Hub : Genes

ZNF749

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.2110 0.0410 8.1e-12 0.176 0.105 0.152 0.154 0.169 6.6e-21 9.0e-13 3.9e-18 2.6e-18 4.6e-20
2 GTEx Brain Caudate basal ganglia 0.2750 0.0820 1.1e-03 0.242 NA 0.195 NA 0.127 1.4e-07 NA 2.9e-06 NA 1.7e-04
3 GTEx Breast Mammary Tissue 0.2080 0.0730 2.6e-03 -0.006 NA -0.001 NA -0.005 9.6e-01 NA 3.9e-01 NA 7.6e-01
4 GTEx Breast Mammary Tissue (Male) 0.1265 0.1198 1.9e-01 -0.010 NA 0.023 NA -0.008 6.2e-01 NA 9.8e-02 NA 5.5e-01
5 GTEx Breast Mammary Tissue (Female) 0.1102 0.1139 2.1e-01 -0.009 NA -0.006 NA -0.005 7.2e-01 NA 5.2e-01 NA 5.1e-01
6 GTEx Cells EBV-transformed lymphocytes 0.3300 0.0960 9.4e-04 0.217 NA 0.212 NA 0.090 1.2e-07 NA 1.8e-07 NA 7.2e-04
7 GTEx Muscle Skeletal 0.0649 0.0291 9.0e-03 -0.001 NA -0.002 NA -0.001 4.6e-01 NA 5.9e-01 NA 3.8e-01
8 GTEx Skin Sun Exposed Lower leg 0.1600 0.0440 6.3e-05 0.099 NA 0.059 NA 0.108 1.4e-08 NA 1.2e-05 NA 3.3e-09
9 GTEx Small Intestine Terminal Ileum 0.2600 0.0940 5.3e-03 0.054 NA 0.019 NA 0.064 2.4e-02 NA 1.2e-01 NA 1.6e-02
10 METSIM Adipose 0.0625 0.0255 3.9e-03 0.008 0.003 0.000 NA 0.008 1.8e-02 9.3e-02 3.8e-01 NA 1.8e-02
11 NTR Blood 0.0208 0.0087 4.1e-03 0.017 0.007 0.013 0.008 0.012 2.3e-06 1.8e-03 3.0e-05 1.2e-03 6.6e-05
12 TCGA Breast Invasive Carcinoma 0.0591 0.0214 8.3e-07 0.030 0.035 0.032 NA 0.030 6.3e-07 9.2e-08 3.6e-07 NA 7.1e-07
13 TCGA Glioblastoma Multiforme 0.3660 0.1200 1.7e-04 0.246 0.149 0.208 NA 0.031 4.6e-08 2.9e-05 6.0e-07 NA 4.1e-02
14 TCGA Kidney Renal Clear Cell Carcinoma 0.0669 0.0357 4.2e-04 0.022 0.029 0.038 NA 0.002 1.3e-03 2.6e-04 4.0e-05 NA 1.9e-01
15 TCGA Ovarian Serous Cystadenocarcinoma 0.2590 0.0710 6.8e-09 0.152 0.165 0.175 NA 0.170 1.9e-10 2.8e-11 6.0e-12 NA 1.2e-11
16 TCGA Prostate Adenocarcinoma 0.1249 0.0442 4.5e-07 0.020 0.054 0.065 NA 0.051 3.4e-03 2.3e-06 2.3e-07 NA 5.0e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16
Bipolar Disorder (2018) 0.2 0.3 1.7 0.1 0.1 0.0 0.0 0.4 0.0 -0.4 -0.2 -1.3 1.1 -0.1 -0.9 0.0 -0.8 -0.3 -0.4
Bipolar Disorder or Schizophrenia 0.1 0.3 2.1 0.6 -0.3 0.0 0.0 1.5 0.4 -0.0 0.3 -0.8 0.8 -0.1 -0.5 0.0 -0.2 -0.7 -0.4
Depressed Affect (Nagel 2018) 1.8 3.7 6.9 2.1 -2.5 0.0 0.0 1.1 2.6 -1.8 2.6 0.9 -1.6 1.7 2.2 -2.0 2.5 -2.5 -1.7
Depression (Nagel 2018) 0.4 0.6 3.0 0.6 -0.7 0.0 0.0 0.8 0.9 -1.7 0.8 -1.1 -0.3 0.0 0.1 -0.5 -0.2 -0.8 -1.4
Intelligence (Savage-Jansen 2018) 0.1 0.4 4.5 0.1 -0.2 0.0 0.0 -0.5 0.2 -0.7 0.2 -2.1 -1.1 0.4 0.2 -0.2 -0.3 0.1 -0.5
Neuroticism (Nagel 2018) 0.9 2.1 6.2 1.8 -1.9 0.0 0.0 0.8 1.9 -0.5 1.8 0.4 -0.8 1.1 2.0 -1.4 2.5 -1.8 -1.0
Schizophrenia (2018) 0.1 0.2 2.0 0.6 -0.5 0.0 0.0 1.4 0.5 0.3 0.5 0.1 0.2 -0.0 0.1 0.0 0.4 -0.7 -0.2
Schizophrenia vs Biploar Disorder 0.7 0.9 2.7 0.4 -1.1 0.0 0.0 1.0 0.8 -1.0 0.9 -0.9 -1.6 0.7 1.4 0.0 1.3 -1.0 -0.3
Worry (Nagel 2018) 0.4 0.9 5.9 1.0 -0.6 0.0 0.0 0.8 0.8 0.6 0.7 0.7 -0.8 0.5 1.7 -0.5 2.4 -0.7 0.8
Alzheimer’s Disease (in mother) 0.3 0.4 1.6 0.7 -0.5 0.0 0.0 1.1 0.3 -0.0 0.3 1.3 -0.2 1.1 0.5 -0.6 0.0 -0.3 0.2
Alzheimer’s Disease (in father) 0.9 1.0 3.7 0.4 -1.0 0.0 0.0 0.7 0.9 -1.9 0.9 1.6 0.7 1.6 -0.0 -1.1 0.5 -1.3 -0.2
Alzheimer’s Disease (including proxy) 1.2 1.8 5.7 1.3 -1.7 0.0 0.0 1.3 1.5 -1.7 1.4 1.2 0.1 2.4 0.9 -1.6 1.0 -1.9 -0.5
Crohns Disease (2017) 0.3 0.6 1.6 1.2 -0.8 0.0 0.0 -0.5 1.1 0.1 1.1 0.1 -0.9 0.6 1.2 -1.0 0.1 -0.8 -0.5
Irritable Bowel Disease (IBD) 0.1 0.2 1.4 0.0 0.0 0.0 0.0 -0.2 -0.0 0.7 0.0 0.5 -0.3 0.3 0.8 0.2 0.2 0.3 1.2
Ulcerative Colitis (UC) 0.3 0.5 3.8 -0.8 0.6 0.0 0.0 0.1 -0.8 0.4 -0.8 0.1 0.4 0.1 0.2 0.9 0.1 0.9 2.0
Major Depression (MDD) 1.8 2.2 3.9 1.5 -1.9 0.0 0.0 1.0 2.0 -1.2 1.9 -1.5 -1.7 1.6 1.6 -1.8 1.0 -1.8 -1.5
Reaction Time 0.2 0.4 2.6 0.4 -0.0 0.0 0.0 0.8 0.4 -0.4 0.3 1.6 -0.3 0.6 0.7 -0.0 0.7 -0.8 0.3
Verbal and Numeric Reasoning (VNR) 0.4 0.9 2.2 -1.3 1.1 0.0 0.0 -1.5 -1.1 0.3 -1.0 -0.5 -0.1 -0.9 -0.9 1.2 -0.8 1.3 0.9
Breast Cancer 0.7 1.7 3.6 -1.9 1.4 0.0 0.0 -1.6 -1.5 -0.3 -1.8 -0.1 -0.3 -1.8 -1.4 1.9 -1.4 1.9 0.1
Ovarian Cancer 3.0 3.9 8.8 -2.7 2.3 0.0 0.0 0.2 -2.5 1.2 -2.3 1.1 -1.0 -2.8 -3.0 2.5 -1.0 2.7 1.9
Prostate Cancer 0.3 0.4 4.0 0.6 -0.2 0.0 0.0 0.9 0.1 -0.2 0.1 -2.0 0.6 -0.2 -0.2 -0.4 -0.4 -0.3 -0.2
Age at First Birth 0.4 0.6 1.7 -0.7 0.8 0.0 0.0 0.1 -1.0 0.5 -1.1 0.1 1.3 -0.9 -1.0 0.8 -0.4 1.1 0.6
Bipolar Disorder (2011) 0.1 0.1 0.5 -0.2 -0.2 0.0 0.0 0.0 -0.1 -0.5 -0.1 -0.2 0.6 0.7 -0.3 0.0 0.2 -0.2 0.2
Body Mass Index (BMI) (2010) 0.7 0.9 5.1 0.8 -0.7 0.0 0.0 0.7 1.2 -0.8 0.9 -1.0 -2.2 0.7 1.0 0.0 0.7 -1.2 -1.0
Coronary Artery Disease (CAD) 2.7 3.2 7.7 -2.6 2.4 0.0 0.0 -0.3 -2.5 1.4 -2.3 -2.0 0.9 -2.8 -1.8 0.0 0.0 2.5 1.9
Crohns Disease (2012) 1.0 1.6 3.6 1.4 -1.7 0.0 0.0 -0.2 1.8 -0.8 1.8 0.3 -1.9 1.6 1.9 0.0 0.0 -1.7 -1.2
Mean Putamen Volume 0.4 0.4 2.4 0.8 -0.4 0.0 0.0 1.5 0.5 0.6 0.7 1.0 0.0 0.5 0.2 -0.7 -0.0 -0.6 -0.6
Fasting Glucose 0.4 0.4 3.0 -0.3 0.3 0.0 0.0 0.5 0.1 -0.5 -0.3 -1.1 0.6 -0.9 -0.0 0.4 -1.7 -0.4 -0.7
HbA1C 1.2 1.3 10.0 -0.1 0.2 0.0 0.0 0.6 -0.7 -0.9 -0.6 -3.2 1.4 -0.2 -1.9 0.0 -1.7 0.6 0.1
