.8 2.6 -1.1 -2.3 -2.7 -0.0 -0.8 6.4 -3.4 -2.2 -0.6 1.3
Leg fat-free mass (right) 1.2 6.4 30.4 2.6 -1.3 -2.4 -3.0 0.4 -0.4 5.5 -3.2 -2.3 -0.4 0.8
Arm fat percentage (left) 0.6 2.3 10.0 -0.8 1.1 1.6 -1.1 -1.4 -1.6 0.3 -3.2 0.5 1.9 1.3
Average weekly red wine intake 0.1 0.1 0.3 -0.4 0.1 -0.1 -0.3 -0.4 -0.0 -0.5 0.4 -0.1 -0.3 0.1
Handedness (chirality/laterality): Left-handed 1.9 2.3 6.4 -2.0 1.4 2.2 2.5 -0.9 -0.2 -1.9 0.6 1.7 1.0 0.3
Mood swings 4.7 8.5 25.6 -2.4 3.0 5.1 2.8 -2.8 -3.2 0.3 -1.1 3.1 2.2 3.4
Loneliness, isolation 1.4 1.9 6.9 -0.9 1.2 2.6 2.0 -1.1 -1.3 1.0 -0.8 1.1 -0.0 1.2
Long-standing illness, disability or infirmity 0.3 0.4 1.3 -0.9 0.2 -0.7 1.2 0.1 0.5 0.4 -0.8 -0.1 0.1 -0.8
Ever had bowel cancer screening 0.2 0.2 1.0 0.3 -0.1 -0.0 -1.0 -0.1 -0.2 0.7 0.1 -0.5 0.3 0.5
Diabetes diagnosed by doctor 0.9 1.6 5.8 -0.0 -0.8 0.6 1.5 1.2 2.0 -0.6 0.6 -0.6 -1.2 -2.4
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.2 0.5 -0.7 0.3 0.3 0.3 -0.0 0.1 -0.5 0.1 0.4 0.7 0.1
Friendships satisfaction 0.3 0.3 0.7 0.2 -0.2 0.8 0.7 -0.2 -0.5 0.7 -0.8 -0.4 -0.6 0.8
Qualifications: nursing, teaching 1.2 1.9 5.6 1.6 -1.2 -2.4 -0.7 1.0 0.9 1.4 1.3 -1.0 -1.8 -0.8
Commuting to job workplace: Walk 0.4 0.5 2.7 -0.6 0.2 -0.9 -0.9 -0.5 0.2 -1.7 -0.6 -0.2 -0.1 -0.3
Eye problems/disorders: Cataract 0.8 0.9 2.2 0.8 -0.9 -1.5 0.5 1.1 0.8 0.9 0.4 -0.8 -1.2 -0.9
Mouth/teeth dental problems: Mouth ulcers 0.1 0.2 0.7 0.4 -0.1 0.8 0.5 -0.0 -0.2 0.5 0.2 0.1 -0.5 0.4
Medication for cholesterol 0.4 0.6 2.9 0.0 0.3 0.1 -1.7 -0.4 -0.7 -0.6 -0.2 0.5 1.5 0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.2 1.4 3.5 -0.7 0.9 1.0 -0.5 -1.2 -1.5 0.3 -1.9 0.1 1.9 1.2
Back pain experienced in last month 1.2 1.8 6.6 0.1 0.4 -0.0 -0.8 -1.2 -1.2 2.3 -2.6 0.1 0.7 1.9
Mineral and other dietary supplements 0.3 0.4 1.4 -0.5 0.5 0.0 0.5 -1.1 -0.5 -1.2 -0.1 0.1 0.5 0.9
Breast cancer (self-reported) 0.9 1.0 4.5 1.4 -1.1 -0.7 -2.1 0.5 0.6 0.3 -0.1 -1.2 -0.9 -0.3
