Best TWAS P=6.64e-09 · Best GWAS P=3.29e-07 conditioned to 1.42e-06
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | PINLYP | 0.25 | 0.06 | lasso | 5 | 0.12 | 5.0e-10 | 4.1 | -5.8 | 6.6e-09 | 0.05 | 0.15 | 0.69 | TRUE |
2 | GTEx | Artery Aorta | PINLYP | 0.29 | 0.10 | lasso | 8 | 0.15 | 8.6e-09 | -4.2 | -5.7 | 1.2e-08 | 0.03 | 0.09 | 0.82 | FALSE |
3 | GTEx | Artery Tibial | ETHE1 | 0.21 | 0.06 | enet | 19 | 0.14 | 2.9e-11 | 4.2 | 5.7 | 1.5e-08 | -0.04 | 0.13 | 0.73 | FALSE |
4 | GTEx | Brain Putamen basal ganglia | PINLYP | 0.46 | 0.14 | lasso | 7 | 0.25 | 1.0e-06 | -4.4 | -5.3 | 8.8e-08 | 0.03 | 0.07 | 0.66 | FALSE |
5 | GTEx | Breast Mammary Tissue | PINLYP | 0.20 | 0.06 | lasso | 8 | 0.11 | 2.9e-06 | -4.4 | -5.6 | 2.1e-08 | 0.03 | 0.08 | 0.80 | FALSE |
6 | GTEx | Colon Transverse | PINLYP | 0.21 | 0.01 | enet | 19 | 0.06 | 1.1e-03 | -4.4 | -5.2 | 1.8e-07 | 0.07 | 0.07 | 0.75 | FALSE |
7 | GTEx | Esophagus Muscularis | PINLYP | 0.20 | 0.12 | lasso | 9 | 0.14 | 4.7e-09 | -4.4 | -5.5 | 3.2e-08 | 0.02 | 0.05 | 0.89 | FALSE |
8 | GTEx | Nerve Tibial | PINLYP | 0.33 | 0.12 | lasso | 4 | 0.26 | 4.0e-18 | 4.0 | -5.1 | 3.0e-07 | 0.09 | 0.15 | 0.70 | FALSE |
9 | GTEx | Thyroid | PINLYP | 0.14 | 0.08 | lasso | 6 | 0.11 | 6.1e-09 | -4.2 | -5.2 | 1.8e-07 | 0.05 | 0.07 | 0.86 | FALSE |
10 | The Cancer Genome Atlas | Lung Adenocarcinoma | ETHE1 | 0.07 | 0.04 | blup | 68 | 0.04 | 1.9e-05 | -4.1 | 5.1 | 3.0e-07 | -0.01 | 0.01 | 0.86 | FALSE |
11 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | ETHE1 | 0.11 | 0.02 | blup | 69 | 0.08 | 4.2e-04 | -3.9 | 5.4 | 7.1e-08 | -0.03 | 0.01 | 0.38 | FALSE |
12 | The Cancer Genome Atlas | Soft Tissue Sarcoma | ETHE1 | 0.14 | 0.03 | blup | 69 | 0.06 | 3.1e-04 | -2.6 | 5.3 | 1.1e-07 | -0.02 | 0.01 | 0.14 | FALSE |
13 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | PHLDB3 | 0.18 | 0.06 | blup | 57 | 0.10 | 8.3e-04 | 3.9 | 5.1 | 2.7e-07 | -0.04 | 0.00 | 0.17 | FALSE |