HDL Cholesterol 2.4 4.0 8.5 -2.3 2.6 0.0 0.0 -2.1 -2.4 1.2 -2.5 -0.3 1.7 -2.8 -2.6 0.0 -2.6 2.9 1.2
LDL Cholesterol 1.0 1.6 4.6 1.7 -1.6 0.0 0.0 2.1 1.6 -0.8 1.7 0.7 -0.0 1.6 0.8 0.0 0.9 -1.8 -1.6
Lupus 0.6 0.9 2.9 -1.2 1.0 0.0 0.0 -0.1 -1.1 0.9 -1.3 -0.4 1.7 -0.5 -0.2 1.0 -0.8 1.0 1.4
Neuroticism (2016) 0.6 0.8 2.9 0.8 -0.7 0.0 0.0 0.8 1.0 -0.7 0.9 1.3 -0.6 -0.2 0.4 -0.3 1.4 -1.7 -1.4
Primary Biliary Cirrhosis 0.3 0.4 1.6 0.5 -0.1 0.0 0.0 -0.2 0.1 -1.2 0.2 -0.9 1.1 -0.3 -0.6 -0.5 -1.2 -0.3 -0.7
Rheumatoid Arthritis 0.8 1.1 5.8 -0.7 0.7 0.0 0.0 0.1 -0.9 -1.2 -1.1 -1.1 0.6 -1.0 -2.0 0.5 -2.4 0.9 -0.6
Schizophrenia (2014) 0.5 1.0 2.7 1.4 -1.2 0.0 0.0 1.0 1.3 -1.6 1.1 -1.4 -0.1 0.9 0.2 0.0 -0.1 -1.5 -1.2
Triglycerides 2.8 4.6 10.0 2.4 -2.9 0.0 0.0 3.2 2.4 -2.0 2.6 -0.7 -1.2 3.0 1.8 0.0 2.4 -3.0 -2.1
Type 2 Diabetes (T2D) (2012) 1.0 1.1 2.8 1.4 -1.2 0.0 0.0 -0.4 1.4 -0.8 1.6 0.2 -1.2 0.7 1.0 0.0 0.8 -1.5 -1.7
Ulcerative Colitis 0.1 0.2 1.0 -0.1 -0.1 0.0 0.0 -1.0 0.1 -0.3 -0.1 0.2 0.5 0.6 0.8 0.0 0.0 0.1 1.0
Blood Eosinophil Count 0.2 1.9 11.6 -0.7 1.1 0.0 0.0 -2.1 -1.0 1.3 -1.2 -3.4 0.2 -1.6 -1.0 0.7 -1.3 1.6 0.6
Blood Platelet Count 0.8 9.5 18.0 -3.1 3.9 0.0 0.0 -2.4 -3.8 3.1 -3.6 -2.0 2.5 -3.5 -4.2 3.4 -3.0 4.1 2.4
Blood Red Count 0.3 2.8 6.7 1.3 -2.2 0.0 0.0 1.1 1.9 -0.4 1.6 1.0 -1.5 2.6 2.2 -1.5 2.3 -2.5 -1.6
Blood White Count 0.3 2.6 5.2 -1.8 1.9 0.0 0.0 -2.2 -1.7 1.8 -1.9 -1.0 -0.0 -2.2 -0.4 1.9 -0.7 2.1 2.3
Heel T-Score 0.1 0.5 2.0 -0.0 0.3 0.0 0.0 0.8 -0.1 1.4 -0.1 -1.2 1.4 -0.5 0.4 -0.3 0.4 -0.1 0.8
BMI 0.0 0.3 1.8 0.0 0.2 0.0 0.0 -0.5 0.0 1.2 0.0 -1.3 0.1 -0.5 0.5 -0.3 -0.1 0.3 0.0
Height 0.8 15.4 28.3 4.6 -5.0 0.0 0.0 1.3 4.8 -1.4 5.3 4.1 -1.4 4.4 3.9 -4.5 4.2 -5.3 -5.0
Waist Hip Ratio (WHR) 0.3 1.2 6.8 -0.8 1.4 0.0 0.0 -0.3 -0.8 0.7 -0.9 -1.2 0.2 -2.6 -1.4 0.9 -1.2 1.2 0.4
Systolic Blood Pressure 0.0 0.1 1.0 0.1 -0.1 0.0 0.0 -0.4 0.3 0.2 0.1 1.0 -0.1 0.2 -0.6 -0.1 0.5 -0.3 -0.2
Smoking Status 0.2 0.5 1.8 0.7 -0.4 0.0 0.0 -0.8 1.0 -0.7 1.0 1.3 -0.2 0.3 0.5 -0.8 0.3 -0.5 -0.7
Allergy or Eczema 0.6 1.7 7.2 -0.9 1.0 0.0 0.0 -1.3 -0.6 -1.2 -0.8 -2.5 -2.7 -0.6 -1.4 1.1 -1.6 0.7 -0.7
Cardiovascular Disease 0.5 1.8 6.4 1.8 -1.4 0.0 0.0 1.4 1.5 0.3 1.4 -0.6 -1.4 1.2 1.0 -1.2 1.5 -1.6 -2.5
Hypothyroidism (self reported) 1.0 2.2 4.6 2.1 -2.0 0.0 0.0 1.1 1.7 -1.8 1.9 0.8 0.5 1.7 1.1 -2.0 1.8 -1.7 -1.1
Respiratory disease 0.3 0.8 7.0 -0.3 0.2 0.0 0.0 1.7 -0.3 0.4 -0.4 -2.6 0.7 0.3 -0.4 0.3 -0.3 0.2 -0.9
Type 2 Diabetes (T2D) (2018) 0.7 1.4 4.2 0.9 -1.3 0.0 0.0 1.1 1.3 -0.1 1.3 0.1 -1.7 0.9 1.6 -0.8 2.1 -1.6 -1.2
Lung FEV1/FVC ratio 0.6 3.3 7.5 -1.9 2.4 0.0 0.0 -2.5 -1.9 2.2 -1.9 -1.0 -0.4 -1.9 -0.8 2.3 -1.3 2.3 2.7
Lung FVC 0.1 0.5 3.9 -0.2 0.1 0.0 0.0 -0.3 0.2 -2.0 -0.1 -0.4 -0.1 0.6 -0.2 -0.1 -1.7 0.1 -0.3
Neuroticism 1.0 2.3 6.7 1.5 -1.7 0.0 0.0 0.7 1.9 -0.7 1.6 1.7 -1.2 1.4 2.3 -1.2 2.6 -1.9 -1.2
Chronotype (morning person) 0.3 0.6 4.6 0.1 -0.0 0.0 0.0 -1.0 -0.2 -1.0 -0.2 -2.1 0.0 0.4 -0.9 -0.3 -1.3 0.5 -0.5
Hair Pigment 0.1 2.2 5.1 -2.0 1.9 0.0 0.0 -1.3 -1.8 0.3 -1.9 -0.5 -0.6 -2.0 -0.9 2.3 -1.5 1.7 1.6
Tanning 0.0 0.5 5.8 -0.1 0.1 0.0 0.0 0.7 -0.1 -0.5 0.1 2.4 0.2 0.2 0.7 0.1 0.4 0.3 -0.2
Hand grip strength (left) 0.3 0.9 3.6 1.2 -1.2 0.0 0.0 -0.1 0.7 -0.0 1.1 -0.1 1.0 1.3 -0.2 -1.5 0.2 -0.9 -1.9
Number of treatments/medications taken 0.3 0.5 2.4 -0.0 0.1 0.0 0.0 1.2 -0.1 0.8 -0.6 0.1 1.1 -0.5 0.5 0.2 1.6 -0.7 -0.3
Average weekly spirits intake 0.7 0.9 4.4 -0.8 1.1 0.0 0.0 -0.3 -1.2 2.1 -0.8 -1.0 0.4 -1.2 -0.8 1.0 -0.1 0.9 1.2
Sensitivity / hurt feelings 0.1 0.2 0.9 -0.5 -0.1 0.0 0.0 -0.5 0.1 -0.4 -0.3 0.1 -0.1 0.1 1.0 0.5 0.8 0.0 0.2
Frequency of depressed mood in last 2 weeks 1.0 1.4 4.2 1.3 -1.4 0.0 0.0 0.8 1.7 -2.0 1.6 0.3 -0.8 0.7 1.1 -1.1 0.9 -1.7 -1.4
Hearing difficulty/problems: Yes 0.5 0.7 7.3 -0.3 0.4 0.0 0.0 1.3 0.0 -0.7 -0.4 -2.7 -0.9 -0.5 0.5 0.6 -0.4 0.1 0.4
Relative age of first facial hair 0.3 0.5 2.3 -0.2 0.1 0.0 0.0 -1.5 -0.2 1.1 -0.2 1.1 -1.5 0.2 -0.4 0.3 0.8 0.1 0.6
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 2.0 1.1 -0.4 0.0 0.0 1.4 0.6 -0.6 0.7 -0.8 0.3 0.4 0.6 -0.7 0.7 -0.6 -0.7
Ever used hormone-replacement therapy (HRT) 0.8 1.0 2.7 -1.4 1.0 0.0 0.0 0.5 -1.2 -0.4 -1.3 1.1 1.7 -0.6 -0.9 1.4 -1.1 0.9 1.1
Ever had hysterectomy (womb removed) 2.6 3.0 5.8 2.3 -2.0 0.0 0.0 2.4 2.1 -1.6 2.4 0.0 -0.2 1.9 1.2 -1.8 0.9 -2.3 -2.3
Systolic blood pressure, automated reading 0.4 1.1 2.1 -1.4 1.3 0.0 0.0 -0.4 -1.3 1.0 -1.4 0.5 0.9 -1.0 -1.3 1.1 -0.4 1.1 1.3
Eye problems/disorders: Diabetes related eye disease 0.9 1.0 4.7 1.1 -0.9 0.0 0.0 2.2 0.9 -0.7 0.8 1.4 -1.0 0.4 0.7 -0.7 1.0 -1.4 -0.9
Angina 0.6 0.8 2.5 -0.8 1.0 0.0 0.0 -0.0 -0.9 1.5 -0.7 1.2 -0.1 -0.7 0.0 0.6 0.8 1.2 1.6
Medication for hormone replacement therapy 0.8 0.9 2.3 -1.2 1.0 0.0 0.0 -1.1 -0.8 0.1 -1.0 1.5 1.4 -1.1 -0.4 1.1 -0.5 0.8 0.9
Vitamin and mineral supplements 1.9 2.5 5.4 -1.6 1.9 0.0 0.0 -0.6 -2.1 1.3 -1.9 -1.1 1.4 -2.3 -2.0 1.8 -1.8 2.0 1.0
Supplements: Zinc 0.6 0.6 3.3 0.5 -0.8 0.0 0.0 0.4 0.9 -1.8 0.7 -0.7 -0.7 1.0 0.7 -0.6 0.4 -1.2 -0.2