Asthma (self-reported) 0.6 1.1 2.9 1.1 -0.7 -0.9 -1.7 0.3 -0.2 1.6 -1.7 -0.8 -0.8 0.1
Osteoporosis (self-reported) 0.7 0.9 1.9 0.7 -1.0 0.4 0.6 1.1 1.4 -0.5 1.3 -0.2 -0.9 -1.3
Osteoarthritis (self-reported) 0.8 1.0 3.5 0.5 -0.1 -1.6 -0.8 -0.5 -0.7 1.5 -1.9 -0.7 0.1 1.0
Medication: Aspirin 0.2 0.2 0.9 0.1 -0.2 -0.1 0.1 0.4 0.4 1.0 0.2 0.1 -0.7 -0.8
Medication: Gliclazide 0.8 0.9 3.2 -0.6 0.9 1.8 1.2 -0.6 -0.8 0.7 -1.0 1.3 0.3 0.1
Illnesses of father: None of the above (group 1) 1.0 1.2 2.2 -0.8 1.1 1.2 -0.4 -1.3 -1.5 -0.5 -1.5 1.2 0.4 1.3
Smoking status: Current 0.5 0.9 2.2 0.5 0.2 0.8 -0.6 -0.2 -0.9 1.5 -1.3 0.1 1.4 1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.7 1.5 3.9 0.3 -0.9 -1.3 2.0 1.3 1.5 -1.2 1.2 -0.8 -0.5 -1.6
Whole body water mass 1.3 7.4 41.7 2.6 -1.1 -2.3 -2.7 0.0 -0.8 6.5 -3.4 -2.2 -0.6 1.3
Leg predicted mass (right) 1.2 6.4 30.0 2.6 -1.3 -2.4 -3.1 0.4 -0.4 5.5 -3.2 -2.2 -0.4 0.8
Arm fat mass (left) 0.7 2.9 13.9 -0.3 0.9 0.9 -1.3 -1.4 -1.7 2.2 -3.7 0.2 1.6 1.7
Number of self-reported non-cancer illnesses 1.2 2.1 11.5 0.7 -0.5 -1.1 0.0 0.1 -0.4 3.4 -2.8 -1.1 -0.5 0.6
Average weekly champagne plus white wine intake 0.4 0.6 1.4 -1.2 0.7 -0.2 1.0 -0.8 -0.1 -0.9 1.2 0.6 0.3 -0.1
Miserableness 4.3 7.4 23.6 -2.4 2.9 4.9 2.0 -2.6 -2.9 -0.7 -1.4 3.3 1.9 2.8
Guilty feelings 5.2 7.7 20.2 -2.9 3.0 4.5 3.5 -2.4 -2.5 -0.8 -0.4 3.6 2.2 2.3
Wears glasses or contact lenses 0.1 0.1 0.5 -0.7 0.1 0.2 0.4 -0.2 0.4 -0.6 0.2 -0.1 0.0 -0.3
Ever taken oral contraceptive pill 1.0 1.1 3.1 -1.8 1.2 -0.4 1.6 -0.6 -0.4 -1.3 0.4 1.2 1.2 -0.1
Hearing aid user 1.1 1.3 4.0 -0.8 0.0 -0.0 1.1 0.5 1.3 -2.0 1.9 0.6 -0.8 -1.4
Mother’s age at death 0.6 0.7 4.0 -1.0 0.3 -0.3 0.9 -0.4 0.4 -2.0 1.2 0.1 -0.3 -0.4
Financial situation satisfaction 0.8 1.1 3.5 -1.3 0.8 1.0 1.2 -0.7 -0.3 -1.9 0.3 1.1 0.9 0.7
Tinnitus: Yes, now most or all of the time 0.1 0.2 1.1 0.2 0.1 -0.2 -0.2 0.1 -0.3 1.1 -0.5 0.2 0.0 0.2
