[Hub]/) : Traits : Trunk fat-free mass :

chr20:19,318,837-22,188,798

Best TWAS P=2.65e-19 · Best GWAS P=7.39e-21 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex C20orf26 0.20 0.17 lasso 6 0.18 4.9e-21 -6.4 6.2 4.8e-10 -0.06 0.38 0.62 TRUE
2 CommonMind Brain Pre-frontal Cortex INSM1 0.07 0.00 bslmm 522 0.02 2.2e-03 4.3 6.2 6.7e-10 -0.01 0.09 0.08 FALSE
3 CommonMind Brain Pre-frontal Cortex PLK1S1 0.08 0.01 lasso 3 0.04 1.1e-05 7.7 7.2 5.3e-13 0.82 0.02 0.98 FALSE
4 GTEx Artery Tibial PLK1S1 0.07 0.08 enet 10 0.08 4.0e-07 9.3 9.0 2.6e-19 0.97 0.01 0.99 TRUE
5 GTEx Esophagus Mucosa PLK1S1 0.11 0.11 lasso 5 0.09 7.8e-07 7.3 7.3 3.5e-13 0.83 0.12 0.87 FALSE
6 GTEx Heart Atrial Appendage PLK1S1 0.15 -0.01 lasso 4 0.00 6.1e-01 1.1 6.2 4.0e-10 0.56 0.05 0.40 FALSE
7 GTEx Skin Not Sun Exposed Suprapubic PLK1S1 0.21 0.09 lasso 6 0.12 5.3e-07 9.0 7.9 3.1e-15 0.93 0.06 0.93 FALSE
8 GTEx Skin Sun Exposed Lower leg PLK1S1 0.15 0.13 enet 10 0.15 3.9e-12 7.4 7.0 2.8e-12 0.83 0.92 0.08 FALSE
9 GTEx Testis PLK1S1 0.64 0.34 enet 33 0.39 1.0e-18 7.4 7.7 1.5e-14 0.79 0.65 0.35 FALSE
10 GTEx Whole Blood PLK1S1 0.08 0.04 enet 9 0.02 4.0e-03 7.4 8.1 7.2e-16 0.89 0.06 0.94 FALSE
11 ROSMAP Brain Pre-frontal Cortex NKX2-2 0.11 0.06 lasso 5 0.06 2.3e-08 5.0 -5.6 1.9e-08 -0.61 1.00 0.00 FALSE
12 ROSMAP Brain Pre-frontal Cortex INSM1 0.19 0.10 lasso 5 0.14 4.3e-17 3.3 5.3 1.3e-07 0.07 1.00 0.00 TRUE
13 YFS Blood CRNKL1 0.21 0.25 enet 18 0.27 2.3e-89 -6.4 -6.2 6.3e-10 0.03 0.34 0.66 FALSE
14 YFS Blood XRN2 0.34 0.61 lasso 10 0.61 3.5e-258 5.5 5.5 3.2e-08 0.49 1.00 0.00 FALSE
15 The Cancer Genome Atlas Breast Invasive Carcinoma PLK1S1 0.05 0.07 enet 9 0.07 5.5e-15 7.1 7.8 7.4e-15 0.88 0.16 0.84 FALSE
16 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma NAA20 0.04 0.01 enet 11 0.02 7.6e-04 -6.9 -5.6 2.6e-08 0.03 0.01 0.62 FALSE
17 The Cancer Genome Atlas Brain Lower Grade Glioma NKX2-2 0.02 0.03 lasso 4 0.02 1.0e-03 5.0 -5.3 1.2e-07 -0.57 0.03 0.70 FALSE
18 The Cancer Genome Atlas Lung Adenocarcinoma PLK1S1 0.04 0.03 blup 64 0.04 4.0e-05 7.4 8.3 8.8e-17 0.88 0.12 0.87 FALSE
19 The Cancer Genome Atlas Pancreatic Adenocarcinoma PLK1S1 0.09 0.02 blup 64 0.05 3.1e-03 7.7 8.3 8.3e-17 0.78 0.03 0.53 FALSE
20 The Cancer Genome Atlas Prostate Adenocarcinoma PLK1S1 0.19 0.12 enet 14 0.13 4.3e-13 7.4 7.4 1.0e-13 0.80 0.91 0.09 FALSE
21 The Cancer Genome Atlas Thyroid Carcinoma PLK1S1 0.06 0.04 lasso 3 0.04 1.5e-04 7.4 7.6 3.9e-14 0.85 0.16 0.59 FALSE