Medication: Co-codamol 0.6 0.6 1.7 -1.3 1.0 0.0 0.0 0.1 -1.1 0.2 -1.1 0.1 0.2 -0.8 -1.1 1.1 -1.0 1.0 -0.2
Medication: Metformin 0.1 0.2 1.0 -0.2 0.4 0.0 0.0 1.0 -0.3 0.3 -0.2 -0.0 -0.3 -0.6 0.0 0.6 -0.2 0.2 -1.0
Diabetes (father) 0.3 0.4 2.8 -0.5 0.4 0.0 0.0 0.1 -0.0 -0.5 -0.4 -0.8 -0.3 -0.5 1.7 0.6 -0.4 0.2 1.1
Diabetes (mother) 0.6 0.8 2.5 -1.1 0.6 0.0 0.0 1.1 -1.1 1.1 -1.1 0.1 1.6 -0.7 -1.1 1.1 0.3 0.8 -0.0
Severe depression (siblings) 0.3 0.3 3.1 0.4 -0.0 0.0 0.0 -0.2 0.1 0.4 0.0 -1.8 -0.9 0.2 0.2 0.0 -0.5 -0.1 -0.5
Pack years adult smoking proportion 0.2 0.3 1.8 0.2 0.1 0.0 0.0 0.5 0.0 0.1 0.2 1.3 -1.4 -0.6 -0.1 0.2 0.9 -0.1 0.0
Impedance of leg (right) 0.4 2.1 4.2 -2.0 1.7 0.0 0.0 -1.9 -1.8 0.6 -1.7 0.9 -0.7 -1.0 -1.3 2.0 -0.2 2.0 2.1
Leg fat-free mass (left) 0.9 4.6 10.7 2.9 -2.7 0.0 0.0 1.7 2.8 -1.1 2.9 0.2 -0.4 2.2 1.8 -2.9 1.1 -3.0 -3.3
Trunk fat percentage 1.3 5.1 11.7 -2.6 3.0 0.0 0.0 -1.9 -2.7 2.7 -2.6 0.2 1.2 -3.4 -2.4 2.5 -1.6 3.1 1.9
Hand grip strength (right) 0.3 0.7 2.8 1.0 -1.0 0.0 0.0 -0.8 0.6 -0.1 1.0 -0.8 0.3 1.3 -0.1 -1.3 0.0 -0.6 -1.7
Townsend deprivation index at recruitment 0.8 1.2 5.2 1.3 -1.2 0.0 0.0 1.2 1.1 -2.3 1.1 1.2 -0.2 1.0 0.5 -1.1 0.4 -0.8 -1.3
Current tobacco smoking 0.9 1.5 2.6 1.5 -1.3 0.0 0.0 1.5 1.6 -0.5 1.5 1.3 -0.5 1.1 1.4 -1.3 1.2 -1.6 -1.3
Average weekly fortified wine intake 0.5 0.6 3.0 -0.8 0.6 0.0 0.0 -0.9 -0.3 0.9 -0.4 0.6 -1.2 -0.5 -0.5 0.7 0.2 0.4 1.7
Maternal smoking around birth 0.3 0.5 2.4 0.3 -0.2 0.0 0.0 -0.9 0.5 -0.2 0.4 1.4 -1.6 0.3 0.3 -0.1 1.1 -0.5 0.3
Fed-up feelings 0.7 1.4 4.2 1.1 -1.4 0.0 0.0 1.2 1.2 -0.2 1.3 2.0 0.2 0.4 1.1 -1.0 2.1 -1.6 -0.8
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.1 0.9 -0.1 0.1 0.0 0.0 -0.6 0.1 -1.0 -0.1 -0.3 -0.1 -0.7 -0.4 0.1 -0.4 0.1 -0.2
Relative age voice broke 0.2 0.4 1.9 -0.3 0.3 0.0 0.0 -0.9 -0.5 0.8 -0.4 0.6 0.8 -0.5 -1.4 0.2 -0.4 0.3 -0.6
Taking other prescription medications 0.6 0.9 5.7 -0.2 0.4 0.0 0.0 2.4 -0.6 1.4 -0.8 -0.3 1.2 -0.9 -0.1 0.8 1.4 -0.1 -0.1
Age when periods started (menarche) 0.2 0.4 2.5 -0.7 0.5 0.0 0.0 1.6 -0.7 0.9 -0.6 -0.1 -0.1 -0.7 -0.8 0.7 0.9 0.2 0.3
Bilateral oophorectomy (both ovaries removed) 2.5 2.9 6.5 2.5 -2.2 0.0 0.0 1.2 2.2 -1.3 2.4 -0.8 -0.2 1.9 1.8 -2.1 0.3 -2.2 -2.2
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.4 1.6 1.0 -0.3 0.0 0.0 -0.7 0.6 0.4 0.7 -0.7 -0.8 0.2 0.2 -1.3 0.2 -0.1 -0.6
Tinnitus: Yes, but not now, but have in the past 0.6 0.6 5.4 -0.8 0.2 0.0 0.0 -0.3 0.1 -1.1 -0.4 -2.3 -1.1 -0.5 0.1 0.7 0.1 0.1 -0.6
Qualifications: CSEs or equivalent 0.2 0.3 0.7 -0.3 0.7 0.0 0.0 -0.2 -0.7 0.6 -0.6 0.0 -0.8 -0.7 0.0 0.6 0.7 0.5 0.5
Serious illness, injury or assault to yourself 1.0 1.2 4.2 1.3 -1.1 0.0 0.0 1.5 1.4 -1.0 1.5 1.0 -1.0 0.4 0.4 -1.1 0.2 -1.3 -2.0
High blood pressure 0.1 0.4 1.9 0.0 -0.1 0.0 0.0 1.2 -0.1 1.4 -0.1 -0.9 0.4 0.3 -0.2 0.3 0.7 -0.2 -1.1
Hayfever, allergic rhinitis or eczema 0.5 1.0 5.8 -1.1 1.0 0.0 0.0 -1.1 -0.8 0.0 -0.9 -0.9 -2.4 -0.7 -1.4 1.3 -0.5 0.6 -0.1
Multivitamins +/- minerals 1.0 1.2 2.4 1.0 -1.2 0.0 0.0 -0.2 1.4 -0.6 1.3 1.5 -0.8 1.6 1.5 -1.3 1.3 -1.4 0.5
Stomach or abdominal pain in last month 0.5 0.6 4.2 0.3 -0.6 0.0 0.0 1.5 0.7 -0.2 0.4 -2.0 -0.2 0.1 1.3 0.2 0.2 -0.7 -0.6
Supplements: Glucosamine 0.1 0.2 1.4 0.1 -0.1 0.0 0.0 -0.7 0.1 -0.5 0.0 -1.2 0.5 -0.5 -0.1 -0.3 0.4 -0.2 -0.1
Diverticular disease/diverticulitis (self-reported) 1.3 1.5 4.7 0.9 -1.0 0.0 0.0 2.0 1.3 0.7 1.1 -1.3 -1.8 1.2 1.5 -0.8 2.2 -1.1 0.0
Medication: Atenolol 0.5 0.6 3.1 -0.7 0.1 0.0 0.0 -0.3 -0.4 1.5 -0.6 0.1 0.1 -0.2 0.6 0.5 1.8 0.6 1.4
Medication: Levothyroxine sodium 1.4 2.3 5.4 2.3 -1.9 0.0 0.0 0.9 1.7 -2.1 2.1 -0.0 -0.4 1.2 1.3 -2.0 1.6 -1.6 -1.9
Sitting height 0.6 4.4 10.7 2.0 -2.6 0.0 0.0 1.0 2.8 -1.9 2.8 1.7 -2.2 3.3 1.4 -2.0 0.1 -2.5 -2.8
Chronic bronchitis/emphysema (father) 1.4 1.6 3.8 -1.3 1.2 0.0 0.0 -0.5 -1.7 0.9 -1.6 -1.7 1.2 -1.6 -1.9 1.2 -1.1 1.3 1.3
High blood pressure (mother) 0.3 0.5 2.8 0.7 -0.7 0.0 0.0 -0.4 0.9 -0.3 0.6 -1.7 -0.3 0.3 0.3 -0.6 0.2 -0.9 -0.9
Body mass index (BMI) 0.2 0.7 2.1 -0.8 1.0 0.0 0.0 0.1 -0.9 1.4 -1.0 -0.9 1.2 -1.5 -0.5 0.5 -0.7 0.9 0.3
Impedance of leg (left) 0.4 2.2 5.2 -1.9 1.7 0.0 0.0 -2.1 -1.8 0.7 -1.6 1.1 -0.5 -1.1 -1.3 1.9 -0.3 2.3 2.0
Leg predicted mass (left) 0.9 4.6 11.0 2.9 -2.7 0.0 0.0 1.8 2.8 -1.1 2.9 0.1 -0.4 2.2 1.7 -3.0 1.1 -3.0 -3.3
Trunk fat mass 0.2 1.1 3.2 -1.0 1.3 0.0 0.0 -1.0 -1.1 1.8 -1.0 0.6 0.7 -1.8 -1.0 0.9 -0.5 1.3 0.5
Waist circumference 0.1 0.3 1.5 -0.0 0.4 0.0 0.0 0.3 -0.0 1.2 -0.1 0.0 1.1 -1.2 -0.2 -0.2 -0.1 0.2 -0.7
Number of incorrect matches in round 1.3 2.2 6.1 1.2 -1.2 0.0 0.0 2.1 1.3 -0.1 0.9 2.5 -1.0 1.8 2.4 -0.9 2.4 -1.6 -0.3
Past tobacco smoking 0.2 0.4 5.2 0.3 -0.3 0.0 0.0 2.3 -0.0 0.8 0.1 -0.4 -0.4 0.2 0.2 -0.1 0.1 -0.4 -0.0
Alcohol usually taken with meals 0.5 0.8 3.0 0.8 -0.7 0.0 0.0 -0.6 0.9 -0.3 1.1 -1.1 -1.7 1.2 1.2 -1.0 -0.0 -1.0 -0.1
Nervous feelings 1.5 2.8 9.5 2.3 -1.8 0.0 0.0 0.4 1.9 0.9 1.8 1.3 -0.0 1.6 2.7 -1.8 3.1 -1.9 -0.5
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.4 4.3 1.2 -1.3 0.0 0.0 -0.4 1.5 -0.6 1.4 0.9 -1.7 1.1 0.9 -1.2 2.1 -1.5 -0.7