Commuting to job workplace: Public transport 0.7 0.8 4.5 -0.8 0.2 -0.5 1.1 0.0 0.5 -0.8 2.1 0.2 0.2 -1.0
Eye problems/disorders: Glaucoma 0.2 0.2 1.5 0.4 -0.3 -0.5 -0.5 0.3 -0.1 1.2 -0.5 -0.0 0.1 0.1
Medication: Blood pressure 0.8 1.6 3.8 0.8 -1.0 -1.1 1.4 1.1 1.2 1.6 0.8 -1.3 -2.0 -1.1
Pain type(s) experienced in last month: Hip pain 0.4 0.6 1.8 -0.5 -0.2 -1.3 0.6 0.6 0.9 -0.7 1.0 -0.3 -0.2 -0.9
Supplements: Fish oil (including cod liver oil) 1.1 1.4 3.0 1.2 -1.2 -0.7 -0.4 1.7 1.2 1.7 0.1 -0.8 -1.5 -1.4
High cholesterol (Self-reported) 0.1 0.1 0.3 0.2 -0.3 0.6 0.1 0.3 0.5 0.2 -0.4 -0.3 -0.4 -0.3
Medication: Bendroflumethiazide 0.7 1.0 6.2 -1.3 0.9 0.3 2.5 -0.7 -0.3 0.4 0.7 0.8 0.3 0.5
Medication: Paracetamol 1.0 1.5 6.0 -0.9 1.0 2.4 0.9 -1.1 -0.7 -0.5 0.4 1.3 1.6 1.2
Medication: Lisinopril 0.5 0.7 3.3 -0.4 0.2 -1.8 -0.0 -0.6 -0.3 0.6 -1.5 -0.7 0.4 0.3
Medication: Atorvastatin 0.1 0.2 1.3 0.1 -0.0 -0.4 -0.0 -0.4 -0.2 0.1 -1.2 -0.1 -0.4 0.1
Illnesses of father: High blood pressure 0.9 1.1 2.0 0.8 -0.9 -1.1 0.4 1.2 1.1 1.0 1.1 -0.5 -1.4 -1.3
Alcohol drinker status: Never 0.2 0.2 0.6 -0.2 -0.3 -0.7 0.3 0.0 0.4 0.3 -0.3 -0.7 -0.8 -0.4
Ever smoked 0.4 0.7 1.6 -0.1 0.7 1.1 0.4 -0.3 -1.1 0.3 -0.4 1.0 1.1 1.3
Basal metabolic rate 1.3 7.4 40.8 2.5 -0.9 -2.0 -2.8 -0.3 -1.1 6.4 -3.8 -2.0 -0.4 1.6
Leg fat percentage (left) 1.3 4.6 11.7 -1.9 2.1 2.7 -0.0 -2.3 -2.4 -0.2 -3.4 1.7 2.2 2.2
Arm fat-free mass (left) 1.1 5.8 32.8 1.5 -0.1 -1.3 -1.9 -0.9 -1.6 5.7 -3.8 -1.2 -0.0 2.0
Number of operations (self-reported) 0.3 0.4 1.7 0.3 -0.0 -0.2 -0.9 -0.2 -0.5 1.3 -0.4 -0.6 0.9 0.7
Average weekly beer plus cider intake 0.5 0.8 3.4 -0.3 0.7 1.9 -0.2 -0.4 -0.7 -0.2 -1.3 1.0 1.1 0.3
Irritability 2.0 3.4 9.2 -1.4 1.6 3.0 2.7 -1.5 -1.4 -0.8 0.5 2.0 1.9 1.8
Risk taking 1.0 1.5 9.0 -1.7 1.0 0.6 1.1 -1.0 -0.2 -3.0 -0.4 0.5 0.3 -0.1
Ever had prostate specific antigen (PSA) test 0.9 1.1 2.8 -0.6 1.0 1.0 -1.7 -1.1 -1.0 -0.6 -0.5 0.8 1.5 1.0
