Best TWAS P=1.76e-08 · Best GWAS P=1.09e-07 conditioned to 0.00435
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Aorta | AC007228.11 | 0.31 | 0.22 | enet | 24 | 0.23 | 6.5e-13 | 5.3 | 5.4 | 7.5e-08 | 0.90 | 0.00 | 0.99 | FALSE |
2 | GTEx | Brain Cerebellum | ZNF471 | 0.24 | 0.25 | enet | 14 | 0.20 | 1.2e-06 | 4.2 | -5.3 | 1.2e-07 | -0.68 | 0.14 | 0.79 | FALSE |
3 | GTEx | Brain Hypothalamus | AC007228.11 | 0.39 | 0.24 | lasso | 6 | 0.22 | 8.8e-06 | 5.3 | 5.4 | 5.8e-08 | 0.96 | 0.01 | 0.98 | FALSE |
4 | GTEx | Cells Transformed fibroblasts | ZNF304 | 0.25 | 0.15 | lasso | 3 | 0.18 | 1.0e-13 | 5.1 | -5.2 | 2.1e-07 | 0.04 | 0.01 | 0.98 | FALSE |
5 | GTEx | Colon Sigmoid | AC007228.11 | 0.21 | 0.19 | lasso | 3 | 0.15 | 7.9e-06 | 5.3 | 5.3 | 1.3e-07 | 1.00 | 0.01 | 0.99 | FALSE |
6 | GTEx | Ovary | AC007228.11 | 0.29 | 0.04 | lasso | 7 | 0.12 | 6.6e-04 | 5.3 | 5.4 | 7.1e-08 | 0.92 | 0.02 | 0.87 | FALSE |
7 | GTEx | Skin Sun Exposed Lower leg | ZNF749 | 0.16 | 0.10 | lasso | 3 | 0.11 | 3.3e-09 | 4.7 | 5.2 | 2.0e-07 | -0.06 | 0.01 | 0.98 | FALSE |
8 | GTEx | Skin Sun Exposed Lower leg | ZFP28 | 0.19 | 0.13 | lasso | 9 | 0.17 | 1.1e-13 | 5.3 | 5.4 | 8.4e-08 | 0.93 | 0.01 | 0.99 | FALSE |
9 | GTEx | Spleen | AC007228.11 | 0.25 | 0.08 | enet | 23 | 0.07 | 6.0e-03 | -4.4 | 5.2 | 2.0e-07 | 0.72 | 0.04 | 0.79 | FALSE |
10 | METSIM | Adipose | ZFP28 | 0.13 | 0.09 | bslmm | 490 | 0.12 | 7.3e-17 | 4.4 | 5.3 | 1.2e-07 | 0.79 | 0.02 | 0.98 | FALSE |
11 | The Cancer Genome Atlas | Colon Adenocarcinoma | ZNF470 | 0.05 | 0.02 | blup | 73 | 0.04 | 3.1e-03 | -4.0 | 5.5 | 4.7e-08 | 0.70 | 0.02 | 0.50 | FALSE |
12 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ZNF470 | 0.06 | 0.02 | blup | 72 | 0.03 | 1.8e-04 | -4.3 | 5.6 | 1.8e-08 | 0.61 | 0.06 | 0.92 | TRUE |
13 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | ZNF749 | 0.26 | 0.15 | enet | 6 | 0.18 | 6.0e-12 | 5.0 | -5.4 | 5.3e-08 | 0.07 | 0.01 | 0.99 | TRUE |
14 | The Cancer Genome Atlas | Stomach Adenocarcinoma | ZNF71 | 0.07 | 0.05 | blup | 78 | 0.02 | 1.6e-02 | -4.0 | 5.2 | 1.9e-07 | 0.48 | 0.02 | 0.66 | FALSE |