Hearing difficulty/problems with background noise 0.3 0.4 2.6 0.5 -0.2 0.0 0.0 1.3 0.6 0.1 0.4 -1.6 -0.6 0.4 1.1 -0.2 -0.2 -0.1 -0.1
Hair/balding pattern: Pattern 2 2.8 3.6 6.5 -2.4 2.3 0.0 0.0 -2.1 -2.1 1.3 -2.3 -1.1 -0.7 -2.6 -1.8 2.5 -2.2 2.2 1.9
Had menopause 0.7 0.9 2.9 -1.3 0.7 0.0 0.0 0.3 -1.3 -0.6 -1.1 1.2 0.8 -0.4 -1.1 1.2 -0.8 0.9 1.7
Had other major operations 3.5 4.3 10.0 2.6 -2.7 0.0 0.0 1.7 2.5 -2.3 2.8 0.5 -1.0 2.2 1.2 -2.1 1.7 -2.6 -3.2
Forced vital capacity (FVC) 0.6 2.5 6.2 1.7 -1.8 0.0 0.0 -0.5 2.1 -2.2 2.0 0.4 -0.5 2.3 0.3 -2.3 -0.3 -1.7 -2.5
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.3 1.3 1.0 -0.3 0.0 0.0 -1.1 0.5 0.7 0.7 -0.2 0.1 0.0 0.2 -1.1 -0.1 0.0 -0.3
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 2.7 -0.1 0.1 0.0 0.0 -1.0 -0.3 0.3 -0.3 -1.6 1.3 -0.1 -0.3 -0.1 -0.5 0.2 0.2
Qualifications: None of the above 0.4 0.8 1.7 -1.3 1.1 0.0 0.0 0.9 -1.1 0.1 -1.3 0.9 -0.2 -0.9 -0.4 1.3 0.2 1.1 1.0
Financial difficulties in last 2 years 3.3 4.4 10.6 2.9 -2.6 0.0 0.0 0.9 3.1 -2.0 2.6 -0.1 -1.6 1.7 1.7 -2.9 0.3 -2.4 -3.2
Mouth/teeth dental problems 0.3 0.5 2.2 -0.0 -0.0 0.0 0.0 -1.0 -0.1 -1.1 -0.1 -0.9 0.1 0.3 -1.3 -0.2 -1.5 0.3 -0.7
Heart attack 0.3 0.4 1.6 -0.7 0.7 0.0 0.0 0.2 -0.8 0.8 -0.6 -0.3 0.5 -1.3 -0.7 0.4 0.2 1.0 0.4
Allergy 0.1 0.3 3.4 0.4 -0.2 0.0 0.0 -0.4 0.1 -0.2 0.3 0.7 1.8 0.0 0.4 -0.6 -0.2 0.2 0.7
Pain all over the body in last month 0.7 0.8 4.1 0.2 0.2 0.0 0.0 -1.1 0.3 -2.0 0.2 -0.9 -1.4 -0.2 -0.1 0.2 -1.7 0.3 -0.8
Diabetes (self-reported) 0.2 0.4 2.0 0.2 -0.5 0.0 0.0 0.5 0.4 -1.2 0.3 -1.2 -0.2 -0.1 -0.1 -0.2 0.0 -0.5 -1.4
Hayfever/allergic rhinitis (self-reported) 0.6 0.8 1.8 1.1 -1.0 0.0 0.0 0.8 0.6 -0.1 0.9 1.1 -0.3 1.3 -0.0 -0.9 1.3 -1.2 -1.4
Medication: Ramipril 0.8 1.0 3.1 1.3 -0.8 0.0 0.0 0.6 0.9 1.1 1.1 1.6 -1.0 0.2 0.9 -1.0 1.8 -0.8 -0.9
Medication: Simvastatin 0.3 0.4 2.1 -0.4 0.2 0.0 0.0 0.5 -0.2 0.9 -0.4 1.2 -1.5 -0.1 0.5 0.5 1.1 -0.2 0.6
Fluid intelligence score 1.0 2.2 4.5 -2.1 1.5 0.0 0.0 -1.8 -1.9 0.9 -1.7 -1.8 0.8 -1.0 -1.5 1.6 -1.2 2.0 1.4
Illnesses of siblings 0.4 0.5 3.1 -0.5 0.3 0.0 0.0 -1.2 -0.2 -1.8 -0.3 1.0 -1.1 -0.1 -0.6 0.3 -0.7 0.3 -0.4
Neuroticism score 1.7 3.5 9.1 2.1 -2.3 0.0 0.0 0.7 2.4 -0.7 2.1 1.3 -1.3 1.9 2.8 -1.7 3.0 -2.6 -1.4
Weight 0.2 1.0 2.7 1.2 -1.2 0.0 0.0 0.8 1.2 0.1 1.3 0.5 0.3 0.7 1.0 -1.5 0.7 -1.2 -1.6
Impedance of arm (right) 1.4 6.7 12.3 -3.1 3.5 0.0 0.0 -3.0 -3.0 0.9 -3.0 0.3 -0.1 -3.3 -3.2 3.3 -2.5 3.5 2.4
Arm fat percentage (right) 1.3 5.1 13.0 -2.6 3.1 0.0 0.0 -1.6 -2.6 2.2 -2.8 -0.6 1.3 -3.6 -2.3 2.5 -2.2 3.0 1.7
Trunk fat-free mass 2.7 15.3 29.6 5.0 -5.1 0.0 0.0 3.2 5.0 -2.6 5.2 0.9 -0.5 4.7 3.8 -5.1 2.7 -5.4 -4.8
Hip circumference 0.1 0.4 1.1 0.6 -0.6 0.0 0.0 0.5 0.5 1.1 0.6 -0.2 0.4 0.1 0.4 -1.0 0.6 -0.5 -1.1
Time employed in main current job 2.0 2.3 6.7 -1.4 1.9 0.0 0.0 -1.3 -1.7 2.2 -1.8 -0.3 0.7 -1.7 -0.5 1.5 -1.3 1.9 2.6
Alcohol intake versus 10 years previously 0.1 0.2 0.8 0.4 0.0 0.0 0.0 -0.2 0.2 0.8 0.0 0.8 0.5 -0.2 -0.6 -0.2 -0.2 0.1 -0.9
Father’s age at death 0.3 0.4 3.6 0.2 -0.2 0.0 0.0 -1.9 0.3 0.5 0.4 0.2 -0.5 0.2 0.9 -0.4 1.1 -0.2 0.6
Worrier / anxious feelings 0.2 0.4 2.2 0.5 -0.2 0.0 0.0 -0.3 0.3 0.8 0.1 0.1 -0.9 0.5 1.0 0.1 1.5 -0.3 1.3
Frequency of tiredness / lethargy in last 2 weeks 1.1 1.7 4.3 1.6 -1.4 0.0 0.0 0.9 2.1 -1.6 1.8 -0.8 -1.9 0.2 1.4 -1.1 0.4 -1.8 -1.4
Falls in the last year 0.5 0.6 2.8 -1.0 1.0 0.0 0.0 -1.2 -0.4 0.5 -0.7 -1.7 -0.5 -1.1 -0.5 0.5 -0.6 0.7 0.4
Hair/balding pattern: Pattern 3 0.7 1.1 3.0 1.5 -1.2 0.0 0.0 1.6 1.0 0.3 1.2 -1.1 1.2 1.2 0.5 -1.7 0.6 -0.8 -0.9
Number of live births 0.2 0.4 2.1 -0.1 0.3 0.0 0.0 -0.4 -0.4 0.5 -0.4 0.0 -1.1 -0.3 0.7 0.7 0.1 0.6 1.5
Forced expiratory volume in 1-second (FEV1) 0.3 1.0 2.5 0.8 -0.9 0.0 0.0 -1.5 1.2 -1.1 1.2 -0.2 -1.0 1.6 0.0 -1.3 -0.5 -0.7 -1.4
Pulse rate 0.3 0.6 3.4 -0.1 0.0 0.0 0.0 1.8 -0.6 0.4 -0.1 1.7 0.6 -0.7 -0.3 0.6 -0.0 0.4 1.0
Happiness 1.5 1.8 3.7 1.1 -1.8 0.0 0.0 1.9 1.3 -1.7 1.2 -0.6 0.3 1.9 1.1 -1.7 1.8 -1.7 -0.8
Noisy workplace 0.3 0.4 1.4 -0.7 0.6 0.0 0.0 0.5 -0.6 0.6 -0.8 0.9 0.7 -0.7 -1.2 0.7 0.4 0.3 -0.5
Qualifications: A levels/AS levels or equivalent 0.3 0.6 2.9 -0.4 0.5 0.0 0.0 -1.2 -0.4 -0.9 -0.3 -1.2 -0.3 -0.7 -1.5 0.2 -1.7 0.6 -0.4
Serious illness, injury or assault of a close relative in last 2 years 1.1 1.3 5.7 0.7 -0.4 0.0 0.0 -1.6 1.0 -2.2 0.8 -1.4 -2.4 0.6 0.1 -0.5 -0.9 -0.6 -1.3
Mouth/teeth dental problems: Dentures 0.2 0.3 1.6 0.0 0.6 0.0 0.0 0.0 -0.5 0.8 -0.5 -0.3 0.7 -1.3 -0.3 0.4 -0.3 0.5 -0.6
Asthma 0.3 0.5 2.5 -0.5 0.5 0.0 0.0 1.6 -0.8 0.8 -1.0 -1.1 1.0 -0.4 -0.1 0.8 0.1 0.3 0.1
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.3 2.1 -0.0 0.3 0.0 0.0 -1.4 -0.1 -0.1 -0.3 -1.2 -0.3 -0.5 0.5 0.2 -0.1 0.8 0.4
Medication: Cholesterol lowering 0.1 0.2 0.9 0.3 0.4 0.0 0.0 -0.1 0.0 0.9 -0.2 0.6 -0.1 -0.8 0.3 -0.1 0.3 0.1 0.2
Depression (self-reported) 1.9 2.2 5.5 2.3 -1.7 0.0 0.0 1.3 1.8 -1.5 1.8 -1.4 -0.5 1.6 1.2 -2.3 1.0 -1.9 -1.0
Medication: Lansoprazole 1.0 1.1 3.7 -0.6 1.1 0.0 0.0 0.2 -1.0 1.9 -1.0 0.2 1.9 -1.8 -1.1 0.7 -0.9 1.1 0.6