Fractured/broken bones in last 5 years 0.4 0.5 1.5 -0.5 0.5 -0.8 -0.6 -1.2 -0.5 -0.9 0.6 0.2 0.6 0.6
Age started oral contraceptive pill 1.4 1.8 5.6 -1.7 1.5 0.1 2.4 -1.6 -1.1 -0.9 0.7 1.5 -0.2 1.2
Diastolic blood pressure, automated reading 0.5 1.5 5.8 1.1 -0.5 -1.1 -1.0 -0.2 -0.7 2.4 -1.9 -0.8 -0.7 1.1
Ever depressed for a whole week 0.1 0.2 0.9 -0.2 0.4 0.9 -0.0 -0.4 -0.4 0.2 -0.1 0.4 0.2 0.5
Unable to work because of sickness or disability 0.2 0.3 1.6 0.2 -0.0 0.3 -0.1 0.3 -0.5 1.2 -0.8 -0.2 0.1 0.5
Commuting to job workplace: Cycle 0.3 0.4 1.5 -0.6 0.2 -0.6 0.6 0.1 0.5 -1.2 0.5 0.4 0.4 -0.7
Myopia 0.7 1.0 4.4 1.3 -1.1 1.0 -0.5 1.2 0.7 2.1 0.0 -0.7 -0.5 -0.3
Vascular/heart problems diagnosed by doctor 0.4 1.1 4.6 -0.2 0.1 1.2 -0.2 0.0 0.4 -2.1 2.0 0.8 0.5 -0.7
Cholesterol lowering medication 1.1 1.6 3.7 1.1 -1.3 -1.1 0.4 1.3 1.6 0.2 0.6 -1.3 -1.9 -1.7
Medication: Omeprazole (e.g. Zanprol) 0.6 0.8 1.7 -0.6 0.8 0.9 -0.3 -0.9 -1.0 0.1 -1.3 0.8 1.0 1.2
Pain experienced in last month 0.5 0.9 4.2 -1.0 1.0 0.2 0.5 -0.5 -0.3 -2.1 1.0 1.2 -0.3 -0.7
Supplements: Calcium 0.7 0.8 2.7 1.6 -1.2 0.1 -0.7 0.7 0.5 1.4 0.5 -0.9 -0.5 -0.1
Basal cell carcinoma (self-reported) 0.4 0.5 2.5 0.8 -0.2 -0.0 0.0 -0.2 -0.4 1.6 -0.5 -0.1 -1.0 0.7
Heart attack/myocardial infarction (self-reported) 0.9 1.2 4.6 1.2 -0.7 -0.2 -0.1 0.1 -0.1 2.1 -2.1 -1.0 -1.0 0.3
Deep venous thrombosis (DVT) (self-reported) 2.5 3.2 5.4 -1.6 2.1 1.4 0.5 -2.1 -2.3 0.6 -1.8 2.0 2.1 2.2
Heart disease (siblings) 0.2 0.3 1.0 0.6 -0.4 -0.0 0.2 0.2 0.2 1.0 -0.8 -0.6 -0.6 -0.3
Alcohol drinker status: Previous 0.4 0.4 1.5 0.5 -0.7 0.3 0.3 1.2 0.9 0.4 0.3 -0.1 -0.0 -1.1
Pack years of smoking 0.3 0.5 1.1 -0.5 0.7 0.0 0.1 -0.9 -1.0 0.5 -1.1 0.4 0.4 0.9
Impedance of whole body 0.2 1.1 4.9 -0.3 0.2 -1.8 1.1 -0.2 0.2 -0.7 2.2 0.1 -1.4 -0.3
Leg fat mass (left) 1.3 5.0 18.9 -1.0 1.8 1.5 -1.1 -2.3 -2.7 1.9 -4.3 1.0 2.1 2.7
Arm predicted mass (left) 1.1 5.8 33.9 1.7 -0.3 -1.3 -1.9 -0.7 -1.4 5.8 -3.7 -1.3 -0.0 1.9