Prospective memory result 2.1 2.6 9.1 0.9 -1.2 0.0 0.0 3.0 1.3 -1.4 1.3 2.4 -1.7 1.3 2.1 -0.4 2.7 -1.5 0.4
Lung cancer (father) 0.8 0.9 7.4 0.7 -0.8 0.0 0.0 2.7 0.4 0.7 0.6 0.2 1.2 1.2 0.8 -0.8 0.3 -0.7 -0.3
Illnesses of mother 0.4 0.5 1.3 -0.9 0.9 0.0 0.0 -1.1 -0.6 0.5 -0.5 1.1 -0.1 -0.7 -0.4 0.6 -0.7 0.9 0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.2 2.9 1.0 -0.9 0.0 0.0 -1.0 1.4 -1.4 1.3 0.3 -1.5 1.7 0.2 -1.3 -0.4 -0.7 -1.6
Pulse wave Arterial Stiffness index 0.8 1.0 2.2 1.2 -1.2 0.0 0.0 0.3 1.2 -0.9 1.3 1.0 -0.0 1.5 1.1 -1.1 1.1 -1.4 -0.0
Impedance of arm (left) 1.7 7.7 14.1 -3.4 3.7 0.0 0.0 -3.1 -3.4 1.6 -3.3 0.2 0.0 -3.4 -3.4 3.6 -2.2 3.8 2.9
Arm fat mass (right) 0.2 0.8 2.2 -0.9 1.1 0.0 0.0 -0.4 -0.9 1.4 -1.0 -0.1 0.9 -1.5 -1.0 0.7 -0.8 0.9 0.1
Trunk predicted mass 2.7 15.4 30.2 5.0 -5.1 0.0 0.0 3.2 5.0 -2.7 5.2 1.0 -0.5 4.7 3.8 -5.1 2.7 -5.5 -4.9
Standing height 1.3 13.2 26.8 4.5 -4.7 0.0 0.0 1.3 4.6 -2.6 5.2 2.9 -1.6 4.7 3.1 -4.5 2.9 -4.7 -4.3
Length of working week for main job 2.2 2.4 4.4 1.9 -1.9 0.0 0.0 0.9 2.0 -1.4 2.0 1.0 -0.7 1.9 1.7 -1.9 1.7 -2.1 -1.4
Exposure to tobacco smoke at home 0.5 0.6 1.8 1.3 -1.0 0.0 0.0 0.2 0.8 0.0 1.0 0.7 -0.3 0.5 0.1 -1.3 0.7 -0.5 -1.4
Breastfed as a baby 0.9 1.1 2.7 1.5 -1.0 0.0 0.0 1.0 1.1 -1.7 1.1 0.6 0.2 1.1 1.4 -1.1 0.9 -0.8 -1.1
Tense / ‘highly strung’ 0.8 1.4 4.5 0.9 -0.7 0.0 0.0 2.1 0.9 0.6 0.7 2.1 -0.7 0.8 1.8 -0.7 2.0 -1.2 0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 4.0 6.1 10.6 3.1 -2.9 0.0 0.0 1.9 3.1 -1.7 3.0 -0.4 -2.8 3.3 2.8 -2.8 2.6 -3.1 -1.6
Hair/balding pattern: Pattern 4 0.9 2.2 10.3 -1.5 1.6 0.0 0.0 -0.2 -1.4 1.8 -1.4 1.8 -1.1 -0.9 1.4 1.7 1.2 1.3 3.2
Birth weight of first child 0.3 0.5 1.9 0.1 0.2 0.0 0.0 -1.3 0.2 -1.4 0.1 1.0 0.5 -0.8 -1.0 -0.2 -1.3 0.0 -0.6
Peak expiratory flow (PEF) 0.1 0.2 0.8 -0.4 -0.0 0.0 0.0 -0.9 0.1 0.9 0.1 -0.0 -0.2 0.8 -0.1 -0.0 -0.5 0.3 0.0
Pulse wave reflection index 0.1 0.2 0.9 0.3 0.1 0.0 0.0 -0.7 0.2 -0.7 0.2 -0.0 -0.4 1.0 0.1 -0.4 0.3 -0.2 -0.3
Ever highly irritable/argumentative for 2 days 1.0 1.2 6.4 -0.8 0.7 0.0 0.0 -1.9 -0.4 1.6 -0.6 -0.8 -2.5 -1.0 0.6 1.0 1.1 0.3 0.7
Loud music exposure frequency 0.5 0.5 2.3 -0.2 -0.0 0.0 0.0 -1.3 0.3 -1.5 0.2 1.2 -1.0 1.1 0.4 0.1 0.0 -0.0 -0.7
Qualifications: O levels/GCSEs or equivalent 0.6 0.9 3.3 1.4 -1.2 0.0 0.0 1.0 0.9 -0.8 1.1 -0.7 0.1 0.8 -0.7 -1.8 0.1 -0.8 -1.4
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 2.0 0.5 -0.7 0.0 0.0 0.0 0.8 -1.1 0.8 0.6 -1.4 0.5 0.9 -0.6 0.6 -0.3 0.1
Blood clot in the leg (DVT) 0.5 0.6 1.7 0.6 -0.6 0.0 0.0 1.3 0.8 -0.9 0.6 -0.3 -1.0 1.0 1.1 -0.3 0.1 -0.9 -1.1
Medication: Paracetamol 0.4 0.6 1.5 -1.0 0.9 0.0 0.0 -1.2 -0.5 -0.5 -1.0 -0.5 -0.5 -1.1 -0.6 1.2 -0.7 0.4 0.4
Headache pain in last month 0.5 0.8 2.4 -1.3 0.8 0.0 0.0 -0.6 -0.6 0.9 -0.9 -1.5 -1.4 -1.0 0.1 1.6 0.7 0.3 0.5
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 1.1 -0.8 0.2 0.0 0.0 -0.4 -0.6 -1.0 -0.3 -0.7 -0.1 -0.2 -1.0 0.5 -0.9 0.6 -0.1
Glaucoma (self-reported) 0.6 0.7 3.6 -0.9 0.8 0.0 0.0 -0.6 -0.8 1.9 -0.8 0.0 -0.7 -0.2 -0.0 1.2 0.4 0.6 1.3
Gout (self-reported) 0.1 0.1 0.7 -0.3 0.3 0.0 0.0 -0.8 -0.3 0.5 -0.4 -0.2 0.6 0.0 -0.3 -0.1 -0.4 0.6 0.0
Hypothyroidism/myxoedema (self-reported) 0.4 0.9 2.3 1.3 -1.1 0.0 0.0 0.8 0.9 -1.5 1.2 0.1 0.7 0.3 0.5 -1.3 1.5 -0.8 -0.6
Medication: Amlodipine 0.3 0.4 2.3 0.3 -0.2 0.0 0.0 1.5 0.0 0.9 -0.1 0.6 1.2 0.3 0.4 -0.1 0.7 -0.2 -0.0
Medication: Ventolin 100micrograms inhaler 0.4 0.5 2.3 0.4 -0.6 0.0 0.0 -0.1 0.4 0.2 0.5 -0.6 0.2 1.0 1.2 -0.3 1.5 -1.0 0.2
Birth weight 0.3 0.6 5.2 -0.1 -0.5 0.0 0.0 2.3 0.2 -0.3 0.4 1.1 0.7 0.7 0.2 0.1 0.3 -0.5 -1.2
Chronic bronchitis/emphysema (mother) 0.3 0.4 1.3 -0.7 0.9 0.0 0.0 -0.2 -0.7 0.3 -0.7 0.3 -0.6 -1.1 -0.7 0.8 0.4 0.5 0.5
High blood pressure (siblings) 0.4 0.6 1.7 1.1 -0.6 0.0 0.0 1.3 1.0 0.9 0.7 -1.2 0.5 0.6 0.6 -1.0 0.8 -0.7 -0.4
Forced vital capacity (FVC), Best measure 0.9 3.3 8.2 2.1 -2.1 0.0 0.0 0.0 2.4 -2.5 2.4 0.5 -1.0 2.6 0.5 -2.5 -0.2 -2.0 -2.9
Body fat percentage 1.0 4.0 9.8 -2.4 2.7 0.0 0.0 -1.5 -2.4 2.4 -2.4 -0.2 1.2 -3.1 -2.0 2.2 -1.3 2.8 1.6
Leg fat percentage (right) 0.7 2.4 5.3 -2.0 2.1 0.0 0.0 -1.0 -1.9 1.7 -2.1 -0.6 0.9 -2.3 -1.0 1.8 -0.7 2.2 1.5
Arm fat-free mass (right) 1.9 9.9 18.6 4.0 -4.2 0.0 0.0 2.8 3.9 -1.7 4.2 1.1 -0.1 3.8 2.9 -4.2 2.4 -4.3 -4.0
Exposure to tobacco smoke outside home 0.6 0.8 2.4 1.1 -0.9 0.0 0.0 0.9 0.9 -1.2 1.1 0.4 -0.5 0.3 -0.1 -1.2 1.6 -1.0 -1.0
Comparative body size at age 10 0.1 0.4 1.1 0.8 -0.5 0.0 0.0 -0.9 0.7 -1.0 0.8 -0.1 0.4 0.2 0.3 -1.1 -0.9 0.1 -0.7
Number of full brothers 0.3 0.4 3.2 0.2 0.1 0.0 0.0 1.0 -0.2 1.1 -0.2 0.5 1.8 -0.1 0.4 -0.1 0.3 0.4 0.1
Worry too long after embarrassment 1.7 2.9 6.2 2.1 -2.1 0.0 0.0 0.1 2.4 -0.4 2.1 1.2 0.3 1.4 2.3 -1.9 2.2 -2.5 -1.8
Seen a psychiatrist for nerves, anxiety, tension or depression 4.1 5.3 10.1 3.2 -2.9 0.0 0.0 2.2 2.8 -2.5 2.7 -0.3 -1.0 2.4 2.3 -2.7 2.7 -3.0 -2.1
Wheeze or whistling in the chest in last year 0.1 0.2 1.3 -0.0 0.1 0.0 0.0 0.5 0.1 0.1 -0.1 -1.1 -0.3 -0.8 0.3 0.2 0.5 -0.3 -1.0
Number of children fathered 0.4 0.4 1.8 0.5 -0.4 0.0 0.0 -0.4 0.8 -0.5 0.6 -0.8 -0.1 -0.2 1.1 -0.6 0.6 -0.4 -1.3
Reason for reducing amount of alcohol drunk: Health precaution 2.6 3.1 10.2 -1.8 2.2 0.0 0.0 -3.2 -1.8 0.2 -2.0 -0.1 -0.2 -2.0 -2.0 1.7 -2.3 2.4 1.1
Age at first live birth 0.3 0.5 2.9 0.7 -0.3 0.0 0.0 -0.8 0.5 -0.5 0.5 -1.6 -1.7 0.1 -0.0 -0.4 -0.8 -0.4 -0.5
Pulse wave peak to peak time 0.6 0.8 1.8 -1.2 1.0 0.0 0.0 -0.4 -1.0 0.8 -1.2 -0.9 0.0 -1.3 -0.9 1.0 -0.9 1.1 -0.0
Health satisfaction 0.6 0.8 2.2 0.7 -0.9 0.0 0.0 1.1 1.1 -0.7 0.8 0.4 -1.3 0.3 1.2 -0.6 1.5 -1.1 -0.6
Shortness of breath walking on level ground 0.5 0.6 2.4 0.7 -0.8 0.0 0.0 1.3 0.4 0.9 0.6 1.1 0.0 0.6 1.0 -0.7 1.6 -0.7 0.6
Qualifications: College or University degree 0.3 1.0 6.0 0.3 -0.3 0.0 0.0 -2.5 0.6 -0.8 0.5 -2.0 -1.1 0.5 -0.4 -0.4 -1.1 -0.0 -1.0
Eye problems/disorders: None of the above 1.2 1.4 3.1 1.2 -1.4 0.0 0.0 -0.9 1.4 -0.3 1.5 1.7 -0.3 1.3 1.5 -1.5 1.7 -1.0 -0.7
Mouth/teeth dental problems: Loose teeth 1.2 1.4 5.9 0.5 -0.7 0.0 0.0 0.6 1.0 1.1 0.7 2.4 -1.6 0.5 2.0 -0.1 2.1 -1.3 0.2
Emphysema/chronic bronchitis 0.3 0.4 4.2 0.3 -0.3 0.0 0.0 2.0 0.2 -0.4 0.2 -0.5 -0.0 0.3 -0.1 -0.3 0.1 -0.5 -0.7
Medication for pain relief, constipation, heartburn 0.4 0.8 1.9 1.2 -1.1 0.0 0.0 0.1 1.0 -1.0 1.3 0.2 -0.5 1.4 0.8 -1.3 0.0 -0.9 -0.7
Neck or shoulder pain in last month 0.4 0.5 1.5 -0.9 1.1 0.0 0.0 -0.2 -0.6 -0.4 -1.1 0.3 -0.9 -1.2 -0.8 1.2 -0.0 0.4 -0.2
Medication: Blood pressure 0.2 0.3 3.1 0.2 0.3 0.0 0.0 0.2 0.0 1.8 -0.2 0.8 0.7 -0.0 0.3 0.1 0.7 -0.0 0.1
Angina (self-reported) 0.8 1.1 3.2 -1.2 1.3 0.0 0.0 -0.6 -1.2 1.5 -1.0 1.1 0.0 -1.0 -0.2 0.9 0.6 1.5 1.8
Migraine (self-reported) 1.2 1.5 5.8 1.0 -1.7 0.0 0.0 1.2 1.1 -0.3 1.0 -0.3 0.4 1.9 1.2 -1.0 2.4 -1.8 -0.9
Medication: Ibuprofen 0.3 0.3 2.8 0.2 0.1 0.0 0.0 -1.7 0.2 -0.3 -0.0 -1.1 -0.2 -0.1 0.9 -0.2 -0.0 0.5 0.1
Medication: Allopurinol 0.4 0.6 1.6 0.8 -0.9 0.0 0.0 1.2 0.6 -0.6 0.8 0.5 1.0 0.8 0.5 -1.3 0.4 -0.4 -1.1
Medication: Omeprazole 0.6 0.7 2.6 -1.3 0.8 0.0 0.0 -0.2 -0.6 0.1 -1.0 -1.6 -0.5 -0.8 -0.9 1.4 -0.9 0.8 -0.3
Medication: Seretide 50 evohaler 0.2 0.3 2.2 -0.5 0.4 0.0 0.0 -0.1 -0.3 0.1 -0.5 -1.5 0.7 -0.3 -0.3 0.7 -0.2 -0.1 -0.2
Mean time to correctly identify matches 0.4 0.7 5.1 0.3 -0.1 0.0 0.0 1.3 0.2 0.1 0.2 2.3 0.6 0.6 0.9 0.0 1.3 -0.8 0.5
Heart disease (mother) 0.5 0.6 5.2 0.6 -0.5 0.0 0.0 -0.9 0.2 -0.4 0.1 -2.3 1.1 -0.3 -0.4 -0.8 -0.5 0.2 -0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.9 1.1 2.9 1.0 -1.1 0.0 0.0 1.3 1.3 -1.6 1.0 -0.9 -0.6 0.8 0.6 -1.0 0.1 -1.7 -1.4
Whole body fat mass 0.1 0.5 2.4 -0.7 0.9 0.0 0.0 -0.4 -0.7 1.6 -0.6 0.5 0.6 -1.3 -0.5 0.5 -0.1 0.9 0.2
Leg fat mass (right) 0.1 0.2 1.0 -0.5 0.5 0.0 0.0 -0.0 -0.4 1.0 -0.5 -0.1 0.6 -0.8 0.0 0.3 0.0 0.6 -0.1
Arm predicted mass (right) 2.1 10.5 19.5 4.1 -4.4 0.0 0.0 2.9 4.0 -1.6 4.3 1.1 -0.4 3.9 2.9 -4.3 2.7 -4.4 -4.1
Pulse rate, automated reading 0.3 1.0 4.1 -0.4 0.2 0.0 0.0 2.0 -0.6 -0.6 -0.3 -0.4 1.2 -0.8 -2.0 0.6 -1.6 0.2 -1.6
Alcohol intake frequency. 1.9 4.4 13.6 2.2 -2.2 0.0 0.0 3.7 2.2 0.2 2.0 1.0 -1.9 2.2 3.1 -1.6 2.9 -2.6 -1.0
Comparative height size at age 10 1.2 6.3 12.9 2.8 -3.2 0.0 0.0 2.2 2.8 -2.4 3.3 2.6 -0.6 3.6 1.8 -2.9 1.9 -3.2 -2.9
Number of full sisters 0.5 0.7 1.8 1.3 -0.8 0.0 0.0 0.7 1.0 -0.4 1.1 0.2 0.2 -0.0 0.5 -1.0 1.4 -0.9 -1.2
Suffer from ‘nerves’ 1.2 1.9 6.7 1.7 -1.3 0.0 0.0 -0.2 1.6 0.4 1.4 1.3 -1.4 1.2 2.6 -1.2 2.1 -1.7 -0.2
Overall health rating 0.5 1.2 4.0 0.7 -0.6 0.0 0.0 1.1 1.2 0.2 0.8 1.3 -1.9 -0.4 1.5 -0.4 2.0 -1.5 -0.6
Chest pain or discomfort 0.7 0.9 3.5 0.8 -0.8 0.0 0.0 1.9 1.3 -0.7 1.0 -0.7 -1.0 0.3 1.9 -0.6 0.8 -1.1 -0.3
Had major operations 0.4 0.5 3.2 0.3 -0.2 0.0 0.0 -0.2 0.8 -0.3 0.8 0.0 -1.8 -0.5 0.3 -0.1 1.2 -0.7 -0.6
Age at last live birth 1.0 1.5 7.4 1.5 -1.0 0.0 0.0 -0.5 1.3 -1.2 1.2 -1.6 -2.7 1.2 0.8 -0.9 0.2 -1.1 -1.2
Family relationship satisfaction 0.3 0.4 3.1 -0.2 -0.2 0.0 0.0 1.0 0.3 -0.8 -0.0 -1.8 0.3 -0.0 -0.5 0.0 -0.8 -0.4 -0.5
Leg pain on walking 0.5 0.7 3.7 -0.7 0.2 0.0 0.0 1.8 -0.4 0.5 -0.5 1.0 -0.5 -0.8 -0.2 0.6 1.9 -0.2 0.1
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.4 1.1 0.6 -0.6 0.0 0.0 -0.3 0.6 -0.8 0.5 0.9 -0.5 0.5 1.1 -0.4 0.9 -0.3 -0.6
Commuting to job workplace: Car/motor vehicle 1.3 1.5 8.2 -1.3 1.3 0.0 0.0 -2.9 -0.9 1.4 -1.3 0.1 -0.1 -1.2 0.2 1.1 -1.1 1.2 1.6
Illness, injury, bereavement, stress in last 2 years 0.9 1.2 2.6 -1.2 0.8 0.0 0.0 0.6 -1.6 1.4 -1.4 1.5 1.4 -0.3 -0.9 1.1 0.8 0.9 1.3
Medication: Aspirin 0.5 0.6 1.9 -0.9 0.7 0.0 0.0 1.2 -0.9 1.4 -0.9 0.2 0.6 -0.9 -0.3 1.0 0.9 0.3 0.4
Supplements: Vitamin C 1.7 2.1 9.5 1.3 -1.4 0.0 0.0 0.6 1.7 -3.1 1.6 -0.8 -1.8 1.4 0.9 -1.4 0.2 -1.2 -2.0
Knee pain experienced in last month 0.1 0.2 1.6 0.0 0.3 0.0 0.0 0.6 -0.1 0.1 -0.2 -0.2 0.7 -1.3 0.4 -0.1 0.5 -0.0 -0.4
Hypertension (Self-reported) 0.2 0.5 2.8 -0.2 0.3 0.0 0.0 1.2 -0.4 1.7 -0.5 -0.8 0.9 -0.1 -0.1 0.5 0.8 0.1 -0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 4.6 -0.8 0.6 0.0 0.0 0.7 -0.6 0.9 -0.8 0.8 2.2 -0.7 -1.0 0.6 -0.7 0.3 0.2
Illnesses of father: Heart disease 0.3 0.4 3.2 -0.0 0.2 0.0 0.0 0.3 -0.4 0.5 -0.4 0.2 -0.9 0.1 0.7 0.5 0.0 0.4 1.8
Illnesses of siblings: Diabetes 0.3 0.3 1.5 -0.5 0.7 0.0 0.0 0.2 -0.7 0.7 -0.8 -0.4 0.3 -1.2 -0.7 0.7 -0.0 0.4 -0.2
Smoking status: Previous 0.4 0.6 7.2 -0.3 0.4 0.0 0.0 -2.7 -0.1 -0.7 -0.2 -0.0 0.6 -0.2 -0.3 0.0 -0.3 0.5 0.5
Forced expiratory volume in 1-second (FEV1), predicted 2.2 4.5 9.3 2.7 -2.7 0.0 0.0 0.3 2.6 -2.0 3.0 0.3 -1.4 2.7 1.2 -2.5 1.6 -2.9 -3.0
Whole body fat-free mass 1.9 10.8 20.9 4.3 -4.3 0.0 0.0 2.7 4.2 -2.1 4.4 0.8 -0.4 3.8 3.1 -4.4 2.2 -4.6 -4.4
Leg fat-free mass (right) 1.1 5.9 13.9 3.3 -3.0 0.0 0.0 1.8 3.2 -1.4 3.4 0.3 -0.5 2.5 2.0 -3.3 1.2 -3.3 -3.7
Arm fat percentage (left) 1.3 5.1 12.4 -2.7 3.1 0.0 0.0 -1.5 -2.7 2.5 -2.8 -0.6 1.1 -3.5 -2.2 2.6 -1.8 3.0 1.9
Average weekly red wine intake 0.8 1.1 3.2 1.4 -1.4 0.0 0.0 -0.8 1.3 0.3 1.4 -0.0 -0.5 1.2 1.8 -1.4 1.0 -1.2 -0.7
Handedness (chirality/laterality): Left-handed 0.4 0.5 1.9 -1.0 0.8 0.0 0.0 -0.1 -0.9 1.0 -1.0 -0.2 0.8 -0.2 0.0 0.9 0.0 0.8 1.4
Mood swings 3.0 5.4 10.1 2.9 -2.9 0.0 0.0 1.4 2.9 -1.3 2.9 1.7 -2.0 2.5 2.6 -2.4 2.7 -3.2 -2.6
Loneliness, isolation 0.8 1.1 4.1 1.1 -1.3 0.0 0.0 0.2 1.2 -1.0 1.2 -0.7 -0.2 1.1 2.0 -0.9 1.2 -1.4 -0.2
Long-standing illness, disability or infirmity 0.1 0.2 0.9 0.0 -0.0 0.0 0.0 0.9 0.2 -0.4 -0.0 0.4 -0.1 -0.6 -0.3 0.1 0.6 -0.2 -0.9
Ever had bowel cancer screening 0.5 0.6 2.4 0.6 -0.4 0.0 0.0 1.3 0.6 0.2 0.7 -0.7 -1.6 0.2 1.0 0.0 1.2 -0.7 -0.2
Diabetes diagnosed by doctor 0.3 0.6 2.2 0.5 -0.8 0.0 0.0 0.7 0.8 -1.0 0.7 -0.1 -0.6 0.5 0.8 -0.4 0.7 -1.1 -1.5
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.6 2.9 0.1 -0.1 0.0 0.0 -0.3 0.1 -1.6 0.1 -1.7 0.3 0.2 -1.1 -0.2 -0.5 0.3 -1.2
Friendships satisfaction 0.7 0.9 2.5 -1.3 1.0 0.0 0.0 -0.7 -1.2 -0.1 -1.3 -1.6 0.0 -0.5 -0.5 1.3 -0.9 1.2 0.8
Qualifications: nursing, teaching 1.7 2.7 8.1 -1.6 2.0 0.0 0.0 -2.9 -1.5 1.3 -1.6 -1.1 -1.0 -2.3 -1.8 1.4 -1.8 2.0 1.3
Commuting to job workplace: Walk 1.5 1.6 7.2 -0.3 0.6 0.0 0.0 0.2 -0.4 -2.1 -0.6 -2.2 0.2 -0.8 -2.3 0.3 -2.7 0.6 -1.4
Eye problems/disorders: Cataract 0.8 0.9 3.7 -0.5 0.7 0.0 0.0 0.6 -0.7 -1.2 -0.8 -1.7 0.6 -0.6 -1.6 0.3 -1.9 0.4 -0.5
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 2.3 -0.3 0.3 0.0 0.0 1.3 -0.4 1.5 -0.2 -0.8 0.1 0.0 0.4 0.2 1.1 0.3 0.9
Medication for cholesterol 0.6 0.9 9.5 0.3 0.3 0.0 0.0 -3.1 0.1 -0.2 0.4 -1.1 -0.6 -0.1 -0.2 -0.6 -1.2 0.8 0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.5 1.6 -0.8 0.6 0.0 0.0 0.2 -0.4 -1.1 -0.6 -0.7 0.8 -0.6 -0.6 1.0 -1.3 0.7 0.4
Back pain experienced in last month 0.4 0.6 2.2 0.2 -0.2 0.0 0.0 1.4 0.7 -0.0 0.6 0.5 -1.5 -0.4 1.0 0.1 0.7 -1.0 -1.0
Mineral and other dietary supplements 0.3 0.3 1.2 -0.5 0.6 0.0 0.0 -0.3 -0.7 0.8 -0.5 -0.6 -0.2 -0.4 -1.1 0.8 -0.5 0.5 0.7
Breast cancer (self-reported) 0.2 0.3 3.5 0.1 -0.0 0.0 0.0 0.4 -0.6 -0.2 -0.1 0.2 -0.1 0.0 -1.9 -0.1 -0.3 0.2 -0.1
Asthma (self-reported) 0.2 0.5 3.4 -0.4 0.4 0.0 0.0 1.9 -0.6 0.5 -0.8 -1.1 0.9 -0.3 0.1 0.7 0.1 0.2 -0.0
Osteoporosis (self-reported) 0.2 0.3 1.0 0.7 -0.5 0.0 0.0 0.9 0.6 -0.6 0.5 -0.2 0.5 0.6 1.0 -0.7 0.5 -0.2 0.2
Osteoarthritis (self-reported) 0.2 0.3 1.3 -0.7 0.6 0.0 0.0 0.1 -0.5 0.8 -0.7 0.1 -0.2 -1.2 -0.2 0.8 0.3 0.2 0.2
Medication: Aspirin 0.3 0.4 2.9 -0.4 0.2 0.0 0.0 1.7 -0.3 1.1 -0.3 0.3 0.7 -0.4 -0.0 0.4 1.2 -0.2 0.0
Medication: Gliclazide 0.2 0.2 0.7 -0.3 -0.4 0.0 0.0 0.4 0.4 0.1 0.2 0.4 0.1 0.2 0.8 0.3 0.7 -0.9 -0.3
Illnesses of father: None of the above (group 1) 0.8 1.0 6.2 0.8 -0.7 0.0 0.0 -0.2 1.3 -0.8 1.3 0.8 -0.5 0.2 1.1 -0.9 0.5 -1.0 -2.5
Smoking status: Current 0.3 0.5 1.5 0.7 -0.6 0.0 0.0 0.9 1.0 -0.2 0.8 1.2 -0.1 0.6 0.7 -0.7 0.5 -1.0 -0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.6 3.4 7.7 2.2 -2.0 0.0 0.0 -0.0 2.4 -2.6 2.2 -0.4 -2.5 2.8 1.0 -2.4 0.1 -1.6 -2.1
Whole body water mass 1.8 10.5 20.1 4.2 -4.2 0.0 0.0 2.7 4.1 -2.0 4.4 0.8 -0.4 3.7 2.9 -4.3 2.2 -4.5 -4.4
Leg predicted mass (right) 1.0 5.6 13.5 3.2 -3.0 0.0 0.0 1.7 3.1 -1.3 3.3 0.2 -0.5 2.4 1.9 -3.3 1.1 -3.2 -3.7
Arm fat mass (left) 0.2 0.8 2.4 -0.9 1.1 0.0 0.0 -0.3 -0.9 1.6 -1.0 -0.0 0.9 -1.5 -0.9 0.7 -0.6 1.0 0.2
Number of self-reported non-cancer illnesses 0.9 1.6 9.6 0.9 -1.0 0.0 0.0 2.5 0.9 0.2 0.8 0.6 -0.8 0.8 1.5 -0.5 3.1 -1.7 -0.6
Average weekly champagne plus white wine intake 0.5 0.7 2.6 -0.9 0.8 0.0 0.0 -1.6 -1.0 0.1 -0.8 -0.7 0.4 -0.5 -1.1 0.3 -1.4 1.2 0.8
Miserableness 2.9 4.9 10.1 2.5 -2.8 0.0 0.0 -0.0 3.2 -2.0 2.9 0.6 -1.2 2.6 2.8 -2.4 2.7 -2.9 -2.2
Guilty feelings 1.9 2.9 5.2 2.0 -2.3 0.0 0.0 0.2 2.1 -0.5 2.3 1.8 -0.6 1.7 2.2 -2.1 2.2 -2.1 -1.3
Wears glasses or contact lenses 0.1 0.1 1.1 0.3 -0.1 0.0 0.0 -0.3 0.2 0.5 0.2 1.0 0.4 -0.1 0.6 -0.1 0.2 0.1 0.4
Ever taken oral contraceptive pill 4.0 4.4 8.0 2.7 -2.6 0.0 0.0 -1.1 2.6 -2.3 2.4 -1.1 0.8 2.5 1.6 -2.8 2.0 -2.8 -2.7
Hearing aid user 0.9 1.0 2.2 1.4 -1.2 0.0 0.0 -0.1 1.1 -0.4 1.0 -1.1 0.0 1.5 0.6 -1.2 1.3 -1.2 -1.1
Mother’s age at death 0.2 0.2 0.7 -0.8 -0.2 0.0 0.0 -0.1 -0.1 0.8 -0.2 0.8 0.7 0.3 0.4 0.6 0.0 -0.1 0.4
Financial situation satisfaction 0.3 0.4 2.2 -0.6 0.0 0.0 0.0 0.5 0.2 -1.0 -0.0 -0.0 -1.5 -0.5 1.0 0.6 0.3 -0.1 -0.2
Tinnitus: Yes, now most or all of the time 1.3 1.6 4.5 1.5 -1.8 0.0 0.0 1.2 1.5 -0.8 1.6 -0.2 -0.2 2.1 1.0 -1.1 1.1 -1.7 -1.4
Commuting to job workplace: Public transport 0.7 0.9 2.3 1.1 -1.1 0.0 0.0 1.4 1.1 -0.5 1.3 0.1 -0.2 1.5 0.8 -1.0 1.1 -1.2 -0.7
Eye problems/disorders: Glaucoma 0.6 0.8 3.4 -0.8 0.7 0.0 0.0 -1.1 -0.8 1.8 -0.8 -0.4 -1.0 -0.1 0.3 1.1 1.1 0.6 1.1
Medication: Blood pressure 0.4 0.8 8.5 0.1 -0.6 0.0 0.0 2.9 0.2 0.2 0.2 0.9 -0.4 0.1 0.0 0.2 1.2 -0.9 -0.7
Pain type(s) experienced in last month: Hip pain 0.7 0.9 4.2 -1.2 1.3 0.0 0.0 -0.0 -1.0 0.1 -1.2 0.1 0.6 -2.1 -1.1 0.9 -0.9 1.1 0.8
Supplements: Fish oil (including cod liver oil) 0.3 0.3 3.0 -0.2 0.0 0.0 0.0 0.9 -0.1 -0.1 -0.2 1.7 0.4 -0.2 0.9 -0.1 0.7 -0.1 0.3
High cholesterol (Self-reported) 0.1 0.1 1.2 0.1 0.1 0.0 0.0 1.1 -0.1 -0.3 -0.3 -0.3 0.1 -0.2 0.0 0.2 -0.0 -0.2 -0.6
Medication: Bendroflumethiazide 0.7 1.0 4.3 -1.2 0.9 0.0 0.0 0.5 -1.1 2.1 -1.1 0.9 0.2 -1.1 -0.2 1.2 0.5 1.0 1.3
Medication: Paracetamol 0.2 0.4 1.3 -0.8 0.7 0.0 0.0 -0.9 -0.3 -0.2 -0.8 -0.7 0.2 -1.1 -0.3 0.9 -0.6 0.2 0.3
Medication: Lisinopril 0.5 0.7 3.0 0.8 -0.8 0.0 0.0 1.0 0.8 -0.2 0.8 -0.4 -0.4 1.1 -0.4 -0.6 0.7 -1.2 -1.7
Medication: Atorvastatin 0.1 0.2 1.2 0.3 0.2 0.0 0.0 -0.1 0.1 0.0 0.1 0.5 0.2 -1.1 -0.0 -0.1 -0.6 0.3 -0.8
Illnesses of father: High blood pressure 0.2 0.3 2.6 -0.0 0.4 0.0 0.0 -0.9 -0.1 0.4 -0.2 -1.6 -0.5 -0.5 -0.5 -0.0 -0.1 0.4 0.2
Alcohol drinker status: Never 1.7 2.1 4.3 1.4 -1.7 0.0 0.0 1.9 1.5 -0.5 1.2 -0.3 -2.1 2.0 1.7 -1.2 2.0 -1.8 -0.7
Ever smoked 0.3 0.5 4.6 -0.4 0.3 0.0 0.0 -2.1 0.1 -1.3 0.1 0.5 -0.4 -0.5 0.1 0.4 -0.1 0.4 -0.1
Basal metabolic rate 1.5 8.1 15.6 3.7 -3.6 0.0 0.0 2.2 3.6 -1.6 3.8 0.6 -0.5 3.2 2.6 -3.8 1.9 -3.9 -3.9
Leg fat percentage (left) 0.7 2.7 6.2 -2.0 2.2 0.0 0.0 -1.0 -2.0 1.9 -2.2 -0.6 1.0 -2.5 -1.1 1.8 -0.8 2.4 1.5
Arm fat-free mass (left) 2.0 10.3 18.7 4.1 -4.2 0.0 0.0 2.6 4.0 -2.1 4.3 1.1 -0.5 3.7 2.9 -4.3 2.4 -4.3 -4.2
Number of operations (self-reported) 2.8 4.1 8.8 2.4 -2.4 0.0 0.0 1.5 2.5 -1.2 2.8 -0.5 -1.1 2.3 1.9 -2.2 3.0 -2.6 -2.4
Average weekly beer plus cider intake 0.4 0.6 3.1 -0.7 0.8 0.0 0.0 0.8 -0.9 0.7 -1.2 0.1 1.8 -0.7 -0.3 0.6 0.0 1.1 0.6
Irritability 1.3 2.2 4.6 1.5 -1.8 0.0 0.0 0.2 2.1 -1.7 1.5 -0.8 -1.6 1.4 1.6 -1.2 1.4 -2.1 -2.0
Risk taking 0.2 0.3 1.1 0.6 -0.5 0.0 0.0 0.9 0.4 -0.9 0.5 -0.4 0.6 -0.1 -0.0 -0.8 -0.0 -0.1 -1.0
Ever had prostate specific antigen (PSA) test 1.3 1.5 5.6 1.4 -1.2 0.0 0.0 1.2 1.2 -0.9 1.4 2.4 -0.9 0.7 0.8 -1.0 2.1 -1.2 -1.0
Fractured/broken bones in last 5 years 2.1 2.7 6.0 2.4 -2.0 0.0 0.0 1.6 2.1 -1.1 2.3 -0.3 -0.6 1.5 1.5 -2.5 1.4 -2.3 -1.7
Age started oral contraceptive pill 0.2 0.3 2.3 0.1 -0.6 0.0 0.0 0.5 0.1 -0.8 0.1 -0.0 1.5 0.6 -0.6 -0.1 -0.0 -0.7 -0.3
Diastolic blood pressure, automated reading 0.2 0.6 2.0 0.5 -1.0 0.0 0.0 1.0 0.9 -1.0 0.7 -0.3 0.1 1.4 0.1 -0.8 -0.1 -1.2 -1.1
Ever depressed for a whole week 0.3 0.4 2.5 -0.5 0.4 0.0 0.0 -0.2 -0.5 0.6 -0.6 -1.0 1.6 -0.1 -0.4 0.1 0.1 0.1 1.0
Unable to work because of sickness or disability 0.3 0.4 2.1 0.9 -0.4 0.0 0.0 0.8 0.5 -1.4 0.5 0.0 -0.0 0.1 -0.1 -0.9 1.0 -0.7 -0.5
Commuting to job workplace: Cycle 1.8 2.2 6.6 1.4 -1.9 0.0 0.0 2.6 1.4 -0.5 1.6 0.7 -0.7 1.8 1.0 -1.4 2.2 -2.1 -1.1
Myopia 0.3 0.4 2.0 -0.5 0.6 0.0 0.0 -1.2 -0.3 -0.4 -0.3 -0.1 -0.4 -0.8 0.1 0.4 -0.6 0.9 1.4
Vascular/heart problems diagnosed by doctor 0.2 0.4 2.3 -0.2 0.1 0.0 0.0 -1.5 0.1 -1.4 0.2 0.7 -0.5 -0.3 0.1 -0.2 -0.9 0.2 1.0
Cholesterol lowering medication 0.9 1.3 9.4 0.6 -1.0 0.0 0.0 3.1 0.8 -0.9 0.5 0.3 -1.4 0.8 0.9 -0.2 1.0 -1.2 -1.4
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 3.2 -0.4 -0.0 0.0 0.0 0.5 0.3 -0.9 -0.1 -1.8 -0.6 -0.1 -0.6 0.3 -0.6 0.1 -1.2
Pain experienced in last month 0.8 1.3 4.8 1.8 -1.5 0.0 0.0 0.3 0.9 -0.7 1.4 -0.3 1.5 2.1 0.1 -2.2 0.0 -0.8 0.0
Supplements: Calcium 0.7 0.7 3.6 -0.3 0.5 0.0 0.0 -1.9 0.3 -0.9 -0.4 -0.9 -1.7 0.1 0.9 -0.1 -1.1 0.3 1.0
Basal cell carcinoma (self-reported) 0.3 0.4 1.6 -0.4 0.2 0.0 0.0 -1.2 -0.2 0.9 -0.2 1.0 0.1 0.3 1.0 0.2 0.5 0.4 1.3
Heart attack/myocardial infarction (self-reported) 0.2 0.2 0.8 -0.4 0.5 0.0 0.0 0.3 -0.7 0.7 -0.5 0.0 0.5 -0.9 -0.5 0.1 0.4 0.8 0.4
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 1.3 0.3 -0.3 0.0 0.0 1.1 0.5 -1.0 0.3 -0.3 -0.9 0.7 0.9 -0.1 -0.1 -0.6 -0.9
Heart disease (siblings) 0.1 0.1 0.4 -0.2 -0.2 0.0 0.0 0.5 0.0 0.6 0.1 0.3 0.5 -0.4 0.2 0.2 0.6 -0.2 -0.2
Alcohol drinker status: Previous 3.5 4.0 9.9 2.1 -2.4 0.0 0.0 3.1 2.3 -1.6 2.2 0.3 -0.7 2.4 2.3 -2.1 2.4 -2.8 -1.2
Pack years of smoking 0.2 0.2 1.1 0.0 0.1 0.0 0.0 0.9 -0.1 -0.2 0.1 1.1 -0.9 -0.6 -0.3 0.2 0.8 -0.1 -0.1
Impedance of whole body 1.1 5.7 11.2 -3.0 3.0 0.0 0.0 -2.9 -2.9 1.3 -2.7 0.7 -0.4 -2.6 -2.6 3.2 -1.5 3.4 2.9
Leg fat mass (left) 0.1 0.4 1.4 -0.7 0.8 0.0 0.0 -0.1 -0.6 1.2 -0.6 0.1 0.6 -1.1 -0.1 0.5 -0.1 0.8 -0.0
Arm predicted mass (left) 1.9 9.6 18.1 3.9 -4.1 0.0 0.0 2.7 3.9 -1.9 4.1 1.1 -0.6 3.5 2.8 -4.1 2.2 -4.3 -4.1